ライフサイエンスコーパス: semen

1 rily by increasing the viral load present in semen.

2 tive immune response, and persistent ZIKV in semen.

3 28 to 41) and 81 days (95% CI, 64 to 98) in semen.

4 an immunodeficiency virus (HIV) RNA decay in semen.

5 rate and precise for detecting EBOV in whole semen.

6 RNA suggests replication in cells present in semen.

7 id tissue, gut-associated lymphoid tissue or semen.

8 virus as they continuously shed EAV in their semen.

9 nfected monocytes and lymphocytes present in semen.

10 ecrease the inflammatory response induced by semen.

11 detecting the presence of Ebola virus RNA in semen.

12 lly occurring peptide fragments derived from semen.

13 blood was 4.0 log IU/mL higher than that in semen.

14 cleavage of prostatic acidic phosphatase in semen.

15 in human, mouse, and nonhuman primate (NHP) semen.

16 ueled by sexual exposure to HIV-contaminated semen.

17 hritis had increased concentration of HIV in semen.

18 t and entry, likely occur in the presence of semen.

19 ia vaginal deposition of Zika virus-infected semen.

20 itabine, maintained HIV-1 RNA suppression in semen.

21 ers of EAV and continue to shed virus in the semen.

22 ast milk (16 months [preliminary data]), and semen (18 months).

23 105 from mouth, 17 from the rectum, one from semen, 69 from urine, and 21 from the vagina.

24 men in this study, ZIKV RNA was cleared from semen after about 3 months.

25 the neutralization of the mucus by alkaline semen, after sexual intercourse, allows virions to cross

26 which gallic acid modifies the properties of semen amyloids, we performed biophysical measurements (a

27 Computer-assisted semen analysis (CASA) of sperm of the same bulls (n = 5)

28 es on the quantity and quality of his sperm, semen analysis is generally used as the proxy to estimat

29 Although semen analysis remains the cornerstone for evaluating ma

30 Sperm concentration from semen analysis was assessed as the primary outcome.

31 ced limits of detection of 1000 copies/mL in semen and 275 copies/mL in blood.

32 HCV RNA levels were correlated in semen and blood (r(2) = 0.142).

33 Limits of detection for both semen and blood increased with longer intervals between

34 Paired semen and blood samples were assayed for HCV RNA levels.

35 r EBOV RNA detection was validated for whole semen and blood using samples obtained from uninfected d

36 the long-term presence of Ebola virus RNA in semen and declining persistence with increasing time aft

37 e fertility preservation techniques, such as semen and embryo cryopreservation, are established and s

38 sistence of the virus in body fluids such as semen and saliva for longer periods of time than in seru

39 quency of isolation of infectious virus from semen and serum samples prospectively obtained from a co

40 tted by mosquitoes, but can persist in human semen and sperm, and sexual transmission has been docume

41 nfection on the male reproductive organs and semen and the immune response of the olive baboon (Papio

42 adily detected in plasma (until day 5 or 7), semen and urine (until days 7 and 14), and saliva (until

43 lar vesicles (EVs) are extremely abundant in semen, and because they play a key role in intercellular

44 re from blood, saliva, urine, aqueous humor, semen, and breast milk from infected or convalescent pat

45 ultrasensitive viral load assays of plasma, semen, and cerebrospinal fluid (CSF) samples to detect H

46 by the parasite have Nosema spores in their semen, and queens artificially inseminated with either N

47 ies, molecular testing for EBOV in blood and semen, and serologic testing of peripheral blood mononuc

48 We collected serum, urine, saliva, semen, and vaginal secretions weekly for the first month

49 eins of the non-cellular microenvironment of semen are potential markers of sperm cryotolerance.

50 ntaining the fertilizing potential of frozen semen as it is manipulated, transported and stored is cr

51 able for all couples, and 1629 men (69%) had semen available for analysis at 6 months after randomiza

52 ozen semen is mishandled, characteristics of semen biology associated with fertility are negatively a

53 ments can better maintain characteristics of semen biology that correlate with fertility when it is m

54 V might persist for months in saliva, urine, semen, breast milk and the central nervous system(8-12).

55 saliva, urine, cerebrospinal fluid (CSF) and semen, but transiently in vaginal secretions.

56 HIV virions are released into semen by various cells of the male genital tract, as wel

57 Viral shedding in the semen can increase the risk of ZIKV transmission through

58 The last 6-month study visit for semen collection occurred during August 2018, with chart

59 In semen collection, semen quality is higher with the penil

60 und increased HIV RNA molecular diversity in semen compared to that in blood in almost all study part

61 inoculated via vaginal deposition of baboon semen containing 10(6) focus-forming units (FFU) of ZIKV

62 ated and decaudated spermatozoa (DDS), whose semen contains abnormal spermatozoa with tailless heads

63 Unlike other human biological fluids, semen contains multiple types of amyloid fibrils in the

64 centration of the monosaccharide fructose in semen contributes significantly to the effect by competi

65 We discovered that the sugar fructose in semen decreases the activity of a broad and potent class

66 n reported to form amyloid fibrils, known as semen-derived enhancer of viral infection (SEVI), that e

67 ctron microscopy and NMR results showed that semen-derived enhancer of viral infection fibrils formed

68 arbonate buffer remain stable over time, but semen-derived enhancer of viral infection fibrils formed

69 est characterized of these fibrils are SEVI (semen-derived enhancer of viral infection), made up of r

70 Seminal factors such as semen-derived enhancer of virus infection (SEVI) fibrils

71 tain factors identified within semen, termed semen-derived enhancers of virus infection (SEVI), have

72 the prevalence of diverse compartmentalized semen-derived lineages in men with or without STI-associ

73 n with confirmed infertility or the need for semen donation who were eligible for standard bolus intr

74 Following semen donation, specimens are either used immediately or

75 hat accurately identified the race of all 18 semen donors in the calibration data set, as well as sev

76 tential to differentiate Caucasian and Black semen donors using chemometrics.

77 esults from a study to determine the race of semen donors.

78 On the other hand, treating commercial semen doses intended for artificial insemination with th

79 HCV RNA was detected in semen during both acute and chronic HCV infection.

80 und that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at

81 Select PFCs were associated with certain semen end points, with the most significant associations

82 Semen EV fractions from acutely infected individuals ind

83 In prior work, we found that semen exosomes (SE) from healthy donors who do not use i

84 Our results clearly indicate that repeated semen exposure can profoundly modulate the FRT microenvi

85 Recent data suggests that higher frequency semen exposure is associated with activation of anti-HIV

86 he female reproductive tract (FRT) following semen exposure.

87 Repeated semen exposures result in lower CCR5 expression in circu

88 Semen fibrils are made up of multiple naturally occurrin

89 A small molecule screen for antagonists of semen fibrils identified four compounds that lowered sem

90 healthy ones, suggesting that deposition of semen fibrils in the lower FRT facilitates clearance of

91 In the presence of semen fibrils, damaged and apoptotic sperm were more rap

92 ence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.

93 fferent males, retaining half of each male's semen for whole genome bisulfite sequencing.

94 espective of illicit drug use or duration of semen freezing.

95 e demonstrated that amyloid fibrils found in semen from healthy and HIV-infected men, as well as seme

96 simple technological improvements to protect semen from inadvertent thermal fluctuations that occur w

97 e conservation of the olfactory detection of semen from jawless vertebrates to humans.

98 We collected blood and semen from people with HIV (PWH) whose epidemiologically

99 We collected blood and semen from people with HIV whose epidemiologically linke

100 This effect of semen fructose likely reduces the efficacy of such inhib

101 V-1) transmission events occur in women when semen harboring infectious virus is deposited onto the m

102 Seminal plasma (SP), the liquid portion of semen, harbors a variety of factors that may favor HIV t

103 t has been shown that short-term freezing of semen has no effect on SE-mediated HIV-1 inhibition.

104 However, no specific compounds in semen have been identified as aphrodisiac pheromones.

105 In semen, HIV-1 particles may exist as free-floating virion

106 uences representative of those of viruses in semen.IMPORTANCE Mucosal transmissions account for the m

107 We report the presence of Ebola virus RNA in semen in a cohort of survivors of EVD in Sierra Leone.

108 rtmentalized viral rebound between blood and semen in one HIV coding region.

109 A validated assay for EBOV RNA detection in semen informs the care of male survivors of Ebola, as we

110 ce a recent publication indicated that human semen inhibited, in a laboratory setting, Zika virus inf

111 The microbiome of semen is a field of increasing scientific interest, alth

112 We conclude that ZIKV-infected semen is a means of ZIKV transmission during pregnancy i

113 Zika virus (ZIKV) ribonucleic acid (RNA) in semen is common after infection.

114 rs refrain from unprotected sex unless their semen is confirmed to be EBOV free.

115 recovery and long-term viral persistence in semen is confirmed.

116 Semen is fundamental for sexual reproduction.

117 Understanding the complex viral milieu in semen is important for HIV transmission but might also p

118 We show that when frozen semen is mishandled, characteristics of semen biology as

119 Semen is not merely a carrier of the virus, but also pro

120 Semen is not merely a carrier of virus but provides an i

121 Virus in semen is replication-competent with no change in viral g

122 Semen is the main vector for HIV transmission and contai

123 Semen is the primary transmission vehicle for various pa

124 Semen is the vehicle for virion dissemination in the fem

125 us polyamine initially identified from human semen, is indeed a milt pheromone.

126 rom healthy and HIV-infected men, as well as semen itself, can markedly enhance HIV infection rates.

127 Using cryopreserved semen, laparoscopic oviductal artificial insemination wa

128 ptidase 2 (KLK2) is a key serine protease in semen liquefaction and prostate cancer together with KLK

129 Our findings suggest that amyloid fibrils in semen may play a role in reproduction by participating i

130 ch far outnumber lymphocytes in HIV-infected semen, may contribute to sexual transmission of HIV from

131 tive assays on the effects of gallic acid on semen-mediated enhancement of HIV infection and inflamma

132 as a non-polyanionic compound that inhibits semen-mediated enhancement of HIV infection and suggest

133 In addition, gallic acid decreased semen-mediated enhancement of HIV infection but did not

134 brils identified four compounds that lowered semen-mediated enhancement of HIV-1 infectivity.

135 Moreover, CLR01 abrogates semen-mediated enhancement of viral infection by prevent

136 th or direction of penile penetration and/or semen movement.

137 ompared to that in blood, HIV RNA rebound in semen occurred significantly later (median of 66 versus

138 First, we found that HIV RNA rebound in semen occurred significantly later and reached lower lev

139 human immunodeficiency virus type 1 (HIV) in semen occurs despite effective antiretroviral therapy (A

140 cytokines/chemokines by Luminex in blood and semen of 21 source partners who transmit ('transmitters'

141 kines/chemokines by Luminex in the blood and semen of 21 source partners who transmitted HIV (transmi

142 We detected ZIKV asRNA in semen of 9 of 19 men (47.4%) diagnosed with ZIKV infecti

143 ucleic acid (RNA) potentially present in the semen of a large number of survivors of Ebola virus dise

144 Ebola virus RNA was detected in the semen of all 7 men with a specimen obtained within 3 mon

145 ission, in which HIV is transferred from the semen of an infected male to an uninfected partner.

146 Ebola virus has been detected in semen of Ebola virus disease survivors after recovery.

147 ZIKV RNA was present in the semen of five of nine baboons.

148 e monocytes far outnumber lymphocytes in the semen of HIV-infected individuals.

149 s known about the properties of EVs from the semen of HIV-infected individuals.

150 Our findings suggest that EVs from the semen of HIV-infected men may significantly impact the l

151 in women occurs via genital exposure to the semen of HIV-infected men.

152 (EBV) were the most commonly detected HHV in semen of HIV-infected participants.

153 and dolutegravir (DTG) concentrations in the semen of HIV-infected patients receiving DTG-based first

154 quitoes, ZIKV RNA is detectable in blood and semen of infected individuals for weeks or months, durin

155 are known to be significantly reduced in the semen of infertile men.

156 deled the presence of Ebola virus RNA in the semen of male Ebola survivors participating in the Poste

157 species Zaire ebolavirus, may persist in the semen of male survivors of Ebola Virus Disease (EVD).

158 Ebola virus has been detected in the semen of men after their recovery from Ebola virus disea

159 inseminated with either Nosema spores or the semen of Nosema-infected males became infected by the pa

160 from nasal secretions, buffy coat cells, and semen of seven experimentally infected and two naturally

161 ere was persistent viral RNA detected in the semen of the patient, accompanied by epididymitis, sugge

162 s, and Ebola virus RNA has been found in the semen of the survivors after 9 months of symptom onset.

163 to identify a pheromone from the milt (fish semen) of sea lamprey (Petromyzon marinus), a jawless fi

164 ic formulations that simulate the effects of semen on HIV-1 infection and inhibition.

165 ing in vivo evidence of competing effects of semen on transmission impacts our basic understanding of

166 component of semen, we injected queens with semen or seminal fluid alone.

167 The non-sperm part of ejaculated semen, or seminal plasma, facilitates the delivery of sp

168 egression to estimate the difference in each semen parameter associated with a one unit increase in t

169 serum OC concentrations are associated with semen parameters among young Russian men.

170 Semen parameters are variable within individuals, but it

171 There were no differences in mean semen parameters between men's first samples and the rem

172 We investigated testosterone production and semen parameters in farmed Arctic foxes by dietary expos

173 rtal serum organochlorine concentrations and semen parameters in young men: the Russian Children's St

174 Semen parameters were assessed as described in the 2010

175 pared with the other 3 groups, whereas other semen parameters were not significantly different betwee

176 Semen parameters, including total sperm number per ejacu

177 dhood organochlorine (OC) exposure and adult semen parameters.

178 ans, and total TEQs were not associated with semen parameters.

179 corresponding toxic equivalents (TEQs) with semen parameters.

180 ns and PCDD TEQs were associated with poorer semen parameters.

181 tions were observed for serum PCDD TEQs with semen parameters.

182 ticular development may be related to poorer semen parameters.

183 Viral RNA in semen persisted for a maximum of 40 months.

184 nd also had statistically significant higher semen pH, and total sperm motility and progressive sperm

185 rnal fertilization such as fish, exposure to semen promotes spawning behaviors.

186 between perfluorinated chemicals (PFCs) and semen quality among 501 male partners of couples plannin

187 Adverse temporal trends in human semen quality and cryptorchidism in infants have been as

188 cid and zinc supplementation in men improves semen quality and increases livebirth rate among couples

189 yle was associated with testicular function (semen quality and reproductive hormones) independent of

190 aimed at identifying average differences in semen quality between individuals.

191 No significant differences were observed in semen quality between TAF and TDF.

192 ctanoic acid (PFOA)] were associated with 17 semen quality end points before Box-Cox transformation.

193 g the relationship between marijuana use and semen quality from young men recruited out of the genera

194 Semen quality has been suggested to be a biological mark

195 Currently, no treatment exists to improve semen quality in most infertile men.

196 improves testicular antioxidant function and semen quality in old male rats.

197 Our study supports the suggestion that semen quality is a strong biomarker of general health.

198 tween persistent environmental chemicals and semen quality is evolving, although limited data exist f

199 In semen collection, semen quality is higher with the penile robe electrical

200 rmations of the genitalia at birth, and poor semen quality later in life.

201 TAF) in the male genital tract (MGT) and the semen quality of individuals infected with human immunod

202 with placebo, did not significantly improve semen quality or couples' live birth rates.

203 d the efficacy of this therapy for improving semen quality or live birth.

204 Most of the semen quality parameters (sperm concentration, motility,

205 urring within 9 months of randomization) and semen quality parameters (sperm concentration, motility,

206 highly associated (r > 0.50, p < 0.05) with semen quality parameters in heat-tolerant and heat-susce

207 adherence to the Mediterranean Diet (MD) and semen quality parameters.

208 herefore contribute to the decline in canine semen quality that parallels that reported in the human.

209 Semen quality was assessed before switching and after 12

210 Semen quality was associated with long-term morbidity, a

211 ased on limited prior evidence for improving semen quality.

212 the negative association of marijuana use on semen quality.

213 ay be contributing to recent reports of poor semen quality.

214 tion were not associated with differences in semen quality.

215 Ebola virus (EBOV) RNA persistence in semen, reported sexual transmission, and sporadic cluste

216 Injection with either seminal fluid or semen resulted in decreased sexual receptivity, increase

217 Men collected a baseline semen sample and another approximately 1 month later.

218 hin individuals, but it is unclear whether 1 semen sample could represent a man's long-term average v

219 The semen sample from one participant tested positive for Eb

220 ed from blood samples from the patient and a semen sample from the survivor were consistent with dire

221 We conclude that 1 semen sample may suffice for studies aimed at identifyin

222 der than 40 years were more likely to have a semen sample test positive than were men aged 40 years o

223 nsemination and requires the processing of a semen sample to remove white blood cells, wash away semi

224 treatment unit and collection of a positive semen sample was 565 days.

225 men had a physical examination, delivered a semen sample, and had a blood sample drawn.

226 The participants delivered a semen sample, had a blood sample drawn, and underwent a

227 a sperm preparation starting with a diluted semen sample.

228 t 18-19 years, 133 young men provided 1 or 2 semen samples (256 samples) collected approximately 1 we

229 linic in Boston, Massachusetts, provided 768 semen samples as part of the Environment and Reproductiv

230 study, we optimized the Xpert EBOV assay for semen samples by adding dithiothreitol.

231 osis tests focus on assessing the quality of semen samples by studying the concentration, total volum

232 nd phylogenetic methods to analyze blood and semen samples collected from 12 persons with HIV who beg

233 EBOV RNA was detected in semen samples from 30% of the survivors tested, with a m

234 HIV-1 env gene was done for paired blood and semen samples from antiretroviral therapy (ART)-naive me

235 Serum and semen samples from men (n = 90) 22-44 years old who part

236 Persistence of Ebola virus (EBOV) RNA in semen samples from survivors was determined.

237 gene (TEX11) open reading frame in blood and semen samples obtained from 289 patients with azoospermi

238 Matched blood and semen samples were collected at all visits, and all addi

239 Paired blood and semen samples were collected from 12 individuals enrolle

240 Semen samples were shipped with freezer packs, and analy

241 Participants' semen samples were tested for Ebola virus RNA by real-ti

242 ed models to compare values from men's first semen samples with their long-term averages and to calcu

243 s been used as a metric for the viability of semen samples.

244 usting for confounders and modeling repeated semen samples.

245 replication competence in ZIKV RNA-positive semen samples.

246 el to show that repeated vaginal exposure to semen significantly reduces subsequent infection by repe

247 We found that whole semen significantly reduces the potency of antibodies an

248 Of 210 participants who provided an initial semen specimen for analysis, 57 (27%) had positive resul

249 38 participants (9%) produced at least one semen specimen that tested positive for Ebola virus RNA.

250 Ebola virus RNA was detected in 86 semen specimens from 19 (73%) participants.

251 HCV RNA was detected in semen specimens from 29 of 66 men (43.9%).

252 onfirmed the presence of infectious virus in semen specimens from 8 of 97 patients for up to 38 days

253 Semen specimens obtained at baseline were tested by mean

254 bola virus (EBOV) RNA and infectious EBOV in semen specimens of 5 Ebola virus disease (EVD) survivors

255 Of these, 24 (63%) provided semen specimens that tested positive 12 months or longer

256 Ninety-eight semen specimens were obtained for Ebola virus (EBOV) RNA

257 -lipid oxidation reactions were monitored in semen stains over time using protein fluorescence and fl

258 n method to assess the time of deposition of semen stains using fluorescence spectroscopy.

259 s able to estimate the time of deposition of semen stains, due to the complex chemistry of the consti

260 evaluation of donor drug-use and duration of semen storage on SE cargo and bioactivity will advance o

261 ortance of the source of SE and condition of semen storage on SE content and function.

262 us infections, in all tissues, including the semen stored in the spermathecae.

263 ficantly different from queens injected with semen, suggesting that components in seminal fluid, such

264 prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmi

265 rolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservo

266 Certain factors identified within semen, termed semen-derived enhancers of virus infection

267 (MHSP) offers Ebola virus disease survivors semen testing for Ebola virus.

268 ansmitted Zika virus disease, and results of semen testing for Zika virus from 2 male travelers.

269 behavioural outcomes from the first national semen testing programme for Ebola virus.

270 ted after receiving two consecutive negative semen tests.

271 n, HIV RNA molecular diversity was higher in semen than in blood in all three coding regions for most

272 Finally, we compare semen that has been mishandled in standard and improved

273 -friendly assay for detection of EBOV RNA in semen that is deployable to multiple sites across Wester

274 Zika virus, and remodels amyloid fibrils in semen that promote viral infection.

275 in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission,

276 d the effects of exposing liquid-stored boar semen to different red light LED regimens on sperm quali

277 This study utilized the sensitivity of semen to heat stress to discriminate the heat-tolerance

278 d, knowledge about the time of deposition of semen traces is extremely valuable to law enforcement ag

279 current gap in intelligence about the age of semen traces that has been challenging the forensic comm

280 xtent and duration of shedding in saliva and semen underscore possible concern for additional neurolo

281 lood, conjunctival, forehead, mouth, rectal, semen, urine, and vaginal specimens for presence of Ebol

282 fluctuations that occur when users mishandle semen using standard equipment.

283 In contrast, the initial semen virus populations during acute infection have unde

284 lization between the transmitters' blood and semen viruses suggests that cell-free blood virus likely

285 viruses showed that they were closer to the semen viruses than to the blood viruses of their transmi

286 H) and testosterone levels or testicular and semen volume.

287 To resurrect the cat model, semen was collected and cryopreserved from a lone, ferti

288 Human and dog semen was collected from registered donors (n = 9) and f

289 For artificial insemination (AI), semen was diluted 1:3 in a lactose-based diluent, with 5

290 A positive RT-PCR in semen was found in ten (5%) of 188 men, at a maximum of

291 Second, we found that the virus in semen was genetically different in some participants com

292 The viral load in semen was undetectable in both plasma (lower limit of de

293 the non-spermatozoa-containing component of semen, we injected queens with semen or seminal fluid al

294 breed broiler PGCs, and using cryopreserved semen, we were able to produce pure offspring.

295 Cytokine concentrations in the blood and semen were also measured, and a reduction in the levels

296 ermatids and rarely a few spermatozoa in the semen were observed.

297 te and able to transmit the virus along with semen, which occasionally leads to queen infections.

298 isit had a viral load >=400 copies/mL in the semen while maintaining viral suppression in the blood.

299 profile of each father's somatic tissue and semen with the methylation profile of his daughters.

300 t vaginal deposition of ZIKV-infected baboon semen would lead to maternal infection and vertical tran