ライフサイエンスコーパス: semaphorin

1 eptors that bind the axon guidance molecules semaphorins.

2 utonomously sensitizes ORN axons to external semaphorins.

3 exinA4 homolog, PLX-1, and two transmembrane semaphorins.

4 for all members of Drosophila class 1 and 2 semaphorins.

5 ll derived factor 1 (Sdf1/Cxcl12) and class3-Semaphorins.

6 cues, such as the cell surface glycoproteins Semaphorin 1a (Sema 1a) and Fasciclin I (Fas I), as embr

7 yl cyclase Gyc76C genetically interacts with Semaphorin 1a (Sema-1a) and physically associates with t

8 The transmembrane proteins semaphorin-1a (Sema-1a) and plexin A function together t

9 redundant functions of N-Cadherin (CadN) and Semaphorin-1a (Sema-1a).

10 ying upregulation of axon-axon attraction by Semaphorin-1a (Sema1a) reverse signaling in the developi

11 We report here that secreted semaphorin 2b (Sema-2b) acts through its transmembrane r

12 Here we show that semaphorin 2b (Sema2b) is a target-derived signal that a

13 Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of the

14 r adiposity demonstrating that disruption of Semaphorin 3 signaling perturbs energy homeostasis.

15 Semaphorin 3A (Sema 3A), a member of semaphorin family,

16 linear regression model, rs139438618 at the semaphorin 3A (SEMA3A [OMIM 603961]) locus was significa

17 ressed genes and we investigated the role of semaphorin 3A (Sema3A) and neuropilin-1 (Nrp-1) in lymph

18 Here, we show that semaphorin 3A (Sema3A) expression overcomes the proinvas

19 ic genes, and that ventral astrocyte-encoded semaphorin 3a (Sema3a) is required for proper motor neur

20 our laboratory has shown that VEGF-A165 and semaphorin 3A (Sema3A) promote vessel maturation through

21 Semaphorin 3A (Sema3A), in addition to its function as a

22 We found that semaphorin 3A (SEMA3A), previously shown to act as a sup

23 Semaphorin 3A (Sema3A), which lies adjacent to this turn

24 Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepe

25 p1), which is sensitive to the repellent cue Semaphorin 3A (Sema3A).

26 ugh the liberation of repulsive guidance cue semaphorin 3A (Sema3A).

27 etic retinopathy (PDR) had elevated vitreous semaphorin 3A (SEMA3A).

28 protein that binds the secreted guidance cue Semaphorin 3A (Sema3A).

29 ion and that the molecular cues netrin 1 and semaphorin 3a are likely to be involved.

30 We show that loss of Semaphorin 3A function or specific deletion of NRP1 in B

31 HMGB1 bound at the semaphorin 3A genomic locus, promoted hetrochromatin for

32 ; in fact, treatment of primary neurons with Semaphorin 3A rescues Ndr2 knock-down-induced dendritic

33 orrespondingly, Ndr2-null mutant mice show a Semaphorin 3A(-/-)-like phenotype of premature dendritic

34 These included semaphorin 3a, a guidance cue in neural development with

35 ), cell migration (Ret and EdnrB signalling, semaphorin 3A, cell adhesion molecules, Rho GTPases), an

36 Here, we demonstrate that semaphorin 3A-mediated growth cone collapse is reduced i

37 n leads to ischemia and angiogenesis through Semaphorin 3A.

38 chemia and pathological angiogenesis through Semaphorin 3A.

39 y into avascular tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with

40 (rs277470) located in a region encoding the semaphorin-3A (SEMA3A) binding domain (meta-analysis p v

41 Semaphorin-3A (Sema3a), a guidance protein secreted by p

42 required for growth cone steering away from semaphorin-3a, a guidance cue that does not activate ER-

43 Semaphorin 3B (SEMA3B) is a secreted axonal guidance mol

44 A neurovascular guiding factor, Semaphorin 3c (Sema3c), is required for the development

45 Thus, semaphorin 3C/3D signaling is an evolutionarily conserve

46 We find that semaphorin-3C (sema3C) induces the collapse of the cytos

47 we show that the secreted guidance molecule semaphorin 3d (Sema3d) is crucial for the normal pattern

48 t guide these axons to the CZ, we found that Semaphorin 3D (Sema3D) is expressed in the anterior bulb

49 We showed recently that semaphorin 3d (Sema3d) mediates endothelial cell repulsi

50 receptor for the vascular guidance molecule semaphorin 3d (Sema3d).

51 domain (Ig), short basic domain, secreted, (semaphorin) 3D (SEMA3D) was significant (P = .0083) and

52 lecules that convert the interaction between Semaphorin 3E (Sema3E) and PlexinD1 into cellular behavi

53 Semaphorin 3e (Sema3e) has been shown previously to repe

54 Semaphorin 3E (Sema3E) has emerged as an essential media

55 e have identified a shared point mutation in semaphorin 3E (SEMA3E) in 2 brothers with Kallmann syndr

56 This study investigated the role of Semaphorin 3E (Sema3E) in host immunity to Leishmania ma

57 ariboni and colleagues identify mutations in semaphorin 3E (SEMA3E) in two brothers with Kallmann syn

58 Semaphorin 3E (Sema3E) is a secreted protein that was in

59 Semaphorin 3E (Sema3E) plays a crucial role in axon guid

60 the striatonigral pathway involving PlexinD1-Semaphorin 3e (Sema3e) signaling.

61 resorption due to an increased secretion of Semaphorin 3E (Sema3E), an osteoclast-inhibiting factor.

62 possible role of a secreted chemorepellent, Semaphorin 3E (Sema3E), in neutrophil migration.

63 Semaphorin 3E (Sema3E), initially identified as a neuron

64 n, which was accompanied by an activation of semaphorin 3E (Sema3E)/PlexinD1 after ischemic stroke.

65 RORalpha modulates semaphorin 3E transcription and neurovascular interactio

66 Previously, we showed an important role of semaphorins 3E (Sema3E) in growth factor-induced airway

67 Here we show that Semaphorin-3E (Sema3E) is a natural negative regulator o

68 We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plex

69 a (RORalpha) as a transcription regulator of semaphorin 3F (SEMA3F), a suppressive microenvironmental

70 st, we found that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among the top 1% underexpress

71 The sensitivity of growth cones to semaphorin 3F and Eph receptor B2, two repulsive guidanc

72 Here we show that the guidance cue, Semaphorin 3F and its receptor Neuropilin 2 (Nrp2), infl

73 Semaphorin 3F, a repulsive ligand to Nrp2, regulates bot

74 (Nrp2), a receptor for the axon guidance cue semaphorin 3F, has important and previously unappreciate

75 helial growth factor (VEGF), VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, a

76 f primary visceral SMCs with the NRP2 ligand semaphorin-3F (SEMA3F) were accompanied by inhibition of

77 addition, we demonstrate that expression of Semaphorin-3F in the OHC region inhibits type I SGN proc

78 are determined, at least in part, through a Semaphorin-3F-mediated inhibitory signal that impedes pr

79 re, we report that the selective knockout of semaphorin 3G (Sema3G) in endothelial cells impaired hip

80 ing proteins have been identified, including semaphorins [4, 5], brain-derived neurotrophic factors (

81 n this study, we show that the transmembrane semaphorin 4A (Sema4A) can also function as a receptor,

82 (T reg) cells in the absence of pDC-derived semaphorin 4a (Sema4a).

83 e show that the immune-cell-expressed ligand semaphorin-4a (Sema4a) and the Treg-cell-expressed recep

84 , protein O-fucosyltranferase 1, Notch1, and semaphorin 4B.

85 In this study, we investigated the role of semaphorin 4C (SEMA4C) in osteosarcoma growth, progressi

86 We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, pla

87 independent mannose-6-phosphate receptor and semaphorin 4C, by the membrane tubulating BAR domain-con

88 , a novel vascular-targeting agent targeting semaphorin 4D (Sema4D) demonstrated impaired tumor growt

89 Semaphorin 4D (Sema4D) is a proangiogenic cytokine produ

90 Semaphorin 4D (Sema4D) plays a role in various cell type

91 We recently reported that Plexin B1, the Semaphorin 4D (Sema4D) receptor, is a tumor-suppressor p

92 m of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PA

93 clasts express the repulsive guidance factor Semaphorin 4D and induce contact inhibition of locomotio

94 proteins, suggesting that both plexin-B1 and semaphorin 4D are important in the promotion of PNI.

95 attracted to nerves that express its ligand, semaphorin 4D, in a Rho/Rho kinase-dependent manner.

96 ficant association to an intergenic SNP near Semaphorin 5A (SEMA5A) and provided evidence for reduced

97 Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene;

98 e including suppression of the gene encoding semaphorin 5B (SEMA5B).

99 Here, we report that Semaphorin-5B (Sema5B) acts as an important mediator of

100 we have found that the transmembrane ligand Semaphorin-5B and its receptor PlexinA1 regulate the deb

101 w finds that protrusion collapse, induced by Semaphorin-5C-Plexin-A interactions at the cell-cell con

102 Deletion of neuronal Nrf2 results in semaphorin 6A (Sema6A) induction in hypoxic/ischemic ret

103 Here, we show that the murine transmembrane semaphorin 6A (Sema6A) is expressed in a subset of On di

104 We find that the transmembrane protein semaphorin 6A (Sema6A) is required for the formation of

105 )-21, -27a, and -146a and diabetes-increased semaphorin 6A (SEMA6A); Ras homolog gene family, member

106 Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical fo

107 expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs.

108 tified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of O

109 embryonic arteriogenic program and activated semaphorin 6A-dependent endothelial cell-cell repulsion.

110 specific spatial and temporal expression of semaphorin 6B (Sema6B) in chick commissural neurons sugg

111 ype B EAE due to neuronal damages induced by semaphorin 6B upregulation on CD4(+) T cells.

112 Semaphorin 7a (Sema 7a) participates in lymphocyte activ

113 DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being highly expressed on acti

114 Here we report that semaphorin 7A (SEMA7A) confers significantly decreased p

115 Semaphorin 7A (Sema7A) is a membrane-associated/secreted

116 Semaphorin 7A (Sema7A) is an atypical member of the sema

117 We determined Semaphorin 7a (Sema7a) localization and abundance in nai

118 report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-in

119 n of bdnf, ngf, and the axon growth promoter semaphorin 7a (sema7a), and as a consequence, their prod

120 lso uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a

121 diated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility

122 Semaphorin 7a is a glycophosphatidylinositol membrane-an

123 ng tumor metastasis; we have identified that semaphorin 7a is a potent driver of ductal carcinoma in

124 Our results suggest that semaphorin 7a may be novel target for blocking breast tu

125 reated with an anti-Plexin C1 antibody and a Semaphorin 7A peptide reduced hepatic ischemia-reperfusi

126 nd semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen a

127 ditional role in EMT via the ERF, regulating Semaphorin-7a and providing a new interconnection betwee

128 Forced expression of Semaphorin-7a in ERF-overexpressing EpRas cells reestabl

129 In contrast, inhibition of Semaphorin-7a in the parental EpRas cells inhibited thei

130 ERF suppressed the TGF-beta-induced EMT via Semaphorin-7a repression.

131 ed phosphorylation of RPS6 and IL-3-enhanced semaphorin-7A translation.

132 o induce the production of proteins, such as semaphorin-7A, without affecting mRNA levels suggests a

133 Semaphorin activates plexin by binding to its extracellu

134 Together, the results suggest that semaphorin activates plexin by disrupting an inhibitory

135 of the immune response, Rho family GTPases, semaphorin and integrin signalling.

136 Thus, PlexinA1 mediates both Semaphorin and Slit signaling, and Slit processing gener

137 SEMA3F is a secreted semaphorin and tumor suppressor downregulated by TGF-bet

138 ins (NRPs), which have well-defined roles in Semaphorin and VEGF signaling, positively regulate HH pa

139 ropilins-1/-2 (NRP1, NRP2) are receptors for semaphorins and angiogenic growth factors, while the GAI

140 europilin 1 (Nrp1), a coreceptor for class 3 semaphorins and growth factors, is highly expressed in v

141 However, semaphorins and plexins are also expressed in the adult

142 and receptors, such as ephrins and Ephs, and semaphorins and plexins, and through expression of clast

143 tute a family of transmembrane receptors for semaphorins and represent critical regulators of various

144 Semaphorins and their receptors plexins have diverse rol

145 The semaphorins and their receptors, the plexins, compose a

146 Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neurona

147 europilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF

148 ) is well known as a co-receptor for class 3 semaphorins and vascular endothelial growth factors, inv

149 re transmembrane receptors that bind class 3 semaphorins and VEGF family members to regulate axon gui

150 an originally defined coreceptor for class 3 semaphorins and VEGF, plays important roles in the immun

151 Semaphorins are a large family of axon guidance molecule

152 Semaphorins are an essential family of guidance cues ubi

153 Semaphorins are dimeric molecules that activate plexin b

154 Semaphorins are key regulators of neural circuit assembl

155 Semaphorins are one of the largest families of guidance

156 Semaphorins are phylogenetically conserved proteins expr

157 Semaphorins are secreted and membrane-bound proteins inv

158 onserved throughout all clades; in contrast, semaphorins are structurally diverse.

159 Choanoflagellate semaphorins are transmembrane proteins with multiple fib

160 Although class-6 semaphorins are transmembrane proteins, they have been i

161 e introduce a tissue-autonomous paradigm for semaphorin-based regulation of collective cell migration

162 different cell types translate extracellular semaphorin binding into intracellular signaling remains

163 f PlexinA4 and its response to activation by semaphorin binding.

164 ascular endothelial growth factor (VEGF) and semaphorin-binding receptor Neuropilin-1 (Nrp-1) emerge

165 ic states has a hereto unappreciated role in semaphorin biology, providing a mechanism by which Sema6

166 Sema3C is cleaved, like other class-3 semaphorins, by furin-like pro-protein convertases (FPPC

167 studies indicate that certain transmembrane Semaphorins can also function as guidance receptors to m

168 We demonstrate that semaphorins can form heterodimers with members of the sa

169 in vitro analyses demonstrate that monomeric semaphorins can mediate a distinctive plexin binding mod

170 n form heterodimers with members of the same semaphorin class.

171 Other previously not yet described semaphorin classes include semaphorins of Ctenophora wit

172 hese substrates, neuropilin-2, is a VEGF and semaphorin co-receptor that is polysialylated on its O-g

173 Semaphorins comprise a large family of ligands that regu

174 Plexins and semaphorins comprise a large family of receptor-ligand p

175 Semaphorins contribute to the balance between excitatory

176 functions in VEGF-dependent angiogenesis and semaphorin-dependent axon guidance, controlling signalin

177 pulation level emerges as a result of global Semaphorin-dependent confinement and broad activation of

178 In a semaphorin-dependent manner, PLX-1 is concentrated at th

179 ted alleles with loss-of-function defects in semaphorin dimerization and binding to their cognate neu

180 wn to affect MET gene (N375S), involving the semaphorin domain, confers exquisite binding affinity fo

181 c-receptor signalling pathway, namely immune semaphorins, facilitating immune cell interactions and t

182 ain insight into the evolution of plexin and semaphorin families.

183 ected specific, non-dimorphic, expression of Semaphorin family members in the mouse mammary gland, wh

184 lexins are key cell-surface receptors of the semaphorin family of cell-guidance signalling proteins a

185 The Semaphorin family of guidance cues, signaling through Pl

186 Semaphorin family proteins are well-known axon guidance

187 rin 7A (Sema7A) is an atypical member of the semaphorin family that is GPI-linked, expressed principa

188 Semaphorin 3A (Sema 3A), a member of semaphorin family, serves as a guidance clue during embr

189 ata show Sema1b is a monomer suggesting that semaphorin function may not be restricted to dimers.

190 Semaphorin functions have been extensively explored in D

191 ng allele on chromosome 7 within the class 3 Semaphorin gene cluster.

192 svirus, (iii) it contains interleukin-10 and semaphorin genes (the first time these have been reporte

193 ing their description as axon guidance cues, semaphorins have been implicated in multiple aspects of

194 Recently, semaphorins have been implicated in the cell-cell commun

195 Semaphorins have crucial roles in several diseases; ther

196 Binding of semaphorin homodimer to plexin brings two plexins in clo

197 tleneck to define roles for glial Netrin and Semaphorin in pioneer- and follower-axon guidance, respe

198 late the response of mDA neurites to soluble semaphorins in a context-specific manner by abolishing t

199 a role that distinguishes Sema5B from other Semaphorins in cochlear development.SIGNIFICANCE STATEME

200 These results reveal a novel role for semaphorins in dendrite patterning and illustrate how ep

201 tent with an ancient function of plexins and semaphorins in regulating cytoskeletal dynamics and cell

202 However, the potential contribution of semaphorins in the regulation of neutrophil migration is

203 Remarkably, we detected plexins and semaphorins in unicellular choanoflagellates, indicating

204 plexin-A1-dependent manner, while most other semaphorins, including antiangiogenic semaphorins such a

205 On the other hand, a peptoid named SICHI (semaphorin-induced chemorepulsion inhibitor), which is p

206 The plexin GAP is activated by semaphorin-induced dimerization, the structural basis fo

207 midline crossing and can mediate precrossing semaphorin-induced repulsion in vitro.

208 How premature semaphorin-induced repulsion of precrossing axons is sup

209 the hybrid domain interface with the plexin-semaphorin-integrin (PSI) domain in different orientatio

210 Pathogenic hantaviruses bind to the plexin-semaphorin-integrin (PSI) domain of inactive, beta3 inte

211 T Sema domain fused to the adjacent Plexins, Semaphorins, Integrins domain (MET Sema-PSI), and the HG

212 Cell-attached semaphorins interact in trans with plexins on opposing c

213 Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepellent that disrupts neural patt

214 Neuropilin1 (Npn1), a receptor for class 3 semaphorins, is required to generate appropriate afferen

215 el endothelial cells and is the only class 3 semaphorin known to be capable of signaling via a plexin

216 Here, we show that mutations in the semaphorin ligand sema-2b lead to a dramatic increase in

217 The Semaphorin ligands and their Plexin receptors are known

218 Semaphorin ligands and their plexin receptors are one of

219 the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic

220 Semaphorin ligands interact with plexin receptors to con

221 Therefore, this immune semaphorin links nerve regeneration and inflammatory pro

222 hat the Rac GAP beta2-Chimaerin is needed in Semaphorin-mediated axonal pruning but not growth cone r

223 ebble and RhoGAPp190 transduce transmembrane semaphorin-mediated guidance cue information that regula

224 subsequent down-regulation, and allowing for semaphorin-mediated repulsion of post-crossing axons.

225 ese findings provide an in vivo link between semaphorin-mediated repulsive axon guidance and alterati

226 gth human PlexinC1 in complex with the viral semaphorin mimic A39R.

227 In the plexin or semaphorin mutants, synaptic domains from both neurons e

228 not yet described semaphorin classes include semaphorins of Ctenophora with tandem immunoglobulin dom

229 mmunoglobulin domains (Sema-IG) and secreted semaphorins of Echinoderamata (Sema-SP, Sema-SI).

230 Semaphorins, originally discovered as axon guidance cues

231 Our findings suggest that blocking the semaphorin pathway should be investigated as a therapeut

232 lay a role in axonal development through the semaphorin pathway, which may serve as a candidate gene

233 Secreted class III Semaphorins play an important role in guidance of neuron

234 Semaphorins play important regulatory roles in diverse p

235 Our data uncover semaphorin-plexin signaling as a central regulatory mech

236 protein 2 (CRMP2/DPYSL2), a mediator of the semaphorin-plexin signaling pathway, as redox-regulated

237 ds on epithelial cell-cell communication via semaphorin-plexin signaling.

238 During neural development, semaphorin-plexin signalling instructs axon guidance and

239 We propose that semaphorin-plexin signalling is an essential platform fo

240 tein implicated in axon growth inhibition by Semaphorin/Plexin complexes.

241 revealed that Abl allows growth factors and Semaphorin/Plexin repellents to combinatorially increase

242 Focusing on Semaphorin/Plexin repulsion, we identified an interactio

243 er a simple biochemical switch that controls Semaphorin/Plexin repulsive guidance.

244 anism regulating dendrite differentiation is Semaphorin/Plexin signaling, specifically through bindin

245 functioning as a molecular sink to sequester semaphorins, preventing premature repulsion of precrossi

246 eutralizing antibodies for components of the Semaphorin receptor complex Nrp1, Chl1, or L1cam.

247 , we demonstrate that neuropilin-1 (NRP1), a Semaphorin receptor expressed in BCs, controls both axon

248 ile central nascent islet cells produced the semaphorin receptor neuropilin 2 (Nrp2).

249 We also show that the semaphorin receptor neuropilin-1 acts cell-autonomously

250 Importantly, we found that the semaphorin receptor Nrp-1 is expressed on the perivascul

251 ads to phosphorylation and activation of the semaphorin receptor Plexin-B1.

252 Plexin-B2 is a semaphorin receptor previously known to act on neuronal

253 We evaluated the contributions of the semaphorin receptor, plexin C1 (PLXNC1), and the exocyti

254 Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nerv

255 ression of neuropilin 1 (Nrp1) and Nrp2, two semaphorin receptors that regulate neuronal cell migrati

256 e receptor and ligand pairing of plexins and semaphorins regulates cellular interactions in a wide ra

257 The mechanisms by which Semaphorin reverse signaling modulates axon-surface affi

258 NRP2, a receptor of VEGFA and semaphorin (SEMA) 3F ligands, is expressed in the vascul

259 human lung carcinoma cell line and identify semaphorin (SEMA) 6A and 6B as receptors for TcsL.

260 e receptors for guidance cues of the class 3 semaphorin (SEMA) family and are expressed in partially

261 Class III Semaphorin (Sema) secreted ligands are known to repel ne

262 A behavioral screen identified roles for Semaphorins (Sema) and Plexins (Plex) in walking behavio

263 Attractive and repulsive molecules such as Semaphorins (Sema) trigger rapid responses that control

264 By analyzing the function of a secreted semaphorin, Sema-2b, in Drosophila olfactory receptor ne

265 ophila, we discovered that the transmembrane semaphorin, Sema-5c, promotes collective cell migration

266 of interaction through which the Drosophila semaphorin Sema1b and mouse Sema6A mediate binding in ci

267 lly characterized as receptors for class III Semaphorin (Sema3) family members, functioning in axon g

268 dothelial growth factor (VEGF) and class III Semaphorin (Sema3) ligand families.

269 endothelial growth factor (VEGF) and class 3 semaphorins (SEMA3).

270 vealed a requirement for VEGF-A, the class 3 semaphorin SEMA3C, and their shared receptor neuropilin

271 rophils can regulate expression of a class 3 semaphorin, SEMA3F, we investigated the role of SEMA3F i

272 The semaphorins Sema3fb and Sema3gb, which are expressed by

273 Class 3 semaphorins (SEMA3s), a group of neuron-secreted axonal

274 eurons, we previously identified the class 4 Semaphorin Sema4D as being required for proper GABAergic

275 and that this induction was regulated by the semaphorin Sema7a, interacting in stimulatory or inhibit

276 Semaphorins (SEMAs) and their Plexin (PLXN) receptors ar

277 Secreted semaphorins signal through neuropilin-2/plexin-A1 recept

278 ission, and electrical activity can modulate semaphorin signaling in neurons.

279 , DCX, at ser327, and phosphorylation of the semaphorin signaling mediator, CRMP-2, at Thr514 were ma

280 Robo-Slit and Plexin-Semaphorin signaling participate in various developmenta

281 d by the combined action of different Plexin/Semaphorin signaling systems, are required for the forma

282 Thus, TRPC5 acts downstream of semaphorin signaling to cause changes in neuronal growth

283 ated with these pathways, notably ephrin and semaphorin signaling.

284 terial-venous patterning via Delta/Notch and semaphorin signaling.

285 rs linked to the corticostriatal pathway and Semaphorin signaling.SIGNIFICANCE STATEMENT The corticos

286 s and reveals a previously unknown effect of Semaphorin signalling on spatial distribution of an acti

287 genes encoding synaptic (Cplx2 and Pclo) and semaphorin signalling pathway (Crmp2, PlexinB1, Fes and

288 Semaphorins, specifically type IV, are important regulat

289 Unlike previously reported semaphorin structures, Sema1a, Sema2a and Sema2b show st

290 other semaphorins, including antiangiogenic semaphorins such as sema3A do not.

291 Plexins are receptors for semaphorins that transduce signals for regulating neuron

292 ivate PlexinA2, which encodes a receptor for semaphorin to guide NCCs into the OFT.

293 Semaphorins typically regulate the motility of neuronal

294 2), a multifunctional nonkinase receptor for semaphorins, vascular endothelial growth factor (VEGF),

295 axon guidance molecules in this process, the Semaphorins, was not explored.

296 Class 3 semaphorins were initially described as axonal growth co

297 counterparts of cellular interleukin-10 and semaphorin, which have not been described previously in

298 Semaphorins, which are PlexA ligands, also regulate tiss

299 We believe that the plexins and semaphorins, which are strongly expressed in both axons

300 from tumor cells contain TGF-beta, C1q, and semaphorins, which promote myeloid tolerogenic activity