ライフサイエンスコーパス: self-tolerant

1 seful (being MHC-restricted) and safe (being self-tolerant).

2 T-cell repertoire that is MHC restricted and self-tolerant.

3 c inhibitory receptors, yet are nevertheless self-tolerant.

4 not regulated by MHC class I and yet remain self-tolerant.

5 hich immature bone marrow B cells can become self-tolerant.

6 mice and TAP-1(-) mice, they are completely self-tolerant.

7 a key role in the generation of a strong yet self-tolerant adaptive immune response, essential in the

8 cyte development and selection important for self-tolerant adaptive immunity.

9 Such NK cells nevertheless remain self-tolerant and exhibit a generalized hyporesponsivene

10 enous Vbeta(+), CD4(+) T cells that are both self-tolerant and functional.

11 s thymocyte development toward production of self-tolerant and functionally competent T cells.

12 Together, these mechanisms ensure a self-tolerant and maximally discriminating NK cell popul

13 cted in the thymus where it is rendered both self-tolerant and restricted to the recognition of major

14 ironments responsible for the development of self-tolerant and self-restricted T cells.

15 tations to make their antibodies genetically self-tolerant and virus specific.

16 ure T cell repertoire is MHC restricted, yet self tolerant at the same time.

17 s the development of distinct populations of self-tolerant B cells and ultimately the production of a

18 Generation of a self-tolerant but antigen-responsive T cell repertoire o

19 to regulate the maturation and selection of self-tolerant CD4+ and CD8+ T cells.

20 ypothesis' to explain the mechanism by which self-tolerant cells could kill targets that had lost sel

21 at respond positively to foreign antigen and self-tolerant cells that respond negatively to self-anti

22 icroenvironments regulate the development of self-tolerant conventional CD4(+) and CD8(+) alphabetaT

23 We hypothesize that these "self-tolerant" epitopes have two desirable properties: t

24 of multiple mechanisms in rendering NK cells self tolerant - including selection for expression of se

25 ecific autoimmune disease, even in otherwise self-tolerant individuals.

26 the transplanted stem cells to develop into self-tolerant lymphocytes.

27 apoptotic signaling during the generation of self-tolerant lymphocytes: the apoptotic death of B and

28 the periphery, where they differentiate into self-tolerant mature CD8 T cells.

29 ls survive both of these processes to form a self-tolerant mature repertoire, mice were constructed w

30 tribute to the alloreactive potential of the self-tolerant murine NK cell repertoire.

31 ymphoid organ generating self-restricted and self-tolerant naive T cells.

32 This process results in two types of self-tolerant NK cells--licensed or unlicensed--and may

33 Foxo pathway probably enables a diverse and self-tolerant population of T cells in the steady state,

34 ptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are gener

35 ion of thymocytes during their selection for self-tolerant receptor specificities.

36 on the efficient generation of a diverse but self-tolerant repertoire of T cells by the thymus throug

37 developing autoimmune reactions by forming a self-tolerant repertoire of T cells.

38 r-specific T cells that are available in the self-tolerant repertoire.

39 We also conclude that a self-tolerant system must have a mechanism of central to

40 maturation of immunocompetent T cells with a self-tolerant T cell antigen receptor repertoire.

41 presenting-cell (APC) subsets in selecting a self-tolerant T cell population remains unclear.

42 The generation of a functional, self-tolerant T cell receptor (TCR) repertoire depends o

43 print upon T cells, screening beneficial and self-tolerant T cell receptor (TCR) specificities.

44 the basis for selection of a functional and self-tolerant T cell repertoire and is quantified by rep

45 opmental program supports the selection of a self-tolerant T cell repertoire capable of responding to

46 ing in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo.

47 splantation in the generation of a broad but self-tolerant T cell repertoire, but it is exquisitely s

48 own to be critically important for shaping a self-tolerant T cell repertoire, its role in MEC maturat

49 generation and maintenance of a diverse and self-tolerant T cell repertoire.

50 fferentiation and selection of a functional, self-tolerant T cell repertoire.

51 ection) of developing thymocytes generates a self-tolerant T cell repertoire.

52 lection, resulting in a self-MHC-restricted, self-tolerant T cell repertoire.

53 icroenvironment directs the development of a self-tolerant T cell repertoire.

54 The ability to activate self-tolerant T cells capable of cross-reacting on self-

55 and selection of functionally competent and self-tolerant T cells.

56 vironment for the development of diverse and self-tolerant T lymphocytes.

57 to the thymus medulla, a site that nurtures self-tolerant T-cell generation following positive selec

58 er of immature thymocytes required to form a self-tolerant T-cell pool.

59 s critical for establishing a functional yet self-tolerant T-cell population.

60 rtance of medullary microenvironments during self-tolerant T-cell production in the thymus.

61 Development of a self-tolerant T-cell receptor (TCR) repertoire with the

62 Generation of a diverse and self-tolerant T-cell repertoire requires appropriate int

63 critical for the development of a mature and self-tolerant T-cell repertoire.

64 the development of a self-MHC-reactive, yet self-tolerant, T cell repertoire.

65 function between thymic APCs in shaping the self-tolerant TCR repertoire and reveal an unappreciated

66 Positive selection of diverse yet self-tolerant thymocytes is vital to immunity and requir