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1  developed murine leukemia virus (MLV)-based self-inactivating and self-activating vectors to show th
2             We developed a novel conditional self-inactivating (C-SIN) vector, TL-SN, by replacement
3                         Substrate-initiated, self-inactivating, cell-penetrating poly(disulfide)s (si
4 ogenic rabies strain, CVS-N2c, to generate a self-inactivating CVS-N2c rabies virus (SiR-N2c).
5  To overcome this limitation, we developed a self-inactivating DeltaG-rabies virus (SiR) that transcr
6                                            A self-inactivating EIAV minimal lentiviral vector that ex
7 omegalovirus minimal promoter, the vector is self-inactivating, eliminating transcription from the lo
8 n H synthase (PGHS) is a self-activating and self-inactivating enzyme.
9                             Using a panel of self-inactivating gamma-retroviral vectors that express
10           We recently developed an insulated self-inactivating gammaretroviral vector, RMSinOFB, whic
11   To overcome these limitations we applied a self-inactivating genomic modification to the less immun
12 Spleen Focus Forming Virus promoter within a self-inactivating HIV-based lentiviral vector.
13  use of cellular promoters in "enhancerless" self-inactivating integrating vectors.
14  results after receipt of a third-generation self-inactivating investigational lentivirus-based CAR T
15 se events prompted the development of safer, self-inactivating lentiviral or gammaretroviral vectors.
16 alovirus (CMV) immediate-early promoter in a self-inactivating lentiviral vector (CSCG) is 4- to 15-f
17 reatment of children with a state-of-the-art self-inactivating lentiviral vector (LV-w1.6 WASp) has r
18  vitro fertilized ova were transduced with a self-inactivating lentiviral vector and transferred into
19 + hematopoietic stem cells transduced with a self-inactivating lentiviral vector containing human ITG
20 c progenitor cells transduced ex vivo with a self-inactivating lentiviral vector encoding a full-leng
21 itor cells (HSPCs) transduced ex vivo with a self-inactivating lentiviral vector encoding human ADA.
22                                            A self-inactivating lentiviral vector harboring these targ
23 e when inserted into the first intron, but a self-inactivating lentiviral vector with an internal cel
24 odeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV vi
25  such an approach using a therapeutic grade, self-inactivating-lentiviral vector, encoding codon opti
26  such an approach using a therapeutic grade, self-inactivating-lentiviral vector, encoding codon-opti
27 row and peripheral blood CD34+ cells using a self-inactivating lentivirus vector (CS-Rh-MLV-E) bearin
28 to 10-fold greater than that utilizing a non-self-inactivating lentivirus vector bearing the cytomega
29 ly integrated reporter system derived from a self-inactivating lentivirus vector, we showed in a BRG1
30                       Given the shift toward self-inactivating long terminal repeats with weaker prom
31 l vectors, including lentiviral vectors with self-inactivating long terminal repeats, have been shown
32 rom the chicken beta-globin locus within the self-inactivating long-terminal repeat.
33 ressed full-length type VII collagen using a self-inactivating minimal lentivirus-based vector.
34                          We have developed a self-inactivating PiggyBac transposon system for tamoxif
35                    A recent study employed a self-inactivating rabies (SiR) virus that enables record
36                                 We developed self-inactivating retroviral vectors that incorporate ge
37 eveloped a reporter assay system employing a self-inactivating retrovirus and analyzed the cystatin C
38     We assessed the efficacy and safety of a self-inactivating retrovirus for the treatment of SCID-X
39                         In addition, using a self-inactivating retrovirus luciferase reporter constru
40                                      Fifteen self- inactivating (SIN) lentiviral vectors using 4 eryt
41 nsduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high
42 e United States to evaluate treatment with a self-inactivating (SIN) gamma-retrovirus vector containi
43 terestingly, the polyadenylation signal of a self-inactivating (SIN) HIV-1 vector was as leaky as tha
44 by use of a high-throughput screen involving self-inactivating (SIN) human immunodeficiency virus typ
45 ted using VSV-G-pseudotyped, 3rd-generation, self-inactivating (SIN) lentivector encoding gp91(phox).
46 no LTR-directed transcription and are called self-inactivating (SIN) lentivectors.
47                                        Via a self-inactivating (SIN) lentiviral vector a 3' RNA trans
48 oth separately and together into a series of self-inactivating (SIN) lentiviral vector backbones.
49 ells are transduced with a minimum amount of self-inactivating (SIN) lentiviral vector containing a p
50 globulin promoter and enhancer elements in a self-inactivating (SIN) lentiviral vector should lead to
51 utside of its normal MLV genome context in a self-inactivating (SIN) lentiviral vector.
52                                              Self-inactivating (SIN) lentiviral vectors have been dem
53                                     Although self-inactivating (SIN) lentiviral vectors with or witho
54 othelial-specific, and doxycycline-inducible self-inactivating (SIN) lentiviral vectors.
55 roviral/lentiviral vectors (gammaRV/LV) with self-inactivating (SIN) long terminal repeats (LTRs) and
56 nternal promoters, chromatin insulators, and self-inactivating (SIN) long terminal repeats (LTRs) may
57                The distinguishing feature of self-inactivating (SIN) retroviral vectors is the deleti
58                                            A self-inactivating (SIN) vector was constructed by deleti
59                                   The use of self-inactivating (SIN) vectors in which a deletion of t
60  version of the DeltaG-Rabies, the non-toxic self-inactivating (SiR) virus, allows the long term gene
61                               We developed a self-inactivating third-generation RPS19-encoding lentiv
62  added safety modification that renders them self-inactivating through the deletion of the 3' U3 enha
63          These effects were abrogated with a self-inactivating vector.
64 omoter and Deltagag(871-1612) were used in a self-inactivating-vector setting that has a further dele
65                                              Self-inactivating vectors devoid of viral long-terminal-
66                                              Self-inactivating vectors with internal heterologous reg
67                                The resulting self-inactivating viruses drive global and persistent ge