ライフサイエンスコーパス: seleno

1 hijacked human proteins is selenoprotein S (selenos).

2 Patients with or without a positive 23-seleno-25-homotaurocholic acid (SeHCAT) scan were recrui

3 urnished the corresponding cyano substituted seleno(3,4-c)thiophene.

4 selenoprotein S (SEPS1, also called SELS or SELENOS), a gene involved in stress response in the endo

5 Previous studies have identified these seleno-alpha-keto acids as potent histone deacetylase in

6 romatographic peak containing a Se-S bridged seleno amino acid with a structure similar to cystine is

7 Variations of protein and seleno-amino acid concentrations were observed between E

8 ide production and trans-sulfuration pathway seleno-amino acids and emphasize the importance of the s

9 This study describes a method for seleno-amino acids determination in Argentinean olive oi

10 s were analyzed for both total Se and single seleno-amino acids determination.

11 ) were introduced for the extraction of free seleno-amino acids from lyophilized and powdered milk sa

12 tical method has been developed to determine seleno-amino acids in proteins extracted from extra virg

13 Recoveries were between 84% and 97% for the seleno-amino acids studied, reaching a detection limit o

14 Seleno-amino acids were determined by liquid chromatogra

15 In a second dimension chromatography seleno-amino acids were determined by reversed-phase chr

16 implemented for targeted analysis of common "seleno-amino acids" and related oxidation products, sele

17 ed by microalgal metabolism into organic Se (seleno-amino acids) and partially removed via gaseous vo

18 d life science studies, including spectra of seleno-amino acids, which show strong similarities with

19 e-assisted acid hydrolysis (MAAH) to release seleno-amino acids.

20 Thermal decomposition of 2a--f and of the seleno analogue 7 in methanol and of 3-methyl-2-nitrosob

21 eriments, we mapped the interaction sites of selenos and nsp7 in the replication complex and showed t

22 We set to study whether selenos and nsp7 interact directly and if they can still

23 , and organic product distributions from the seleno- and thiocarbonyl reactions closely resemble each

24 methanol of 623, 654, and 680 nm for thio-, seleno-, and telluropyrylium dyes, respectively, and gen

25 Using biochemical assays, we show that selenos binds directly to nsp7.

26 Primary allylic selenosulfates (seleno Bunte salts) and selenocyanates transfer the ally

27 In addition, we found that selenos can bind to nsp7 when it is in a complex with th

28 XAS experiments in the presence of seleno-CoA reveal a Cu-S(3)Se environment with a 2.4-A S

29 H) coupling in the NMR spectrum for the P(V)-seleno compounds and a bathochromic shift of the NH abso

30 Seleno-compounds demonstrated enhanced activity and sele

31 ids analysis, selenocysteine was the primary seleno-containing species.

32 rsenic-containing analogues of the thio- and seleno-cyanate anions, PCSe(-) , AsCS(-) , and AsCSe(-)

33 sed 2,5-cyclohexadienone frameworks via thio(seleno)cyanative ipso-cyclization in the presence of cer

34 plants, the chloroplast is the location of (seleno) Cys formation and a location of Fe-S cluster for

35 The enzyme is active on both seleno-Cys and Cys but has a much higher activity toward

36 the biosynthesis of Se-methylseleno-Cys from seleno-Cys and S-methyl-methionine.

37 Using seleno-Cys as a substrate, it was found that 25% to 30%

38 scenario is confirmed via maturation with a seleno-Cys carrier to form HydA1-Se, where the incorpora

39 oduce the S of iron (Fe)-S clusters, whereas seleno-Cys lyase activity is needed for the incorporatio

40 NifS-like protein, more similar to bacterial seleno-Cys lyases than to Cys desulfurases.

41 Seleno-Cys methyltransferase is found to be expressed in

42 Seleno-Cys methyltransferase is the enzyme responsible f

43 alian enzymes that instead contain an active seleno-Cys.

44 of elemental selenium (Se) and alanine from seleno-Cys.

45 The ready incorporation of seleno-cysteine and methionine instead of their natural

46 etermining seleno-methionine (SeMet), methyl-seleno-cysteine and seleno-cystine in extra-virgin olive

47 thionine (SeMet), methyl-seleno-cysteine and seleno-cystine in extra-virgin olive oil (EVOO) was deve

48 Selenite, seleno-cystine, and seleno-methionine exert this effect

49 Treatment with ethionine and seleno-D,L-ethionine, two inhibitors known to have I50 v

50 Additionally, these seleno-derivatives evidenced an ability to overcome cisp

51 ve-induced synthesis of structurally diverse seleno-dibenzocyclohepten-5-ones and seleno-spiro[5.5]tr

52 n an alternative method for the synthesis of seleno-dibenzocycloheptenones and seleno-spiro[5.5]trien

53 he Au(III) derivative is an inhibitor of the seleno-enzyme thioredoxin reductase, while the Cu(II) co

54 kbone and stabilized by an adjacent thio- or seleno-ether functionality that engages the bismuth cent

55 In their oxidized sulfo and seleno forms, the P-diphenyl compounds are present as an

56 Here we employ heterologously expressed seleno-fragments to overcome the placement and size rest

57 Further conversion of the seleno-functionality afforded other valuable furan deriv

58 eld novel unsymmetrical gem-diarylmethylthio/seleno glycosides while retaining the anomeric stereoche

59 , enabling attachment to silicon via thio or seleno groups without handling free thiols or selenols.

60 methodology toward multisubstituted 3-thio-, seleno-, halo-, aryl-, and alkyl-furans and pyrroles, as

61 was developed using a previously unreported seleno-Hugerschoff reaction, allowing the challenging ki

62 While the role of selenos in the viral life cycle is not yet known, it has

63 and the intrinsically disordered segment of selenos-including the reactive selenocysteine-exposed an

64 x and showed that the hydrophobic segment of selenos is essential for binding to nsp7.

65 s to synthesize in situ either CH3SeH and/or seleno-keto acid metabolites.

66 nds of selenium: seleno-l-methionine, methyl-seleno-l-cysteine, l-selenocystine, methaneseleninic aci

67 investigated chemical compounds of selenium: seleno-l-methionine, methyl-seleno-l-cysteine, l-selenoc

68 Consequently, the antioxidant seleno-l-methionine, the specific ERK1/2 inhibitor PD980

69 Antioxidant seleno-l-methionine; chemical inhibitors of p38, ERK1/2,

70 An analytical method for determining seleno-methionine (SeMet), methyl-seleno-cysteine and se

71 Selenite, seleno-cystine, and seleno-methionine exert this effect but selenate does no

72 The structure was solved by substituting seleno-methionine for natural sulphur-methionine in FlhD

73 1) for selenocysteine, selenomethionine, and seleno-methyl-selenocysteine, respectively.

74 Seleno-methylselenocysteine was determined with values r

75 undergoes a [2,3]-sigmatropic rearrangement (seleno-Mislow-Evans rearrangement) with H(2) O(2) , foll

76 then leveraged through the application of a seleno-multifunctional peptide platform, tailored to the

77 We postulated that the seleno-organic compound ebselen would attenuate neutroph

78 r been restricted to solid-phase synthesized seleno-peptides and thus constrained by where the seleno

79 Peroxiredoxin 6 (Prdx6), a unique non-seleno peroxidase, is a bifunctional protein with GSH pe

80 and superior anion binding properties of the seleno-phosph(V)azanes give them applications as synthet

81 Here, a broad family of layered metal thio(seleno)phosphate materials that are moderate- to wide-ba

82 Layered thio- and seleno-phosphate ferroelectrics, such as CuInP(2)S(6), a

83 The dephosphorylated 4'-seleno product can be further processed by downstream bi

84 lly stimulates incorporation directed by the seleno protein P and phospholipid hydroperoxide glutathi

85 ent with the enaminone moiety, followed by a seleno-Pummerer reaction.

86 diverse seleno-dibenzocyclohepten-5-ones and seleno-spiro[5.5]trienones by selenylative carbannulatio

87 nthesis of seleno-dibenzocycloheptenones and seleno-spiro[5.5]trienones through the radical cyclizati

88 tivation of diselenides and oximes to access seleno-substituted isoquinoline and isoindole derivative

89 With the use of selenols, meso-seleno-substituted porphyrins can also be prepared simil

90 blish an enzymatic approach to synthesize 4'-seleno sugars in a radical-mediated manner and provide a

91 transcribed with all nucleoside 5'-(alpha-P-seleno)triphosphates (NTPalphaSe, including A, C, G, and

92 2'-Deoxynucleoside 5'-(alpha-P-seleno)-triphosphates (dNTPalphaSe) have been convenient

93 lenocysteine and 2-selenouridine residues in seleno-tRNA.

94 ch sources of selenium-dependent enzymes and seleno-tRNAs.

95 lenium-dependent formate dehydrogenase H and seleno-tRNAs.

96 ed for synthesis of selenocysteine (Sec) and seleno-tRNAs.