ライフサイエンスコーパス: sensitize @2 to

1 IgE reactivity of HDM-allergic and non-HDM-sensitized individuals to 15 HDM allergens was establish

2 Re-exposure of sensitized mice to 2,4-dinitrofluorobenzene (DNFB) elici

3 Ulp2 loss sensitizes cells to 6-azauracil, a hallmark of transcrip

4 g the small molecule inhibitor, CX-4945, can sensitize MB cells to a well-known and tolerated chemoth

5 FliP expression sensitizes cells to a number of chemical agents, and mut

6 ion of the T-cell co-stimulatory ligand CD80 sensitizes murine tumors to a FAK inhibitor and show tha

7 l-mesenchymal transition (EMT) phenotype and sensitizes PDAC cells to a clinical inhibitor of HSP90,

8 These data reveal a mechanism by which SS sensitizes the endothelium to a cytokine-induced ER stre

9 tion of HIV-1 Env State 2A has been shown to sensitize infected cells to ADCC.

10 uble Env and virions from the viral inoculum sensitizing uninfected cells to ADCC prior to de novo En

11 CD73 expression on infiltrating T cells and sensitizes resistant tumors to agonistic anti-4-1BB ther

12 ithromycin activity by a factor of 2,133 and sensitized P. aeruginosa to all tested antibiotics.

13 eta1-Ser108 on the regulatory beta1-subunit, sensitizing AMPK to allosteric drugs, and activates sign

14 o necessary and sufficient for club cells to sensitize mice to Alp1.

15 This metabolism-epigenome link sensitizes chromatin methylation to altered SAM abundanc

16 ta suggest that constitutive ESX-5 secretion sensitizes M. tuberculosis to an immune response that st

17 (TRAIL) and its receptor, death receptor 4, sensitizing cells to an autocrine loop of TRAIL-mediated

18 OCCC, we find that shRNA silencing of SPINK1 sensitizes tumor cells to anoikis and inhibits prolifera

19 blocked metastasis and increased survival by sensitizing cancer cells to anoikis, thereby reducing th

20 d with the IL-6Ralpha inhibitor tocilizumab, sensitizing cells to anoikis in vitro and reducing metas

21 In contrast, genetic targeting of MDK sensitized melanoma cells to anti-PD-1/anti-PD-L1 treatm

22 Additionally, treatment with DON sensitized pancreatic tumors to anti-PD1 therapy, result

23 n of CIITA increased T cell infiltration and sensitized tumors to anti-PD-1 therapy.

24 filtration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.

25 anoma development and Siah2 loss in the host sensitizes melanoma to anti-PD-1 therapy.

26 oma cells to interferon gamma (IFNgamma) and sensitizes melanoma to anti-PD-1 treatment in mice, depe

27 ) could lower the amount of EPI necessary to sensitize bacteria to antibiotics that are efflux substr

28 and that this phenomenon can be exploited to sensitize bacteria to antibiotics.

29 Perturbations to OM lipid asymmetry sensitize the cell to antibiotics.

30 Might COVID-19 vaccines sensitize humans to antibody-dependent enhanced (ADE) br

31 small molecules that expose Env to nnAbs and sensitize infected cells to antibody-dependent cellular

32 NC5 potently restricts HIV-1 infectivity and sensitizes the virus to antibody-mediated neutralization

33 This, in turn, sensitized cells to apoptosis in response to TNF alpha a

34 Silencing Klf10 also sensitized primary hepatocytes to apoptosis along with i

35 3 degradation in a dose-dependent manner and sensitized these cells to apoptosis.

36 of these genes increases CHOP expression and sensitizes cells to apoptosis induced by multiple ER str

37 We show that IL-21 sensitizes Treg cells to apoptosis by interfering with t

38 Elevated MYC expression sensitizes tumor cells to apoptosis but the therapeutic

39 to-FAP-induced mitochondrial dysfunction and sensitized cells to apoptotic cell death.

40 ons suggest a precision medicine approach to sensitize HER2- cancers to approved anticancer medicines

41 Clinically, DDX3 may be targetable for sensitizing ARL/- CRPC to AR-directed therapies.

42 Targeting MPO expression or enzyme activity sensitized AML cells to AraC treatment by triggering oxi

43 demonstrated that miR-1291 was effective to sensitize PC cells to arginine deprivation treatment and

44 However, IL-27 sensitizes NK cells to augment both in vitro and in vivo

45 lly, we demonstrate that high RepoMan levels sensitize cancer cells to Aurora-B inhibitors.

46 Conversely, ERF115 sensitizes cells to auxin by activating ARF5/MONOPTEROS,

47 n of DNA-PK or PTEN, or inhibition of DNA-PK sensitized recovering BLBCs to AZD1775 by abrogating rep

48 eric enamide and imine functionalities under sensitized irradiation leads to azetidine products in go

49 inhibitor of host glutamine metabolism that sensitizes amastigotes to azoles.

50 nclusion, we demonstrate targeting CDK5 will sensitize pancreatic cancers to Bcl-2 protein inhibitors

51 mors and specific knockdown of Mcl-1 broadly sensitizes glioblastoma cells to Bcl-xL inhibition-media

52 genetic or pharmacological targeting of CDK5 sensitizes pancreatic cancers to Bcl-2 inhibitors, such

53 he resulting reduction of BET protein levels sensitized cancer cells to BET inhibitors.

54 disrupting the functionality of ENL further sensitized leukaemia cells to BET inhibitors.

55 models and, conversely, knockdown of SMARCA4 sensitized resistant cells to BETi.

56 apoptotic BH3 family members MCL1 and BCL-XL sensitizing PTCL cells to BH3 mimetic drugs.

57 al in vitro studies supported that endotoxin sensitizes hepatocytes to bile-acid-induced cell death.

58 ential of cholangiocytes that differentially sensitized them to biliatresone.

59 on of Raf1-tr, and reintroduction of Raf1-tr sensitized the cells to bleomycin-induced apoptosis.

60 Pan-HSPA inhibition sensitized NSCLC cells to bortezomib, but not to platinu

61 r tissue damage, organisms typically display sensitized responses to both noxious or normally innocuo

62 sion robustly activated the MAPK pathway and sensitized cells to BRAF and MEK inhibitors.

63 ng p53 blocks the slow-cycling phenotype and sensitizes melanoma cells to BRAF/MEK inhibition.

64 Two sensitized [URE3] to Btn2, Cur1, and Hsp42, but in diffe

65 We show that chronic alcohol feeding sensitizes rat hepatocytes to Ca(2+) -mobilizing hormone

66 knockout impaired in vitro DNA resection and sensitized cells to camptothecin and olaparib treatment.

67 Additionally, elevated ISG15 levels sensitize cells to cancer chemotherapeutic treatments.

68 hat deletion of the m(6)A demethylase Alkbh5 sensitized tumors to cancer immunotherapy.

69 n of RUVBL1 or TIP60 in various cancer cells sensitized them to cell death induced by proteasome inhi

70 t the division plane during constriction and sensitizes cells to cell-wall-specific antibiotics.

71 8(+) T cell-mediated antitumor immunity, and sensitizes resistant tumors to checkpoint blockade.

72 ribosylation-dependent DNA damage repair and sensitizes tumor cell to chemically synthesized PARP inh

73 Our data suggests, ROR1 inhibition sensitizes BC cells to chemo drugs.

74 ATR inhibition combined with oxaliplatin to sensitize cells to chemotherapy as a therapeutic option

75 inhibition of beta-catenin decreased ARC and sensitized AML cells to chemotherapy.

76 Inhibition of PIM sensitized NSCLC cells to chemotherapy and produced a sy

77 ed the viability and motility of TNBC cells, sensitized TNBC cells to chemotherapy, and restricted th

78 ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not

79 1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induce

80 actor and vascular cell adhesion molecule 1, sensitizes DTCs to chemotherapy.

81 onse of GBM cells, and tested whether ERbeta sensitizes GBM cells to chemotherapy.

82 ses ARE-bearing TNFalpha and DUSP1 mRNAs and sensitizes leukemic cells to chemotherapy.

83 ly attenuate cellular migration/invasion and sensitize ovarian cancer to cisplatin.

84 dentified several molecular players that can sensitize tumor cells to cisplatin-induced apoptosis (se

85 Targeting hsp90B sensitized cancer cells to cisplatin predominantly throu

86 NOX4 activity, imbalanced redox status, and sensitized cancer cells to cisplatin treatment in patien

87 ation and invasion of HOS and 143B cells and sensitized cells to cisplatin.

88 Inhibiting AP-1 or BMI1 sensitized tumors to cisplatin-based chemotherapy, and i

89 s of the short PolH transcript significantly sensitizes cancer cells to cisplatin treatment.

90 Inhibition of c-Myc-miR-137-EZH2 pathway re-sensitizes resistant cells to cisplatin.

91 tumors reduced Jab1/Csn5 expression, thereby sensitizing NPC cells to cisplatin-induced apoptosis bot

92 have been shown to reprogram tumor cells and sensitize them to clinically used chemotherapy.

93 Inhibition of MCL-1 or mTORC1 signaling sensitized cells to clinically relevant doses of sunitin

94 in different species, including humans, and sensitizes their response to cold temperature by inducin

95 -mediated depletion of thioredoxin reductase sensitized beta-cells to continuously generated H(2)O(2)

96 or progenitor cells from bone marrow and to sensitize cancer cells to conventional chemotherapy and

97 mosensitization strategies have been used to sensitize cancer cells to conventional drugs, but their

98 ns increased H3K9me3 and H3K36me3 levels and sensitized resistant cells to CP.

99 knockdown of p62 or inhibition of NF-kappaB sensitized tumor cells to CQ, resulting in increased apo

100 at DNAJA1 inhibition is a potent strategy to sensitize cancer cells to current and future therapeutic

101 hat NSAC1003 slows RecB relative to RecD and sensitizes it to cut DNA when the leading helicase RecD

102 yltriazolobenzimidazole, mimics Chi sites by sensitizing RecBCD to cut DNA at a Chi-independent posit

103 sufficient to induce adrenergic identity and sensitize cells to CYC065.

104 ace expression of TNF receptor-1 (TNFR1) and sensitized NSCLC cells to cytokine-induced apoptosis.

105 antibody (mAb) inhibits SOX4 expression and sensitizes TNBC cells to cytotoxic T cells.

106 INCR1 knockdown sensitizes tumor cells to cytotoxic T cell-mediated kill

107 se that defects in beta-spectrin and tau may sensitize neurons to damage.

108 cells and dendritic cells of house dust mite-sensitized mice to dampen IFN-beta expression and preven

109 The absence of JB12 sensitized Huh-7 to death caused by proteotoxic agents a

110 t inhibits both autophagy and senescence and sensitizes cells to death.

111 avage causes mitochondrial fragmentation and sensitizes cells to death.

112 ity control system in which hypomodification sensitizes tRNAs to decay mediated by the RNA degradosom

113 showing better clinical efficacy in patients sensitized only to Der p 1 and/or Der p 2 as compared wi

114 r membrane permeability enhancers profoundly sensitizes Escherichia coli to designed LpxH inhibitors.

115 oncogenic increases in cellular biosynthesis sensitize cells to disruption of protein homeostasis.

116 , reduces BRCA1 expression, disrupts HR, and sensitizes cells to DNA crosslinkers and poly(ADP-ribose

117 wn dramatically decreases BER efficiency and sensitizes cells to DNA damaging agents.

118 Loss of DEK induces genome instability and sensitizes cells to DNA double strand breaks (DSBs), sug

119 d primary GBM cells demonstrated that ERbeta sensitizes GBM cells to DNA damaging agents including te

120 The inhibition of C3a receptor sensitized PCa epithelia to docetaxel in a synergistic m

121 15 and its derivatives may have potential in sensitizing cancer cells to DR5 activation-based cancer

122 eplication, and when expressed alone, E4orf4 sensitized transformed cells to drug-induced toxicity.

123 DarG(Mtb) triggers a DNA-damage response and sensitizes Mtb to drugs targeting DNA metabolism and res

124 DSBs by impairing NHEJ repair, and thereby, sensitizing neurons to DSB stress.

125 DSBs, which inhibits BRCA1 recruitment, and sensitizes cells to DSBs from IR or stalled replication

126 ced short palindromic repeats (CRISPR)-Cas9, sensitized P9 pups to E. coli K1 bacteremia.

127 on on Abeta treatment in the presence of the sensitizing nAChRs, linked to early-stage Abeta-induced

128 Also, increased EGFR expression sensitized cells to EGFR inhibitors.

129 portantly, combinatorial LY2157299 treatment sensitized PC cells to enzalutamide, leading to synergis

130 yrosine kinase, as a therapeutic target that sensitizes TNBC cells to EPA.

131 Loss of ER stress-induced CMA activation sensitizes cells to ER stress-induced death.

132 1 depletion by shRNA or degradation by hemin sensitizes cells to ETC inhibitors such as metformin(5,6

133 r FA level, which perturbs ER morphology and sensitizes yeast to FA-induced lipotoxicity.

134 the counter electrode for a fiber-shaped dye-sensitized solar cell to fabricate a self-powered fiber-

135 of FSP1 may provide an effective strategy to sensitize cancer cells to ferroptosis-inducing chemother

136 sistant to ferroptosis and AMPK inactivation sensitizes these cells to ferroptosis.

137 ble of undergoing direct photoionization and sensitized photooxidation to form radical cation species

138 Its selective blockade sensitizes tumor cells to gemcitabine in vitro, and gene

139 ch-dependent transcription at other loci and sensitize tissues to gene dose based upon signal duratio

140 Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have show

141 Depletion of USP22 sensitized cells to genotoxic insult, and the role of US

142 Targeting MEK1/2 sensitizes AML blasts to genotoxic agents, indicating a

143 ibits cell division, while sosA inactivation sensitizes cells to genotoxic stress.

144 , we reported that the Drosophila aGPCR CIRL sensitizes sensory responses to gentle touch and sound b

145 from podocytes decreased H3K27me3 levels and sensitized mice to glomerular disease.

146 Consistently, miR-135 silencing sensitizes PDAC cells to glutamine deprivation and repre

147 ) and wild-type (WT) mice were sensitized or sensitized/challenged to HDM, and hallmark features of a

148 Indeed, application of 2 sensitized cells to Herceptin.

149 overexpression exacerbated glucotoxicity and sensitized cardiomyocytes to HG, whereas its deletion pr

150 secrete one or more peptide hormones, likely sensitizing these cells to high ER protein-folding stres

151 ncoding lysine-specific demethylase 1 (LSD1) sensitizes DIPG cells to histone deacetylase (HDAC) inhi

152 using clinical-grade blocking antibodies re-sensitizes tumors to hormone deprivation in vitro and in

153 JB5 in CCA cells that overexpressed MIR21 re-sensitized them to HSP90 inhibitors.

154 We devised a sensitized screen to identify natural metabolites capabl

155 roach to inhibit two of Nef's activities and sensitize the virus to immune clearance.

156 munomodulatory effects of niraparib that may sensitize tumors to immune checkpoint blockade therapies

157 ing response rates, strengthening efforts to sensitize tumors to immune-mediated attack.

158 In this study, we show that ARID2 knockout sensitizes melanoma to immune checkpoint inhibitors.

159 follistatin in combination with anti-PD1 re-sensitizes resistant tumors to immunotherapies.

160 nd highlight a novel therapeutic approach to sensitize EBV+ lymphomas to immunotherapy.

161 primary preclinical and clinical efforts to sensitize PDAC to immunotherapy.

162 Epha2 deletion reversed T cell exclusion and sensitized tumors to immunotherapy.

163 Ptgs2 deletion reversed T cell exclusion and sensitized tumors to immunotherapy; pharmacological inhi

164 The inhibition of PARP1 sensitizes LSCs to immunotherapy, highlighting its poten

165 ting enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcomes resist

166 st rapid rate of postnatal growth, which may sensitize ECs to impaired mitotic spindle function.

167 Epicutaneous treatment of sensitized animals led to induction of blocking IgG, and

168 llosteric but not catalytic AURKA inhibitors sensitize cancer cells to inhibition of the CDC7 kinase

169 f G (alphaq) both reduces TRPM8 activity and sensitizes the channel to inhibition by decreased levels

170 t affinity of TRPM8 for PI(4,5)P(2) and thus sensitizes the channel to inhibition induced by decreasi

171 no effect on insulin action in lean mice but sensitizes the liver to insulin during the challenge of

172 Knockdown of FTO sensitizes melanoma cells to interferon gamma (IFNgamma)

173 B cells were depleted in HDM-sensitized animals to investigate the importance of B ce

174 natorial PARPi and DNMTi therapy to robustly sensitize NSCLC cells to ionizing radiation in vitro and

175 iosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation.

176 Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation

177 on of lipid synthesis prevented dormancy and sensitized the organisms to isoniazid.

178 in cardiomyocytes increased cAMP levels and sensitized cardiomyocytes to isoprenaline-induced augmen

179 mitogen-activated protein kinase signaling, sensitized cells only to josamycin but not to other anti

180 Consequently, E4orf4 inhibits DNA repair and sensitizes transformed cells to killing by DNA-damaging

181 Knockdown of these target genes sensitized cells to known ferroptosis inducers, while PA

182 Childhood adversity may sensitize certain individuals to later stress which trig

183 after heparin exposure, but only a subset of sensitized patients progress to life-threatening complic

184 We found that CCL2 and CCL5 sensitized hepatocytes to lipopolysaccharide-induced liv

185 se of cationic dyes could induce interesting sensitizing properties to low-dimensional metal-halide c

186 moke increased ER stress in acinar cells and sensitized the pancreas to LPS-induced pathology.

187 ment of latency I EBV+ Burkitt lymphoma (BL) sensitized cells to lysis by EBV-specific cytotoxic T ce

188 NF (BAF) complex mutated in nearly all MRTs, sensitized cells to MDM2 and MDM2/4 inhibition by enhanc

189 m to membrane lipid diversity, which further sensitizes tumours to metabolic stress.

190 ermittent fasting before metformin treatment sensitized tumors to metformin and significantly reduced

191 gen peroxide distributes oxidative stress to sensitize the network to mitochondrial criticality.

192 co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential los

193 nail function restores 4E-BP1 expression and sensitizes cancer cells to mTOR kinase inhibitors by enh

194 tion of gamma1-AMPK, the lack of gamma2-AMPK sensitizes the heart to myocardial ischemia/reperfusion

195 However, Ripk1(K612R/K612R) mutation sensitizes cells to necroptosis and caspase-1 activation

196 bit virus infection directly but are able to sensitize viral particles to neutralization by otherwise

197 ctose in the medium) and glucose deprivation sensitizes these cells to nitric oxide-mediated inhibiti

198 tin ligase substrate adaptor DCAF15 strongly sensitized cancer cells to NK-mediated clearance.

199 Sensitized responses to non-nociceptive stimuli were una

200 Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives

201 tested a model that altered Pol II activity sensitizes cells to nucleotide depletion.

202 pressed in ovarian cancer and depleting BRD9 sensitizes cancer cells to olaparib and cisplatin.

203 a second allergen, ovalbumin (OVA), in mice sensitized dually to OVA and Fel d 1.

204 he rate-limiting enzyme in PGE(2) synthesis, sensitized OXR cells to oxaliplatin.

205 8-oxoG repair in cells, and UV-DDB depletion sensitizes cells to oxidative DNA damage.

206 In contrast, induction of cydDC sensitizes cells to oxidative stress and aminoglycosides

207 arge B-cell lymphoma cell growth and further sensitized cells to OxPhos inhibition.

208 , and inhibition of the Hif1alpha-PD-L1 axis sensitizes AML cells to p53 activation.

209 by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histo

210 establish BRCAness in cancer cells and thus sensitize cells to PARP inhibitor treatment.See related

211 Furthermore, depletion of USP52 sensitizes cells to PARP inhibition in a CtIP-dependent

212 FZD10 or inhibition of the Wnt/beta-catenin sensitizes resistant cells to PARPi.

213 momas, produce high amounts of IFN-gamma and sensitize tumors to PD-1/programmed cell death ligand 1

214 nto otherwise immunologically "cold" tumors, sensitizing tumors to PD-1 checkpoint blockade.

215 d by using intraperitoneal challenge of mice sensitized intragastrically to peanut extract.

216 ant of peanut, and children who were neither sensitized nor allergic to peanut.

217 tylated polyamines into the prostatic lumen, sensitizing them to perturbations of connected metabolic

218 Notably, depletion of MEK5/ERK5 sensitized SCLC cells to pharmacologic inhibition of the

219 418, a geranylgeranyl transferase inhibitor, sensitizes xenotransplanted tumours to photodynamic ther

220 We evaluate antibody binding from sensitized patients to pig cells and engineered single a

221 ed to deafness disrupt phospholipid binding, sensitize the channel to PIP(2) depletion from hair cell

222 nhibitors decreased proteasome activity, and sensitized myeloma cells to PIs.

223 mutations in well-defined functional domains sensitize cancers to PORCN inhibitors.

224 Our work adds to elegant studies in the sensitized laboratory strain to present a mechanistic un

225 and to identify genes whose loss-of-function sensitizes cancer cells to PRMT5 inhibition, we performe

226 asymmetric arginine methyltransferase, also sensitizes cells to PRMT5 inhibition.

227 strate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a su

228 fering RNA-mediated knockdown (k/d) of eIF4E-sensitized CRPC cells to RAD001+bicalutamide, whereas eI

229 approach to overcoming this limitation is to sensitize BCBMs to radiation by inhibiting their ability

230 Thirty-three of these lncRNA hits sensitize cells to radiation, and based on their express

231 cGRS-1 selectively decrease tumor growth and sensitize glioma cells to radiation therapy.

232 ction, also known as UTMD, has been shown to sensitize solid tumors to radiation in preclinical model

233 pression of LRRC31 suppresses DNA repair and sensitizes BCBMs to radiation.

234 Moreover, our PARG inhibitor sensitizes cells to radiation-induced DNA damage, suppre

235 Knockdown of MDA-9/Syntenin sensitizes GBM cells to radiation, reducing postradiatio

236 C(KLAKLAK)(2) has been attributed to the AMP sensitizing cells to reactive oxygen species (ROS), maki

237 ar translocation and H1.2 polyubiquitination sensitized cells to replication stress and limited cell

238 pression in CC-RCCVHL cells is sufficient to sensitize them to ROCK inhibition.

239 NP interactions to sensitize GBM to RT and TMZ were shown to involve these

240 est that pharmacological mTOR inhibition may sensitize GSCs to selective PI3Kalpha inhibition.

241 cted on DCs from draining lymph nodes of OVA-sensitized skin to selectively suppress their ability to

242 In contrast, TAX1BP1 depletion sensitizes cells to several forms of aggregate-induced p

243 We show that the HPV16 E6/E7 oncoproteins sensitize HNSCC cells to single-agent WEE1i treatment th

244 not only accelerated tumor growth, but also sensitized tumors to small molecule inhibitors of PHGDH.

245 the use of methotrexate, an antifolate drug, sensitizes cancer cells to sorafenib, a targeted therapy

246 These molecular substrates sensitize cardiomyocytes to spontaneous Ca(2+)-releases

247 s, BMP7v exerts an antiangiogenic effect and sensitizes tumor cells to standard chemotherapy regardle

248 ry mediators to their dural receptive field, sensitize their responses to stimulation of the posterio

249 r, two TRAPP-interactive signaling proteins, sensitizing cells to stress-induced apoptosis.

250 Thus, hua-pep mutants provide an unique sensitized background to study ovule morphogenesis when

251 disease and be adapted to reduce the risk of sensitizing individuals to subsequent exposure to DENV,

252 cines inducing cross-reactive antibodies and sensitizing people to subsequent DENV infection.

253 ion of tumor-infiltrating CD8(+) T cells and sensitizing tumors to subsequent anti-PD-1.

254 -induced deficiencies in DSB repair pathways sensitized MPN cells to synthetic lethality triggered by

255 FTO inhibition sensitizes leukemia cells to T cell cytotoxicity and ove

256 gamma stimulation, suggesting that IFN-gamma sensitizes these leukemias to T cell killing by mechanis

257 rvention to block melanoma tumour growth and sensitize tumours to targeted therapy via epigenetic rep

258 tion or TBM mutated TRF1 expression markedly sensitizes cells to telomere oxidative damage as well as

259 proliferation and survival of GBM cells and sensitized them to temozolomide (TMZ)-induced apoptosis

260 dipocytes) promoted metastatic initiation by sensitizing melanoma cells to TGF-beta.

261 s of CXADR led to hyperactivation of AKT and sensitized cells to TGFbeta1-induced EMT.

262 l changes (i.e. the glucagon/insulin ratio), sensitize AMPK activation to the energetic stress induce

263 ivity is the mechanism for R122H mutation to sensitize mice to the development of pancreatitis.

264 t only induce cell killing but also potently sensitize PEL to the proapoptotic agents tumor necrosis

265 er cell lines, we show that low ATIP3 levels sensitize tumors to the effects of taxanes but not DNA-d

266 absence of IL10R specifically on macrophages sensitized infant mice to the development of colitis.

267 However, depleting Mdm4 sensitized p53-/- cells to the nucleoside analog gemcita

268 t expression in EC with CEC phenotype, which sensitized these cells to the promigratory effects of LS

269 zinc finger E-box binding homeobox 1 (ZEB1) sensitized tumor cells to the antiproliferative activity

270 ata demonstrate that oncogenic KRAS activity sensitizes cells to the effects of mortalin depletion, s

271 ];[Gln1476-Gln1478del] overexpression, which sensitizes cells to the endoplasmic reticulum (ER) stres

272 in vitro, and loss or overexpression of ycaQ sensitizes E. coli to the nitrogen mustard mechlorethami

273 ng that promotes perinatal HPC expansion and sensitizes progenitors to the leukemogenic FLT3(ITD) mut

274 hic and causes heme deficiency, which likely sensitizes the cells to the HU-induced oxidative stress.

275 s used to determine whether the HCS mutation sensitizes the skeleton to the osteolytic effects of tum

276 thway had the opposite effect on Salmonella, sensitizing cells to the infection.

277 lucose oxidase for starving cancer cells and sensitizing them to thermal ablation.

278 atients with severe Ana o 3 anaphylaxis were sensitized only to this component and had no concomitant

279 timulation of nociceptors during development sensitizes nociceptor presynapses to this feedback inhib

280 n impaired survival of drug-resistant cells, sensitized them to TKIs in vitro, and markedly eliminate

281 ntenance and that treatment with CX-4945 can sensitize MB cells to TMZ treatment.

282 n also be investigated in future studies for sensitizing glioblastoma cells to TMZ and other drugs av

283 pathway and that inhibition of this pathway sensitizes cells to TNBC-relevant chemotherapy, uncoveri

284 nists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-alpha-induced killing while sim

285 tic lethality and showed that ATR inhibition sensitizes tumors to TOP1 inhibitors.

286 for the treatment of RCC, has been shown to sensitize cancer cells to TRAIL-induced apoptosis, in pa

287 D1 promoter via NFkappaB and AP-1 sites and sensitized cells to TRAIL-induced apoptosis.

288 IR knockdown in TRAIL-resistant PANC-1 cells sensitized them to TRAIL-induced apoptosis.

289 YAP1 depletion sensitized neuroblastoma cells to trametinib, while over

290 is a novel regulatory factor; its depletion sensitized cells to treatment with ICL-inducing agents a

291 TNT disruption sensitizes PCa to treatment-induced cell death.

292 Moreover, we demonstrated that RCN2 knockout sensitized HCC cells to tyrosine kinase inhibitors, incl

293 gnaling, conferred IL-3 hypersensitivity and sensitized the cells to various MEK inhibitors.

294 low concentrations of CDC7 inhibitor TAK-931 sensitized resistant cells to Vemurafenib and reduced th

295 by affect expression of Bcl-XL and Mcl-1 and sensitize CLL cells to venetoclax.

296 roduction of SDHC R72C mutant, independently sensitize resistant MM to venetoclax.

297 nment and the activating mutations appear to sensitize the tumors to Wnt-Rspo synergy.

298 of Axin and identifies USP7 as a target for sensitizing cells to Wnt/beta-catenin signaling.

299 pGs inserted into some regions of the genome sensitize the virus to ZAP antiviral activity more effic

300 reasing ceramide levels by multiple pathways sensitizes cells to ZIKV infection.