ライフサイエンスコーパス: selenoprotein

1 utilize selenium from Gpx3, the other plasma selenoprotein.

2 ion, thereby inhibiting the synthesis of the selenoprotein.

3 previously proposed catalytic tetrad in this selenoprotein.

4 rms part of the coding sequence in bacterial selenoproteins.

5 edox motifs govern much of the reactivity of selenoproteins.

6 dentify known selenoproteins and predict new selenoproteins.

7 in supporting accuracy of Sec insertion into selenoproteins.

8 that is, the incorporation of selenium into selenoproteins.

9 (SECIS) in the 3'-UTR of mRNAs of eukaryotic selenoproteins.

10 e genomic presence of both Sec machinery and selenoproteins.

11 selenocysteine, the amino acid that defines selenoproteins.

12 ine the impact on UGA recoding in individual selenoproteins.

13 as associated with a lack of testis-enriched selenoproteins.

14 ired for the production of at least 25 human selenoproteins.

15 selenocysteine (Sec), generating a family of selenoproteins.

16 quired for the optimal expression of certain selenoproteins.

17 the metabolism of selenium for synthesis of selenoproteins.

18 iciently determine whether a genome contains selenoproteins.

19 hould enable many further studies of diverse selenoproteins.

20 nally in a small fraction of proteins called selenoproteins.

21 gesting its effect is not through binding to selenoproteins.

22 ion of stress-related, but not housekeeping, selenoproteins.

23 prokaryotic and eukaryotic genomes encoding selenoproteins.

24 of the element required for the synthesis of selenoproteins.

25 e plasma at the expense of its intracellular selenoproteins.

26 In particular, fungi were deemed devoid of selenoproteins(4,5,8).

27 In order to synthesize selenoproteins, a translational reprogramming event must

28 odest selenium (Se) deficiency, nonessential selenoprotein activities and concentrations are preferen

29 vide insight into the function of individual selenoprotein activity in maintaining cutaneous homeosta

30 review about half of the 25 known mammalian selenoproteins; all of those with mouse knockout or huma

31 accurately curated and annotated datasets of selenoprotein and SCR transcript and protein records to

32 Deficiency of Se decreases the activity of selenoproteins and can compromise immune and thyroid fun

33 ectively impairs synthesis of stress-related selenoproteins and demonstrates the importance of tRNA m

34 r translation in the 5'-UTRs for a subset of selenoproteins and for ribosome pausing near the UGA-Sec

35 ntial trace element used for biosynthesis of selenoproteins and is acquired either through diet or ce

36 c) is found in the catalytic centers of many selenoproteins and plays important roles in living organ

37 Seblastian is able to both identify known selenoproteins and predict new selenoproteins.

38 e results suggest that optimal expression of selenoproteins and selenium-dependent production of COX-

39 thod combines the accurate quantification of selenoproteins and selenometabolites by species unspecif

40 hepatocyte selenium between the synthesis of selenoproteins and the synthesis of selenium excretory m

41 m is regulated in the body to maintain vital selenoproteins and to avoid toxicity.

42 crophages indicated that macrophage-specific selenoproteins and upregulation of 15-PGDH expression we

43 ting in 247 selenoprotein genes encoding 322 selenoproteins, and 93 genes exhibiting SCR encoding 94

44 Selenoproteins are a diverse group of proteins containin

45 Selenoproteins are a family of proteins that share the c

46 Selenoproteins are a group of selenocysteine-containing

47 Selenoproteins are a unique family of proteins, characte

48 Selenoproteins are essential in vertebrates because of t

49 Selenoproteins are essential molecules for the mammalian

50 indicate that, despite scattered occurrence, selenoproteins are found in all kingdoms of life.

51 As the roles of these selenoproteins are further characterized, a better under

52 UGA is normally a translational stop signal, selenoproteins are generally misannotated and designated

53 Selenoproteins are important enzymes involved in antioxi

54 ertheless, selenoprotein P and several other selenoproteins are known to contain multiple selenocyste

55 Many selenoproteins are oxidoreductases in which the reactive

56 Selenoproteins are present in all three domains of life

57 Selenoproteins are proteins containing an uncommon amino

58 Selenoproteins are proteins that contain the amino acid

59 Selenoproteins are proteins that incorporate selenocyste

60 Selenoproteins are unique as they contain selenium in th

61 an of mammalian cells by identifying several selenoproteins as new targets of senescence.

62 ssential trace element, is incorporated into selenoproteins as selenocysteine (Sec), the 21st amino a

63 in Escherichia coli However, obtaining pure selenoproteins at high yields is limited by the accumula

64 ively enhances the expression of a subset of selenoproteins at the translational level.

65 Production of designer proteins with Sec (selenoproteins) at desired positions is now possible wit

66 next to evaluate a possible interference of selenoprotein biosynthesis by the antibiotics and elucid

67 e interfering activity of aminoglycosides on selenoprotein biosynthesis can be severe, but depend on

68 Genetic disruption of selenoprotein biosynthesis had no effect on lifespan and

69 Selenoprotein biosynthesis relies on the co-translationa

70 se (Scly) is the enzyme that supplies Se for selenoprotein biosynthesis via decomposition of the amin

71 l for the SelA-tRNA(Sec)-SPS interaction and selenoprotein biosynthesis, as revealed by functional co

72 ether, our results provide new insights into selenoprotein biosynthesis, demonstrating for the first

73 Since tRNASec is a key component in selenoprotein biosynthesis, its efficient identification

74 Sec insertion into natural positions within selenoproteins, but do so in a selenoprotein-specific ma

75 gned to selenocysteine during translation of selenoproteins by a mechanism involving a 3 untranslated

76 , promotes selenocysteine incorporation into selenoproteins by a still poorly understood mechanism.

77 ence for the existence of a selenoprotein or selenoproteins capable of acting as a tumor suppressor i

78 y acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated com

79 correlates with the presence of this labile selenoprotein complex and is absent in a selD or an xdh

80 Selenoproteins contain the amino acid selenocysteine (Se

81 al light on the phylogenetic distribution of selenoprotein containing genomes.

82 ec) allows the production of new recombinant selenoproteins containing structural motifs such as sele

83 ysteine machinery and expression of abundant selenoproteins; copper balance is affected by lipid meta

84 This exogenous selenoprotein could only be expressed when the Drosophil

85 affinity for Derlin-2, suggesting that these selenoproteins could determine the nature of the substra

86 ontrol mice, in which female islets showed 5 selenoproteins decreased and one increased versus male i

87 Thus, two selenoprotein-dependent maternal-fetal selenium transfer

88 UGA codons as selenocysteine (Sec) codons in selenoproteins depends on a selenocysteine insertion seq

89 emented Trsp(fl/fl)Cre(WT) mice that express selenoproteins driven by tRNA(Sec) (Trsp), whereas N. br

90 ec insertion sequence (SECIS) element in the selenoprotein-encoding mRNA and competes with UGA-direct

91 ng Sec into proteins and in dysregulation of selenoprotein expression and function upon antibiotic tr

92 Pathogenic mutations in SECISBP2 reduce selenoprotein expression and lead to phenotypes associat

93 investigated how oxidative stress influences selenoprotein expression as a function of different sele

94 armacological inhibition of 15-PGDH, lack of selenoprotein expression in macrophages, and depletion o

95 The moderate impairment of selenoprotein expression in neurons led to astrogliosis

96 Selenoprotein expression is determined by hierarchical m

97 m levels were shown to control gene-specific selenoprotein expression primarily at the translation le

98 ests sex-specific hierarchical mechanisms of selenoprotein expression that may influence islet biolog

99 tween selenium levels in the culture medium, selenoprotein expression, and replicative life span of h

100 selenium deficiency, there is a hierarchy of selenoprotein expression, with certain selenoproteins sy

101 , which also results in extensive changes in selenoprotein expression.

102 y of nucleolin for a SECIS and its effect on selenoprotein expression.

103 F4a3 links selenium status with differential selenoprotein expression.

104 c, led to the discovery of a novel bacterial selenoprotein family, and shed additional light on the p

105 As with other members of the selenoprotein family, selenoprotein N incorporates selen

106 his family is the most widespread eukaryotic selenoprotein family.

107 In the current study, we targeted specific selenoproteins for epidermal deletion to determine wheth

108 vant ribonucleoprotein complex important for selenoprotein formation.

109 Selenoproteins fulfil essential roles in many organisms(

110 cly and Sepp1 work cooperatively to maintain selenoprotein function in the mammalian brain.

111 ary history of SPS genes, providing a map of selenoprotein function spanning the whole tree of life.

112 Seblastian is a new method for selenoprotein gene detection that uses SECISearch3 and t

113 sense codons, resulting in misannotation of selenoprotein gene products and failure to predict SCR.

114 Many species are completely devoid of selenoprotein genes and lack the ability to synthesize S

115 ructure, the SECIS element, at the 3' UTR of selenoprotein genes and recodes a UGA codon within the c

116 Sequence (RefSeq) dataset, resulting in 247 selenoprotein genes encoding 322 selenoproteins, and 93

117 overy of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance

118 For this reason, we have now fully annotated selenoprotein genes in 58 animal genomes.

119 an automatic annotation pipeline to annotate selenoprotein genes in other animal genomes.

120 ial effects on translation of histone genes, selenoprotein genes, and S-adenosylmethionine decarboxyl

121 aims to provide high-quality annotations of selenoprotein genes, proteins and SECIS elements.

122 In selenoprotein genes, the Sec specific tRNA (tRNASec) dri

123 rolixus has experienced an extensive loss of selenoprotein genes, with its repertoire reduced to only

124 the homocysteine-induced suppression of the selenoprotein glutathione peroxidase 1 (GPx-1) and endot

125 e thresholds for the optimal activity of the selenoproteins glutathione peroxidase 3 (GPx3; <86.9 ng

126 ulated the mRNA of the most abundant hepatic selenoprotein, glutathione peroxidase-1 (Gpx1), to 15% o

127 The other extracellular selenoprotein, glutathione peroxidase-3 (Gpx3), has not

128 GPX) activity, the latter due largely to the selenoprotein GPX3 secreted by the kidneys, were measure

129 Five selenoproteins (Gpx4, Txnrd1, Txnrd2, Dio3, and Sepp1) w

130 Selenoprotein H (SelH), a nuclear selenoprotein, is prop

131 ized to maintain the expression of essential selenoproteins has not been elucidated.

132 The discovery of multiple selenoproteins has raised tantalizing questions about th

133 Several selenoproteins have essential functions in development.

134 omeostasis, but some invertebrates that lack selenoproteins have recently been identified.

135 oproteins most important to them, creating a selenoprotein hierarchy in the cell.

136 um where it is needed, creating a whole-body selenoprotein hierarchy.

137 disorder with defective biosynthesis of many selenoproteins, highlighting their role in diverse biolo

138 SPS is itself a selenoprotein in many species, although functionally equ

139 er understand the function and regulation of selenoproteins in antioxidant defense and redox homeosta

140 we used TargeTron to investigate the role of selenoproteins in C. difficile Stickland metabolism and

141 The unique roles of selenoproteins in human health and their chemical reacti

142 )LysM(Cre)) were used to examine the role of selenoproteins in macrophages on disease progression and

143 Selenoproteins in macrophages protect mice from dextran

144 ation, our objective was to demonstrate that selenoproteins in macrophages were essential to suppress

145 ously demonstrated that targeted loss of all selenoproteins in mouse epidermis disrupted skin and hai

146 hich is encoded by the stop codon, UGA, into selenoproteins in murine EMT6 cells.

147 The annotations of selenoproteins in new genomes usually contain many error

148 Reduced levels of selenoproteins in peripheral blood cells were associated

149 base of Dikarya, resulting in the absence of selenoproteins in Saccharomyces cerevisiae and other wel

150 that is co-translationally incorporated into selenoproteins in the form of the 21st amino acid, selen

151 is shifted to needy cells and then to vital selenoproteins in them to supply selenium where it is ne

152 For several selenoproteins in which loss of Secisbp2 resulted in gre

153 spond to ferroptotic stimuli by induction of selenoproteins, including antioxidant glutathione peroxi

154 roteomics analyses show global enrichment of selenoproteins, including GPX4, by NRF2 downregulation,

155 beta-carotene metabolism, and in several key selenoproteins indicates the potential importance of mic

156 ntified a selective up-regulation of several selenoproteins involved in antioxidant defense (Gpx1, Gp

157 We observe that the expression of several selenoproteins involved in antioxidant defense is specif

158 hesis of selenocysteine-containing proteins (selenoproteins) involves the interaction of selenocystei

159 he expression of GPx-1 and a subset of other selenoproteins is dependent on the methylation of the tR

160 activity of thioredoxin reductase 1, another selenoprotein, is increased.

161 Selenoprotein H (SelH), a nuclear selenoprotein, is proposed to carry redox and transactiv

162 Selenoprotein K (Sel K) is a selenium-containing protein

163 Selenoprotein K (SelK) is an 11-kDa endoplasmic reticulu

164 tudies demonstrated that genetic deletion of selenoprotein K (Selk) led to decreased Ca(2+) flux in a

165 tudy, we identify a novel target of calpain, selenoprotein K (SelK), which is an endoplasmic reticulu

166 as demonstrated by using macrophages lacking selenoprotein K, which is required for FcgammaR-induced

167 effect could be ascribed to the function of selenoprotein K.

168 Most fungal selenoproteins lack consensus Sec recoding signals (SECI

169 Malfunctions of selenoproteins lead to various human disorders including

170 eased hepatic oxidative stress, but maintain selenoprotein levels and circulating Se status.

171 of GABAergic inhibition, and increases brain selenoprotein levels.

172 Selenoprotein M (SelM) is a thioredoxin-like endoplasmic

173 organism produces an SDMH and probed whether selenoproteins may play a role in biofilm physiology.

174 e incorporation occurs during translation of selenoprotein messages by redefinition of UGA codons, wh

175 Unlike epidermal ablation of all selenoproteins, mice ablated for GPx4 recovered after 5

176 he UGA-Sec codon in those mRNAs encoding the selenoproteins most affected by selenium availability.

177 limiting, cells utilize it to synthesize the selenoproteins most important to them, creating a seleno

178 The interaction of eIF4a3 with the selenoprotein mRNA prevents the binding of SECIS binding

179 ducing Sepp1 mRNA, the most abundant hepatic selenoprotein mRNA, only to 61%.

180 ed to SECISBP2: binding of SECIS elements in selenoprotein mRNAs and facilitation of co-translational

181 downstream of UGA-Sec codons for a subset of selenoprotein mRNAs and that the selenium-dependent effe

182 nce element in the 3' untranslated region of selenoprotein mRNAs as well as Sec insertion sequence bi

183 e deficiency for translation of nonessential selenoprotein mRNAs except Dio1.

184 on sequence element located in the 3' UTR of selenoprotein mRNAs, selenium bioavailability, and, poss

185 cifically delivered at defined UGA codons in selenoprotein mRNAs.

186 affinity to SECIS elements from a subset of selenoprotein mRNAs.

187 and Mical2 and reduced back to methionine by selenoprotein MsrB1, supporting actin disassembly and as

188 Mutations in the human SEPN1 gene, encoding selenoprotein N (SepN), cause SEPN1-related myopathy (SE

189 Here we report that Selenoprotein N (SEPN1) is a type II transmembrane prote

190 similar to myopathies caused by mutations in selenoprotein N (SEPN1).

191 h the reduction of deiodinase activities and selenoprotein N expression in humans.

192 h other members of the selenoprotein family, selenoprotein N incorporates selenium in the form of sel

193 Incorporation of selenium into ~25 mammalian selenoproteins occurs by translational recoding whereby

194 Selenoproteins of L. donovani are not required for the g

195 sia provides evidence for the existence of a selenoprotein or selenoproteins capable of acting as a t

196 ws the order: glutathione peroxidase (GPX) ~ selenoprotein P (SELENOP) > selenocystamine (SeCA) > oth

197 However, human selenoprotein P (SelenoP) has a redox-functioning seleno

198 iosynthesis of the selenium (Se) transporter selenoprotein P (SELENOP) is particularly sensitive to a

199 A coding for the selenium transport protein, selenoprotein P (SELENOP), which in vertebrates may cont

200 GPx-2), thioredoxin reductase-1 (TrxR-1) and selenoprotein P (SeP) mRNA expression and GPx-1 enzyme a

201 ckdowns of the SEPP1 gene, which encodes the selenoprotein P (SeP) protein, have been shown to increa

202 Selenoprotein P (Sepp1) and its receptor, apolipoprotein

203 in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop se

204 The liver synthesizes selenium-rich selenoprotein P (SEPP1) and secretes it into the plasma

205 type II diabetes risk, and plasma levels of selenoprotein P (SEPP1) have been positively correlated

206 ciency by curtailing excretion and secreting selenoprotein P (Sepp1) into the plasma at the expense o

207 Selenoprotein P (Sepp1) is an important protein involved

208 Among selenoproteins, selenoprotein P (Sepp1) is particularly distinctive due

209 Selenoprotein P (Sepp1) is taken up by receptor-mediated

210 oprotein S (SelS) production and circulating selenoprotein P (Sepp1) levels are significantly diminis

211 quantification of selenium (Se) included in selenoprotein P (SEPP1), an important biomarker for huma

212 sported from the liver to target tissues via selenoprotein P (SEPP1).

213 Nevertheless, selenoprotein P and several other selenoproteins are kno

214 To optimize the plasma selenoprotein P concentration in this study, 50 microg S

215 roxidase activity and in plasma selenium and selenoprotein P concentrations were measured.

216 describe for the first time the presence of selenoprotein P in human breast milk.

217 Selenoprotein P increased significantly in all selenium

218 Plasma selenoprotein P is a useful biomarker of status in popul

219 , and recognizing the important functions of selenoprotein P, these results provide important evidenc

220 and known to be correlated with circulating selenoprotein P, was the biomarker chosen.

221 t dependent on cis-acting elements unique to selenoprotein P.

222 was fully dependent on the supplies of Se by selenoprotein P.

223 roRNA 671-5p and downstream the antifibrotic selenoprotein P1 as common effectors of the antifibrotic

224 F4a3 binds SECIS elements from non-essential selenoproteins, preventing Sec insertion.

225 The micronutrient selenium is essential for selenoprotein production and is transported from the liv

226 that the observed deficit in stress-related selenoprotein production is likely mediated by reduced e

227 ation to >90%, and also doubles the yield of selenoprotein production.

228 resulted in a hierarchical up-regulation of selenoproteins, protected HEK293 cells from reactive oxy

229 The formed hAGT selenoprotein repairs the DNA damage caused by the methy

230 Selenocysteine (Sec) incorporation into selenoproteins requires a Sec Insertion Sequence (SECIS)

231 Synthesis of selenoproteins requires recoding of internal UGA stop co

232 Synthesis of selenoproteins requires the decoding of a UGA codon as s

233 The synthesis of selenoproteins requires the translational recoding of th

234 uced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype.

235 the specific incorporation of selenium into selenoproteins, results in a significant growth defect a

236 Selenoprotein S (SelS or VIMP) is an intrinsically disor

237 Hepatic glutathione peroxidase 1 (GPx1) and selenoprotein S (SelS) production and circulating seleno

238 ukaryotic protein family that includes SelK, selenoprotein S (SelS), and distantly related proteins.

239 Selenoprotein S (SelS, VIMP) is an intrinsically disorde

240 IMP (VCP-interacting membrane protein)/SelS (selenoprotein S) localizes to the endoplasmic reticulum

241 Among selenoproteins, selenoprotein P (Sepp1) is particularly

242 The 15-kDa selenoprotein (Sep15) is a thioredoxin-like, endoplasmic

243 tion that uses SECISearch3 and then predicts selenoprotein sequences encoded upstream of SECIS elemen

244 Gene reconstruction revealed standard selenoprotein sequences except for GPx1, which had an ea

245 itions within selenoproteins, but do so in a selenoprotein-specific manner, and that this process is

246 ese effects could be explained by the use of selenoprotein-specific SECIS elements.

247 model by reducing the expression of multiple selenoproteins (SPs) in mouse prostatic epithelium.

248 gene duplications from an ancestral metazoan selenoprotein SPS2 gene that most likely already carried

249 omethylation, which alters the expression of selenoproteins such as GPx-1 to contribute to a proather

250 lso with genetic dysfunction of nonessential selenoproteins, suggesting that Se deficiency could be a

251 Exposure to AgNPs leads to the inhibition of selenoprotein synthesis and inhibition of TrxR1.

252 chanisms of selenocysteine incorporation and selenoprotein synthesis are discussed in light of these

253 determine if the effects of Secisbp2 loss on selenoprotein synthesis could be attributed entirely to

254 nscript-selective translational repressor of selenoprotein synthesis during selenium deficiency.

255 ncy (the lack of selenium for the process of selenoprotein synthesis even though selenium intake is n

256 on the translational mechanisms controlling selenoprotein synthesis in mouse liver.

257 Selenoprotein synthesis programmed by UAG in Geodermatop

258 Auranofin, a known inhibitor of selenoprotein synthesis showed the same sensitivity towa

259 We have recently developed a SECIS-free selenoprotein synthesis system that site-specifically--u

260 llows selenium to be recycled for additional selenoprotein synthesis.

261 scribe the engineering of EF-Tu for improved selenoprotein synthesis.

262 ant role in regulation of selenocysteine and selenoprotein synthesis.

263 corresponding mouse element did not support selenoprotein synthesis.

264 in the Secisbp2 gene that partially disrupt selenoprotein synthesis.

265 e importance of tRNA modification for normal selenoprotein synthesis.

266 hy of selenoprotein expression, with certain selenoproteins synthesized at the expense of others.

267 er, the abundance of the naturally occurring selenoprotein that contains 10 Sec residues (SEPP1) sugg

268 dothyronine deiodinases (Dios) are important selenoproteins that control the concentration of the act

269 Selenium is incorporated into selenoproteins that have a wide range of pleiotropic eff

270 Most selenoproteins that have been functionally characterized

271 tion of deubiquitinases, b-AP15 inhibits the selenoprotein thioredoxin reductase (TrxR).

272 The human selenoprotein thioredoxin reductase 1 (TrxR1), encoded b

273 rain C321.DeltaA, we could produce mammalian selenoprotein thioredoxin reductases with unsurpassed pu

274 enes has drawn attention to the relevance of selenoproteins to health.

275 we provide a ranked list of newly predicted selenoproteins together with their annotated cysteine-co

276 As selenoprotein transcript levels and localization did not

277 Sbp2 deficiency in pancreatic beta-cells on selenoprotein transcript profiles in the pancreatic isle

278 The differential impact of Sbp2 deletion on selenoprotein transcription between sexes suggests sex-s

279 also plays an essential role in stabilizing selenoprotein transcripts by antagonizing nonsense-media

280 atic beta-cells altered expression of only 3 selenoprotein transcripts in male islets, whereas 14 tra

281 abrogates SECIS binding and does not support selenoprotein translation above the level of a complete

282 ng protein 2 (SBP2) is a critical protein in selenoprotein translation that also plays an essential r

283 lted in residual activity and caused reduced selenoprotein translation, as demonstrated by ribosomal

284 Selenoproteins typically contain a single selenocysteine

285 nadequately explain the abundance of various selenoproteins under normal and pathological conditions,

286 These findings indicate that the selenoprotein uptake mechanisms ensure selenium transfer

287 Selenoproteins use the rare amino acid selenocysteine (S

288 orporated as selenocysteine into at least 25 selenoproteins using a unique translational UGA-recoding

289 Selenocysteine is inserted into selenoproteins via the translational recoding of a UGA c

290 The human selenoprotein VIMP (VCP-interacting membrane protein)/Se

291 Selenoprotein W (SEPW1) is a ubiquitous, highly conserve

292 Expression of 69 genes, including selenoproteins W1 and K, which are genes involved in cyt

293 Examination of Sec insertion into other selenoproteins was consistent with this model.

294 enium incorporation machinery indicated that selenoproteins were necessary for H-PGDS expression and

295 ione peroxidase 1 (GPx1) band, whereas other selenoproteins were preserved.

296 ovide manually curated annotations for human selenoproteins, whereas we use an automatic annotation p

297 ted into proteins during translation to form selenoproteins which serve a variety of cellular process

298 vertebrates, fruit flies preserve only three selenoproteins, which are not essential and play a role

299 selenocysteine, it belongs to the family of selenoproteins, which are typically oxidoreductases.

300 The parasite was found to encode three selenoproteins, which were only expressed in the presenc