ライフサイエンスコーパス: selectively block

1 The tumor cell uptake can be selectively blocked.

2 in long lasting nonkilling cell couples was selectively blocked.

3 -promoting cytokine if the Stat1 function is selectively blocked.

4 nd reservoirs--transmission to the cocoon is selectively blocked.

5 A new approach for the synthesis of selectively blocked 3-amino-3-deoxyaldopentoses is prese

6 ithin a given cell can lead to strategies to selectively block a function.

7 early limited by the lack of inhibitors that selectively block a single kinase implicated in neoplast

8 ate (Gleevec); Novartis], which potently and selectively blocks Abl kinase activity, implicate AFKs i

9 bitory kappa B (IkappaB) kinase (dnIkk) that selectively blocked activation of NF-kappaB caused loss

10 Here we report that TLY012 selectively blocks activation of dermal fibroblasts and

11 injections of pharmacologic agents known to selectively block activity of particular cells and circu

12 Co-administration/pretreatment of naloxone selectively blocked activity in pulvinar, pons and poste

13 tics of both analgesia and algesia; naloxone selectively blocks activity in areas associated with alg

14 d thus we used antisense oligonucleotides to selectively block AH VIP production in male and female w

15 entrations of picrotoxin (</= 30 muM), which selectively blocked alpha homomeric GlyRs.

16 used a polyamine agent, philanthotoxin, that selectively blocks AMPA receptors lacking GluR2 subunits

17 To identify drug targets to selectively block aromatase and estrogen production in b

18 is a bona fide target whose inhibition would selectively block aromatase expression in breast, while

19 ow dose of amiloride used in our experiments selectively blocked ASICs, whereas the high dose blocked

20 c T lymphocyte antigen 4 (CTLA-4) engagement selectively blocked augmentation of gene regulations by

21 tigen-specific immunotherapy, an approach to selectively block autoimmune diabetes, generally decline

22 roscopy suggested that amelogenin assemblies selectively blocked b-axial development, resulting in th

23 e have designed two CD28 peptide mimics that selectively block B7:CD28 interactions.

24 ore, we developed a functional CD28 mimic to selectively block B7:CD28 interactions.

25 TLA4-Ig or mutant CTLA4-Ig (Y100F-Ig), which selectively blocks B7.1.

26 Thus, NCoRi selectively blocked basal transcription of several thyro

27 activation of NF-kappaB in FM B cells, which selectively blocked BCR stimulation of cell survival and

28 IgG) that mimics the BDNF receptor, TrkB, to selectively block BDNF in the hippocampus during 3 days

29 membrane-proximal C terminus dileucine motif selectively blocked beta(2)-AR interaction with Rab8, wh

30 tions in regulating CD8(+) T-cell responses, selectively blocking beta-catenin with a pharmacological

31 ide and benzisothiazolone derivatives, which selectively block binding of the estrogen receptor to it

32 termini of a protein that it is possible to selectively block binding surfaces on the protein when i

33 Hydrophobic substitutions for Arg343 selectively blocked binding of a monoclonal antibody (Hy

34 vator p300, whereas the helical domain alone selectively blocks binding to p300.

35 inculin, and a point mutation in this region selectively blocks binding to the Arp2/3 complex.

36 Hu proteins, we have shown that Hu proteins selectively block both cleavage and poly(A) addition at

37 In human platelet-rich plasma (PRP), RvE1 selectively blocked both ADP-stimulated and thromboxane

38 en hENT1 activity on the plasma membrane was selectively blocked by 10 nm nitrobenzylthioinosine.

39 I(K,f) was selectively blocked by 30 nm IbTx but was unaffected by

40 omain mediates these actions of Homer and is selectively blocked by a peptide that mimics the Homer l

41 Zap70 mutant whose catalytic activity can be selectively blocked by a small-molecule inhibitor.

42 in acutely isolated slice preparations were selectively blocked by antagonists of Kv1.3, illustratin

43 ate (cGMP) levels, with all of these effects selectively blocked by CK2 inhibitors.

44 is permeable to K(+) and Na(+) ions, and is selectively blocked by Cs(+) and ZD7288.

45 ated by increased firing frequencies, and is selectively blocked by cyclosporin A and FK506.

46 on progesterone treatment, and this was also selectively blocked by dynasore.

47 stimulate feeding which is respectively and selectively blocked by GABA(A) (bicuculline) and GABA(B)

48 anosine incorporation into nucleic acids was selectively blocked by Imm-H with no effect on guanine,

49 formation, and oocyte fate determination are selectively blocked by low levels of microtubule-depende

50 C proliferation and ERK phosphorylation were selectively blocked by neutralization of AREG.

51 al tegmental area (VTA); these responses are selectively blocked by pretreatment with corresponding G

52 The slow component of inhibition was selectively blocked by regulator of G protein signalling

53 showed that these epileptogenic effects are selectively blocked by the alpha-amino-3-hydoxy-5-methyl

54 nt potentiation through a mechanism that was selectively blocked by the BDNF scavenger TrkB-Fc, the T

55 When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus tox

56 The fast component of inhibition was selectively blocked by the Gbetagamma-binding region of

57 -1 promoter that was activated by MEKK-1 and selectively blocked by the MEK1,2 inhibitor PD98059.

58 ces Xenopus laevis oocyte maturation that is selectively blocked by two ras-p21 peptides, 35-47, also

59 contrast, when the cervical generators were selectively blocked, C8 DR stimulation was unable to act

60 Consistent with this, selectively blocking calcium-permeable AMPARs with Naspm

61 Micromolar Ni(2+), an agent that selectively blocks CaV3.2 but not CaV1.2/CaV3.1, was fir

62 glycosphingolipids (GSLs; a subgroup of SLs) selectively blocked caveolar endocytosis and decreased c

63 tides with optimum PPII helical content that selectively block CD80-receptor interactions.

64 n LFA-1 and was prevented by antibodies that selectively block cell adhesion mediated by ICAM-1.

65 ion of Cdc34 protein levels in early mitosis selectively blocked centromere protein E (CENP-E), a mit

66 B cells 15 h after LPS plus IL-4 stimulation selectively blocked Cepsilon GLT expression and IgE secr

67 eaving antisense oligonucleotides (ASOs), we selectively blocked CGG RAN.

68 Furthermore, selectively blocking CICR with ryanodine slowed the Ca2+

69 act directly on purified gamma-secretase to selectively block cleavage of APP- but not Notch-based s

70 Owing to their capacity to selectively block contact system-driven coagulation, bot

71 Hence, ARM1 selectively blocks conversion of LTA4 into LTB4, althoug

72 N(2)O selectively blocked currents arising from the Ca(v)3.2 b

73 Cx43 gap junctions, indicating that spermine selectively blocks Cx40 gap junctions.

74 The antimalarial drug mefloquine, which selectively blocks Cx50 and not Cx46 GJs, shows the same

75 pharmacologic characterization of nanobodies selectively blocking CXCR2, the most promiscuous of all

76 As with ERK activation, stromal contact selectively blocked delayed but not early Rap1 activatio

77 vel 19S regulatory particle inhibitor b-AP15 selectively blocks deubiquitylating activity of USP14 an

78 controls mesenchymal lineage progression by selectively blocking differentiation of osteoblasts and

79 Antisense oligodeoxynucleotides can selectively block disease-causing genes, and cancer gene

80 lation of N- and M-type currents but did not selectively block distinct G-protein pathways.

81 T), we were able to rapidly, reversibly, and selectively block dopamine D1 and D2 receptors (D1R and

82 with upstream deficiencies, suggesting that selectively blocking downstream targets may result in a

83 Here, we selectively block either postsynaptic firing in individu

84 ts alone and in complex with antibodies that selectively block either semaphorin or vascular endothel

85 defect at different interneuron subtypes, we selectively blocked either N-type or P/Q-type Ca(2+) cha

86 a history of dependence, and CRF antagonists selectively block emotionality, excessive alcohol drinki

87 identify two small-molecule inhibitors that selectively block endosome-to-Golgi retrieval of ricin a

88 negative reagents, it may now be possible to selectively block events postulated to be dependent on p

89 Low-dose NTX selectively blocks excitatory opioid receptors at their

90 the isolated variable domain of PKC-epsilon selectively blocked exogenous activation of the megakary

91 work indicated that yeast Srs2 DNA helicase selectively blocks expansions in vivo.

92 l interfering RNAs (siRNAs) can potently and selectively block expression of mutant K6a.

93 inical setting, RNA interference was used to selectively block expression of specific isoforms of Ras

94 Accordingly, SARI selectively blocks expression of the transformed state i

95 r the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription.

96 ools demonstrated that they were all able to selectively block F-LMP1-induced NFkappaB activity that

97 d Rac1 activation, thus, FHL2 inhibition can selectively block FAK-Rac1 axis in podocyte and prevent

98 development by stimulating cell survival by selectively blocking Fas-mediated apoptosis.

99 C-terminal FGF23(180-251) competitively and selectively blocked FGF23 action without disrupting PTH

100 These results indicate that INA selectively blocks fusion of the virus with the target c

101 C152S mutant in cells or providing a drug to selectively block GAPDH S-nitrosylation both made heme i

102 The drug CGP3466B, which potently and selectively blocks GAPDH nitrosylation and GAPDH-Siah bi

103 el small molecule Gbetagamma inhibitors that selectively block Gbetagamma-binding interactions, inclu

104 Rather, 4-methylumbelliferone directly and selectively blocked gene products associated with the pr

105 ells from GLT, we identified compound A that selectively blocked GLT-induced apoptosis in rat insulin

106 This was accomplished by selectively blocking group I or II receptors while unila

107 introduction of a bulkier valine side chain selectively blocked GTP binding by steric occlusion of t

108 t virus (AAV-HDAC3(Y298H)-v5), we found that selectively blocking HDAC3 deacetylase activity in eithe

109 These compounds establish the feasibility of selectively blocking hdm2-mediated ubiquitination of p53

110 udy suggest that the DRBP76:NF45 heterodimer selectively blocks HRV2 IRES-driven translation initiati

111 ve renewed hope for developing strategies to selectively block hyperactive RAS function.

112 markably low doses of CTX-B (10 ng/kg, s.c.) selectively blocks hyperalgesic effects elicited by morp

113 ata show that inhibiting Dectin-2 expression selectively blocked Hyphae-induced NF-kappaB, whereas in

114 e kinase Akt, a downstream effector of PI3K, selectively blocked IFN-beta-mediated induction of the b

115 of PI3-kinase activity by the drug LY294002 selectively blocked IGF- but not PDGF-mediated muscle ce

116 Selectively blocking IKCa1 channels with clotrimazole or

117 n primary Mphi, using short interfering RNA, selectively blocked IL-12 production and normalized the

118 When heme biosynthesis is selectively blocked in hem1Delta mutant cells, the heme

119 Temperature-sensitive aep3 mutants are selectively blocked in incorporating [(35)S]methionine i

120 When heme biosynthesis is selectively blocked in mutated S. pombe cells, their abi

121 ant cultures, we show that bud initiation is selectively blocked in the prospective respiratory regio

122 -catenin signaling by dominant negative Tcf4 selectively blocked in vitro transformation by Gli1.

123 Sterols selectively block incorporation of SCAP into these vesic

124 ally, we confirmed that the d-AP-5 infusions selectively blocked induction of long-term potentiation,

125 encodes a saturable restriction factor that selectively blocks infection by N-tropic or B-tropic mur

126 hat bind to G protein betagamma subunits and selectively block interactions between betagamma subunit

127 lated with IL-13 in the presence of Abs that selectively block interactions of IL-13 with IL-13Ralpha

128 Xestospongin C (XeC) was shown to selectively block IP(3)-induced Ca(2+) release and IP(3)

129 Jip1 gene (Thr(103) replaced with Ala) that selectively blocks JIP1-mediated JNK activation.

130 2+) concentrations caused channel occlusion, selectively blocking K(+) fluxes towards the cytoplasm.

131 esic assays; however, gene knockout of JNK 1 selectively blocked kappa-receptor inactivation, whereas

132 Concanavalin A (Con A), which selectively blocks KAR desensitization, markedly increas

133 nyl)bis(azanediyl )) diethaneamine.2HCl] (8) selectively blocked Kv1.1 channels (IC50 approximately 1

134 le of presynaptic Kv1 channels in the rat by selectively blocking Kv1.1 and Kv1.2 containing channels

135 n showed that low concentrations of A-803467 selectively block "late" sodium current and shorten acti

136 tumor glucocorticoid activity, which in turn selectively blocks local COX-2 activity.

137 mouse embryonic fibroblasts and macrophages selectively blocks LPS-induced production of the pro-inf

138 In TG mice whose endothelial NF-kappaB was selectively blocked, LPS caused significantly less hypot

139 studies confirmed that these autoantibodies selectively blocked M(3) receptor activation.

140 (peptide 5b) and (168)P-I(185) (peptide 6a), selectively blocked mAb7 binding to soluble CD9 and to C

141 Furthermore, erlotinib selectively blocked mammalian target of rapamycin signal

142 itors, orthovanadate and phenylarsine oxide, selectively block mGluR-LTD induced by application of th

143 Disruption of mGluR-Homer interactions selectively blocks mGluR activation of the phosphoinosit

144 Here, we found that selectively blocking mGluR5 significantly reduced the ba

145 Selectively blocking mitogen-activated protein kinase (M

146 ptor inactivation, whereas deletion of JNK 2 selectively blocked MOR inactivation.

147 We examined infarct volume after selectively blocking muscarinic M1 receptors with dicycl

148 tylcholinergic influence over D1R-neurons by selectively blocking muscarinic M4 receptors in the NAc-

149 Cnk1 is a druggable target whose inhibition selectively blocks mutant KRas activation, making Cnk1 a

150 t blocks all sulfation or with an siRNA that selectively blocks N-sulfation significantly reduced erb

151 Ziconotide (formerly SNX-111) selectively blocks N-type voltage-sensitive calcium chan

152 We suggest the ideal myotonia therapy would selectively block NaPIC and spare the transient Na(+) cu

153 We used TTX and mu-conotoxin GIIIB to selectively block Nav1.4 in SD muscle and found that the

154 ntified mutations on the capsid surface that selectively block NC envelopment without affecting NC ma

155 TTX at 100 nm, which selectively blocks neuronal isoforms of Na+ channels, pr

156 r study demonstrates that reovirus infection selectively blocks NF-kappaB, likely to counteract its a

157 Drugs that selectively block nitric oxide synthase (NOS) 2 enzyme a

158 mbinant monoclonal anti-AQP4 antibodies that selectively block NMO-IgG binding to AQP4.

159 lls from our patient and PEL cell lines, AZT selectively blocked nuclear entry of the NF-kappaB heter

160 echanistic studies showed that sulfasalazine selectively blocks nuclear factor-kappaB-dependent gene

161 n cells with stratified dendrites, this drug selectively blocks On responses.

162 findings identify a therapeutic strategy to selectively block oncogenic KRas activity through the PH

163 More recent strategies aimed at selectively blocking one of the key factors upstream rat

164 on, as established using a novel approach to selectively block only the sustained actin dynamics.

165 line food intake, whereas intra-BLA muscimol selectively blocked only DAMGO-induced food intake, leav

166 y reconstituting type I NKT cells as well as selectively blocking or activating type II NKT cells wit

167 limited, largely because of difficulties in selectively blocking other inhibitory neural pathways.

168 develop a new class of Notch inhibitors that selectively block outcomes that depend on Notch dimeriza

169 Based on our results, selectively blocking p38 activation with the SB202190 in

170 of TF signaling, antibody inhibition of EPCR selectively blocked PAR activation by the ternary TF-FVI

171 Finally, we find cathepsin inhibitors selectively block particle-induced NLRP3 activation, ind

172 smic face of a G-protein-coupled receptor to selectively block pathologic signaling while preserving

173 ents suggest a potential therapeutic role of selectively blocking PD-L1 in the recipient.

174 P/ABP and PICK1) and the phospho form (which selectively blocks PICK1) attenuated LTD induction by gl

175 ution containing 10 microm Ruthenium Red (to selectively block plasma membrane-localized receptors) a

176 Manipulations that selectively block post-Golgi trafficking halt dendrite g

177 These results show that selectively blocking presynaptic A2A receptors could pro

178 Pertussis toxin, a G(i/o) inhibitor, selectively blocked priming by C3a but had no effect on

179 tanding of these issues may point to ways of selectively blocking pro-death signalling in neurologica

180 -circuiting mechanism wherein the LRR domain selectively blocks productive aminolysis, but not the no

181 ls Hsp70 and MEK inhibitor combinations that selectively block proliferation of AML12(DNAJ-PKAc) cell

182 ografts demonstrated that inhibition of CHK1 selectively blocked proliferation of cells and tumors ex

183 pendent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of vari

184 ta defects with combinatorial drug treatment selectively blocked proliferation of wild-type aneuploid

185 ive small molecule ERalpha biomodulator that selectively blocks proliferation of drug-resistant ERalp

186 idues 119-136 of hamster PrP (Ha119-136) can selectively block PrP-res formation in cell-free systems

187 Inhibition of CaMKII selectively blocked recycling and caused intracellular a

188 lds a dominant-negative PACS-1 molecule that selectively blocks retrieval of PACS-1-regulated cargo m

189 Moreover, we generated anti-LRP4 antibodies selectively blocking sclerostin facilitator function whi

190 w-dose naltrexone or nor-binaltorphimine may selectively block signaling by endogenous GM1-sensitized

191 ken together, these data indicate that SOCS3 selectively blocks signaling by IL-6, thereby preventing

192 ted in non-neuronal cells, and that RGS2 can selectively block slow muscarinic inhibition while leavi

193 Together these results suggest that RGS2 selectively blocked slow inhibition by functioning as an

194 rupted Gapds expression by gene targeting to selectively block sperm glycolysis and assess its relati

195 tering common dynamic behaviors derived from selectively blocked splicing reactions, SiMCAn was able

196 The ability of RGS2 and PLCbeta1ct to selectively block stimulation indicates these proteins f

197 ing of the antibody had a functional effect, selectively blocking store-operated Ca(2+) channel activ

198 -1460, an inhibitor of GluA2-lacking AMPARs, selectively blocked synaptic excitation of FSIs but not

199 rly endosomal sorting in hippocampal neurons selectively blocks synaptic clustering of PSD95beta but

200 To selectively block T reg cell function in the skin, we re

201 for organ-transplant recipients are used to selectively block T-cell activity without global immunos

202 STAT5 signaling in activated CD4(+) T cells selectively blocked T(FH) cell differentiation and GCs,

203 These data indicate that N(2)O selectively blocks T-type but not HVA Ca(2+) currents in

204 nstrate that inhibiting PKC activity in vivo selectively blocks tanning and reduces basal pigmentatio

205 By reconstructing or selectively blocking TCR-stimulated signaling pathways,

206 affect leukocyte adhesion or locomotion but selectively blocks TEM, suggesting a role for upward arr

207 SE differentiation can be enhanced by selectively blocking TGFbeta-RI signaling.

208 This compound selectively blocked Th17 differentiation, significantly

209 ntial for the design of molecules that might selectively block the acyl-CoA binding site.

210 Specific antagonists that selectively block the alpha9alpha10 channel could be val

211 trum antiprotozoal and antifungal drugs that selectively block the capping of pathogen-encoded mRNAs.

212 therapeutic applications for molecules that selectively block the endogenous generation of fucosylat

213 Lin28A and Lin28B selectively block the expression of let-7 microRNAs and

214 y of 18-MC might be related to an ability to selectively block the expression of sensitized extracell

215 By using catechol to selectively block the fast current, we completely occlud

216 applied at concentrations and durations that selectively block the hyperpolarization-activated, catio

217 HCV infection, we showed that the compounds selectively block the initiation of replication of incom

218 tively slow binding antagonist, was found to selectively block the late signaling of the receptor, su

219 Amiloride was the first organic blocker to selectively block the native T-type calcium channel, but

220 ia a retrovirus-mediated gene transfer could selectively block the nuclear translocation of endogenou

221 ization experiments reveal that the peptides selectively block the nucleocytoplasmic shuttling of the

222 By applying inhibitors to selectively block the ubiquitin proteasome system (UPS)

223 of the RhoA-noninteracting PLD1 mutant I870R selectively blocked the A3 agonist (Cl-IBMECA, 10 nM)-in

224 t alter AQP4 activity, whereas bacopaside II selectively blocked the AQP1 water channel (IC50 18 muM)

225 munoprecipitation assay indicated that Eri-B selectively blocked the binding between NF-kappaB and th

226 yl)-1H-imidazole (i.c.v.)] and found that it selectively blocked the conditioned place aversion cause

227 endritic MAP1B increase by both pathways, it selectively blocked the DHPG- and not the NMDA-induced A

228 pEPSC amplitude in both control and cKO, but selectively blocked the enhancement of PTP in cKO, witho

229 We have selectively blocked the expression of LAMP-2A in mouse f

230 al injections of the GABAA agonist muscimol, selectively blocked the expression of SFiA while having

231 gene encoding the transcription factor T-bet selectively blocked the formation and antigen-specific r

232 trahydroisoquinoline-6,7-diol hydrochloride] selectively blocked the growth of C6 glioma leaving norm

233 On gene expression analysis, LY294002 selectively blocked the induction of a subset of 14 LPS/

234 The drug orteronel selectively blocked the lyase reaction of P450 17A1 but

235 recordings showed that linopirdine and XE991 selectively blocked the M current at neuroprotective con

236 We found that the D1 antagonist SCH23390 selectively blocked the maintenance but not the inductio

237 inical experiments demonstrated that PLX4032 selectively blocked the RAF/MEK/ERK pathway in BRAF muta

238 ptor antagonists xestospongin C and caffeine selectively blocked the second phase, but not the initia

239 (1)/S transition phase of the cell cycle and selectively blocked the serum-stimulated expression of c

240 Application of curare (d-tubocurarine) selectively blocked the Si3 synapses in both species.

241 otein WASP; inhibition of podosome formation selectively blocked the transcellular route of diapedesi

242 hat vaccine-elicited neutralizing antibodies selectively blocked the transmission of more sensitive c

243 igase activity, inhibits immune responses by selectively blocking the binding of NF-kappaB and STAT1

244 th this, enhancing S408/9 phosphorylation or selectively blocking the binding of the beta3 subunit to

245 mechanism underlying losartan's benefits by selectively blocking the effects of angiotensin IV (AngI

246 -paclitaxel in ABCB1 overexpressing cells by selectively blocking the efflux function of ABCB1, but n

247 auses significant defects in skeletogenesis, selectively blocking the elongation of skeletal rods tha

248 We tested the possibility of selectively blocking the excitability of primary sensory

249 arly-onset hyperphagia and severe obesity by selectively blocking the expression of the proopiomelano

250 mitochondrial JNK signaling is inhibited by selectively blocking the interaction between JNK and Sab

251 ism: they act at post-translational level by selectively blocking the maturation of the viral hemaggl

252 G354S) cells but not siRNA-treated cells, by selectively blocking the mutant channels.

253 However, strophanthidin, which selectively blocks the alpha1 isoform, was more effectiv

254 ibition of the alpha(4)-paxillin interaction selectively blocks the alpha4-dependent cellular respons

255 the alpha-4,3 family of alpha-conotoxins and selectively blocks the alpha9alpha10 nAChR subtype, in c

256 icking of internalized Ag-BCR complexes, and selectively blocks the BCR-mediated processing and prese

257 ICG-001 selectively blocks the beta-catenin/CBP interaction with

258 Knockdown of Rpl22 in zebrafish embryos selectively blocks the development of T lineage progenit

259 ptide was expanded into a larger ligand that selectively blocks the E17K Akt1 interaction with its PI

260 urther report that silencing of AgRP neurons selectively blocks the effect of cold exposure to increa

261 ging evidence that oxytocin specifically and selectively blocks the enhanced motivation for alcohol d

262 otope tracing methods, to establish that 968 selectively blocks the enhancement in glutaminolysis nec

263 ammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory ge

264 al reduction of striatal dopamine levels and selectively blocks the induction of long-term potentiati

265 lly stable peptidyl inhibitor, CNI103, which selectively blocks the interaction between calcineurin a

266 loped an anti-FGF19 monoclonal antibody that selectively blocks the interaction of FGF19 with FGFR4.

267 velopmentally regulated RNA binding protein, selectively blocks the processing of pri-let-7 miRNAs in

268 etion were largely blunted by AMD3100, which selectively blocks the SDF1 receptor CXCR4.

269 d invasion of diverse sarcoma cell types and selectively blocks the survival of bone sarcoma cells.

270 The K120R mutation selectively blocks the transcription of proapoptotic tar

271 Akt inhibition selectively blocks the transcriptional activation of Ets

272 6446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of

273 Saxitoxin (STX) selectively blocks the voltage-gated sodium channel at t

274 s, enhancing phosphorylation of GABA(A)Rs or selectively blocking their interaction with AP2 may prov

275 outes; however, because of the difficulty in selectively blocking these routes in vivo, their roles i

276 mate transporter (GLT-1) from VTA astrocytes selectively blocks these avoidance behaviors and spares

277 ubtypes, alpha3beta2 versus alpha6beta2, and selectively blocks these two subtypes when compared with

278 ect the inhibition of IP6K2, suggesting that selectively blocking this interaction could provide effe

279 rived compound, sparstolonin B (SsnB), which selectively blocks TLR2- and TLR4-mediated inflammatory

280 FP7 selectively blocked TLR4 stimulation, but not TLR1/2, TL

281 ain inhibitors, antimycin A and myxothiazol, selectively blocked TNF-alpha-inducible expression of Mn

282 -inhibitor, DRB, or by small interfering RNA selectively blocked TNFalpha stimulation of IL-8 mRNA pr

283 binding moiety [TNFRI-AlbudAb]) was used to selectively block TNFRI.

284 nterest in pharmacological agents capable of selectively blocking tonically activated NMDARs while le

285 luble glycoprotein 130 fusion protein, which selectively blocks trans-signaling, was injected after 3

286 WT AAK1 overexpression selectively blocks transferrin (Tfn) receptor and LRP en

287 l subunits containing synthetic 18S rRNAs by selectively blocking translation from endogenous (pactam

288 1 activity as stem cells exit the cell cycle selectively blocks translation of these transcripts.

289 ibodies against the Kex2p and Vps10p C-tails selectively block transport of Kex2p and the Kex2-Vps10p

290 We conclude that Srs2 selectively blocks triplet repeat expansions through its

291 ted the NGF-induced endocytosis of TrkA, and selectively blocked TrkA-mediated cytoplasmic signaling

292 ontraction coupling, using 200 nmol/L TTX to selectively block TTX-sensitive INa.

293 Deficiency of tPA selectively blocked tubular epithelial-to-myofibroblast

294 We show that TGZ selectively blocked tumor necrosis factor-alpha-induced

295 factor 1 (SDF-1) and VCAM-1, which could be selectively blocked using a specific CXCR4 inhibitor and

296 at blocks the alpha(4)-paxillin interaction, selectively blocked VCAM-1 stimulation of alpha(L)beta(2

297 te in collagen XIII for alpha1beta1 integrin selectively block VLA1-positive monocyte migration in tr

298 m of thalamus-evoked inhibition at PT cells, selectively blocking VM-evoked dendritic Ca(2+) spikes.

299 based on the alpha-hairpinin scaffold, which selectively blocks voltage-gated potassium channels K(v)

300 ic" signaling, and this Ca(2+) influx can be selectively blocked without reducing cardiac contractili