ライフサイエンスコーパス: semisynthetic

1 Semisynthetic access has also been limited by the lack o

2 design and synthesis of structurally defined semisynthetic adaptors we refer to as "switch" molecules

3 ave developed a method of discriminating two semisynthetic aequorin variants from one another using t

4 Acylfulvenes (AFs) are a class of semisynthetic agents with high toxicity toward certain t

5 ielding six-step convergent synthesis of the semisynthetic alkaloid (-)-perhydrohistrionicotoxin is d

6 Semisynthetic aminoglycoside derivatives may provide a m

7 -50 binding and competition experiments with semisynthetic aminoglycosides and neomycin B and tobramy

8 Omadacycline is a semisynthetic aminomethylcycline antibacterial derived f

9 ction of GM1 ganglioside, whereas LIGA 20, a semisynthetic analog of GM1, substantially reduced both

10 Epothilone B (BMS-247550) is a semisynthetic analog of the natural product epothilone B

11 BMS-247550 is a semisynthetic analog of the natural product epothilone B

12 stem analysis for the S(2) site of KcsA, its semisynthetic analog, and valinomycin yields the free en

13 ounds have served as the starting points for semisynthetic analogs with improved properties.

14 ination drugs containing artemisinin (or its semisynthetic analogs), known as artemisinin combination

15 led that metabolites 2-4 and, in particular, semisynthetic analogue 5, are strong growth inhibitors o

16 tive CRPC cell line, with paclitaxel and its semisynthetic analogue docetaxel decreases expression of

17 n a previous report, a seven-membered D-ring semisynthetic analogue of cyclopamine, IPI-269609 (2), w

18 TNP-470, a semisynthetic analogue of fumagillin, was studied in vit

19 using the folate ligand to target a potent, semisynthetic analogue of the microtubule inhibitor tubu

20 6-Hydroxymethylacylfulvene (MGI-114) is a semisynthetic analogue of the toxin illudin S, a product

21 nd resistance have led to efforts to prepare semisynthetic analogues (i.e., KW-2149 (3), BMS-181174 (

22 macrolide antibiotic erythromycin A and its semisynthetic analogues have been among the most useful

23 Here, semisynthetic analogues of hit were designed, synthetize

24 Semisynthetic analogues such as FK973 (3) and FK317 (4)

25 ealth, chemists have succeeded in generating semisynthetic analogues that sometimes overshadow the or

26 de series, 6, 7, 10, 11, 20, and 22, and the semisynthetic analogues, 30, 31, 33, and 36, inhibit con

27 Intensive semisynthetic and biosynthetic efforts have been directe

28 ts replenished the arsenal of antibiotics by semisynthetic and to a lesser degree fully synthetic rou

29 atural product family, including biomimetic, semisynthetic, and de novo synthetic strategies.

30 N-Benzyladriamycin-14-valerate (AD 198) is a semisynthetic anthracycline with experimental antitumor

31 We demonstrate that the resultant semisynthetic anti-idiotype peptibodies kill tumor cells

32 ronan shows promise as an example of a novel semisynthetic anti-inflammatory molecule.

33 New classes of molecules, including semisynthetic antibacterial compounds and newer generati

34 ) that are an important source of natural or semisynthetic anticancer drugs.

35 Several semisynthetic antimitotic alkaloids are emerging as poss

36 methylacylfulvene (HMAF; MGI 114) is a novel semisynthetic antitumor agent derived from the sesquiter

37 erpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs.

38 he production of paclitaxel, specifically, a semisynthetic approach and the application of biocatalys

39 e]-hydrogenase maturation by using a defined semisynthetic approach in which [Fe(I)(2)(mu-SH)(2)(CO)(

40 This semisynthetic approach is likely to be applicable to the

41 The semisynthetic approach relies on the solid-phase peptide

42 route to produce betaMdeltaVL, an efficient semisynthetic approach that employs high-yielding chemic

43 We used a semisynthetic approach to generate modular ubiquitin-bas

44 Utilizing our recently published semisynthetic approach to the (3'S)-K-252a diastereomer,

45 Building on the classical knowledge-based semisynthetic approach, we engineer ~15 kDa nanosensors

46 different acyl tails were synthesized via a semisynthetic approach.

47 ovo synthetic approach that could offer what semisynthetic approaches do not.

48 es for PglC, PglJ, and PglB are prepared via semisynthetic approaches.

49 rse structures not accessible by traditional semisynthetic approaches.

50 ss toward the goal of developing a supply of semisynthetic artemisinin based on production of the art

51 The semisynthetic artemisinin derivatives such as artesunate

52 rrently treated as a waste in the industrial semisynthetic artemisinin process.

53 present a complete process for production of semisynthetic artemisinin.

54 Semisynthetic artemisinins and other bioactive peroxides

55 ents, and limited proteolysis assays on this semisynthetic ATP-linked protein, we have obtained uniqu

56 ly stable oxime linkage to furnish the first semisynthetic bacterial-based immunogen construct target

57 resent study, we describe a novel library of semisynthetic bile acid derivatives obtained by modifica

58 ndogenous bile acids and currently available semisynthetic bile acids are poorly selective toward GP-

59 y chromophore substitution experiments using semisynthetic bilin monoamides, which indicate that the

60 This was further confirmed using a semisynthetic biotinylated p300 HAT domain that could be

61 Here, we describe a unique semisynthetic bispecific antibody that uses site-specifi

62 em, we tested a library of bioengineered and semisynthetic borrelidin analogs for their antimalarial

63 from dihydroartemisinin, a small array of 16 semisynthetic C-10 pyrrole Mannich artemisinin derivativ

64 Herein, we disclose a semisynthetic, catalytic approach for structure diversif

65 wiss, Phadia and Siemens) with and without a semisynthetic CCD blocker with minimized potential for n

66 (PET), high-density polyethylene (HDPE), and semisynthetic cellulose (S.S. Cellulose), and in Lake Er

67 However, recent work using a semisynthetic channel that is unable to adopt a constric

68 ibilities for combinatorial biosynthesis and semisynthetic chemistry because of the introduction of f

69 hen combinatorial biosynthesis is coupled to semisynthetic chemistry.

70 udy performed simultaneous identification of semisynthetic chlorophyllin (Cu-Chl) and synthetic food

71 We show that these semisynthetic, circularly permuted acetylated proteins r

72 antitative assessment of these synthetic and semisynthetic colorants was determined by using analytic

73 This tubulin-binding semisynthetic compound is a selective and potent anti-br

74 Here we explored the capability of a semisynthetic compound to intercept mTOR signaling.

75 and colleagues recently demonstrated that a semisynthetic compound was able to selectively stabilize

76 mycins has been shown to produce a series of semisynthetic compounds, the dihydropacidamycins, with a

77 Comparison against a set of new, semisynthetic concanamycins revealed that substituents a

78 nus of the nisin A/B ring system to generate semisynthetic constructs that display potent inhibition

79 A strategy for the preparation of semisynthetic copper(II)-based catalytic metalloproteins

80 determine the DNA-binding specificity of the semisynthetic covalent DNA-binding polyamide tallimustin

81 discovery of IPI-926 (compound 28), a novel semisynthetic cyclopamine analogue with substantially im

82 We generated 100 different semisynthetic data sets for each F-ratio and evaluated t

83 he approach was validated through the use of semisynthetic data, which was a combination of real envi

84 if spaced closely), as we demonstrate using semisynthetic datasets, performing ChIP-seq for the TF T

85 in mice of natural product gossypol and its semisynthetic derivative apo-gossypol, compounds that bi

86 s to examine whether GM1 ganglioside and its semisynthetic derivative LIGA20 activate various neurotr

87 PG490-88, a semisynthetic derivative of a novel compound PG490 (trip

88 PG490-88 is a water soluble, semisynthetic derivative of a novel compound PG490 (trip

89 Amikacin, the semisynthetic derivative of kanamycin, is commonly used

90 PG490-88, a semisynthetic derivative of PG490 (triptolide, present i

91 lide, a constituent of PG27) and PG490-88 (a semisynthetic derivative of PG490) suppressed rejection

92 adin-Darby canine kidney epithelial cells: a semisynthetic derivative of quinocarmycin (also known as

93 a novel aminomethylcycline antimicrobial and semisynthetic derivative of tetracycline.

94 Artesunate (ART), a semisynthetic derivative of the Artemisinin plant, is ap

95 47, 6alpha-ethyl-chenodeoxycholic acid) is a semisynthetic derivative of the primary human bile acid

96 Artemisinin and its semisynthetic derivatives (ART) are crucial medicines in

97 cal evaluation of crocin 1, safranal and its semisynthetic derivatives as selective inhibitors of fiv

98 Using suvanine as a novel hit, a library of semisynthetic derivatives has been designed and prepared

99 ir effectiveness as antifungal agents, three semisynthetic derivatives have been developed and approv

100 to further probe the mechanism of action, 19 semisynthetic derivatives of gedunin were prepared and t

101 products produced by soil microorganisms or semisynthetic derivatives of natural products.

102 f GPI-0100, a widely used complex mixture of semisynthetic derivatives of Quillaja saponaria (QS) Mol

103 ied conductance behavior in a membrane using semisynthetic derivatives of the ion-channel-forming pep

104 of a new class of anticancer agents that are semisynthetic derivatives of the mushroom toxin illudin

105 Semisynthetic derivatives of vancomycin with enhanced bi

106 ities of a number of related metabolites and semisynthetic derivatives revealed key features required

107 hibit bacterial protein synthesis, and their semisynthetic derivatives, such as dalfopristin-quinupri

108 gues of the insect molting hormone and their semisynthetic derivatives, were tested for their activit

109 nts, and larger glycosaminoglycans and their semisynthetic derivatives.

110 nthetic means or modifications by late-stage semisynthetic derivatization in ways that enhance their

111 The structure was elucidated through the semisynthetic derivatization of starting material via ch

112 an analogue class presently inaccessible by semisynthetic derivatization of the natural product, by

113 By using semisynthetic 'designer' chromatin containing H2B-Ub bea

114 taining 5% sucrose polybehenate was fed in a semisynthetic diet to rats and mice.

115 l, and control diet C was a standard AIN-76A semisynthetic diet which is lower in fat content and hig

116 Rats were fed semisynthetic diets containing either juniper berry oil,

117 ice and studied on both low-fat and high-fat semisynthetic diets.

118 umor cell population following exposure to a semisynthetic dimerizing ligand, AP20187.

119 al malaria, development of clinically useful semisynthetic drugs for severe and complicated malaria (

120 lex has 350-500-fold lower activity than the semisynthetic enzyme produced by peptide ligation.

121 As the viral structure ensures semisynthetic enzymes remain linked to the genetic seque

122 biochemical platform for engineering de novo semisynthetic enzymes, functionally modular and widely s

123 ent the need for cultivation of mayapple and semisynthetic epimerization and demethylation of podophy

124 We demonstrated the generality of semisynthetic epitope construction with 13 diverse kinas

125 one, 17beta-trenbolone, for the nonsteroidal semisynthetic estrogen agonist, alpha-zearalanol, and th

126 Ethinyl estradiol is a semisynthetic estrogen compound found in birth control p

127 Flavopiridol is a novel semisynthetic flavone derivative of the alkaloid rohituk

128 Although flavopiridol, a semisynthetic flavone, was initially thought to be a spe

129 Flavopiridol is a semisynthetic flavonoid that inhibits cyclin-dependent k

130 uld detect both green coloured synthetic and semisynthetic food colorants by a single run and could b

131 ate, chondroitin sulfate A, heparin, and the semisynthetic fully sulfated chondroitin sulfate, FSCS,

132 GABA-Snifit is a semisynthetic fusion protein containing the GABA(B) rece

133 conformation of the carboxyl terminus of the semisynthetic G protein, we applied high resolution solu

134 ted a marked loss of signal intensity in the semisynthetic Galpha subunit but not in free peptide sub

135 tion in a more native system, we generated a semisynthetic Galpha subunit, site-specifically labeled

136 A semisynthetic gene encoding the entire protein sequence

137 Our method, using semisynthetic GFP as a readout, is facile, sensitive, la

138 Oritavancin is an investigational semisynthetic glycopeptide with potent in vitro activity

139 ncomycin; some of the most promising include semisynthetic glycopeptides, quinupristin-dalfopristin,

140 ased on phosphorylation-mediated assembly of semisynthetic green fluorescent protein (GFP).

141 Semisynthetic green fluorescent proteins (GFPs) can be p

142 pombe and chromatin substrates that contain semisynthetic H2Bub1.

143 pH 7.4 than is artelinic acid (1), a leading semisynthetic, herb-derived antimalarial trioxane drug c

144 We have prepared semisynthetic histone H3 acetylated at Lys-115 and/or Ly

145 cleosomes reconstituted from recombinant and semisynthetic histones on barcoded DNA prior to immunopr

146 d in the rest of the PLA(2), we have created semisynthetic human group IB PLA(2) in which the N-termi

147 g motif opens avenues for the engineering of semisynthetic hybrid RiPP products.

148 of the protein folding behavior reveals that semisynthetic Im7 analogues are well suited for protein

149 mino-17-demethoxygeldanamycin (17-AAG)1 is a semisynthetic inhibitor of the 90 kDa heat shock protein

150 naptic factors, we developed and validated a semisynthetic inhibitory network that approximates simul

151 acid (GLCA) (its glycine conjugate), and the semisynthetic isomers, 7alpha-OH- and 12alpha-OH-cholano

152 Using the semisynthetic KcsA and KvAP channels, we show that block

153 wo-dimensional infrared (2D IR) spectra of a semisynthetic KcsA channel with site-specific heavy ((13

154 uctural studies based on chemically modified semisynthetic KcsA channels along the selectivity filter

155 Importantly, MD simulations reveal that the semisynthetic KcsA(D-ala77) channel can adopt an asymmet

156 by analysis of galectin-3 interaction with a semisynthetic ligand, F3.

157 tivity of this conjugate as well as of other semisynthetic lipid A derivatives was also reported.

158 Oritavancin is a semisynthetic lipoglycopeptide analogue of vancomycin th

159 Telavancin is a semisynthetic lipoglycopeptide derivative of vancomycin.

160 overed in 2000 and became the first marketed semisynthetic lipoglycopeptide in 2009.

161 The TEM precursor and several semisynthetic lipopeptide TEM derivatives showed rapid b

162 properties of sdAbs, we constructed a large, semisynthetic llama sdAb library.

163 We now report a series of semisynthetic LMB derivatives showing substantially impr

164 Solithromycin (1), a third-generation semisynthetic macrolide discovered by combinatorial copp

165 particular, ketolides, a promising class of semisynthetic macrolides with activity against erythromy

166 copy, using externally fluorescence-labeled, semisynthetic malpinin or a biosynthetically alkyne-tagg

167 Semisynthetic, mechanism-based protein inhibitors of ubi

168 e typically collected from cultures grown in semisynthetic medium in vitro.

169 ations, but the protein-free fusion of those semisynthetic membranes is unexplored to date.

170 dependable production method to replace the semisynthetic method currently in place, which relies on

171 Here, we present a semisynthetic method for preparing mammalian thioredoxin

172 Here we report a site-specific, semisynthetic method for the production of bispecific an

173 Herein we report a semisynthetic method of producing membrane-anchored prot

174 Here, we describe a semisynthetic method that relies upon sequential express

175 ill rest with those who employ synthetic and semisynthetic methodology as well as natural product iso

176 N(alpha)-acetylated alpha-syn first using a semisynthetic methodology based on expressed protein lig

177 e of molecules that would be inaccessible by semisynthetic methods (presently the only means of tetra

178 The development of semisynthetic methods for the site-specific introduction

179 Semisynthetic modification of 1 provided several analogs

180 Semisynthetic modification of its glycolic acid subunit

181 Aside from accessible semisynthetic modifications of existing functional group

182 of sulfation was confirmed using a panel of semisynthetic modified heparins with variable levels of

183 structure and biology by fabricating defined semisynthetic modular proteoglycans that can be tailored

184 Functional characterization of the folded semisynthetic NaK channels indicates that it is function

185 he recombinant peptide thioester to form the semisynthetic NaK polypeptide.

186 Development of exosome-based semisynthetic nanovesicles for diagnostic and therapeuti

187 he proteins were efficiently assembled via a semisynthetic native chemical ligation strategy.

188 Acylfulvenes comprise a family of semisynthetic natural product derivatives with potent an

189 Here, we show that a semisynthetic nontoxic tubulin-binding agent, 9-bromonos

190 end, we covalently associated LSD1-CoREST to semisynthetic nucleosomal particles.

191 d synthetic (fentanyl, remifentanil) and the semisynthetic opioid (oxycodone) would also potentiate s

192 is limited to changes following natural and semisynthetic opioids, despite recent increases in synth

193 developed an unnatural base pair (UBP) and a semisynthetic organism (SSO) that imports the constituen

194 We have created a bacterial semisynthetic organism (SSO) that retains an unnatural b

195 ird base pair would lay the foundation for a semisynthetic organism with an expanded genetic code and

196 plications and also lay the foundation for a semisynthetic organism with an expanded genetic code.

197 ions and would also lay the foundation for a semisynthetic organism.

198 a coli, thus making the world's first stable semisynthetic organism.

199 in vitro and in the in vivo environment of a semisynthetic organism.

200 plications as well as for the engineering of semisynthetic organisms (SSOs) that store and retrieve i

201 ibiting properties of natural, synthetic, or semisynthetic origin are being discovered and/or develop

202 eveloped a physiological microenvironment of semisynthetic origin, called gelatin methacryloyl (GelMA

203 Cellulosic, both natural and semisynthetic particles, were the composition mostly fou

204 alization studies and functional analyses of semisynthetic PEGylated Rab1, Rab5, Rab7, and Rab35 prot

205 al cysteine side-chain protection in the two semisynthetic peptide substrates, we were able to rule o

206 or potentially useful for the preparation of semisynthetic peptides and proteins incorporating charge

207 ed a method of targeting idiotype by using a semisynthetic personalized therapeutic that is more prac

208 Here we describe "semisynthetic" pH-sensitive protein conjugates with orga

209 We used a semisynthetic phage display human antibody library to ra

210 Specifically, we screened a naive human semisynthetic phage library against RBD, leading to the

211 ized immunoglobulin products, or transfusing semisynthetic platelet substitutes (thromboerythrocytes,

212 Lefamulin, previously known as BC-3781, is a semisynthetic pleuromutilin antibiotic that was approved

213 A new series of semisynthetic pleuromutilin derivatives were synthesized

214 ped for measuring nanogram concentrations of semisynthetic pneumocandin antifungal agents in human pl

215 Semisynthetic pneumocandin L-733,560 was conjugated to s

216 ida albicans mutants resistant to the potent semisynthetic pneumocandin L-733,560.

217 ul for quantitating plasma levels of related semisynthetic pneumocandins including clinical candidate

218 Semisynthetic polymers and polysaccharides as sources of

219 Such semisynthetic preparation of sex pheromones is a novel a

220 hat will facilitate ongoing efforts on their semisynthetic preparation.

221 Controlled genes are expressed from a strong semisynthetic promoter repressed by the prokaryotic TetR

222 oter failed to activate transcription from a semisynthetic promoter, and this failure was not due to

223 ld not be activated by receptor; whereas the semisynthetic protein demonstrated functionality that wa

224 The resulting semisynthetic protein has enhanced affinity for the expr

225 Semisynthetic proteins engineered to contain non-coded e

226 potential for FRET between mixtures of these semisynthetic proteins.

227 of the streptamine ring of other natural or semisynthetic pseudodisaccharide aminoglycoside scaffold

228 Our design originates a vast class of semisynthetic rare-cleaving DNA nickases, which are esse

229 tivity of individual kinases, we developed a semisynthetic reaction scheme, which results in the affi

230 Thus, this semisynthetic reassembly process offers a general route

231 .A pair is replaced with inosine (I) in both semisynthetic ribozymes and oligonucleotide mimics of th

232 Rifampin, a semisynthetic rifamycin, is the cornerstone of current t

233 Among many semisynthetic rifamycins, benzoxazinorifamycins have gre

234 satile biocatalyst that converts an array of semisynthetic roquefortine C derivatives bearing indolin

235 f the de novo route complements the existing semisynthetic route from chlorophylls and should enable

236 rotein folding pathways, we have developed a semisynthetic route toward the immunity protein Im7.

237 cated reaction sequence into widely utilized semisynthetic routes to next generation Taxol (paclitaxe

238 we use expressed protein ligation to produce semisynthetic SAHH acetylated at Lys(401) and Lys(408) a

239 he positive control GPI-0100, a well-studied semisynthetic saponin adjuvant mixture derived from Quil

240 The semisynthetic saponin adjuvants have shown significantly

241 Here, a modular semisynthetic scheme is introduced to govern the release

242 ve used an experimental approach utilizing a semisynthetic scheme that employs native chemical ligati

243 The semisynthetic scheme was also employed to construct a va

244 A novel semisynthetic scheme was developed to couple amine-react

245 Minocycline is a semisynthetic second-generation tetracycline that exerts

246 hod allows production of a fully functional, semisynthetic selenoenzyme that is amenable to structure

247 The performance of these semisynthetic sensor proteins makes them attractive for

248 A novel semisynthetic sequence to QS-7-Api has also been establi

249 g structure-based design, we generated a new semisynthetic series of spectinomycin analogs with selec

250 Biological evaluation of these semisynthetic sesquiterpene lactone derivatives in HeLa

251 xpressed protein ligation, we have generated semisynthetic SHP-1 proteins containing phosphotyrosine

252 regulation by phosphorylation, we generated semisynthetic site-specifically tetra-phosphorylated PTE

253 a morpholino glycone previously reported in semisynthetic sordarin derivatives with broad spectrum a

254 ong our 22 collected naturally occurring and semisynthetic stilbenic compounds, significantly attenua

255 A novel, entirely carbohydrate, semisynthetic STn-polysaccharide (PS) A1 conjugate was p

256 Here, we describe chemical and semisynthetic strategies for site-specific incorporation

257 Our semisynthetic strategy for generating site-specifically

258 lenges, we developed a general and efficient semisynthetic strategy that enables the site-specific in

259 Here we report a concise semisynthetic strategy to access diverse 2- and 4-deoxyg

260 We describe here a semisynthetic strategy to identify inhibitors based on t

261 A semisynthetic strategy to obtain monophosphoryl lipid A

262 Here, we describe a general semisynthetic strategy to obtain these oligoribonucleoti

263 ensive account chronicles the evolution of a semisynthetic strategy toward these molecules from (+)-c

264 e development and application of a versatile semisynthetic strategy, based on a combination of sortas

265 cium to the group A component of natural and semisynthetic streptogramin mixtures is a prerequisite f

266 Although several successful semisynthetic studies have been performed to elucidate s

267 of 2-debenzoyl-7,13-diacetylbaccatin III, a semisynthetic substrate, to 7,13-diacetylbaccatin III, a

268 These semisynthetic substrates were evaluated as Csk substrate

269 nt (Ser->Cys) thioesterases was reacted with semisynthetic substrates.

270 alphaHL pores with one semisynthetic subunit were then used as nanoreactors for

271 Following folding, the semisynthetic sulfoprotein was shown to exhibit potent b

272 ves of the opioid family, including natural, semisynthetic, synthetic, and endogenous neuropeptide op

273 A second semisynthetic system is also reported that makes use of

274 The semisynthetic tail-phosphorylated Csk showed evidence of

275 for new antibiotics has been met largely by semisynthetic tailoring of natural product scaffolds dis

276 Docetaxel is a semisynthetic taxane, a class of anticancer agents that

277 plored because of limitations in traditional semisynthetic techniques.

278 Omadacycline is a semisynthetic tetracycline antibiotic.

279 Minocycline is a semisynthetic tetracycline derivative with activity agai

280 bial low doses of the commercially available semisynthetic tetracycline doxycycline, have been used i

281 Minocycline is a semisynthetic tetracycline with antiinflammatory propert

282 Minocycline, a semisynthetic tetracycline, has been shown to be neuropr

283 We now report that minocycline, a semisynthetic tetracycline, recently shown to have neuro

284 Semisynthetic tetracyclines used in the adjunctive treat

285 We produced the semisynthetic thioredoxin reductase with a total yield o

286 This novel semisynthetic translation system is a powerful tool for

287 (efficacy/toxicity) as that of water-soluble semisynthetic trioxane artelinic acid (5).

288 The semisynthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(

289 esized and chemically characterized a novel, semisynthetic triterpenoid derivative, 3-cinnamoyl-11-ke

290 Semisynthetic triterpenoids such as bardoxolone methyl (

291 g them with synthetic tRNAs, we formulated a semisynthetic tRNA complement for all 20 amino acids.

292 be Ub E1 in these two states, captured using semisynthetic Ub probes.

293 ine 1 and to the carrier protein KLH to form semisynthetic vaccine 2.

294 carrier proteins (CRM197 and PorA) enabled a semisynthetic vaccine to be generated; this was then inv

295 The semisynthetic version of thioredoxin reductase that we p

296 Vinorelbine (Navelbine), an amphiphilic semisynthetic Vinca alkaloid, has displayed superior act

297 The semisynthetic vitamin E derivative alpha-tocopheryloxyac

298 Chlorophyllin, a mixture of semisynthetic, water-soluble derivatives of chlorophyll

299 ivity relationships, we obtained natural and semisynthetic withanolides 1, 2a, 2c, and 3-36 and compa

300 t properties of self-assembled structures of semisynthetic zinc chlorins (ZnChls) in the solid state