ライフサイエンスコーパス: self-association

1 l N-terminus of MEILB2 and preventing MEILB2 self-association.

2 with the Dicer-binding region implicated in self-association.

3 rrays to undergo salt-induced compaction and self-association.

4 ia electrostatic surface anchoring and chain self-association.

5 ations that make TRBP more like PACT enhance self-association.

6 ion of a conserved leucine residue abolishes self-association.

7 d the M1 protein potently and weakened M1-M1 self-association.

8 ut chemical cross-linking, demonstrated RGS7 self-association.

9 ogen bonds according to reliable patterns of self-association.

10 de the hindrance that His-36 puts on KIR2DL1 self-association.

11 utations on these residues disrupt AIM2(PYD) self-association.

12 ional role in destructosome assembly through self-association.

13 ing the catalytic cycle that promotes alphaS self-association.

14 o 152) to identify determinants required for self-association.

15 to ensure aqueous solubility and discourage self-association.

16 KD approximately 0.26 muM and is capable of self-association.

17 rovide a lead to develop inhibitors of Abeta self-association.

18 ate subdomain of HSA domain 3 inhibits Abeta self-association.

19 hown to serve as a potent inhibitor of Abeta self-association.

20 a helix within the SAM domain contributed to self-association.

21 ins to solvent and may serve as hotspots for self-association.

22 interaction and, surprisingly, promote Upf1 self-association.

23 oncentration-dependent stability and dynamic self-association.

24 s for effects on Abeta(1-42) aggregation and self-association.

25 tural asymmetry that arises from heteromeric self-association.

26 ntly affect overall chromatin compaction and self-association.

27 and F3 subdomains are important for kindlin self-association.

28 drophobic region and the C terminus, prevent self-association.

29 ge numbers of endogenous RNAs, promoting its self-association.

30 oncentration-dependent stability and dynamic self-association.

31 reservoir for free inhibitor and preventing self-association.

32 its well-known ionic-strength-dependent weak self-association.

33 aphy is a powerful tool for studying protein self-association.

34 rations studied with no evidence of catalyst self-association.

35 with histone-modifying, histone-binding, and self-association activities.

36 ervation consistent with a model wherein Rev self-association acts to transiently mask the NES peptid

37 aggregation by altering kinetics of protein self-association, affecting folding of protein monomers,

38 arameter than the chemical shift for probing self-association, aggregation and inter-molecular intera

39 p between conformational changes and protein self-association/aggregation remains elusive due to the

40 led-coil structural feature involved in HOP2 self-association, allow us to explain important aspects

41 Moreover, we find that YY1 self-association also occurs in vivo using bimolecular f

42 of the second ExsA monomer in the absence of self-association also required the presence of a high-af

43 ast, deletion of the H5 alpha helix impaired self-association and anti-CD3 induced AP1/NFAT transcrip

44 Arsenite stress stimulates LRRK2 self-association and association with protein phosphatas

45 s C-terminal OB-fold domain (OB4) to mediate self-association and binding to Cdc13A.

46 y, the distinctive Ag43a L shape facilitates self-association and cell aggregation.

47 tations in the truncated region also abolish self-association and cell-death signaling.

48 ster and insulate the enclosed genes through self-association and chromatin looping.

49 utant, we found that PINK1 stimulated Parkin self-association and complex formation upstream of mitoc

50 a bolaamphiphile in aqueous media, underwent self-association and develop a hydrophilic aggregate.

51 ization loss mutant of RNF144A still retains self-association and E3 ligase activity, which can be bl

52 rylation of Rapsn, which is required for its self-association and E3 ligase activity.

53 Self-association and electron microscopy studies reveale

54 tify kindlin-3 point mutations that decrease self-association and enhance integrin binding, affording

55 ns within C(H)2 and C(H)2s that are prone to self-association and establishing the differences in sta

56 ing the molecular mechanisms involved in the self-association and fibrillization of monomeric soluble

57 ically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear p

58 picomolar affinity, but undergoes reversible self-association and has a poor pharmacokinetic profile

59 owing for the study of high-affinity protein self-association and hetero-association.

60 binds disordered proteins and promotes their self-association and higher order assembly.

61 anism by which MLL-AF6, through constitutive self-association and in cooperation with DOT-1L, activat

62 n sites were substituted with Asp) perturbed self-association and inhibited DEAD-box helicase 3 (X-li

63 chain length at position 233 in HrpS affects self-association and interaction with the HrpR and demon

64 eraction overlap with those required for ASC self-association and interaction with the PYDs of inflam

65 Protein instability leads to reversible self-association and irreversible aggregation which is a

66 -36 side chain prevents constitutive KIR2DL1 self-association and ITIM phosphorylation.

67 interfaces in the KAP1 TRIM responsible for self-association and KRAB binding and establishes their

68 lophilic (Ni(II) ...Ni(II) ) interactions in self-association and ligand-exchange processes.

69 patches may form the hot spots in AIM2(PYD) self-association and may represent a common mode of PYD/

70 testing of the biological role of arrestin-1 self-association and pave the way to elucidation of full

71 R2DL1-H36A) resulted in constitutive KIR2DL1 self-association and phosphorylation, as well as recruit

72 trinsic disorder of the Abeta peptide drives self-association and progressive reordering of the confo

73 The assembly is mediated by ASC self-association and protein interactions via its two De

74 lation of apoptosis and inflammation through self-association and protein-protein interactions mediat

75 ires specific cleavage between F1 and F2 for self-association and rearrangement into stable postfusio

76 sugars (mono- and disaccharides) on caffeine self-association and solubility.

77 insight into the competition between solvent self-association and solvent-solute interactions in thes

78 lecular complex formation prevents IAPP from self-association and subsequent aggregation, reducing T2

79 secondary signal relies on EGF-induced EGFR self-association and switches suppressive recycling to d

80 heparin binding protein that modulates this self-association and that the IL-37 dimers must block th

81 s that the TM domain is required for RNF144A self-association and that the self-association may be pa

82 ly disordered middle region of SKIP mediates self-association and that this self-association enhances

83 ion, we have characterized ASC and NLRP3 PYD self-association and their intermolecular interaction by

84 albumin (HSA) is a potent inhibitor of Abeta self-association and this novel, to our knowledge, funct

85 derstand the fundamentals of their molecular self-association and to unveil their application spectru

86 Interestingly, RNF144A-G252D still preserves self-association and ubiquitin ligase activity but loses

87 es membrane localization but is defective in self-association and ubiquitin ligase activity.

88 t on avidity, demanding appropriate receptor self-association and/or HA multimerization.

89 s in attention, memory, interpretations, and self-associations), and patient-reported symptoms (perse

90 erplay of amino acid composition, structure, self-association, and adhesion modality in a panel of va

91 C at the interface), transient multicellular self-association, and dynamical escape from the interfac

92 nker length could affect nucleosome folding, self-association, and interactions.

93 astin has a decreased propensity for initial self-association, and it cross-links aberrantly into den

94 FSHR self-association appears to be required for receptor cou

95 ENTH domain membrane binding and ENTH domain self-association are also discussed.

96 usion, both proper membrane localization and self-association are important for RNF144A function.

97 t critical protein-protein interfaces in BAK self-association are limited to the alpha2-5 homodimeriz

98 ErbB2 oncogene, and find that insertion and self-association are strongly coupled in receptor homodi

99 and try to determine whether differences in self-association are sufficient to induce large changes

100 reduction of stable surface interactions and self-association, as confirmed by atomic force microscop

101 Indeed, W324 was necessary for CtBP2 self-association, as shown by analytical ultracentrifuga

102 electrophoretic assays, and Mg(2+)-dependent self-association assays to study intrinsic folding of li

103 12-WFL, has been shown to undergo reversible self-association at high concentrations and exhibited po

104 e consistent with a monomer-dimer reversible self-association at pH 2.5, 3.5, 6.5, and 7.5.

105 ility when compared with magainin 2, resists self-association at the membrane surface and penetrates

106 d acceptor solutes must compete with solvent self-association, because the amide H-bond donor site is

107 Computational prediction of such a self-association behavior is advantageous early during m

108 S) moieties has been demonstrated to exhibit self-association behavior to give various distinguishabl

109 rrestin superfamily have great propensity of self-association, but the physiological significance of

110 viously proposed for the inhibition of Abeta self-association by another plasma and cerebrospinal flu

111 n modulating its conformational dynamics and self-association by disrupting the disulfide bridge (Cys

112 Ultra-weak self-association can govern the macroscopic solution beh

113 Self-association, coimmunoprecipitation with HopBA1, and

114 ver, when the task was such that ingroup and self associations competed, only the self-advantage was

115 According to the results, self-association constant of beta-carotene in the presen

116 2-mers also form duplexes, but the observed self-association constants are strongly affected by fold

117 ociate both in vitro and in planta, and this self-association correlates with their cell death signal

118 The mutations included a Nab3 self-association defect, a Nab3-Nrd1 heterodimerization

119 s L137, C139, L140, K141, and L148 exhibited self-association defects and were required for maximal a

120 e SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse d

121 n these proteins, which, as we show, feature self-association-dependent NAD(+) cleavage activity asso

122 The self-association/dissociation of Grb2 represents a switc

123 e show that a novel N-terminal coil, the APC self-association domain (ASAD), found in vertebrate and

124 nduced LCR-promoter looping by tethering the self-association domain (SA) of Ldb1 to the beta-globin

125 Heterologous self-association domain cryptochrome 2 promotes formatio

126 Additionally, we identified a Tango1 self-association domain that is essential for formation

127 Ss even in the presence of intact C-terminus self-association domain.

128 y N-terminal region flanking the coil-coiled self-association domain.

129 NA export and stress granule formation, both self-association domains are independently required for

130 SKIP mediates self-association and that this self-association enhances the interaction of SKIP with k

131 n required for both cell death signaling and self-association extends to amino acid 142, thus includi

132 uctural and functional studies indicate that self-association facilitates the binding of E2A-PBX1 to

133 s were found to display remarkably different self-association features and optical properties, which

134 The unique dependence on self-association for E2A-PBX1 oncogenic activity suggest

135 role for the SAM domain in mediating SLP-76 self-association for T-cell function.

136 age association state for rapidly reversible self-associations from which the free energy of binding

137 Collectively, we reveal self-association functions as an additional mode of Gle1

138 ation previously hypothesized to disrupt OAS self-association had only a minor effect on OAS2 activit

139 tion rates of amyloid beta peptide (Abeta40) self-association, implicated in Alzheimer's disease.

140 tion suggests that the transporter undergoes self-association in a concentration-dependent manner.

141 We now show that Hed1 undergoes self-association in a Rad51-dependent manner and binds s

142 terface involved in the tubulin longitudinal self-association in a way that inhibits nucleotide excha

143 sed mutant arrestin-1 with severely impaired self-association in mouse rods and analyzed mice of both

144 Although foldamer self-association in nonpolar chloroform increased with l

145 e and properties of the macrocycles, such as self-association in solution and optical and electrochem

146 ant for good ionophoric activity than strong self-association in the bilayer.

147 , because both CMV and HSV gH/gL demonstrate self-association in the FRET system.

148 We evaluated possible self-association in this inverted tandem conjugate via a

149 tercellular interactions and is capable of a self-association in trans.

150 nants of CTCF clustering, we found that CTCF self-association in vitro is RNase sensitive and that an

151 with TRAF6, was unable to cause either TRAF6 self-association, induce the TRAF6-TAK1 association, or

152 in mammalian cells, and we propose that this self-association inhibits integrin binding and kindlin l

153 ble competition between Gal3-Gal80 and Gal80 self-association interactions.

154 lysis, the sigma(54) binding loop 1, and the self-association interface.

155 activity of plant TIR domains require known self-association interfaces and a putative catalytic glu

156 pAA afforded peptide 7HSAP1, which undergoes self-association into a nanotube via noncovalent interac

157 ation, forms reversible fibrils, and enables self-association into assemblies required for TORC1 inhi

158 false positives in drug discovery is ligand self-association into large colloidal assemblies that no

159 ng a point mutation that blocks SAM-mediated self-association into the yan genomic locus and compared

160 Self-association is a common phenomenon in biology and o

161 Uncontrolled self-association is a major challenge in the exploitatio

162 VWF self-association is accelerated by shear stress.

163 In contrast, Gle1 self-association is dispensable for phosphorylation and

164 Here, we find that Gle1 self-association is driven by two distinct regions: a co

165 Such mutation-driven ENL self-association is functionally linked to enhanced chro

166 A key endogenous inhibitor of Abeta self-association is human serum albumin (HSA), which bin

167 Understanding the nature and mechanisms of self-association is important for modulating these syste

168 Therefore, ExsA self-association is indispensable and provides an attrac

169 er, a thorough analysis of the role for Gle1 self-association is lacking.

170 iate into Fn14 dimers, and we show that Fn14 self-association is mediated by an 18-aa region within t

171 dlin-3 can self-associate and that kindlin-3 self-association is more robust.

172 Based on these data, ExsA self-association is necessary to overcome inhibition by

173 liest events in amyloid beta-protein (Abeta) self-association is nucleation of Abeta monomer folding

174 dly dissociates from flexible DNA when RAD51 self-association is perturbed.

175 rms small single-stranded oligomers, but its self-association is stronger than that of DIX.

176 Unfortunately, weak self-association is technically extremely difficult to s

177 of exenatide to the membrane surface and its self-association (K(d) = 46 muM) suggested the possibili

178 iners exhibit good water solubility and weak self-association (Ks </= 624 M(-1)).

179 nserved GRASP domain of GRASP65 disrupts its self-association, leading to a loss of Golgi membrane te

180 microtubule lattice regulates reversible tau self-association, leading to localized, dynamic condensa

181 sults suggest that an A52 dimer causes TRAF6 self-association, leading to TAK1 recruitment and p38 ac

182 Dynamic, higher-order protein self-association may be a general mechanism to concentra

183 hat cis intramolecular interaction and trans self-association may be general mechanisms for regulatio

184 ed for RNF144A self-association and that the self-association may be partially mediated through a cla

185 These studies suggest that oligomeric self-association may compensate for the inability of mon

186 , previous observations of higher-order MinE self-association may explain this inhibition.

187 achieve multivalency through this multisite self-association mechanism facilitated by fuzzy interact

188 y structural asymmetry and that this unusual self-association mechanism is conserved from flies to hu

189 r data reveal an unexpected diversity in the self-association mechanism of TRIMs that might be crucia

190 Our results support the notion that kindlin self-association negatively regulates integrin binding.

191 Self-association occurred independent of ubiquitination

192 Hill-Scatchard model whereby the Abeta(1-40) self-association occurs cooperatively and generates Abet

193 We observed that VWF self-association occurs during adsorption of VWF onto su

194 wo-hybrid experiments demonstrate that CtBP1 self-association occurs within the nucleus, and depends

195 rations but below the concentration at which self-association occurs) at different water pH (pH 0.3 t

196 However, how the oligomeric state and self-association of ACMSD are controlled in solution rem

197 The result is that self-association of alcohols does not compete with solva

198 Self-association of amyloid beta (Abeta) peptides is a h

199 We propose a model of how self-association of apoA-IV can result in spherical lipo

200 solvophobic and van der Waals forces in the self-association of apolar chains.

201 ed the influence of pH and salt-types on the self-association of bovine IF(1) and the folding of its

202 ogical systems and nanoscale assemblies, the self-association of DNA is typically studied and applied

203 ate and invertebrate APCs, directly mediates self-association of Drosophila APC2 and plays an essenti

204 ar interaction between these two domains and self-association of each of these domains.

205 the complex assembles and prevents possible self-association of harmonin-a.

206 We identified key residues required for the self-association of HrpR (D32, E202 and K235) with HrpS

207 We have investigated the weak self-association of human growth hormone (hGH, KD = 0.90

208 definition of the factors that influence the self-association of IF(1) is a key to understanding the

209 omers in individual VWF multimers and on the self-association of individual VWF multimers into larger

210 d that ITIM phosphorylation is controlled by self-association of KIR and that His-36 serves as a gate

211 y, these higher-order assemblies involve the self-association of LANA into supermolecular spirals.

212 tural model for EGFR multimerization through self-association of ligand-bound dimers, in which the ma

213 ctures formed by reversible Mg(2+)-dependent self-association of linear 12-mer nucleosomal arrays usi

214 We hypothesized that impairing self-association of M1 through a small molecule 'wedge',

215 trometry we map the residues responsible for self-association of MEDI1912 and show that disruption of

216 embrane penetration of H(0) is important for self-association of membrane-bound dAmp-BAR and EndoA1-B

217 ify the amino acids responsible for aberrant self-association of monoclonal antibodies and the design

218 and pressures up to 1 kbar are reached, the self-association of Na25'-GMP is most favoured.

219 compared with the calculated DeltaG for the self-association of NHERF1.

220 Nucleotide binding stimulates self-association of NrdR, with tri- and diphosphates sti

221 we address the question of the impact of the self-association of nucleoid proteins on their architect

222 Our in vitro studies demonstrate that self-association of nucleosomal arrays under a wide rang

223 The self-association of prion protein (PrP) is a critical st

224 Self-association of proteins is important in a variety o

225 mediates methyl-beta-cyclodextrin-sensitive self-association of purified gB.

226 druplex ligands were designed to exploit the self-association of quartets, being themselves synthetic

227 The self-association of R10 is stronger at lower ionic stren

228 neurons, activation of Rab5 and CC-dependent self-association of SNX16 lead to its endosomal enrichme

229 ts indicate that SMN tetramers are formed by self-association of stable, non-dissociating dimers.

230 We propose that reversible self-association of tau molecules, gated by the microtub

231 o and is a major signal for cross-beta-sheet self-association of the 49-mer Phe521Leufs peptide ident

232 ciently inhibits amyloid seeding by impeding self-association of the amyloid-driving strands F and H

233 the formation of chiral helical polymers by self-association of the BTA monomers through noncovalent

234 These results lead us to the conclusion that self-association of the G domains cannot be responsible

235 l line of experiments to detect and map weak self-association of the G domains, we analyzed NMR chemi

236 bridge at the SAM polymer interface, reduces self-association of the isolated SAM domain as well as h

237 These data suggest that self-association of the minimal CC domain is necessary f

238 Here we find that self-association of the Nek9-CTD is needed for Nek7 acti

239 entrifugation showed concentration-dependent self-association of the peptide into a hexamer.

240 sic optoelectronic properties as well as the self-association of the PN-heterocycles.

241 rin complex show that ligand binding induces self-association of the protein-carbohydrate complex int

242 d through Brownian dynamics simulations that self-association of the proteins dramatically increases

243 nal properties of KIR2DL4 may be mediated by self-association of the receptor.

244 Here we demonstrate that self-association of the serine-aspartate repeat protein

245 The process involves the pH-triggered self-association of the spidroin N-terminal domain (NTD)

246 in domain severely reduced the efficiency of self-association of the VCC monomer with the beta-barrel

247 Self-association of therapeutic monoclonal antibodies (m

248 The self-association of these proteins in the presence of Zn

249 lts are in line with the solution studies of self-association of ureas.

250 Here, we show that self-association of Xenopus laevis Mcm10 is mediated by

251 ential manner to partition, fuse, and direct self-association of Xi compartments required for proper

252 sess the impact of tannin oxidation on their self-association, oligomeric procyanidins were oxidized

253 D complex and provide first-time evidence of self-association on its luminal side.

254 cipients), post-translational modifications, self-association, or ligand binding.

255 mental validation in order to illustrate the self-association outcomes predicted by the three metrics

256 eosinophils and clarify how its polymorphic self-association pathways regulate toxicity intra- and e

257 In contrast to self-association, PBX1 protein domains that mediate inte

258 sed to demonstrate that while extensive urea self-association persists in the flexible semiopen compl

259 while Gn possesses a significantly stronger self-association potential.

260 ered disulfide bridge in m01s eliminated the self-association process and rendered this mAb fragment

261 echanistic aspects that underpin intertwined self-association processes in proteins.

262 Rather, their self-association properties must also be investigated in

263 We attribute differences in the self-association properties of Loqs, TRBP and PACT to di

264 y inactive, degradation product with altered self-association properties.

265 e two alpha-catenin variants differ in their self-association properties: at physiological temperatur

266 The self-association property of Nab3 adds to the previously

267 ing, and computational modeling to study the self-association-related multivalency of galectin-3 at t

268 e hypothesize that allosterically controlled self-association represents the first step of VLP assemb

269 Disruption of self-association resulted in decreased binding to T3SS p

270 ine, and myo-inositol have a tendency toward self-association; sorbitol and most other nonrenal osmol

271 hat both the amphiphilic environment and the self-association state of CcO affect its kinetic stabili

272 e the inter-relationship of foldamer length, self-association strength, and ionophoric ability, which

273 veral mechanisms, including protein binding, self-association, subcellular localization, and phosphor

274 first time, we have found a fully reversible self-association (tetramerisation) within this family of

275 structural architecture, accounting for PRC2 self-association that has long been implicated.

276 icA levels, we identified a Mg(2+)-dependent self-association that occludes the ompA-recognition regi

277 uires elucidation of the structural basis of self-association, the conformational heterogeneity of di

278 ee self-interacting regions and two types of self-association, the N-to-C terminal and the N-to-N ter

279 is finding indicated that, in the absence of self-association, the NTD prevents binding by a second m

280 er transferrin is also able to inhibit Abeta self-association through direct binding of Abeta.

281 anges in conformation that facilitates their self-association to form pores in the mitochondrial oute

282 y affected its cellular functions, including self-association, Tyr(925) phosphorylation, paxillin bin

283 nimal model that von Willebrand factor (VWF) self-association under shear stress can be modulated by

284 h NLRP3, rationalizing the model whereby ASC self-association upon recruitment to NLRP3 promotes clus

285 m thermodynamics and kinetics of folding and self-association using dynamic light scattering, stopped

286 idine-4-ylethynyl)benzene, which can undergo self-association via hydrogen bonding (H-bonding) to for

287 Self-association via the coiled-coil has been suggested

288 l cellular LOX-1 NTF levels which, following self-association via their transmembrane domain, can act

289 ACMSD self-association was affected by pH, ionic strength, and

290 ntacts.The dynamic strength of the homomeric self-association was measured as a function of calcium i

291 To test the role of arrestin-1 self-association, we expressed oligomerization-deficient

292 sis, we propose a molecular model for e-gp41 self-association, which can guide the production of solu

293 indicate that ELP[V5G3A2-150] undergoes weak self-association with increasing temperature, and above

294 gammaS-crystallin reveals weak monomer-dimer self-association with K(D) = 24 mM, corresponding to a s

295 e absence of H1-4 sufficed to support SLP-76 self-association with smaller microclusters that neverth

296 tides to systematically explore biomolecular self-association with the ESI-mass spectrometry (MS) tit

297 ds of point mutations on helix insertion and self-association within the bacterial inner membrane.

298 g structural rigidity and promoting receptor self-association within the biological membranes.

299 e results suggest that interference with VWF self-association would be a new approach to treating thr

300 t the inter-protein interaction modulated by self-association yields functional changes observable fr