ライフサイエンスコーパス: seminal

1 n in the absence of natural selection, was a seminal advance in evolutionary biology.

2 Recent seminal advances in itch circuitry within the nervous sy

3 The study of EB has led to seminal advances in our understanding of cutaneous biolo

4 s for correlated quantum matter, we envision seminal advances in predicting many-body quantum states

5 eir basic metabolism, this review highlights seminal advances made over the last decade and identifie

6 Numerous seminal and contemporary theories on SUD etiology posit

7 ities will be explained and exemplified with seminal and cutting-edge in vivo studies.

8 In this Review, we cover seminal and recent examples of tandem, sequential and do

9 Seminal animal research directly linked prenatal and ado

10 First introduced in a seminal article by Wertheimer in 1923, the theory explai

11 ographies of systematic reviews and selected seminal articles and contributions from Expert Panel mem

12 Seminal articles from elsewhere in the literature that s

13 These results also underline the seminal biological relevance of the regulation of electr

14 The cytokine profile in seminal, but not in the peripheral blood, was significan

15 Our approach is inspired by seminal, but so far largely neglected models of cortico-

16 However, since the seminal call for animal models of HIV-1/AIDS in 1988, th

17 er magma fragments during eruption remains a seminal challenge in volcanology.

18 This may reflect direct effects of seminal chemicals on sperm function and quality.

19 es and materials, with a particular focus on seminal contributions and the advantages and disadvantag

20 Pascale Cossart, whose seminal contributions are honored in this issue of Molec

21 pioneer and codiscoverer of B-1 cells, whose seminal contributions enhanced our understanding of this

22 She made seminal contributions in these areas.

23 Samuel I. Rapaport made seminal contributions to our basic understanding of bloo

24 Journal of Molecular Biology recognizes his seminal contributions to science in general and structur

25 ector: Aleksei Yevgen'evich Chichibabin made seminal contributions to the chemistry of pyridines.

26 Investigators at these Centers have made seminal contributions to understanding human brain and b

27 Seminal cytokine profiles correlated with transmission o

28 Seminal cytokine profiles correlated with transmission o

29 Seminal cytokine spectra might be a contributing determi

30 Seminal cytokine spectra might be a contributing determi

31 posure to cigarette smoke is associated with seminal defects and with congenital anomalies and childh

32 The seminal description of the cellular restriction factor A

33 Yet, seminal discoveries in the past 5 years have clarified t

34 This review provides an overview of seminal discoveries made through the use of GEM models f

35 Since the seminal discovery of the SMA-causing gene in 1995, resea

36 We thus made the seminal discovery that sCLU expression in M-MDSCs accoun

37 s hypertrophic cardiomyopathy, recapitulated seminal disease phenotypes including cardiac hypercontra

38 This Review both discusses the seminal early studies and explores cutting-edge novel te

39 ow-up was also associated with the risk of a seminal event.

40 We provide a seminal example of the utility of the 1,2-azaborine moti

41 In a seminal example, Schonecker showed that copper and O2 pr

42 devices are based on porphyrin derivatives, seminal examples of the application of corroles or other

43 Seminal experiments(2,3) suggest that correlated noise i

44 We conducted seminal field studies to compare three insecticide resis

45 A seminal finding in monkey research is that neurons in th

46 One of the seminal findings of Ohsumi was on the role ubiquitin-lik

47 These seminal findings strongly suggests that azlocillin can b

48 In this review, we summarize some of the seminal findings that yield important insight into the c

49 thods for measuring P450 activities and many seminal findings.

50 little is known about concomitant changes in seminal fluid (SF) and its molecular composition, despit

51 t of semen, we injected queens with semen or seminal fluid alone.

52 id changes in sperm velocity are mediated by seminal fluid and the effect of seminal fluid on sperm v

53 g differential impacts of aging on sperm and seminal fluid and trade-offs between them or, more broad

54 In Drosophila melanogaster, proteins in the seminal fluid are responsible for important female postm

55 of male survivors clear Ebola virus RNA from seminal fluid at 115 days (90% prediction interval 72-16

56 We observed that either LPD sperm or seminal fluid at conception impaired adult offspring vas

57 Participants provided samples of seminal fluid at follow-up every 3-6 weeks, which we tes

58 These findings are consistent with seminal fluid components manipulating queen eyesight to

59 ophila melanogaster accessory glands secrete seminal fluid components that enhance fecundity.

60 perm are well known, we do not know how much seminal fluid deteriorates in comparison.

61 We demonstrate that seminal fluid deterioration contributes to male reproduc

62 Seminal fluid does more than transport sperm.

63 field trials revealed that queens receiving seminal fluid flew two days earlier than sister queens i

64 firmed reports of Zika virus (ZIKV) in human seminal fluid for months after the clearance of viremia

65 lastic adjustment of ejaculate quality, that seminal fluid harbours the mechanism for the rapid adjus

66 uencing and electroretinography to show that seminal fluid induces a decline in queen vision by pertu

67 an ideal habitat for microbes or a potential seminal fluid microbiome (SFM).

68 from male accessory glands (MAG), which make seminal fluid molecules, female Ae. aegypti become resis

69 mean clearance rate of Ebola virus RNA from seminal fluid of -0.58 log units per month, although the

70 n by mosquitoes, ZIKV can be detected in the seminal fluid of affected males for extended periods of

71 e potential impacts of male PHF7, existed in seminal fluid of Nilaparvata lugens (NlPHF7), on fecundi

72 mediated by seminal fluid and the effect of seminal fluid on sperm velocity directly impacts paterni

73 Injection with either seminal fluid or semen resulted in decreased sexual rece

74 analyse the dynamics of virus persistence in seminal fluid over time.

75 egs with distinct phenotypes both respond to seminal fluid priming, but the Foxp3 epigenetic signatur

76 ickly lead to a change in the quality of the seminal fluid produced by a male Chinook salmon as he re

77 as immunosuppressive [12, 13], and the male seminal fluid protein Sex Peptide (SP) activates JH bios

78 Seminal fluid proteins (SFPs) are emerging as fundamenta

79 Seminal fluid proteins (SFPs) exert potent effects on ma

80 Male Seminal Fluid Proteins (SFPs) transferred during copulat

81 ndent control over the transfer of sperm and seminal fluid proteins (SFPs) under different levels of

82 's physiology through interactions with male seminal fluid proteins (SFPs).

83 Cross-species transfer of sperm and active seminal fluid proteins including HP-I may contribute to

84 melanogaster, mating and the receipt of male seminal fluid proteins results in reduced resistance to

85 ng that components in seminal fluid, such as seminal fluid proteins, are largely responsible for stim

86 exhibited lower expression of genes encoding seminal fluid proteins, which mediate the female respons

87 duced either by mating itself or by sperm or seminal fluid proteins.

88 We enrolled 26 participants and tested 130 seminal fluid specimens; median follow up was 197 days (

89 y mimicked by a stable synthetic simulant of seminal fluid that we formulated.

90 N: Time to clearance of Ebola virus RNA from seminal fluid varies greatly between individuals and cou

91 transcriptional changes of queens receiving seminal fluid were not significantly different from quee

92 fully functional germline (sperm) and soma (seminal fluid) components.

93 use the same allocation rules for sperm and seminal fluid, and (iii) experience changes in current a

94 scribe the diverse features and functions of seminal fluid, and its role in evolution and medicine.

95 The cytokine profile in seminal fluid, but not in peripheral blood, was signific

96 heral Tregs (pTregs) respond to male partner seminal fluid, Foxp3(+)CD4(+) Tregs were examined in the

97 ribe the dynamics of Ebola virus RNA load in seminal fluid, including clearance parameters.

98 pTregs are sensitive to local regulation by seminal fluid, providing a candidate mechanism warrantin

99 ed with semen, suggesting that components in seminal fluid, such as seminal fluid proteins, are large

100 queen post-mating changes are influenced by seminal fluid, the non-spermatozoa-containing component

101 Such effects could be due to the seminal fluid, which is slightly basic and enriched with

102 mating, sex peptide-a protein from the male seminal fluid-triggers many behavioural and physiologica

103 mong CD4(+) T cells expanding in response to seminal fluid.

104 eproductive tract, which produce and secrete seminal fluid.

105 mpetition, promoting compositional change in seminal fluid.

106 in the mother's breast milk and the father's seminal fluid.

107 Zn-finger transcription factor PQM-1 promote seminal-fluid-induced killing.

108 that modification to the cellular make-up of seminal-fluid-producing tissues is an important factor i

109 eting males; both are usually transferred in seminal fluids and represent forms of chemical mate guar

110 rus are rendered temporarily unattractive by seminal fluids containing myristyl acetate and geranylge

111 10 d, viral RNA was detectable in saliva and seminal fluids until the end of the study, 3 weeks after

112 ic molecules regulating immune plasticity is seminal for understanding the inherent regulatory potent

113 t lethal stress originally identified during seminal genetic experiments that defined the SecY-depend

114 s presented significantly increased rates of seminal HHV shedding compared with HIV-uninfected contro

115 The seminal hit molecule was discovered by virtual screening

116 Seminal HIV RNA and DNA from 7 human herpesviruses (HHVs

117 common and was significantly associated with seminal HIV RNA shedding.

118 ostly intermittent, but its association with seminal HIV RNA was the strongest.

119 Seminal HIV transmission from men to their partners rema

120 Seminal HIV-1 RNA was detected in 24% (37 of 155), 10% (

121 by comparing historic plankton tows from the seminal HMS Challenger Expedition (1872-1876) with the r

122 Seminal human immunodeficiency virus (HIV) transmission

123 synthesis of alkyl boronic esters, from the seminal hydroboration methods of H.

124 The seminal importance of detecting ions and molecules for p

125 udy, we showed that mitochondria also have a seminal influence on cells' energy metabolism and on pho

126 perimental advances pushed the phenomenon to seminal innovative applications, its basic observation h

127 tructures of the PRC2 core complex, yielding seminal insights into its catalytic mechanism, substrate

128 As a seminal investigation into the photocapacitive character

129 In this review, we use Metchnikoff's seminal lectures as a starting point to discuss the trem

130 , stay apprised on emerging data, and review seminal literature on respiratory failure.

131 ears ago this month, Thomas Gold published a seminal manuscript suggesting the presence of a "deep, h

132 RNA viruses, and the multiple, seminal mentors who taught me their secrets, have define

133 ve thiosemicarbazone and its zinc complex as seminal metal-free and transition-metal-free examples.

134 Temporal patterning is a seminal method of expanding neuronal diversity.

135 g evidence is beginning to indicate that the seminal microbiome has important implications for the re

136 d to unravel the true nature and role of the seminal microbiome.

137 A seminal microeconomic model of opportunity costs-a mecha

138 t (Saccharomyces cerevisiae) has served as a seminal model in studies of membrane dynamics.

139 olecules, thus defining a "protocell," was a seminal moment in the emergence of life on Earth and lik

140 ur results highlight the important role that seminal monocytes may play in HIV transmission in vivo,

141 ripheral blood mononuclear cells (PBMCs) and seminal mononuclear cells (SMCs) at the end of the dosin

142 tion factor" because of previously published seminal mouse genetic studies; however, mutations in MIT

143 nd Other Enterobacteriaceae) has contributed seminal multicenter data describing risk factors and cli

144 a-protein peptide (Abeta), thought to be the seminal neuropathogenetic agent in AD, its fast aggregat

145 ein (Abeta) assembly is hypothesized to be a seminal neuropathologic event in Alzheimer's disease (AD

146 This article reviews the recent seminal observations of Vgamma2Vdelta2 T cells in protec

147 benzyne itself, being the basis of Wittig's seminal observations on biphenyl synthesis from phenyl l

148 These advances have propelled seminal opportunities for successful variant-targeted di

149 f this area with a focus on what we consider seminal opportunities for the chemistry community to con

150 Since a seminal paper by Crick and Koch (1998) claimed that a sc

151 with limbic encephalitis, and the subsequent seminal paper describing the clinical phenotype and immu

152 5 decades since Altmann (1974) published her seminal paper on the methods for the observational study

153 f halide perovskites, with a large number of seminal papers in the 1980s and 1990s.

154 ef from 1971 to 2010, JBC has published many seminal papers in the fields of chromatin structure, epi

155 dy the coassembly process of PAP(248-286), a seminal peptide that displays both amyloid-forming and a

156 al plasma) but in the presence of NPD or LPD seminal plasma (devoid of sperm).

157 ral blood mononuclear cells (PBMCs; n = 72), seminal plasma (n = 20), cerebrospinal fluid (CSF; n = 3

158 weeks post-switch, we measured HIV-1 RNA in seminal plasma (SP) and blood plasma (BP), tenofovir (TF

159 etroviral drug families on viral kinetics in seminal plasma (SP) of treatment-naive HIV-infected pati

160 red (LOQ 40 copies/mL) in blood plasma (BP), seminal plasma (SP), rectal fluid (RF), and cervicovagin

161 Seminal plasma (SP), the liquid portion of semen, harbor

162 h may facilitate HIV transmission.IMPORTANCE Seminal plasma (SP), the major vehicle for HIV, can modu

163 IV-1 infection and inhibition in whole human seminal plasma and a synthetic simulant that we formulat

164 However, the unstable nature of human seminal plasma and its toxic effects on cells in culture

165 histopathological variables, sperm quality, seminal plasma and plasma oxidative stress, seminal plas

166 Infection and inhibition in whole human seminal plasma are accurately mimicked by a stable synth

167 of differentially expressed proteins in the seminal plasma as diagnostic biomarker for primary and s

168 Standardization of seminal plasma derived PSA calibrant molecular form mass

169 nducted to characterize proteomic profile of seminal plasma from men with primary, or secondary infer

170 tion fluid derived from epididymal flush and seminal plasma from the prostate and seminal vesicle was

171 ion fluid generated from epididymal flush or seminal plasma from ZIKV infected males at 14 and 35 DPI

172 lored the relationship of HIV-1 in blood and seminal plasma in the presence and absence of urethritis

173 Seminal plasma is a critical and complex fluid that carr

174 is unknown which compounds in spermatozoa or seminal plasma may be involved in the regulation of sper

175 The seminal plasma of some species with internal fertilizati

176 ed that %ViableSperm of bulls was related to seminal plasma peroxiredoxin-5, spermadhesin-1 and the s

177 Our results elucidate a mechanism whereby a seminal plasma pheromone attracts ready-to-mate females

178 This report is the largest dataset of bovine seminal plasma proteins.

179 The present study investigated the seminal plasma proteome of Holstein bulls with low (LF;

180 Proteome of seminal plasma provides profound information related to

181 To this end, seminal plasma purified PSA standards from different com

182 paternal low protein diet in a sperm and/or seminal plasma specific manner.

183 nd cardiovascular function in a sperm and/or seminal plasma specific manner.

184 rdiovascular function through both sperm and seminal plasma specific mechanisms over successive gener

185 ascular homeostasis and define the sperm and seminal plasma specific programming effects on cardiovas

186 mplified from cell-free HIV RNA in blood and seminal plasma using the MiSeq Illumina platform.

187 seminal plasma and plasma oxidative stress, seminal plasma vitamin E, and plasma testosterone levels

188 ived from either NPD or LPD sperm (devoid of seminal plasma) but in the presence of NPD or LPD semina

189 ample to remove white blood cells, wash away seminal plasma, and reduce sample volume.

190 le removing white blood cells, replacing the seminal plasma, and reducing the volume of the sample to

191 We detected VEGF-C in seminal plasma, and sperm liquefaction occurred concurre

192 The non-sperm part of ejaculated semen, or seminal plasma, facilitates the delivery of sperm to the

193 Sperm characteristics, oxidative stress of seminal plasma, serum and sperm membrane fatty acids, di

194 s for the quantitation of HIV RNA in CSF and seminal plasma.

195 translational modifications (PTMs) in bovine seminal plasma.

196 talization, and viral diversity in blood and seminal plasma.

197 253 (5%) cervicovaginal lavages, 20/322 (6%) seminal plasmas, and 6/85 (7%) rectal secretions.

198 on marmoset (Callithrix jacchus) has taken a seminal position in neurobiological research, fueled in

199 These findings, together with seminal prior results from various groups, provide valua

200 all future methods that try to address this seminal problem in drug discovery.

201 isms underlying the long-term changes led by seminal products have been extensively studied.

202 n, and a selection of COF nanolayers showing seminal properties and potential material applications.

203 ed in 1948, the Framingham Heart Study was a seminal prospective cohort study of 5,209 adult resident

204 Seminal protein-unbound DTG concentrations exceeded the

205 t include posttranslational modifications to seminal proteins and altered seminal proteome compositio

206 erved across all Glossina species while male seminal proteins are rapidly evolving.

207 There were 338 seminal proteins differentially expressed (p < 0.05) in

208 -mated behavioral state, normally induced by seminal proteins following copulation.

209 Other seminal proteins received in the first mating 'primed' t

210 Seminal proteins were analyzed by label free mass spectr

211 re make highly specific contributions to the seminal proteome and ejaculate function; alternatively,

212 odifications to seminal proteins and altered seminal proteome composition and transfer.

213 itative proteomics, we reveal changes to the seminal proteome that surprisingly encompass alterations

214 ns aim at maximizing their own gains, recent seminal psychological work suggests that our behavior is

215 The seminal publication of Altmann et al. in Bioinformatics

216 isuospatial attention has been shown by four seminal, published studies in monkeys (Macaca mulatta) p

217 he thyroid and with thyroid cancers, raising seminal questions about the role of the immune system in

218 Yet, seminal questions remain largely unaddressed including w

219 The present findings throw up a surfeit of seminal reasons behind the semi-synthetic modification o

220 RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibit

221 Seminal replication of multiple HHVs is common in our HI

222 This perspective discusses seminal research directions for the MI field that have t

223 pithelium has been the subject of decades of seminal research, and emerging technologies, including s

224 d endocytosis was proposed 40 years ago in a seminal review by Joseph Goldstein, Michael Brown, and R

225 Based on multivariate analysis, BSP5 and seminal ribonuclease defined the HF phenotype, while spe

226 bly in vivo The tumor suppressor p53 plays a seminal role in cancer development.

227 stals, thin films and nanostructures plays a seminal role in expanding the frontiers of quantum mater

228 gnetic resonance imaging in the rat played a seminal role in guiding optimization efforts, culminatin

229 r density of lateral roots (LRs) and thinner seminal roots (SRs), whereas OsDGK1-overexpressing plant

230 ar determinants underlying the senescence of seminal roots in hydroponically grown barley (Hordeum vu

231 This study included 453 longitudinal seminal samples from 195 HIV-infected men from the San D

232 Primary Infection Resource Consortium and 67 seminal samples from HIV-negative healthy controls.

233 ture of atomic vapors made possible numerous seminal scientific achievements including time-keeping,

234 (20E), which is packaged together with other seminal secretions into a gelatinous mating plug and tra

235 STAT1 activation served as the seminal signaling molecule that produced the proinflamma

236 This result represents a benchmark for the seminal statements of molecular-frame strong-field physi

237 Attention is given to the seminal stoichiometric organometallic studies which led

238 Seminal studies analyse crime records through historical

239 mical biosensor-based lab-on-a-chip devices, seminal studies discussing important fundamental knowled

240 While seminal studies established primary reactivity patterns,

241 Seminal studies have shown that the proto-oncogene MYC p

242 Recent seminal studies in non-human primate models have demonst

243 In this review, we discuss seminal studies incorporating IVM that have advanced our

244 Indeed, these seminal studies laid the foundations for the field.

245 n Part 3, we draw on and present some of the seminal studies of empathy that can be found in the work

246 Seminal studies of the thalamocortical circuit in the vi

247 nding steps has been revealed since Wegner's seminal studies on filament assembly almost 40 years ago

248 We recount pioneering work and seminal studies performed within the last 10 years descr

249 del, we simulate experimental data from four seminal studies that microstimulated or inactivated a ke

250 for bacterial identification, including some seminal studies to detect bacteria at the single-cell le

251 A thorough overview is undertaken, from the seminal studies until the present day, of the key mechan

252 Seminal studies using squid as a model led to breakthrou

253 These results extend the seminal study in follicular lymphoma (FL) from the Natio

254 Hille's (1971) seminal study of organic cation selectivity of eukaryoti

255 y of human populations by Harry Harris, this seminal study provided the first relatively unbiased pic

256 This seminal study spurred the search for B-cell regulatory p

257 We examine how this seminal study was pivotal to our understanding of CME an

258 ioinformatic developments have upgraded this seminal technique, making analysis more sensitive and ef

259 and review the scientists who introduced the seminal terminology, concepts, methodological approaches

260 Extracellular and intracellular seminal TFV distribution differs between TAF and TDF.

261 organization of society lies at the core of seminal theories in human geography that have strongly i

262 rt in two-dimensional systems given that the seminal theory for transport in disordered metals predic

263 Importantly, the Green Box represents a seminal type of C(60/70) host where electron-rich PDI mo

264 ctivation also resulted in transformation of seminal vesicle epithelial cells in Pten-null mice.

265 tection of extracapsular extension (ECE) and seminal vesicle infiltration (SVI) in patients with pros

266 level, primary Gleason grade greater than 3, seminal vesicle invasion, and higher number of removed a

267 ical margin status, extracapsular extension, seminal vesicle invasion, lymph node invasion, and andro

268 HIP1R mRNA levels were decreased in seminal vesicle tissue from mice bearing miR-23b/-27b-tr

269 ush and seminal plasma from the prostate and seminal vesicle was obtained from ZIKV inoculated and sh

270 of recipient mice reduced androgen-dependent seminal vesicle weight (8.3 vs 26.7 mg; p < 0.05), but d

271 ifferentiated nonprostatic mouse epithelium (seminal vesicle) is sufficient for respecification to pr

272 lesion, region (prostate, including bed and seminal vesicle, or extraprostatic, including all lymph

273 ults in obstruction of the proximally placed seminal vesicle.

274 Furthermore, the involvement of seminal vesicles and other extracapsular extension were

275 The seminal vesicles are paired organs of the male reproduct

276 Although congenital anomalies of seminal vesicles are usually asymptomatic, they may lead

277 Congenital anomalies of seminal vesicles include agenesis, hypoplasia, duplicati

278 r urogenital organs, congenital anomalies of seminal vesicles may accompany other urinary or genital

279 t reductions (~40%) of spermatozoa stored in seminal vesicles of males, resulting in decreased egg vi

280 eks were much reduced; however, SC-SF-1(-/-) seminal vesicles weights were comparable suggesting inta

281 inical importance of congenital anomalies of seminal vesicles with images of some rare and previously

282 specified for anatomic locations (prostate, seminal vesicles, local lymph nodes, distant lymph nodes

283 in 20 fractions in 5 weeks) to prostate and seminal vesicles.

284 ed MSM to their partners, independently from seminal viral load.

285 ed MSM to their partners, independently from seminal viral load.

286 episodes, 15 episodes (17%) had instances of seminal viral shedding >=400 copies/mL despite viral sup

287 the treatment of cancer, give an overview of seminal work and discuss future challenges and our persp

288 In this Review we outline both seminal work and recent advances in our understanding of

289 Following seminal work by Maxwell and others on criteria for stiff

290 He has published seminal work demonstrating the importance of the microbi

291 We shine a spotlight on his seminal work describing how the innate ability of embryo

292 In 1961, seminal work identified major risk factors for CHD (high

293 In his seminal work in the 1970s, Robert May suggested that the

294 This is in stark contrast with seminal work in the reinforcement and decision-making li

295 is includes revisiting the insights from the seminal work on the theory of ET and time-resolved measu

296 Just over a century ago, Lewis published his seminal work on what became known as the covalent bond,

297 n precision spectroscopy and metrology since seminal works of Hansch et al.

298 s of unsymmetrical biaryls, built around the seminal works of Pschorr, Gomberg and Bachmann more than

299 r has been a major topic of debate since the seminal works on cooperation in the 1960s.

300 In this review, we return to seminal works on this topic before summarizing the chang