ライフサイエンスコーパス: selector

1 sarily weaker than strong agonists (negative selectors).

2 tions as a multiplexer with arabinose as the selector.

3 ted with distinct structural features of the selector.

4 ing more strongly associated with the chiral selector.

5 hat is, to use it as both solvent and chiral selector.

6 yte in the gas phase to the dissolved chiral selector.

7 s using only beta-cyclodextrin as the chiral selector.

8 pite the high retentitivity of the quinidine selector.

9 that this component is most likely a chiral selector.

10 ool can be remarkably effective as a feature selector.

11 raphy (2D-LC) setup including several column selectors.

12 alytes with the cationic headgroup of chiral selectors.

13 tures, were investigated as potential chiral selectors.

14 Without a negative selector, 19-fold affinity improvement (clone Q, where Q

15 nable acousto-optical filter as a wavelength selector, a novel approach to a broadband stimulated Ram

16 Transcription factors called terminal selectors activate identity-specific effector genes duri

17 Taken together, terminal selectors activate identity-specific genes and make non-

18 n via protonation and the rest of the chiral selector, affords selector-analyte complexes in the elec

19 We also demonstrate that using a threshold selector algorithm for probability adjustment leads to m

20 ty values that are produced by the threshold selector algorithm impact the protein inference stage pe

21 of a cost matrix and a probability threshold selector algorithm to the learning task further improves

22 h have rather limited capabilities as chiral selectors, aliphatic- and aromatic-functionalized CF6s p

23 and the rest of the chiral selector, affords selector-analyte complexes in the electrospray ionizatio

24 The relationship between the ratio of the selector-analyte complexes in the electrospray ionizatio

25 ing increasing attention as a useful feature selector and classifier.

26 L-His was used as a chiral ligand-exchange selector and copper (II) as a central ion.

27 gene regulatory mechanism involving terminal selector and FoxO transcription factors mediating dynami

28 in neurons that lack their resident terminal selector and genetic epistasis studies with H3K9 methylt

29 the proper combination of highly cooperative selector and pre-pattern factors present in the cell.

30 The obligate integration of selector and signaling protein inputs on cis-regulatory

31 graphy using beta-cyclodextrin as the chiral selector and sodium taurocholate as the micelle-forming

32 y and the molecular interactions between the selector and the analyte.

33 0 built-in algorithms of feature extractors, selectors and classifiers in BIOCAT.

34 study whereby the characterization of chiral selectors and identification of optimal separation condi

35 nd GATA3 operate as serotonergic neuron fate selectors and regulate the differentiation of serotonerg

36 of serving simultaneously as solvent, chiral selector, and fluorescent reporter in chiral analytical

37 characteristics which are highly suitable to selector application for x-point memory arrays.

38 olipids, suggesting that different molecular selectors are at play in these organisms but serve a com

39 to achieve separation of enantiomers, chiral selectors are designed to display differential affinity

40 Terminal selectors are transcription factors (TFs) that establish

41 enantiomers, thereby eliminating the chiral selector as a source of physical contamination of the en

42 m/z 1991.9 peak was isolated by a timed ion selector as the precursor ion for further MS analysis.

43 mentum separator, rather than a droplet size selector, as it removes droplets having larger sizes or

44 with sulfated beta-CD (S-beta-CD) as chiral selector at low pH and reverse polarity.

45 Attachment of a chiral selector based on L-valine-3,5-dimethylanilide through a

46 isia, mutational analysis was performed with selector-based, high-throughput sequencing.

47 iomers using 15% beta-cyclodextrin, a chiral selector, but not with alpha- or gamma-cyclodextrins.

48 n which a partial resolution with one chiral selector can be brought to baseline with one of the othe

49 ations can be done in two ways: (1) a chiral selector can be dissolved in an achiral ionic liquid, or

50 tion of a novel morphogenetic regulator to a selector cascade causes cellular instability, resulting

51 oviral cDNA expression libraries, transduced selector cells expressing single cDNAs were stimulated w

52 With GM2 as a negative selector, clone Y (where Y is the symbol for tyrosine) w

53 An unusual class of chiral selectors, cyclofructans, is introduced for the first ti

54 Furthermore, efficiency of the negative selector depends on its cross-reactive affinity with the

55 ites of CNTs or graphite with small molecule selectors--designed to interact with specific classes of

56 ificantly increases the efficiency of chiral selector determination by eliminating the need for multi

57 iral phosphorus compound, was achieved using selectors developed from a small peptide library.

58 Selector devices are indispensable components of large-s

59 otential applications as a highly non-linear selector element in emerging nonvolatile memory (NVM) an

60 een these methods were observed at the stage selector element, -50 region, of gamma-globin promoter.

61 e CACCC and TATA elements, but not the stage selector element, inhibit inappropriate embryonic/fetal

62 rol region and of the TATA, CACCC, and stage selector elements of the gamma-globin promoter, in compe

63 fficients (catalyst precursors) as prebiotic selectors emerges.

64 A motorized filter cube selector facilitated imaging every 5 seconds at 1 of 3 d

65 During eye development, the selector factors of the Eyeless/Pax6 or Retinal Determin

66 in AWC(ON), thus acting as a transcriptional selector for a randomly specified neuronal identity.

67 Thus, UNC-3 is a terminal selector for cholinergic motor neuron differentiation wh

68 while the overlapping svb function is a key selector for epidermal structures under the control of w

69 was found to be a broadly applicable chiral selector for micellar electrokinetic chromatography.

70 nteraction set, we find that the best single selector for negative interactions is a lack of co-funct

71 l IL serving both as solvent and as a chiral selector for the determination of enantiomeric purity.

72 contains a PDZ domain and serves as a cargo selector for the retromer complex.

73 loride (DTC), has been evaluated as a chiral selector for the separation of optical isomers of organi

74 re library components for their potential as selectors for chiral chromatography is described.

75 6 L-amino acid anilides, which are potential selectors for chiral HPLC, was synthesized in solution a

76 oyl)leucine were prepared and used as chiral selectors for enantiomer discrimination in single-stage

77 e misfolded proteins via action as substrate selectors for quality control (QC) machines that fold or

78 Selection of chiral selectors for the resolution of racemic N-(1-naphthyl)le

79 eoselective antibodies as tailor-made chiral selectors for the separation of enantiomers in HPLC unde

80 The best selector from the library was identified by a deconvolut

81 ion, six CSPs were prepared using individual selectors from the library, and screening results indica

82 crease the system's scalability: Feature Set Selector (FSS) and Template.

83 ar dynamics simulations to show that peptide selector function correlates with protein plasticity, an

84 single point mutation, which altered in vivo selector function in a predictable way.

85 Skn-1 proteins, and suggest that the pharynx selector function of CncB is highly conserved on some br

86 It also suggests that the neuronal fate selector function of GATAs is modulated by their cofacto

87 revealing 'temporal modularity' in terminal selector function.

88 llosterically, resulting in enhanced peptide selector function.

89 Using the less efficient negative selector GD3, a clone mixture (Q, V, and Y, where V is t

90 V axis, along with apterous (ap) as a dorsal selector gene [5], mediating cell interactions by regula

91 Here, we report that Fezf2 is a selector gene able to regulate the expression of gene se

92 ntral appendage that forms in the absence of selector gene activity is leglike but consists of only t

93 like appendages could have developed without selector gene activity.

94 The selector gene apterous (ap) is expressed in dorsal cells

95 on, it is clear that key functions of the ap selector gene are mediated by only a small number of dow

96 Expression of the mec-3/unc-86 selector gene complex induces the differentiation of the

97 e cis-regulatory logic on which the terminal selector gene concept is based may contribute to the evo

98 The Drosophila selector gene cut is a hierarchal regulator of external

99 The neural selector gene cut, a homeobox transcription factor, is r

100 sociated with otd repression of the homeotic selector gene Deformed (Dfd).

101 stral regulatory hierarchy in development of selector gene differentiation of serial elements.

102 rmation in the abdomen by repressing the leg selector gene Distalless, whereas Antennapedia (Antp), a

103 ompartment, distinguished by activity of the selector gene engrailed (en) in P but not A compartment

104 Ubx, in combination with the posterior selector gene engrailed (en), represses dally expression

105 men and wing P compartment cells express the selector gene engrailed and secrete Hedgehog protein whi

106 vels of Taranis, expression of the posterior selector gene engrailed is silenced through an autoregul

107 have assumed that the presence or absence of selector gene expression autonomously drives the express

108 process, which requires tight regulation of selector gene expression to specify individual organ typ

109 us far described, we argue that fkh is not a selector gene for salivary gland development and that th

110 Dar1 likely functions as a terminal selector gene for the basic layout of neuron morphology

111 t non-VMH identity, suggesting that Rax is a selector gene for VMH cellular fates.

112 d tubulogenesis in the ASP and that homeotic selector gene function is necessary for the temporal and

113 t of ectopic expression of HoxB4, a homeotic selector gene implicated in self-renewal of definitive H

114 subtype-specific genes identifies Tlx3 as a selector gene in ES cells undergoing neural differentiat

115 that the activity of a neuron type-specific selector gene is modulated by a variety of distinct mean

116 The context-dependent function of Tlx3 as a selector gene may be used to establish a novel strategy

117 nhanced variability in the expression of the selector gene mec-3, which is needed, together with unc-

118 show that ray identities are patterned by a selector gene mechanism in a manner similar to other ser

119 lished later by the expression of the dorsal selector gene pannier (pnr).

120 o foregut (pharynx) cells in response to the selector gene PHA-4/FoxA.

121 the T-box gene TBX-38 and express the organ selector gene PHA-4/FoxA.

122 t known for its fundamental role as a dorsal selector gene required for patterning and growth of the

123 This confirms the role of Hoxa2 as a selector gene specifying second arch fate.

124 One selector gene that promotes the identities of a subset o

125 A-interference, a functional analysis of the selector gene tiptop and the Hox gene Antennapedia in On

126 We propose that Tbx1 acts in the manner of a selector gene to control neural and sensory organ fate s

127 Here we show that in Drosophila the Hox selector gene Ultrabithorax (Ubx) modulates morphogen si

128 g primordium is defined by expression of the selector gene vestigial (vg) in a discrete subpopulation

129 g primordium is specified by activity of the selector gene vestigial (vg).

130 Within this outgrowth, the wing selector gene vg is activated in some cells, changing th

131 spatially restricted expression of labial, a selector gene with a role in cell type specification in

132 f cJun that regulates tlx3, a glutamate/GABA selector gene, accounting for calcium-spike BDNF-depende

133 artment by induction of apterous, the dorsal selector gene, and consequently also controls wing devel

134 these data indicate that hth is an antennal selector gene, and that Antp promotes leg development by

135 expression of a sensory neuron-type-specific selector gene, che-1, which encodes a zinc-finger transc

136 Head specification by the head-selector gene, orthodenticle (otx), is highly conserved

137 homothorax, a previously identified antennal selector gene, to induce antennal differentiation.

138 otypes are consistent with Lmx1a's role as a selector gene.

139 and that there is no master, salivary gland selector gene.

140 ss echinoderms and an example of a "terminal selector" gene that controls cell identity.

141 ar identity through direct repression of Hox selector genes and effector genes.

142 y differences in cell affinity controlled by selector genes and intercellular signals.

143 Members of one subclass, Pax6, function as selector genes and play key roles in the retinal develop

144 nts, we studied the function of the homeotic selector genes APETALA3 (AP3) and PISTILLATA (PI), which

145 In insects, selector genes are thought to modify the development of

146 t sites "terminal selector motifs." Terminal selector genes assign individual neuronal identities by

147 body parts differ in size, the ways in which selector genes create size differences are unknown.

148 epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) a

149 ventral appendages that depend on different selector genes for their unique identities.

150 Selector genes generate these differences by altering th

151 es for Lhx2 that acts as one of the terminal selector genes in controlling principal properties of ne

152 The dispersal of selector genes in the genomes of arthropods in conjuncti

153 tested by examination of the distribution of selector genes in the genomes of arthropods.

154 Selector genes modify developmental pathways to sculpt a

155 vide a potentially general mechanism for how selector genes modify organ sizes.

156 ies that there is a common ground state that selector genes modify to generate these different append

157 s cells with higher levels of Dally and that selector genes modulate organ development by regulating

158 ins and restriction to the dorsal eye by the selector genes of the Iroquois complex (Iro-C).

159 The homeotic selector genes of the red flour beetle, Tribolium castan

160 Here, we demonstrate that homeotic selector genes provide positional information that deter

161 sequenced the region containing the homeotic selector genes required for proper development of the he

162 propriate expression of several head capsule selector genes such as cut, Lim1 and wingless.

163 veloping systems, in some cases by acting as selector genes that define compartment identity.

164 ans and appendages are regulated by specific selector genes that encode transcription factors that re

165 y organogenesis, which requires the input of selector genes that specify the identity of various morp

166 l seeing animals is controlled by a group of selector genes that together forms the retinal determina

167 I propose to term these TFs "terminal selector genes" and their cognate cis-regulatory target

168 to repress the transcription of non-retinal selector genes, thereby allowing induction of the retina

169 the correct segmental expression of homeotic selector genes.

170 al class of transcription factors encoded by selector genes.

171 sayed with regard to the floral homeotic ABC selector genes.

172 red to repress the expression of non-retinal selector genes.

173 ing that the zebrafish Hox PG2 genes act as "selector genes."

174 ecific identities through the expression of 'selector' genes [1,2,4].

175 hought that the posterior expression of the 'selector' genes engrailed and invected control the subdi

176 A small number of major regulatory (selector) genes have been identified in animals that con

177 tivated by two visual-specific transcription selectors, Glass and Sine Oculis, that bind to an enhanc

178 The trifunctional selector has three important properties: it noncovalentl

179 The selector homeoprotein Even skipped (Eve) plays a very sp

180 Our results raise the possibility that each selector homeoprotein may directly regulate the expressi

181 The selector homeoproteins are a highly conserved group of t

182 controlled by Eve and probably by the other selector homeoproteins as well.

183 Previously, the Drosophila selector homeoproteins Eve and Ftz were shown to bind wi

184 Suspecting that the selector homeoproteins may affect many more genes than p

185 ctly or indirectly controlled by most or all selector homeoproteins.

186 rtholog mef2cb, or that it is related to the selector (homeotic) gene function of mef2ca.

187 homeodomain proteins encoded by the homeotic selector (Hox) gene complexes and increase their DNA-bin

188 Homeotic selector (Hox) proteins often bind DNA cooperatively wit

189 pairs was obtained with addition of a chiral selector (i.e., beta-cyclodextrin) in the running buffer

190 w the choice of data set size, regressor and selector impact the design.

191 ine, the Integral Membrane Protein Stability Selector (IMPROvER) provides a rational approach to vari

192 The use of a guanosine gel as a chiral selector in capillary electrophoresis is introduced.

193 ased Ovonic threshold switches (OTS) used as selectors in cross-point memory arrays is derived from d

194 n, transcription factors operate as terminal selectors in distinct combinations in different neuron t

195 memristor that negates the need for external selectors in large arrays.

196 miconductor technology, and require external selectors in order for large memristor arrays to functio

197 s therefore proof the role of the 'substrate selector' in plant PPOs.

198 en separated using these ionic liquid chiral selectors include alcohols, diols, sulfoxides, epoxides,

199 Here we present integrative risk gene selector (iRIGS), a Bayesian framework that integrates m

200 As a second application, the selector is used for automated screening of single-molec

201 e isoform selectivity found on quinine-based selectors is explained by van't Hoff plots, revealing a

202 t moieties of the original cinchonan-derived selector, it was shown that intercalation by the quinoli

203 ontaining a subset of the amino acid anilide selector library was screened for enantioselectivity.

204 Terminal selectors mediate this restriction at least partially by

205 t property-most often, affinity for a target selector molecule.

206 ognate cis-regulatory target sites "terminal selector motifs." Terminal selector genes assign individ

207 Derivatives of the chiral selector N-(3,5-dinitrobenzoyl)leucine were prepared and

208 fic effector genes, indicating that terminal selectors not only activate effector gene batteries but

209 Activated sludge was sampled from an anoxic selector of a municipal wastewater treatment plant (WWTP

210 cally expressed C. elegans CHE-1, a terminal selector of ASE sensory neuron identity.

211 eviously showed that UNC-3/Ebf, the terminal selector of C. elegans cholinergic motor neurons (MNs),

212 ecificity by modeling the neuron as a biased selector of hair-cell polarity and find evidence for bia

213 etabolites concentrations) probably acted as selector of metabolic pathways, favoring H(2)-producing

214 zing the activity of broadly acting terminal selectors of neuron identity in a subtype-specific fashi

215 contrast, removal of the respective terminal selectors of other sensory, inter-, or motor neuron type

216 mplementation of a high mass quadrupole mass selector on the recently introduced Orbitrap Exactive EM

217 onsists of 81 peptide-based potential chiral selectors on polymeric synthesis resins.

218 r needed to immobilize the identified chiral selectors onto silica gel proved important in the chiral

219 ed lag model (DLM), least absolute shrinkage selector operator (LASSO), simple artificial neural netw

220 enantiomers in solution without using chiral selectors or circularly polarized light.

221 he obligate integration of inputs of a field-selector (Otx2) and localized signaling (Notch) within t

222 t the environment not only acts as an active selector over the genotypes, but also enhances the capac

223 The strategy of a terminal selector preventing a transcriptional switch may constit

224 Selector probes enable the amplification of many selecte

225 ne that automates the procedure of designing selector probes for exon resequencing applications.

226 SCALLOPED, the DNA binding component of the selector protein complex for the Drosophila wing field,

227 The Scalloped selector protein controls wing development in Drosophila

228 The modification of selector protein DNA-binding specificity by co-factors a

229 gulated by multiple signaling pathways and a selector protein during Drosophila wing development.

230 controlling wing development, including the selector protein Engrailed.

231 site for the fetal/erythroid-specific stage selector protein in the gamma-promoter abolished the add

232 The Abdominal-B selector protein induces organogenesis of the posterior

233 Similarly, insertion of the stage selector protein site into the beta-promoter boosted enh

234 that TnsC interacts directly with the target selector protein TnsD.

235 element, we demonstrate that Apterous (Ap, a selector protein), and the Notch and Wingless (Wg) signa

236 sequence-specific DNA binding of the target selector protein, TnsD.

237 combinatorial peptide library using mu4 as a selector protein.

238 ors) and several binding sites for the stage selector protein.

239 as a novel role as a positive actin-binding "selector" protein that promotes the access of other prot

240 Combinatorial regulation by selector proteins and signal transducers is likely to be

241 tions between extradenticle and the homeotic selector proteins and that extradenticle is not simply a

242 tegration of multiple signaling pathways and selector proteins can be achieved during wing developmen

243 tory DNA may be a general mechanism by which selector proteins control extensive genetic regulatory n

244 nderstood how the target selectivity of most selector proteins is determined in vivo.

245 The DNA-binding domains of selector proteins often exhibit relatively low DNA-bindi

246 ting the DNA-binding specificity of homeotic selector proteins.

247 inger transcription factor locus, a terminal selector required to specify the identity of the ASE neu

248 rimental proof of the role of the 'substrate selector' residue in plant polyphenol oxidases.

249 hensive with advanced features like sequence selector, search set builder, enzyme chooser, access to

250 s, including optical filtering, polarization selectors, sensing, lasers, modulators and nonlinear opt

251 utually exclusive nature of the docking site:selector sequence interactions suggests that the formati

252 Strikingly, each selector sequence is complementary to a portion of the d

253 n downstream of constitutive exon 5, and the selector sequences, which are located upstream of each e

254 a mem-ristor and a trilayer crested barrier selector, showing repeatable nonlinear current-voltage s

255 at the metalloid center acts as the topology selector stabilizing only one conformation of the macroc

256 columns packed with highly efficient chiral selectors (sub-2 mum fully porous and 2.7 mum fused-core

257 e contamination, a negatively charged chiral selector, sulfated beta-cyclodextrin (sulfated beta-CD),

258 phila TCF (dTCF) and the Vestigial/Scalloped selector system and that temporal control is provided by

259 We developed the Tree-Based Alignment Selector (T-BAS) toolkit to allow evolutionary placement

260 y is currently the most industrially favored selector technology.

261 ing to develop a rapid, automatic SMFM trace selector, termed AutoSiM, that improves the sensitivity

262 tion of chiral analyte molecules with chiral selectors that could potentially be applied to the study

263 We find that selectors that use information about the prediction unce

264 software system GEMS (Gene Expression Model Selector) that automates high-quality model construction

265 based on oligonucleotide constructs, called selectors, that guide the circularization of specific DN

266 sing an anti-D-amino acid antibody as chiral selector, the L-enantiomers eluted with the void volume,

267 ause of the synthetic nature of these chiral selectors, the configuration of the stereogenic center c

268 ption factor ttx-3, which acts as a terminal selector to drive the terminal differentiation program o

269 n modification acts downstream of a terminal selector to restrict plasticity.

270 pared by covalent attachment of the Whelk-O1 selector to spherical, high-surface-area 1.7-mum porous

271 to prevent misincorporation and as positive selectors to enhance correct incorporation.

272 3, and N(6) of purine dNTPs both as negative selectors to prevent misincorporation and as positive se

273 A terminal selector transcription factor, CHE-1, is required for th

274 ne gene and ectopic expression of a terminal selector transcription factor.

275 figuration and neuron-type-specific terminal selector transcription factors.

276 Crosses between the puDeltatk selector transgenic line and existing cre lines will fac

277 ed by the specific combination of a terminal selector type of transcription factors that also specify

278 c regulatory signature and cognate, terminal selector-type transcription factors that define the enti

279 collaboration with non-sex-specific terminal selector-type transcription factors, whereas the sex spe

280 the dual function of the conserved terminal selector UNC-3 (Collier/Ebf).

281 The conserved COE-type terminal selector UNC-3 not only controls the expression of trait

282 that are directly activated by the terminal selector UNC-3.

283 Another C. elegans terminal selector (UNC-30/Pitx) also exhibits temporal modularity

284 mpounds was achieved using DTC as the chiral selector under optimized background electrolytic conditi

285 ndividual components of the materials; and a selector uses these predictions and their uncertainties

286 s further deconvoluted until the single best selector was found.

287 ta-cyclodextrin, a negatively charged chiral selector, was used for the enantiomeric separation of ra

288 The chiral selectors were designed to remove the ionization site fr

289 bonding groups and d-carbohydrates as chiral selectors were developed to achieve control over the chi

290 Four chiral selectors were examined under various conditions to expl

291 Cyclodextrins as common chiral selectors were used as model complexation agents.

292 We propose a method, Scellector (single cell selector), which uses haplotype information to detect am

293 her proteins, including a putative substrate selector, which associate with the enzyme in yeast and m

294 are accomplished by the addition of a chiral selector, which causes the different enantiomers of an a

295 olution of the two pseudoenantiomeric chiral selectors, which differ in absolute stereochemistry and

296 Here, we report on a selector with a large drive current density of 34 MA cm(

297 plexes of cinchona alkaloid carbamate chiral selectors with N-dinitrobenzoylleucine enantiomers and a

298 It is also demonstrated that selectors with separation factors as low as 1.4 could be

299 type of velocity-insensitive adiabatic spin selector, with potential application in devices such as

300 sited TaN1+x /Ta2 O5 /TaN1+x crested barrier selector yields a large nonlinearity (>10(4) ), high end