ライフサイエンスコーパス: semialdehyde

1 ation (alpha-amino adipic and gamma-glutamic semialdehyde).

2 roxyanthranilate to 2-amino-3-carboxymuconic semialdehyde.

3 te decarboxylase (Kgd) and produces succinic semialdehyde.

4 tRNA-bound glutamate to produce glutamate 1-semialdehyde.

5 tRNA-bound glutamate to produce glutamate 1-semialdehyde.

6 version of trans-3-haloacrylates to malonate semialdehyde.

7 of 3-bromo- and 3-chloroacrylate to malonate semialdehyde.

8 a-ketoglutarate decarboxylation was succinic semialdehyde.

9 he conversion of lysine to alpha-aminoadipic semialdehyde.

10 for d-glycerate biosynthesis from tartronate semialdehyde.

11 pha-hydroxy- delta-carboxymethyl cis-muconic semialdehyde.

12 ndent cleavage of carnitine to TMA and malic semialdehyde.

13 ginine yields guanidine and 2-aminoadipate-6-semialdehyde.

14 xin propionate 3-nitronate (P3N) to malonate semialdehyde.

15 g gamma-aminobutyrate conversion to succinic semialdehyde.

16 tion of the carbonylated product aminoadipic semialdehyde.

17 nia, inorganic phosphate, and 2-aminoadipate semialdehyde.

18 ion of cis-3-haloacrylates to yield malonate semialdehyde.

19 ysine degradation product, alpha-aminoadipic semialdehyde.

20 somers of 3-chloroacrylate to yield malonate semialdehyde.

21 eptane-1,7-dioate into pyruvate and succinic semialdehyde.

22 eta-hydroxy acid substrates to corresponding semialdehydes.

23 ted with fruit flavor and aroma (glutamate-1-semialdehyde 2,1-aminomutase, anthocyanin 5-aromatic acy

24 A) which is rearranged to ALA by glutamate 1-semialdehyde-2,1-aminomutase (GSA-A) in the second step.

25 eductase, and the second enzyme, glutamate-1-semialdehyde-2,1-aminomutase, are encoded by the nuclear

26 ulted in an increased synthesis of glutamate semialdehyde, 5-aminolevulinic acid, magnesium-porphyrin

27 ccumulation of toxic levels of a-aminoadipic semialdehyde (a-AASA), piperideine-6-carboxylate (P6C),

28 abolites in PDE, including alpha-aminoadipic semialdehyde (a-AASA), piperideine-6-carboxylate (P6C),

29 the activity of alpha-aminoadipic acid-delta-semialdehyde (AAS) dehydrogenase in liver and plasma lev

30 e condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, w

31 ermined that glutamate, rather than succinic semialdehyde, accounts for the metabolic phenotype of ga

32 dation of vitamin B(6) and produces succinic semialdehyde, acetate, ammonia, and carbon dioxide from

33 etamidomethylene)succinate to yield succinic semialdehyde, acetic acid, carbon dioxide, and ammonia.

34 te, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS), can nonenzymatically cyclize to for

35 ic intermediate, a-amino-B-carboxymuconate-e-semialdehyde (ACMS), can nonenzymatically cyclize to for

36 the quantitation of glutamic and aminoadipic semialdehydes after their reduction to hydroxyaminovaler

37 The lysyl oxidation product adipic semialdehyde (allysine, ALL) and its oxidized end-produc

38 e-6-carboxylic acid (P6C), alpha-aminoadipic semialdehyde (alpha-AASA) and pipecolic acid both in bra

39 The latter is due to alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase deficiency, asso

40 ideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase.

41 tamyl-tRNA reductase (GluTR) and glutamate-1-semialdehyde aminotransferase (GSAAT).

42 chlorophyll biosynthetic enzyme glutamate 1-semialdehyde aminotransferase (GSAT), is specifically in

43 he level of transcripts encoding glutamate-1-semialdehyde aminotransferase (GSAT), phytoene desaturas

44 tly, GSA is rearranged to ALA by glutamate-1-semialdehyde aminotransferase (GSAT).

45 sis relating to the mechanism of glutamate 1-semialdehyde aminotransferase (GSAT).

46 chlorophyll biosynthetic enzyme glutamate 1-semialdehyde aminotransferase was previously shown to be

47 on of RNA secondary structure, and glutamate semialdehyde aminotransferase, an enzyme involved in ini

48 binant Chlamydomonas reinhardtii glutamate-1-semialdehyde aminotransferase.

49 elta(1)-pyrroline-5-carboxylate to glutamate semialdehyde and a protected conduit for the transport o

50 alpha-aminoadipate semialdehyde and gamma-glutamate semialdehyde contents i

51 , resulting in its conversion to l-glutamate semialdehyde and guanidine.

52 ble to capture the substrates aspartate-beta-semialdehyde and phosphate as an active complex that doe

53 needed to synthesize L-lysine from aspartate semialdehyde and pyruvate have been identified in a numb

54 he biosynthesis of L-lysine from L-aspartate semialdehyde and pyruvate in bacteria.

55 ion-independent decarboxylation of malonate semialdehyde and represents one of three known enzymatic

56 Succinic semialdehyde and succinate are also identified as produc

57 ation (alpha-amino adipic and gamma-glutamic semialdehydes) and Schiff base cross-links.

58 ically to release 2 mol of ammonium, malonic semialdehyde, and carbon dioxide.

59 y-5-ketofructose 1-phosphate and l-aspartate semialdehyde are precursors to DHQ.

60 sults indicate that glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-ca

61 The pathway uses aspartate beta-semialdehyde as the aminopropyl group donor and consists

62 small proteins containing the aspartic acid semialdehyde (Asa) side chain can be easily prepared by

63 condensation of pyruvate and beta-aspartate semialdehyde (ASA) to form a cyclic product which dehydr

64 icolinate from pyruvate and L-aspartate beta-semialdehyde (ASA).

65 from spermidine, dependent on aspartate beta-semialdehyde (ASA).

66 umophila by disruption of the aspartate-beta-semialdehyde (asd) gene.

67 We then introduced a malonic semialdehyde biosynthesis pathway split between differen

68 of the reaction was confirmed to be malonate semialdehyde by (1)H and (13)C NMR spectroscopy, and kin

69 -aminoadipic acid to alpha-aminoadipic-delta-semialdehyde by a complex mechanism involving two gene p

70 , malonyl-CoA, is further reduced to malonic semialdehyde by an NADPH-dependent malonyl-CoA reductase

71 ly to glutamate and alpha-aminoadipate-delta-semialdehyde by SDH.

72 verts trans-3-chloroacrylic acid to malonate semialdehyde by the addition of H(2)O to the C-2, C-3 do

73 zation of the C-3 carbonyl group of malonate semialdehyde by the cationic Pro-1.

74 including 5-carboxymethyl-2-hydroxymuconate-semialdehyde (CHMS) dehydrogenase (CHMSD), 5-carboxymeth

75 tion of PDC is 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) dehydrogenase, which acts on the sub

76 the C269S/glutamine and CPS/glutamate gamma-semialdehyde complexes, which serve as mimics for the Mi

77 Urinary L-alpha-aminoadipic semialdehyde concentration was determined by liquid chro

78 idino group and conversion to gamma-glutamyl semialdehyde, consistent with previous metal-catalyzed o

79 minoadipate semialdehyde and gamma-glutamate semialdehyde contents increased by 23.17% and 123.12%, r

80 of measurement of urine L-alpha-aminoadipic semialdehyde/creatinine ratio and mutation analysis of A

81 yme alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) as a potential mechan

82 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) has revealed that thi

83 Alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is a widespread enzym

84 cens alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase (ACMSD) is critically depende

85 alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is the key enzyme reg

86 yme alpha-amino-beta-carboxy-muconic-epsilon-semialdehyde decarboxylase (ACMSD) plays an important ro

87 alpha-Amino-beta-carboxymuconate-e-semialdehyde decarboxylase (ACMSD) plays an important ro

88 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) show a five-coordinat

89 of both QPRT and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD); impaired activity of

90 Malonate semialdehyde decarboxylase (MSAD) from Pseudomonas pavon

91 Malonate semialdehyde decarboxylase (MSAD) from Pseudomonas pavon

92 Malonate semialdehyde decarboxylase (MSAD) has been identified as

93 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase could regulate the enzyme act

94 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase from Pseudomonas fluorescens

95 -1, of which 85% are present in the malonate semialdehyde decarboxylase subgroup.

96 SD (alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase) is a key metalloenzyme criti

97 led that of alpha-amino-beta-carboxymuconic--semialdehyde decarboxylase, a class III amidohydrolase,

98 Succinate semialdehyde dehydrogenase (ALDH5A1, encoding SSADH defi

99 is superfamily, the enzyme 2-aminomuconate-6-semialdehyde dehydrogenase (AMSDH), is a component of th

100 Aspartate-beta-semialdehyde dehydrogenase (ASADH) catalyzes a critical

101 Aspartate-beta-semialdehyde dehydrogenase (ASADH) catalyzes the second

102 ate in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase (ASADH) from Haemophilus infl

103 The structure of aspartate-beta-semialdehyde dehydrogenase (ASADH) from Methanococcus ja

104 Aspartate-semialdehyde dehydrogenase (ASADH) is a key enzyme in th

105 Aspartate-beta-semialdehyde dehydrogenase (ASADH) lies at the first bra

106 Aspartate beta-semialdehyde dehydrogenase (ASADH) lies at the first bra

107 se of this bifunctional enzyme and aspartate semialdehyde dehydrogenase (ASADH), the enzyme that cata

108 SC608 is an aspartate semialdehyde dehydrogenase (asd) derivative of SC602 (ic

109 enes encoding a CoA-dependent methylmalonate semialdehyde dehydrogenase (dntE), a putative NADH-depen

110 etermined for Eschericia coli aspartate beta-semialdehyde dehydrogenase (ecASADH), an enzyme of the a

111 sociated with reduced expression of succinic semialdehyde dehydrogenase (encoded by ALDH5A1), and wit

112 e transaminase (GabT and PuuE), and succinic semialdehyde dehydrogenase (GabD and PuuC).

113 /B), GABA-aminotransferase (gab-T), succinic semialdehyde dehydrogenase (gabD1/gabD2), alpha-ketoglut

114 dehydrogenase (PRODH) and L-glutamate-gamma-semialdehyde dehydrogenase (GSALDH) domains.

115 encodes an NAD(+)-dependent glutamate gamma-semialdehyde dehydrogenase (GSALDH), which irreversibly

116 otype, while a null mutant of methylmalonate semialdehyde dehydrogenase (MMSD, At2g14170) resulted in

117 aeruginosa, which encodes methylmalonic acid semialdehyde dehydrogenase (MSDH) and is involved in val

118 The structure of the methylmalonate semialdehyde dehydrogenase (MSDH) from Bacillus subtilis

119 glutarate decarboxylase (Sll1981), succinate semialdehyde dehydrogenase (Slr0370), and/or in gamma-am

120 Inherited succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hyd

121 Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare

122 Succinic semialdehyde dehydrogenase (SSADH) deficiency, a rare me

123 The gene encoding succinate semialdehyde dehydrogenase (UGA5) was identified and fou

124 kely MSI target genes to be the aminoadipate-semialdehyde dehydrogenase AASDH and the solute transpor

125 dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase active sites.

126 The succinic-semialdehyde dehydrogenase activity of GabD and its indu

127 Succinic semialdehyde dehydrogenase activity was detected in Mtb

128 hydrogenase Hpd1p, and the putative malonate semialdehyde dehydrogenase Ald6p essentially contribute

129 iR-275 and miR-305 directly target glutamate semialdehyde dehydrogenase and AAEL009899, respectively,

130 proline dehydrogenase and l-glutamate-gamma-semialdehyde dehydrogenase catalytic modules.

131 As succinic semialdehyde dehydrogenase converts succinic semialdehyd

132 Succinic semialdehyde dehydrogenase deficiency is a rare disorder

133 Succinic semialdehyde dehydrogenase deficiency may be an underrec

134 in sequences indicates that 2-aminomuconic 6-semialdehyde dehydrogenase has a high degree of identity

135 hosphate between aspartokinase and aspartate semialdehyde dehydrogenase in E. coli and suggest that A

136 ined 92 mutated genes, including a succinate-semialdehyde dehydrogenase in the gamma-aminobutyric aci

137 opantetheinylation of the alpha-aminoadipate semialdehyde dehydrogenase involved in lysine catabolism

138 lustrating how NAD(P)(+)-dependent succinate semialdehyde dehydrogenase of Escherichia coli (Sad) is

139 Multiple sequence alignment of various semialdehyde dehydrogenase protein sequences indicates t

140 Based on the paralogous aspartate-beta-semialdehyde dehydrogenase structurally characterized wi

141 The gene encoding 2-aminomuconic semialdehyde dehydrogenase was identified by matching th

142 The iolA (mmsA) gene encoding methylmalonate semialdehyde dehydrogenase was not regulated by IolR.

143 In the present work, 2-aminomuconic semialdehyde dehydrogenase was purified and characterize

144 el 2-oxoglutarate decarboxylase and succinic semialdehyde dehydrogenase were identified in the cyanob

145 r alpha-ketoglutarate decarboxylase/succinic semialdehyde dehydrogenase) plays a minimal role in ener

146 5'-phosphate-dependent enzyme, and succinic semialdehyde dehydrogenase, a NADP(+)-dependent enzyme.

147 ical arrangement of PRODH, l-glutamate-gamma-semialdehyde dehydrogenase, and C-terminal domains, incl

148 erse metabolic pathways, including aspartate semialdehyde dehydrogenase, arginine decarboxylase gene

149 In mice deficient in succinic semialdehyde dehydrogenase, high plasma concentrations o

150 An enzyme of this pathway, 2-aminomuconate-6-semialdehyde dehydrogenase, is responsible for 'disarmin

151 carboxylase, GABA transaminase, and succinic semialdehyde dehydrogenase, leading to an increase in GA

152 lutarate decarboxylase, along with succinate semialdehyde dehydrogenase, may form an alternative path

153 ly regulates the expression of the succinate-semialdehyde dehydrogenase, Sad (also known as YneI), an

154 tervening reaction in the pathway, aspartate semialdehyde dehydrogenase.

155 carboxylase, GABA-transaminase, and succinic semialdehyde dehydrogenase.

156 variants lead to deficiency of a-aminoadipic semialdehyde dehydrogenase/antiquitin, resulting in accu

157 h degree of identity with 2-hydroxymuconic 6-semialdehyde dehydrogenases.

158 ptides, such as peptides containing glutamic semialdehyde derived from the oxidative damage of argini

159 methodology aimed at generating glutamate-5-semialdehyde from arginine residues within peptides and

160 e alpha-aminoadipic (AAS) and gamma-glutamic semialdehydes (GGS) increased when cooking at 60 degrees

161 glutamate is then converted to a glutamate 1-semialdehyde (GSA) by glutamyl-tRNA reductase (GTR) in a

162 d glutamate is then converted to glutamate 1-semialdehyde (GSA) by glutamyl-tRNA reductase (GTR).

163 ts glutamate of glutamyl-tRNA to glutamate 1-semialdehyde (GSA) which is rearranged to ALA by glutama

164 es resulting from reactions with glutamate 1-semialdehyde (GSA), 4,5-diaminovalerate (DAVA), and 5-am

165 the intermediates P5C and l-glutamate-gamma-semialdehyde (GSA).

166 which irreversibly converts glutamate gamma-semialdehyde (GSAL), a mitochondrial intermediate of the

167 5-carboxylate (P5C) and/or L-glutamate-gamma-semialdehyde (GSAL).

168 aldehyde analogs, including 2-hydroxymuconic semialdehyde, hexaldehyde, and benzaldehyde.

169 d the NADH-dependent reduction of tartronate semialdehyde, identifying this protein as a tartronate s

170 ted with a suitably protected glutamyl-gamma-semialdehyde in a Julia-Kocienski olefination reaction.

171 teratively at C5 to yield gamma-Me-Glu-gamma-semialdehyde in equilibrium with the cyclic imine produc

172 minophenol is cleaved to 2-aminomuconic acid semialdehyde in the nitrobenzene-degrading strain Pseudo

173 mediates, gamma-hydroxybutyrate and succinic semialdehyde, inactivated the AttJ repressor in vitro an

174 acetaldehyde, presumably through a malonate semialdehyde intermediate.

175 sformation of the 3-haloacrylate to malonate semialdehyde involves Pro-1 as well as an arginine, two

176 2-Aminonumconic 6-semialdehyde is an unstable intermediate in the biodegra

177 Malonate semialdehyde is analogous to a beta-keto acid, and enzym

178 This observation suggests that malonate semialdehyde is the first product released by the enzyme

179 degradation pathway, the substrate, succinic semialdehyde, is shunted towards production of 4-hydroxy

180 nzyme followed by L-alpha-aminoadipate-delta-semialdehyde ( L-AASA) which adds in rapid equilibrium p

181 posed pathways to beta-alanine from malonate semialdehyde, l-alanine, spermine, dihydrouracil, and ac

182 ndent dehydrogenation of l-alpha-aminoadipic semialdehyde/L-Delta1-piperideine 6-carboxylate.

183 es the reduction of succinyl-CoA to succinic semialdehyde onwards in the cycle.

184 is inactive in the ionization of tartronate semialdehyde phosphate (TSP), whereas both E168Q and E21

185 ns- or cis-3-haloacrylates to yield malonate semialdehyde, presumably through unstable halohydrin int

186 gase, two enzymes that synthesize tartronate semialdehyde, producing an operon clearly designed for d

187 arginine sites prone to forming glutamate-5-semialdehyde PTM within the human proteome.

188 ar expression of AKR family member, succinic semialdehyde reductase (AKR7A2) that reduces toxic aldeh

189 er evidence for identification as tartronate semialdehyde reductase is the observation that the codin

190 o-4-deoxy-(D)-glucarate aldolase, tartronate semialdehyde reductase, a glycerate kinase that generate

191 de, identifying this protein as a tartronate semialdehyde reductase.

192 reduction of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyce

193 B is produced from the reduction of succinic semialdehyde (SSA) by the activity of GHB dehydrogenase.

194 eto-heptane-1,7-dioate aldolase and succinic semialdehyde (SSA) dehydrogenase (SSADH)) have been iden

195 showing much higher affinities for succinic semialdehyde (SSA) than does AKR7A1.

196 hydes, including growth-inhibitory succinate semialdehyde (SSA).

197 repressing function is relieved by succinate semialdehyde (SSA).

198 of ALDH1, ALDH2, ALDH4, ALDH10 and succinic semialdehyde (SSDH) genes have been emerged.

199 thway by CRISPR deletion of the aminoadipate-semialdehyde synthase (Aass) gene.

200 encoding the antioxidant enzymes aminoadipic semialdehyde synthase (Aass), NAD(P)H quinone oxidoreduc

201 ously been referred to as "alpha-aminoadipic semialdehyde synthase," and we have tentatively designat

202 proline dehydrogenase and alpha-aminoadipic semialdehyde synthase.

203 yield a carbonyl compound (alpha-aminoadipic semialdehyde) that can be further oxidised to alpha-amin

204 In the P5CDH active site, l-glutamate-gamma-semialdehyde (the hydrolyzed form of Delta(1)-pyrroline-

205 with pyridoxamine 5'-phosphate and succinic semialdehyde, the products of a GABA-dependent aminotran

206 AD(+)-dependent oxidation of 2-aminomuconate semialdehyde to 2-aminomuconate.

207 same as that of YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.

208 se superfamily member that converts malonate semialdehyde to acetaldehyde by a mechanism utilizing Pr

209 s an aldol condensation with the l-aspartate semialdehyde to form 2-amino-3,7-dideoxy-D-threo-hept-6-

210 to catalyze the decarboxylation of malonate semialdehyde to generate acetaldehyde.

211 the NAD(+)-dependent oxidation of glutamate semialdehyde to glutamate, which is the final step of pr

212 se that catalyzes the oxidation of glutamate semialdehyde to glutamate.

213 semialdehyde dehydrogenase converts succinic semialdehyde to succinate, an intact gamma-aminobutyrate

214 ected conduit for the transport of glutamate semialdehyde to the P5CDH active site.

215 y-5-ketofructose 1-phosphate and l-aspartate semialdehyde to yield ADH.

216 Aminoadipic semialdehyde was also measured in protein extracts from

217 o catabolic products, glutamate and succinic semialdehyde, we sought to determine which was responsib

218 Glutamic and aminoadipic semialdehydes were also detected in rat liver proteins,

219 an is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvat

220 The product of the reaction is malonate semialdehyde, which was confirmed by its characteristic

221 endent enzyme that degrades GABA to succinic semialdehyde, while reduction of GABA concentration in t

222 r gamma-aminobutyric acid (GABA) to succinic semialdehyde with concomitant conversion of pyridoxal 5'