ライフサイエンスコーパス: self-complementary

1 This method is applied to a model set of self-complementary 10-base-pair sequences in which the p

2 The reaction of the self-complementary 12-mer duplex 5'-[d(ATATGTACATAT)(2)]

3 The reactions of (15)N-1 with the self-complementary 12-mer duplexes 5'-[d(ATATGTACATAT)(2

4 sis (FSCE) has been used to separate two non-self-complementary 12mer oligonucleotide duplexes: d(AAA

5 the free state and Hiwi1 PAZ domain bound to self-complementary 14-mer RNAs (12-bp + 2-nt overhang) c

6 In this article the self-complementary 16 bp oligodeoxynucleotide (CATGTGACG

7 employed to determine the structures of four self-complementary 16 bp oligonucleotides including LTR

8 Derivatives of the self-complementary 2-guanidiniocarbonyl pyrrole 5-carbox

9 of activated PNAs where every 4-mer has its self-complementary 4-mer.

10 uble-stranded DNA molecules derived from the self-complementary 5'-d(TTACGTACGTAA) sequence following

11 by ultraviolet-activated cross-linking of a self-complementary 5-bromodeoxyuridine (5BrU)-substitute

12 sistance we determined crystal structures of self-complementary A-form DNA decamer duplexes containin

13 the fates of single-strand rAAV (ssAAV) and self-complementary AAV (scAAV) genomes in cell lines def

14 arization-dependent and orientation-specific self-complementary AAV (scAAV) vectors as a reporter sys

15 Self-complementary AAV (scAAV) vectors have been develop

16 n-label trial (NCT02161380), the study drug (self-complementary AAV [scAAV]2(Y444,500,730F)-P1ND4v2)

17 Self-complementary AAV cassettes containing codon optimi

18 We constructed a self-complementary AAV having mutant capsids with the ES

19 SMA-like disease with a human SMN-expressing self-complementary AAV vector - a vector that leads to e

20 The self-complementary AAV vector preparation appears to con

21 fferent coding regions of HBV delivered by a self-complementary AAV vector showed better antiviral ef

22 nd full capsids for both single-stranded and self-complementary AAV vectors indicate that the genomes

23 were equally evident for single-stranded and self-complementary AAV vectors.

24 rates for site-specific integration than are self-complementary AAV vectors; the absence of DNAPKcs d

25 Self-complementary AAV-induced acute liver injury appear

26 1a (CARap1a) into the RPE of wild type mice, self-complementary AAV2 (scAAV2) vectors driven by two d

27 Neither single-stranded nor self-complementary AAV2/9 triggered a microglia-mediated

28 nonhuman primates, hepatotoxicity following self-complementary AAV9 administration varies from asymp

29 Next, using self-complementary AAV9 clinical candidate vector, we sh

30 Here, we show that self-complementary AAV9, bearing MeCP2 cDNA under contro

31 an unprecedented stability for dimers of its self-complementary acceptor-acceptor-donor-donor (AADD)

32 Concurrently, we generated a self-complementary adeno-associated viral (AAV) vector c

33 acy of peripheral venous administration of a self-complementary adeno-associated viral vector encodin

34 , Mokola and Ross River viral envelopes) and self-complementary adeno-associated viral vectors, serot

35 virus (cceAAV) vector is a new generation of self-complementary adeno-associated virus (scAAV) vector

36 six weeks following intravenous injection of self-complementary adeno-associated virus (scAAV) withou

37 We recently demonstrated that self-complementary adeno-associated virus 9 (scAAV9) can

38 delivery approach for JNCL by generating two self-complementary adeno-associated virus 9 (scAAV9) con

39 explored a gene delivery approach using two self-complementary adeno-associated virus 9 (scAAV9) con

40 ed if systemic delivery of a codon-optimized self-complementary adeno-associated virus bearing WT-TME

41 evaluated the ability of single-stranded and self-complementary adeno-associated virus pseudotype 2/9

42 We then generated the virus particle, self-complementary adeno-associated virus serotype 2 car

43 B, gene therapy that is mediated by a novel self-complementary adeno-associated virus serotype 8 (AA

44 ivity in vivo, miR-23a was expressed using a self-complementary adeno-associated virus serotype 9 (sc

45 intracerebroventricularly (i.c.v.) delivered self-complementary adeno-associated virus serotype 9 (sc

46 a survival motor neuron-1 transgene using a self-complementary adeno-associated virus serotype 9 abo

47 Administration of a self-complementary Adeno-Associated Virus vector express

48 l dose-escalation study of scAAV9/JeT-GAN (a self-complementary adeno-associated virus-based gene the

49 ately into plasmid vectors for generation of self-complementary adeno-associated virus.

50 en validated this combination approach using self-complementary adenoassociated virus serotype 9 (scA

51 d a single dose of a serotype-8-pseudotyped, self-complementary adenovirus-associated virus (AAV) vec

52 The host structure is composed of two self-complementary alpha,gamma-cyclic peptides bearing a

53 duced by bleomycin-catalyzed cleavage of the self-complementary alternating copolymer poly(dGdC).

54 ingle-stranded, 80-mer oligonucleotides with self-complementary, alternating purine-pyrimidine sequen

55 oxylic acid.pyridine hydrogen bond and (2) a self-complementary amide.amide hydrogen-bond interaction

56 The oligonucleotides are designed to be self-complementary and have the same chemical compositio

57 nsduction enhancement among single-stranded, self-complementary, and fragment vectors and found that

58 ong cooperative narcissistic self-sorting of self-complementary angle bars in cyclic aggregates towar

59 O design contains four pairs of miniaturized self-complementary antennas (SCAs) fed by pairs of indep

60 artphone antenna design using dual-polarized self-complementary antennas that could possess anti-inte

61 es, pair with themselves to form an unusual "self-complementary" antiparallel duplex containing (GGA)

62 a In wild-type (WT) cells, 6mA occurs at the self-complementary ApT dinucleotide, mostly in full meth

63 permits the formation of a steric zipper-two self-complementary beta sheets that form the spine of an

64 Previously, we inserted two self-complementary beta-hairpin enhancing motifs into a

65 ed through the spontaneous assembly of ionic self-complementary beta-sheet oligopeptides under physio

66 l in which a dimeric duplex is formed at the self-complementary CATG tetranucleotide sequence with ex

67 melting analysis and NMR, using hybrids with self-complementary CG zipper arms or non-self-complement

68 Self-complementary chimeric oligonucleotides (COs) compo

69 Self-complementary chimeric oligonucleotides that consis

70 lete genomes, including many that lost their self-complementary configuration.

71 These ODN have a self-complementary core sequence and a 3' end poly(G) tr

72 mers of the form d(ATTA-XGCX-TAAT) and their self-complementary counterparts suggest that actinomycin

73 within a (G-C-G-C).(G-C-G-C) segment in the self-complementary d(A1-A2-G3-C4-G5-C6-T7-T8) duplex.

74 inding and the curved Scatchard plot for the self-complementary d(CGTCGACG) may thus be attributed to

75 The hairpin conformation, dominant for self-complementary d(T(m)-A(n)) oligos in solution, is d

76 Two series of self-complementary daisy chain monomers, in which a seco

77 The titration of Lambda-Rh into the self-complementary decamer containing the recognition se

78 The alternating self-complementary decamer d(GCACGCGTGC) crystallizes in

79 Daunoform reacts with the self-complementary deoxyoligonucleotide (GC)4 faster tha

80 Three sets of semi-self-complementary deoxyribonucleotide decamers with the

81 The self-complementary design of these modules facilitates t

82 ) is very high due in part to formation of a self-complementary dimer comprised of two "saddle shaped

83 The EryCIII subunits form an extensive self-complementary dimer interface at the center of the

84 The formation and properties of self-complementary dimers and a closed tetrameric square

85 When flanked by conserved sequences, the self-complementary diSSR (AT)n was also associated with

86 A parallel study was performed on the self-complementary diSSRs (AT)n and (GC)n.

87 base mismatch formed by the 8-OG:G pair on a self complementary DNA dodecamer duplex d(CGCGAATT(8-O)G

88 ant single-stranded DNA (ssDNA), or dimeric, self-complementary DNA (scDNA) genomes.

89 The non-self-complementary DNA decamer C-A-A-A-G-A-A-A-A-G/C-T-T

90 the high-resolution solution structures of a self-complementary DNA decamer duplex featuring a single

91 lysis of crystal structures of cLNA modified self-complementary DNA decamer duplexes revealed that th

92 enzymatic, and spectroscopic study of three self-complementary DNA decamer duplexes, d[GCGAATT-3'-3'

93 three-dimensional solution structure of the self-complementary DNA dodecamer (CGT_GACGT_TACG above G

94 monia upon the structure and dynamics of the self-complementary DNA dodecamer [d(CGCAGATCTGCG)]2.

95 An NMR analysis of a self-complementary DNA duplex 5'-labeled with Cy3 shows

96 For this purpose we chose a non-self-complementary DNA duplex containing the biologicall

97 mperature, and self-complementary versus non-self-complementary DNA linker strands (1- versus 2-compo

98 a model solution of poly-l-lysine (PLL) and self-complementary DNA nanostars (NSs) as functions of t

99 doxorubicin plus formaldehyde react with the self-complementary DNA octamer (GC)4 to yield five drug-

100 mor drugs adriamycin and daunomycin with the self-complementary DNA oligonucleotide GCGCGCGC, (GC)4,

101 These results suggest that annealing of self-complementary DNA sequence engages an alternative t

102 temperature induced melting transition of a self-complementary DNA strand covalently attached at the

103 e Y704A, E562A, and E564A mutants containing self-complementary DNA were compared with virus containi

104 We compared the hydration of self-complementary DNA, RNA and 2'-O-methyl (2'-OMe) oli

105 es of modified oligonucleotides based on the self-complementary dodecamer d(CGCTAATTAGCG) were synthe

106 The crystal structure of the non-self-complementary dodecamer DNA duplex formed by d(CG[5

107 d by (1)H NMR spectroscopy using a series of self-complementary dodecamer oligonucleotides that conta

108 AQS2 bound to a specially designed synthetic self-complementary dodecanucleotide (5'-CGCGAATTCGCG-3')

109 In the crystal, this oligomer forms a self-complementary double helix in the asymmetric unit.

110 ee-dimensional solution structure of the RNA self-complementary duplex [formula in text] was derived

111 ee-dimensional solution structure of the RNA self-complementary duplex [sequence: see text] was deriv

112 ons that included the coupled equilibrium of self-complementary duplex and non-self-complementary dup

113 s compared with the crystal structure of the self-complementary duplex d[GCGTATMOEACGC]2, which conta

114 a comparative spectroscopic study of a novel self-complementary duplex decamer, d(GCGAAT-3'-3'-(alpha

115 librium of self-complementary duplex and non-self-complementary duplex denaturation.

116 were investigated for four 40 base pair, non-self-complementary duplex DNA oligomers.

117 were investigated for six 22-base pair, non-self-complementary duplex DNA oligomers.

118 One strand formed a partial self-complementary duplex that was more stable than the

119 hic studies at 2.5 mM reveal an antiparallel self-complementary duplex with the same base pairing as

120 ers d(CGCAAATTTGCG) and d(TCAAGGCCTTGA) form self-complementary duplexes that present distinct target

121 formed between one of three 14-base pair non-self-complementary duplexes with variable GC content and

122 erature or transitions indicative of partial self-complementary duplexes.

123 andard 40 nt ribozyme (MDR40) that lacks the self-complementary ends.

124 The 10mer self-complementary extended oligodeoxynucleotide 5'-d(xA

125 ort regulatory RNAs processed from partially self-complementary foldbacks within longer MIRNA primary

126 novel serotypes AAV7 and AAV8 and containing self-complementary genomes in the nonhuman primate liver

127 were performed for both single-stranded and self-complementary genomes.

128 The nucleobase, having self-complementary H-bonding faces, mimics both T and A

129 er region to facilitate the unwinding of its self-complementary hairpin structure, thereby subsequent

130 ining a pendant lactam functional group form self-complementary hydrogen bonded 'dimers of dimers' in

131 These polymers assemble through self-complementary hydrogen bonding and by physical enca

132 A combination of self-complementary hydrogen bonding and metal-ligand int

133 cal outcome of the assembly is controlled by self-complementary hydrogen bonding between both individ

134 such dimers, which stabilize each other with self-complementary hydrogen bonds, by encapsulation insi

135 ilies of chiral amine derivatives, featuring self-complementary hydrogen-bond donor and acceptor grou

136 additional waters on the upper rim create a self-complementary hydrogen-bonding pattern for capsule

137 rvey of 14 tandem inosine pairs and 8 tandem self-complementary inosine pairs is also provided.

138 n of 2,11-dithia[3.3]paracyclophanes through self-complementary intermolecular and transannular amide

139 n of homo- and heterochiral dimers involving self-complementary intermolecular hydrogen bonds is resp

140 ble, and reusable, is comprised of a single, self-complementary, methylene blue-labeled DNA probe pos

141 netically the solution-state assemblies of a self-complementary monomer comprising a BB(4+) ring appe

142 sight into the aggregation behaviour of such self-complementary monomers are presented.

143 opic method for detection of duplex forms of self-complementary nucleic acid sequences has been imple

144 C, G, or T, were synthesized along with the self-complementary octamer (5meCG)4.

145 t despite the absence of a GpC sequence, the self-complementary octamer d(CGTCGACG) binds strongly to

146 gly and cooperatively to a non-GC containing self-complementary octamer d(CGTCGACG) with a 2:1 drug t

147 A self-complementary ODN uniformly substituted with dI and

148 ion structure of an interstrand cross-linked self-complementary oligodeoxynucleotide containing direc

149 investigated as a stable surrogate using the self-complementary oligodeoxynucleotide sequence 5'-d(AG

150 Four self-complementary oligodeoxyribonucleotide sequences we

151 This self-complementary oligomer crystallizes in space group

152 between the 3,6- and 2,7-carbazoles and the self-complementary oligomer d(GCGAATTCGC) have been used

153 -linked benzimidazole derivative, 5, and the self-complementary oligomer d(GCGAATTCGC) have been used

154 CE experiments with the self-complementary oligomers d(CGAGCTCG) and d(CGTCGACG)

155 led the motions of a DNA duplex built from a self-complementary oligonucleotide (5-CTTATPPPZZZATAAG-3

156 15)NH(2))}](4+) (1,1/t,t-6,2,6, 1') with the self-complementary oligonucleotide 5'-{d(ATATGTACATAT)(2

157 Moreover, the self-complementary oligonucleotide alpha-ATATATATAT did

158 nion can selectively oxidize guanines in the self-complementary oligonucleotide duplex d(AACGCGAATTCG

159 l]-1,3-dimethylthiourea (ACRAMTU) to various self-complementary oligonucleotide duplexes has been stu

160 preferred DNA-binding site 5'-AATT within a self-complementary oligonucleotide, 5'-d(CTTAATTCGAATTAA

161 We constructed 34 self-complementary oligonucleotides containing altered c

162 we tested these predictions using synthetic self-complementary oligonucleotides containing variant t

163 mycin A2 (Fe-BLM) to calf thymus DNA and the self-complementary oligonucleotides d(CGCGCG) and d(ATAT

164 Alternating self-complementary oligonucleotides starting with a 5'-p

165 The interactions of self-complementary oligonucleotides with a group of meta

166 In this model, two self-complementary, or palindromic, sequences (PAL1 and

167 Specifically, we introduced self-complementary ortho-alkoxy-benzamide hydrogen-bondi

168 on kinetics and mechanism within a family of self-complementary pairs of 10-mer DNA oligomers by inte

169 nd that, independent of the tether backbone, self-complementary "palindromic" sticky ends readily for

170 and formation mechanism of the structurally self-complementary {Pd84} = [Pd84O42(PO4)42(CH3CO2)28](7

171 A series of partially self-complementary peptide nucleic acid (PNA) oligomers

172 We report here the reassembly of an ionic self-complementary peptide RADARADARADARADA (RADA16-I) t

173 s applied to the design and synthesis of two self-complementary phosphine oxide-iodotriazole hybrids

174 onal silencing of single-stranded as well as self-complementary rAAV genomes.

175 rand DNA synthesis, precluding inhibition of self-complementary rAAV, and did not affect the prior st

176 Using self-complementary recombinant AAV (scAAV) vectors, we g

177 Self-complementary recombinant adeno-associated virus (s

178 urons of the dorsal root ganglia (DRGs) with self-complementary recombinant adeno-associated virus se

179 om both single-stranded and double-stranded (self-complementary) recombinant AAV2 vectors preferentia

180 The high binding affinity between the self-complementary replicating templates that allows the

181 A) reporter-probe biosensor that displaces a self-complementary reporter, while target miRNA binds to

182 orming standard Watson Crick base-pairs with self-complementary residues C16-G17-C18-C19 and A12-G13,

183 By expressing two self-complementary RNA constructions designed to initiat

184 The crystal structure of a self-complementary RNA duplex r(GGGCGCUCC)2with non-adja

185 The equilibrium folding of a series of self-complementary RNA duplexes and the unmodified yeast

186 ters are reported for duplex formation of 48 self-complementary RNA duplexes containing Watson-Crick

187 ters are reported for duplex formation of 40 self-complementary RNA duplexes containing wobble termin

188 Subsequently a self-complementary (sc) AAV serotype 2/8 expressing mG1h

189 Transduction of SMG epithelia with self-complementary (sc) AAV2 expressing fibroblast growt

190 osine to phenylalanine (Y-F) capsid mutant), self-complementary (sc) AAV2/8 (single Y-F capsid mutant

191 We used self-complementary (sc) AAV2/8 vector to develop an RNAi

192 Titer-matched single-stranded (ss) and self-complementary (sc) AAV9 carrying the green fluoresc

193 alysis of murine liver transduced with these self-complementary (sc) vectors demonstrated rapid forma

194 The IL-1Ra gene was delivered by a self-complementary (sc)-recombinant adeno-associated vir

195 Studies comparing the transduction of short self-complementary (scAAV) to full-length conventional A

196 is sufficient conformational freedom of the self-complementary segment to interact with other molecu

197 Our genome-wide analysis revealed that self-complementary segments are found in almost all prot

198 haperoning effects have evolved to constrain self-complementary segments from interaction with each o

199 All of these are built from a single self-complementary sequence (5'-CTSZZPBSBSZPPBAG) that i

200 ve this, we modified a DNA target, which has self-complementary sequence able to form a hairpin loop,

201 ted to form a stem-loop structure that has a self-complementary sequence at one end.

202 ype 2 (HIV-2) RNA occurs by interaction of a self-complementary sequence exposed in the loop of stem-

203 A dimer initially forms via a self-complementary sequence in the dimer initiation site

204 This effect was not observed in a control self-complementary sequence of identical length and base

205 TLC1 dimerization depends on a unique 6-base self-complementary sequence, which closely mimics palind

206 Despite having self-complementary sequences at their substrate-binding

207 structure shows how even stem-loops without self-complementary sequences can facilitate the intermol

208 e model for bimolecular hybridization of non-self-complementary sequences that can be used to calcula

209 in monomer-length catalytic RNAs which have self-complementary sequences that can occupy their trans

210 IS), competes directly with the annealing of self-complementary sequences to form a metastable kissin

211 In the dimer, two self-complementary sequences, PAL1 and PAL2, form interm

212 ssociation rates is slower than those of the self-complementary sequences, whereas that of the dissoc

213 ighly conserved GACG tetraloops that are not self-complementary sequences.

214 Although a self-complementary serotype 8 adeno-associated virus (sc

215 The melting curve of the self-complementary single strand was also measured in so

216 on the modulation of thrombin activity by a self-complementary single stranded DNA (scssDNA), which

217 Microarrays were fabricated by immobilizing self-complementary single-stranded oligonucleotides, whi

218 the supramolecular polymer with only weakly self-complementary stickers is a solid, whereas the supr

219 s of each DNA single-strand base pair with a self-complementary strand to form an octamer B-DNA duple

220 propyl-2'-deoxyuridine residues (one on each self-complementary strand) lowers the stability of the d

221 hairpin helices (formed from folding of one self-complementary strand).

222 melting analysis of these 19-base, partially self-complementary strands performed in 115 mM Na+ yield

223 ular curvature to favor the assembly of four self-complementary subunits into a pseudo-spherical caps

224 Molecules with self-complementary surfaces interact through weak interm

225 The self-complementary systems based on Thy exhibit lamellar

226 ith self-complementary CG zipper arms or non-self-complementary TC dimer arms.

227 One is a self-complementary tetraloop (H1), but the other two ste

228 ere DNA pentamer sequence TGRAA form stable "self-complementary" [TGRAATGRAA]2 duplexes (R = G or A)

229 Daisy chain architectures, made by the self-complementary threading of an axle covalently linke

230 The strategically positioned self-complementary triple H-bonding arrays DDA and AAD f

231 leobases) featuring polymerizable groups and self-complementary triple H-bonding motifs DDA and AAD a

232 tritopic molecule, functionalized with three self-complementary ureidopyrimidinone (UPy) motifs.

233 d transduction with both single-stranded and self-complementary vector genomes.

234 DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA lin

235 d rAAV8), and influenced single-stranded and self-complementary virions to comparable extents.

236 mismatches resembles those of strong-binding self-complementary -XGCY- sites which are known to be in

237 tches is comparable to the strong binding of self-complementary-XGCY-sequences.

238 Specifically, we demonstrated that the novel self-complementary Y733F capsid mutant AAV2/8 (sc-Y733F-