ライフサイエンスコーパス: sensitive period

1 ime that pups first begin to leave the nest (sensitive period).

2 depend on sensory experience during an early sensitive period.

3 characterize the timing and duration of this sensitive period.

4 early phase, appearing slightly later in the sensitive period.

5 ence and is often enhanced during a juvenile sensitive period.

6 by imitating a tutor song during a juvenile sensitive period.

7 es to clarify the parameters defining such a sensitive period.

8 tors with whom they interact during an early sensitive period.

9 odor learning circuit characteristic of the sensitive period.

10 atal Day 8) and after (Postnatal Day 12) the sensitive period.

11 E release associated with termination of the sensitive period.

12 of amygdala-dependent fear learning during a sensitive period.

13 perience during a developmentally restricted sensitive period.

14 uditory space map was restricted to an early sensitive period.

15 rus across childhood, suggesting a potential sensitive period.

16 major depressive disorder (MDD) during this sensitive period.

17 posed to gonadal hormones during a perinatal sensitive period.

18 tagmus-induced visual deprivation during the sensitive period.

19 , is dependent on experience and linked to a sensitive period.

20 time course of pendular nystagmus during the sensitive period.

21 ed by complex sounds in a series of distinct sensitive periods.

22 lishing synaptic patterning during perinatal sensitive periods.

23 s and requires sensory input during distinct sensitive periods.

24 nal abuse or neglect during segment-specific sensitive periods.

25 privation coincides with early developmental sensitive periods.

26 abitat and (3) alteration of activity during sensitive periods.

27 d to artemisinin exposures during the embryo sensitive period (6-12 wk gestation) were as follows: aH

28 rience and refutes the existence of an early sensitive period: A short period of experience, even whe

29 behaviors, and (3) a dopamine- and serotonin-sensitive period affecting aggression, impulsivity and b

30 ed the effect of genetic pathways regulating sensitive periods, alone and in interaction with common

31 Disruption of NE signaling during this sensitive period also caused altered LC autoreceptor fun

32 Dark-rearing, which prolongs the sensitive period, also prolongs the expression of the Ca

33 s focused on animals prior to the end of the sensitive period and did not examine the visual cortex s

34 gain mechanistic insight into this dopamine-sensitive period and its impact on behavior.

35 childhood may be attributable to it being a sensitive period and may play a role in the subsequent r

36 r how SEP shapes DNAm profiles-accumulation, sensitive period and mobility.

37 both the biology of the brain's postischemic sensitive period and the difficult question of what kind

38 n human neuroimaging can help elucidate both sensitive periods and neurobiological consequences of ex

39 tionship between the epigenome and postnatal sensitive periods and plasticity, and the impact of earl

40 gs from human and animal studies focusing on sensitive periods and their regional and circuit specifi

41 irds must hear the sounds of adults during a sensitive period, and must hear their own voice while le

42 earning and the restriction of learning to a sensitive period, and what factors explain the highly se

43 ed PDGFRB gene-is involved in morphogenesis, sensitive periods, and in the endogenous chiral mechanis

44 atural history of amblyopia, its origins and sensitive periods, and the brain mechanisms that underly

45 mpact of temperature variation during thermo-sensitive periods (anthesis and grain-filling; TSP) of w

46 While allowing for adaptation, such sensitive periods are also vulnerability windows during

47 attributable to adversity during early-life-sensitive periods are at least partially amenable to int

48 Genes involved in regulating sensitive periods are differentially expressed across th

49 in intake, especially during developmentally sensitive periods, are poorly understood.

50 b) adrenalectomy developmentally extends the sensitive period as indicated by odor-shock-induced odor

51 bitory tone, sculpted during a developmental sensitive period, as a key regulator and potential thera

52 life-course models that consider critical or sensitive periods, as well as accumulation over the enti

53 We test the hypothesis that adolescence is a sensitive period because of the active development of co

54 ans are an excellent model for investigating sensitive periods because training starts early and can

55 del system, we discovered the existence of a sensitive period, before 4 mo, when exposure determines

56 fluenced by environmental experience during "sensitive periods," before onset of behavioral function.

57 ure-sensitive apx-1 mutant has a temperature-sensitive period between the 4-cell and 8-cell stages.

58 e we investigated neural correlates of these sensitive periods by assessing developmental changes in

59 ehaviorally and neurophysiologically defined sensitive periods by taking into account differences in

60 disruption to the gut microbiome during this sensitive period can have potentially long-lasting impac

61 Abnormal visual experience during the sensitive period can lead to amblyopia, a developmental

62 Environmental insults during sensitive periods can affect hippocampal development and

63 Disturbances to social development in sensitive periods can cause enduring and distressing dam

64 Identifying these sensitive periods can inform when and how parenting is a

65 nist use between the 2-month embryologically sensitive period (case window) and the 2 months precedin

66 period slices reverts synaptic plasticity to sensitive period characteristics.

67 Although sensitive-period control paired odor-shock pups learned

68 prevented by transcription blockers, with a sensitive period corresponding to the period of activity

69 who were exposed to thalidomide early in the sensitive period (days 20 to 26+/-).

70 The results suggest that sensitive period deficits in fear conditioning may be re

71 for social interaction, and we propose that sensitive-period disruption of such internal brain commu

72 ion, but conclude that better delineation of sensitive periods, dose-response relationships, and long

73 his suggests maternal care quality may alter sensitive-period duration.

74 The effects on NH4Cl preference reflect a sensitive period during development because adult rats r

75 Thus, P2-21 is a sensitive period during which 5-HT modulates adult anxie

76 eveal that postnatal days 10-21 constitute a sensitive period during which alterations in NE signalin

77 Adolescence is a very sensitive period during which cognitive competences are

78 underscore the importance of childhood as a sensitive period during which cumulative stress exposure

79 ty/depression-like behavior, and P22-41 is a sensitive period during which DA and 5-HT bi-directional

80 d that begins in utero and overlaps with the sensitive period during which maternal immune activation

81 They also reveal an early-life sensitive period during which trkB-ERK42/44 tone determi

82 e hypothesized that their involvement shapes sensitive periods during development.

83 However, there is limited evidence on sensitive periods during the first 18 years of life.

84 However, the sensitive periods during which gut bacteria are establis

85 The auditory cortex has sensitive periods during which it is maximally receptive

86 ed.Our results indicated distinct adolescent-sensitive periods during which stress can sex-dependentl

87 Development passes through sensitive periods, during which plasticity allows for ge

88 These findings may indicate a sensitive period early in life for acquiring rhythm in p

89 itating conspecific songs of adults during a sensitive period early in life.

90 gnals that are learned by imitation during a sensitive period early in life.

91 esting-state connectivity, consistent with a sensitive period ending with adolescence for the amygdal

92 In the rat the sensitive period ends sometime after postnatal day 50 (P

93 Whether comparable sensitive periods exist for non-sensory cortices, such a

94 capacity indicate that JH titers during the sensitive period (first day post-emergence) regulates th

95 second decade of life, possibly reflecting a sensitive period for adapting to one's social environmen

96 s during the gastrula stage, which is the RA-sensitive period for anterior/posterior (A/P) patterning

97 ge at implant beyond 2.5 years, suggesting a sensitive period for bimodal integration in speech perce

98 risk in the postpartum period, a potentially sensitive period for caries development.

99 The most stress-sensitive period for cngc16 pollen was during germinatio

100 on Pet-1, thus revealing an early postnatal sensitive period for control of 5-HT excitability genes.

101 from caregivers cues the termination of the sensitive period for environmental input into emotion ne

102 deprivation is delayed until P30, after the sensitive period for experience-dependent changes in bul

103 major stress in early childhood, implying a sensitive period for exposure, and were evident in both

104 Adolescence is a sensitive period for frontal cortical development and co

105 roke recovery studies identify an optimal or sensitive period for intensive motor training after stro

106 ry brainstem during development and during a sensitive period for ipsilateral sprouting, so we hypoth

107 Rs), we studied the relationship between the sensitive period for monocular deprivation and the expre

108 t of glutamate receptors correlates with the sensitive period for monocular deprivation in the visual

109 hese results provide empirical evidence of a sensitive period for motor recovery in humans.

110 served only in early childhood, suggesting a sensitive period for nature exposure.

111 hese findings identify an activity-dependent sensitive period for prefrontal circuit maturation and h

112 Thus, our findings identify adolescence as a sensitive period for prefrontal microglia to act on cogn

113 early postnatal development may represent a sensitive period for race perception.

114 Neonates have a sensitive period for rapid, robust odor learning charact

115 The sensitive period for risk exposure and extent that risk

116 ic arbor of spiny neurons expands during the sensitive period for song learning, and this initial gro

117 e transformed into motor gestures during the sensitive period for song learning.

118 isition of a normal vocal pattern during the sensitive period for song learning.

119 nd undergo large-scale retraction during the sensitive period for song learning.

120 sing them to loud white noise throughout the sensitive period for song learning.

121 n death in young birds that are entering the sensitive period for song learning.

122 hese results may reflect that childhood is a sensitive period for telomere attrition.

123 In addition, we emphasise adolescence as a sensitive period for the confluence of alcohol harmful e

124 Adolescence is a sensitive period for the development of habitual eating

125 Here we show that adolescence is a sensitive period for the emergence of prefrontal cogniti

126 at the periadolescent transition is indeed a sensitive period for the functional maturation of prefro

127 y adolescence and suggest an early childhood sensitive period for these effects.

128 cuitry is highly indicative of an adolescent sensitive period for threat response regulation.

129 We conclude that there is a sensitive period for visual specialization in MT/MST.

130 these circuits are adult-like throughout the sensitive period for vocal learning and remain stable de

131 n DLM axon arbors occur at the height of the sensitive period for vocal learning, and hence may repre

132 ely important for song production during the sensitive period for vocal learning, and the overall siz

133 Adolescence is a sensitive period for weight gain and risky health behavi

134 hese findings provide important clues to how sensitive periods for auditory feedback and vocal plasti

135 Moreover, sensitive periods for changes in individual pathways are

136 Although sensitive periods for depression likely arise through a

137 to examine the neural mechanisms regulating sensitive periods for learning.

138 te that the timing and even the existence of sensitive periods for plasticity of a neural circuit and

139 downregulates sharply prior to the onset of sensitive periods for plasticity, yet the functional imp

140 nce and that spine turnover increases during sensitive periods for sensory map formation.

141 OTC shows resilience, highlighting different sensitive periods for specific brain regions and computa

142 Previous studies have identified sensitive periods for the developing barn owl during whi

143 In this review, we describe sensitive periods for the development of EFs and the eff

144 evelopmental trajectories, whether there are sensitive periods for these effects, as well as whether

145 ng the combined effect of common variants in sensitive period genes and time-varying exposure to two

146 ased gene expression in the post-temperature sensitive period gonads.

147 by adverse environmental conditions during a sensitive period in adulthood (the first day post-emerge

148 mr1KO BLA exhibit hyperexcitability during a sensitive period in amygdala development.

149 rly institutionalization, suggest a possible sensitive period in cognitive development, and underscor

150 s identified the early postnatal period as a sensitive period in cortical development, research to da

151 These results suggest a sensitive period in development in which the hippocampus

152 Training during a sensitive period in development may have greater effects

153 lacks Met transcript during the insecticide-sensitive period in development.

154 tively, providing experimental evidence of a sensitive period in humans during which the environment

155 to the harshness of the environment during a sensitive period in infancy.

156 ning task is consistent with the notion of a sensitive period in language learning: Children show bet

157 To test for a sensitive period in MT/MST development, we used fMRI to

158 al studies indicate that fetal life may be a sensitive period in relation to bone growth and minerali

159 asticity that has been documented during the sensitive period in young children and animals leaves th

160 c variation and environmental insults during sensitive periods in brain development have long-term co

161 study of optimal environmental input during sensitive periods in brain development.

162 wo factors having the greatest impact during sensitive periods in development.

163 re access to bilateral auditory input during sensitive periods in human development.

164 n shown to alter neural plasticity and shift sensitive periods in perceptual development.

165 pend on experiential factors during specific sensitive periods in the animal's development.

166 mPFC-BLA transmission and point to potential sensitive periods in the development of this critical ne

167 Cognitive priors and sensitive periods in their expression may also provide c

168 lopment through focused interventions during sensitive periods in their maturation.

169 During sensitive periods in utero, gonadal steroids help organi

170 eminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting

171 Early life is a sensitive period, in which enhanced neural plasticity al

172 this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress i

173 ith early physical neglect during one common sensitive period involving all segments except the splen

174 The sensitive period is a special time for auditory learning

175 d capacity for behavioural learning during a sensitive period is associated with enhanced spine dynam

176 This sensitive period is coincident with low endogenous corti

177 y relayed by the thalamus during a postnatal sensitive period is essential for proper cortical matura

178 At the beginning of the sensitive period, just after zebra finches have fledged

179 Findings suggest a sensitive period leading to lasting alterations in somat

180 ral circuits are remodeled during restricted sensitive periods, leading to the emergence of precise p

181 ized that low corticosterone levels modulate sensitive-period learning.

182 complexity of depression etiology through a sensitive period lens.

183 Visual deprivation during a developmental sensitive period markedly alters visual cortical respons

184 rom Walasek and colleagues demonstrates that sensitive periods may emerge later in development when t

185 was associated with a downregulation of the sensitive-period mediator gene DIO2 (iodothyronine deiod

186 Our results are consistent with a sensitive-period model when examining CVD and T2D gene e

187 ment, which impacts adult behavior, but 5-HT-sensitive periods, neural substrates, and behavioral con

188 Infant rats exhibit sensitive-period odor learning characterized by olfactor

189 ation modulates olfactory bulb correlates of sensitive-period odor learning in a manner consistent wi

190 how that (a) exogenous CORT prematurely ends sensitive-period odor-shock-induced preferences; (b) adr

191 psychological changes that occur during this sensitive period of a woman's life.

192 cocaine exposure during the developmentally sensitive period of adolescence.

193 dicate that administration of SSRIs during a sensitive period of brain development results in long-la

194 decreased amygdala Mecp2 expression during a sensitive period of brain sexual differentiation disrupt

195 ic variation in parental presence during the sensitive period of childhood affects the recruitment of

196 Exposure to adversity in utero at a sensitive period of development can bring about physiolo

197 tata) learn a specific song pattern during a sensitive period of development, after which song change

198 t environmental fluctuations during the most sensitive period of development, allowing coherent adapt

199 harmacological receptor antagonists during a sensitive period of development.

200 ut only when this activation occurs during a sensitive period of development.

201 transiently inactivating VH in rats during a sensitive period of development.

202 erall, these data support the existence of a sensitive period of early gestation when epigenetic prog

203 whereby a stimulus or insult at a critical, sensitive period of early life has permanent effects on

204 erience of a particular temperature during a sensitive period of embryogenesis sculpts not only the p

205 The developing fetus represents a highly sensitive period of exposure to endocrine disrupting com

206 pse stability and suggest the existence of a sensitive period of heightened hippocampal plasticity in

207 immune activation or dysregulation during a sensitive period of hippocampal development can precipit

208 the emergence of learning deficits during a sensitive period of hippocampal development.

209 perimenopausal brain are characterized by a sensitive period of hormone responsiveness, and in both

210 ve, IGF-II needs to be administered within a sensitive period of memory consolidation.

211 de by which impaired sensory gating during a sensitive period of neonatal neurodevelopment promotes a

212 Exploiting this sensitive period of neural development, we modified exis

213 impairment is attributable to a short-lived sensitive period of postischemic plasticity defined by u

214 The temperature-sensitive period of rpm-1 coincides with the time of syn

215 tural changes in the song circuit during the sensitive period of song development and provide evidenc

216 rces the view that pregnancy may be the most sensitive period of the life cycle in which nutritional

217 The temperature-sensitive period of the mutant is during early embryogen

218 with the deprivation experienced during the sensitive period of visual development.

219 rams critical for synaptic refinement during sensitive periods of brain development.

220 Refinement of topographic maps during sensitive periods of development is a characteristic fea

221 Maternal overnutrition during sensitive periods of early development increases the ris

222 f BLA neurons, and many more have identified sensitive periods of emotional maturation.

223 ncerns in childhood, but less is known about sensitive periods of exposure or persistence into later

224 There was some suggestion of sensitive periods of exposure to care, whereby individua

225 was either disabled or an infant, suggesting sensitive periods of exposure.

226 f pathogen ecology can be leveraged to align sensitive periods of gestation with the low-transmission

227 c maturational stages, neural circuits enter sensitive periods of heightened plasticity, during which

228 Depression during sensitive periods of social development may have consequ

229 We note cohesive evidence for sensitive periods of susceptibility to stress exposure a

230 The gene set regulating sensitive period opening associated with increased depre

231 This thalamic sensitive period overlaps temporally with experience-dep

232 ogeniculate connectivity during the thalamic sensitive period (P20-30).

233 Odor was paired with 0.5 mA shock in either sensitive-period (P8) or postsensitive-period (P12) pups

234 on lifecourse models (accumulation, critical/sensitive periods, pathways).

235 An understanding of sensitive period phenomena and mechanisms separate from

236 he initiation, closure, and reinstatement of sensitive period plasticity has emerged from extensive r

237 eriod pups, but no significant plasticity in sensitive period pups incapable of learning odor aversio

238 ficant long-term synaptic plasticity in post-sensitive period pups, but no significant plasticity in

239 has taught us valuable information regarding sensitive periods, rearrangement of synaptic connections

240 We draw upon the model of sensitive period regulation within the visual system, an

241 ent by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in t

242 lifecourse epidemiology with early life as a sensitive period, SEP across the lifecourse and social m

243 of central nervous system development, such sensitive periods shape the formation of neurocircuits t

244 oline's effect on EI suggests that potential sensitive periods should be considered in future work.

245 learning in the zebra finch occurs during a sensitive period similar to that for human speech.

246 GABA(A) receptor blockade in post-sensitive period slices reverts synaptic plasticity to s

247 y brain-derived neurotrophic factor during a sensitive period soon after these neurons reach destinat

248 During a perinatal sensitive period, steroid hormones, in particular estrad

249 rather than olfactory bulb changes underlie sensitive period termination.

250 sults suggest corticosterone is important in sensitive-period termination and developmental emergence

251 Because sensitive-period termination coincides with a declining

252 d, we explored the role of corticosterone in sensitive-period termination.

253 steroid hormone exposure during a perinatal sensitive period that alters subsequent hormonal and non

254 utations broadly disrupted a developmentally sensitive period that corresponded to the period of heig

255 Our study defines a birth and serotonin-sensitive period that enables concerted adaptations of T

256 sensory system development, (2) a serotonin-sensitive period that impacts cognition, anxiety- and de

257 Specifically, we review (1) a serotonin-sensitive period that impacts sensory system development

258 Such knowledge of sensitive periods that determine the developmental traje

259 Neuroplasticity during sensitive periods, the molecular and cellular process of

260 We further narrowed this sensitive period to around the timing of neurogenesis by

261 ) must be exposed to an adult tutor during a sensitive period to develop normal adult song.

262 y in a'/B' Kenyon cells during a young adult sensitive period to downregulate spontaneous activity an

263 l mechanism by which estradiol acts during a sensitive period to establish a profound and lasting sex

264 on temperature during a critical temperature sensitive period (TSP) determines sexual fate of the ind

265 uggest that therapeutic interventions during sensitive periods, typically before the onset of clear n

266 ty, and find ways to augment and prolong the sensitive period using pharmacological agents or noninva

267 0 genes) shown in animal studies to regulate sensitive periods using summary data from a genome-wide

268 pendular nystagmus during each decile of the sensitive period was associated with an additional 0.022

269 Among females, the mid- to late adulthood sensitive period was the best-fitting life-course model,

270 Potential sensitive periods were explored by estimating population

271 Very early childhood appears to be a sensitive period when exposure to adversity predicts dif

272 Adolescence in human males is a hormonally sensitive period when many adult behaviors develop, incl

273 and that middle childhood may be a potential sensitive period when socioeconomic instability is espec

274 Our study reveals an adolescent sensitive period when top-down neurons integrate local c

275 ebra finches and other songbirds, there is a sensitive period when young birds memorize a song that w

276 ach, we tested the hypothesis that there are sensitive periods when adversity induces greater DNAm ch

277 y time during childhood or whether there are sensitive periods when exposure to particular types of m

278 re exposed to adversity, particularly during sensitive periods when these adversities may have even m

279 d the existence of developmental windows (or sensitive periods) when experience can have lasting effe

280 ene expression patterns during the perinatal sensitive period, when organizational gonadal hormones e

281 Data support a possible sensitive period where functional connections between co

282 ical findings may reflect the existence of a sensitive period where the functional connections betwee

283 action of ORC axons and glial cells within a sensitive period, whereas targeting of ORC axons appears

284 dings provide evidence for a developmentally sensitive period whereby subcortical structures in young

285 t into gene function and identifies critical sensitive periods whereby genetic factors may influence

286 hat corticolimbic regions have two different sensitive period windows of enhanced plasticity when mal

287 Childhood is a sensitive period with rapid brain development and physio

288 early-life experiences, particularly during sensitive periods, with impact on cognitive and emotiona