ライフサイエンスコーパス: sensory hair cell

1 number of cell types of the inner ear (e.g., sensory hair cells).

2 high-fidelity information transfer from the sensory hair cell.

3 uma disrupts cochlear blood flow and damages sensory hair cells.

4 rgan of birds lead to robust regeneration of sensory hair cells.

5 the ribbon synapse, in developing zebrafish sensory hair cells.

6 tion to the organ of Corti, as well as fewer sensory hair cells.

7 rchitecture in the developing stereocilia of sensory hair cells.

8 tube closure and misorientation of inner ear sensory hair cells.

9 ts that include the degeneration and loss of sensory hair cells.

10 s; no connexin expression occurs in auditory sensory hair cells.

11 spase-dependent apoptotic death in inner ear sensory hair cells.

12 Our sense of hearing requires functional sensory hair cells.

13 suggesting that some may be newly generated sensory hair cells.

14 he unique actin-rich structures of inner ear sensory hair cells.

15 anch refinement before forming synapses with sensory hair cells.

16 part from electrical tuning intrinsic to the sensory hair cells.

17 cuticular plate and stereocilia of cochlear sensory hair cells.

18 l production of endolymph, the fluid bathing sensory hair cells.

19 a travelling wave, stimulating the cochlea's sensory hair cells.

20 he unique actin-rich structures of inner ear sensory hair cells.

21 to the ear's receptors, the mechanoreceptive sensory hair cells.

22 nonquantal (NQ) synaptic inputs from Type I sensory hair cells.

23 ycle and upregulates genes characteristic of sensory hair cells.

24 causes of ARHL, one common factor is loss of sensory hair cells.

25 ctor, Anc80L65, shown to transduce 80-90% of sensory hair cells.

26 ction channels at the tip of hair bundles in sensory hair cells.

27 ogical properties similar to those of native sensory hair cells.

28 also contributes to pathological changes in sensory hair cells.

29 ving from ion-channel resonance within their sensory hair cells.

30 toh1, plays a key role in the development of sensory hair cells.

31 otransduction in the hair bundle of auditory sensory hair cells.

32 cal transduction of sound is accomplished by sensory hair cells.

33 that project from the apical surface of the sensory hair cells.

34 nels and mediate the electrical responses of sensory hair cells.

35 that project from the apical surface of the sensory hair cells.

36 s onto immotile kinocilia that protrude from sensory "hair" cells.

37 asal cochlea without a corresponding loss of sensory hair cells, 5) significantly delayed auditory br

38 How and when sensory hair cells acquire the remarkable ability to det

39 nce suggests that synaptic rearrangements on sensory hair cells also contribute to auditory functiona

40 ans consist of similar cell types, including sensory hair cells and associated supporting cells.

41 rgan of the inner ear, contains two types of sensory hair cells and at least seven types of supportin

42 -based cilia that extend from the surface of sensory hair cells and attach to biomineralized 'ear sto

43 (ABR) and reduced number of synapses between sensory hair cells and auditory neurons.

44 he development, maintenance, and function of sensory hair cells and auditory neurons.

45 erventions for the prevention of the loss of sensory hair cells and cochlear synaptopathy.

46 critical for the polarized morphogenesis of sensory hair cells and for hearing.

47 elial components of the inner ear, including sensory hair cells and innervating afferent neurons, ari

48 enzymatic dissociation of styryl dye-labeled sensory hair cells and non-sensory cells is a valid meth

49 try was used to generate pure populations of sensory hair cells and non-sensory cells.

50 lian cochlea contains an invariant mosaic of sensory hair cells and non-sensory supporting cells remi

51 ory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arran

52 aused by the irreversible damage of cochlear sensory hair cells and nonsensory supporting cells.

53 n cochlea is composed of a regular mosaic of sensory hair cells and nonsensory supporting cells.

54 The morphology of sensory hair cells and otoacoustic emissions that depend

55 n central auditory pathways and in inner ear sensory hair cells and skeletal and smooth muscle cells.

56 Gipc3 localizes to inner ear sensory hair cells and spiral ganglion.

57 d a dissociated cell culture system in which sensory hair cells and supporting cells can be generated

58 The sensory hair cells and supporting cells of the organ of

59 hes, so as to generate a balanced mixture of sensory hair cells and supporting cells.

60 tonotopic map during the differentiation of sensory hair cells and the auditory pathway.

61 located in homologous positions between the sensory hair cells and the cation secretory epithelial c

62 2a was found to localize to the kinocilia of sensory hair cells and the primary cilia of nonsensory s

63 Sensory hair cells and their associated non-sensory supp

64 dwide, produced primarily by the loss of the sensory hair cells and their associated spiral ganglion

65 ntary roles in the coordinated maturation of sensory hair cells and their innervation.

66 ast to the mammalian cochlea, can regenerate sensory hair cells and thereby recover from deafness wit

67 ube closure and the orientation of inner ear sensory hair cells, and is mediated by a conserved nonca

68 s proneuromast cells the potential to become sensory hair cells, and lateral inhibition mediated by D

69 TRPML3 is expressed by inner ear sensory hair cells, and we were intrigued by the fact th

70 timeline of aminoglycoside-induced inner ear sensory hair cell apoptotic death that includes an 18-ho

71 tereociliary bundle orientation in inner ear sensory hair cells - appear to be mechanistically relate

72 Mechano-sensory hair cells are arranged in precise rows, with on

73 brations of the stereociliary bundles on the sensory hair cells are converted into electrical signals

74 Sensory hair cells are coordinately oriented within each

75 Sensory hair cells are exquisitely sensitive vertebrate

76 Sensory hair cells are mechanoreceptors of the auditory

77 Sensory hair cells are mechanoreceptors required for hea

78 y epithelia, stereociliary hair bundles atop sensory hair cells are mechanosensory apparatus with pla

79 At the inner ear, sensory hair cells are refined to enhance sensitivity, d

80 Sensory hair cells are the essential mechanotransducers

81 Mechanosensitive sensory hair cells are the linchpin of our senses of hea

82 underlying the maintenance of these delicate sensory hair cells are unknown.

83 Neurons with high metabolic demands, such as sensory hair cells, are especially dependent on precisel

84 The receptor potential of sensory hair cells arises from the gating of mechanosens

85 he cochlea, adorned with precisely patterned sensory hair cell arrays and uniformly oriented hair bun

86 DH15) is required for mechanotransduction in sensory hair cells as a component of the tip link.

87 etween cochlear primary afferent neurons and sensory hair cells as a particularly vulnerable componen

88 trate that dopamine receptors are present in sensory hair cells at synaptic sites that are required f

89 l for p-AMPKalpha significantly increased in sensory hair cells at that time.

90 ing, restores harmonin protein expression in sensory hair cell bundles, prevents hair cell loss, impr

91 the mammalian cochlea relies not only on the sensory hair cells, but also on the surrounding non-sens

92 the mammalian cochlea relies not only on the sensory hair cells, but also on the surrounding nonsenso

93 Loss of sensory hair cells causes permanent hearing and balance

94 ithelia, and a unique orientation pattern of sensory hair cell ciliary bundles on the saccular sensor

95 be present in only a few tens of copies per sensory hair cell, compounding the difficulty.

96 Sensory hair cells convert mechanical motion into chemic

97 Inner ear sensory hair cells convert mechanical stimuli into elect

98 air change in the seed region of miR-96, the sensory hair cells crucial for hearing fail to develop f

99 auses of sensorineural hearing loss, induces sensory hair cell damage in the cochlea.

100 ian vertebrates remains quiescent even after sensory hair cell damage.

101 s signaling pathway is sufficient to prevent sensory hair cell death and hearing loss.

102 Here, we investigate pathomechanisms of sensory hair cell death and suggest a novel target for p

103 sitive to cisplatin-induced hearing loss and sensory hair cell death in the organ of Corti, the mamma

104 macrophages coupled with live imaging after sensory hair cell death in zebrafish, we find that the s

105 molecular mechanisms involved in regulating sensory hair cell death is critical towards developing e

106 and progressive hearing loss accompanied by sensory hair cell death.

107 causes permanent hearing loss as a result of sensory hair cell death.

108 Auditory sensory hair cells depend on stereocilia with precisely

109 Sound detection in auditory sensory hair cells depends on the deflection of the ster

110 e-loxP fate mapping, we show that vestibular sensory hair cells derive from a previously neurogenic r

111 ng pathways and factors function to modulate sensory hair cell development and regeneration.

112 Myo7a is expressed very early in sensory hair cell development in the inner ear.

113 Sensory hair cells die after acoustic trauma or ototoxic

114 In the developing cochlea, sensory hair cell differentiation depends on the regulat

115 organ, the cochlea, affects the survival of sensory hair cells during aminoglycoside ototoxicity, a

116 Barhl1 is expressed in all sensory hair cells during inner ear development, 2 days

117 ated transport of GLUT4, mechanosensation in sensory hair cells, endocytosis, transcription of DNA in

118 Sensory hair cells express all LRRC8 isoforms, whereas o

119 The timing of apoptotic signaling in sensory hair cells following systemic aminoglycoside tre

120 In the cochlea, MYO7A is present in the sensory hair cells from embryonic stages of development,

121 ry and vestibular systems, by protecting the sensory hair cells from injury and preserving signal det

122 auditory function but also to protection of sensory hair cells from secondary degeneration.

123 lian cochlea and are thought to originate in sensory hair cells from the intrinsic nonlinearity assoc

124 e in the selection and/or differentiation of sensory hair cells from within the established primordiu

125 Recent studies of sensory hair cells have highlighted the possible molecul

126 e zebrafish mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell surviva

127 Sensory hair cell (HC) loss is a major cause of permanen

128 ssociated with gene mutations that result in sensory hair cell (HC) malfunction.

129 Sensory hair cells (HC) in the cochlea detect and transd

130 ner ear cochlear supporting cells (SCs) into sensory hair cells (HCs) after damage, thus causing perm

131 tory sensory epithelium, composed of mechano-sensory hair cells (HCs) and highly specialized glial-li

132 Sensory hair cells (HCs) are the mechanoreceptors within

133 Mammalian inner ear and fish lateral line sensory hair cells (HCs) detect fluid motion to transduc

134 ENT: Hearing and balance rely on specialized sensory hair cells (HCs) in the inner ear (IE) to convey

135 Hearing and balance rely on specialized sensory hair cells (HCs) in the inner ear (IE) to convey

136 Loss of sensory hair cells (HCs) in the mammalian inner ear lead

137 Sensory hair cells (HCs) in the utricle are mechanorecep

138 rosensory epithelium develops as a mosaic of sensory hair cells (HCs), and their glial-like supportin

139 Mechano-sensory hair cells (HCs), housed in the inner ear cochle

140 t elongation and planar polarity of resident sensory hair cells (HCs), including the shape and orient

141 ss through the irreversible loss of cochlear sensory hair cells (HCs).

142 ession delays the differentiation of mechano-sensory hair cells (HCs).

143 a multi-functional mural cell essential for sensory hair cell heath and normal hearing.

144 oud noise has been shown to affect inner ear sensory hair cells in a variety of deleterious manners,

145 Sensory hair cells in avian vestibular organs also under

146 mice, both in vitro and in vivo We show that sensory hair cells in Csa(-/-) and Csb(-/-) mice fail to

147 The regeneration of sensory hair cells in lateral line neuromasts of axolotl

148 al tuning confers frequency selectivity onto sensory hair cells in the auditory periphery of frogs, t

149 Recent studies have demonstrated that sensory hair cells in the avian inner ear are reproduced

150 Sensory hair cells in the avian utricle SE are in a cons

151 The perception of sound relies on sensory hair cells in the cochlea that convert the mecha

152 ical signals occurs at the hair bundles atop sensory hair cells in the cochlea, by means of mechanose

153 of Tmie results in postnatal alterations of sensory hair cells in the cochlea, including defects in

154 Sensory hair cells in the cochlea, like most neuronal po

155 nt extension (CE) and uniform orientation of sensory hair cells in the cochlea.

156 Sensory hair cells in the cochleae of birds are regenera

157 ars to be primarily required for survival of sensory hair cells in the developing ear and lateral lin

158 Sensory hair cells in the ear utilize specialized ribbon

159 , ototoxic drugs, infections, and aging kill sensory hair cells in the ear, causing irreversible hear

160 ) signaling and are prominently expressed in sensory hair cells in the ear.

161 minant calcium-binding protein in a class of sensory hair cells in the frog ear.

162 The mechanoreceptive sensory hair cells in the inner ear are selectively vuln

163 log 1 (Atoh1) governs the development of the sensory hair cells in the inner ear led to therapeutic e

164 including open neural tube, misalignment of sensory hair cells in the inner ear, and shortened long

165 the orientation of stereociliary bundles of sensory hair cells in the inner ear.

166 es, the mechanically sensitive organelles of sensory hair cells in the inner ear.

167 n the hair bundle, the apical compartment of sensory hair cells in the inner ear.

168 val of photoreceptor cells in the retina and sensory hair cells in the inner ear.

169 Sensory hair cells in the inner ears of nonmammalian ver

170 Sensory hair cells in the mammalian cochlea convert mech

171 Two types of sensory hair cells in the mammalian cochlea signal throu

172 orientation of stereociliary bundles of the sensory hair cells in the mammalian cochlea.

173 li, and detailed ultrastructural analysis of sensory hair cells in the organ of Corti of the inner ea

174 ing pathway regulates the differentiation of sensory hair cells in the vertebrate inner ear [1] [2] [

175 Atoh1 is required for differentiation of sensory hair cells in the vertebrate inner ear.

176 tate the formation of presynaptic ribbons in sensory hair cells in the zebrafish lateral line.

177 tains cells that can divide and generate new sensory hair cells in vitro.

178 Vestibular sensory hair cells, in contrast, expressed only alpha 9

179 Morphogenesis of sensory hair cells, in particular their mechanotransduct

180 Each unit consists of sensory hair cells intercalated by nonsensory supporting

181 r organ suggests the active motor process in sensory hair cells is ancestral.

182 AMP-activated protein kinase (AMPK) alpha in sensory hair cells is noise intensity dependent and cont

183 Hearing impairment due to the loss of sensory hair cells is permanent in humans.

184 ance of the apical and basal compartments in sensory hair cells is poorly understood.

185 ndrome III), but the role of clarin-1 in the sensory hair cells is unknown.

186 Loss of sensory hair cells leads to deafness and balance deficie

187 Losing either type of cochlear sensory hair cells leads to hearing impairment.

188 In mammals, damage to sensory hair cells leads to hearing or balance deficits.

189 Sensory hair cell loss is a major contributor to disabli

190 Sensory hair cell loss is the major cause of hearing and

191 up to ~50% of patients by causing selective sensory hair cell loss.

192 Sensory hair cell losses lead to hearing and balance def

193 Sensory hair cell losses underlie the vast majority of p

194 e deficits due to an inability to regenerate sensory hair cells lost to inner ear trauma.

195 malian species can regenerate their auditory sensory hair cells, mammals cannot.

196 Deflection of the hair bundle atop a sensory hair cell modulates the open probability of mech

197 t to induce ectopic otic vesicles possessing sensory hair cells, neurofilament innervation in a thick

198 In the inner ear, sensory hair cells not only detect but also amplify the

199 enotypes, including heart failure, decreased sensory hair cell numbers in the otic vesicle and neurom

200 In the sensory hair cell of the inner ear, the extracellular st

201 In sensory hair cells of auditory and vestibular organs, th

202 Expression of Sema signaling genes in the sensory hair cells of both the auditory and vestibular o

203 a elongation and actin polymerization in the sensory hair cells of mammals.

204 Transmembrane Channel-Like (Tmc) 1 or 2 into sensory hair cells of mice with hearing and balance defi

205 In auditory sensory hair cells of rats (Sprague Dawley) of either se

206 n situ hybridization revealed alpha9 mRNA in sensory hair cells of the chick cochlea.

207 The function of sensory hair cells of the cochlea and vestibular organs

208 In sensory hair cells of the cochlea, it is associated tran

209 In the sensory hair cells of the cochlea, myosin VI is expresse

210 ein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafnes

211 vestibular ganglion (CVG) that innervate the sensory hair cells of the inner ear are derived from the

212 Sensory hair cells of the inner ear are exposed to conti

213 Sensory hair cells of the inner ear are susceptible to d

214 Sensory hair cells of the inner ear are the mechanoelect

215 aminoglycoside antibiotics are taken up into sensory hair cells of the inner ear by receptor-mediated

216 Sensory hair cells of the inner ear express multiple phy

217 Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate si

218 The sensory hair cells of the inner ear undergo apoptosis af

219 Sensory hair cells of the inner ear utilize specialized

220 i projecting from the apical surfaces of the sensory hair cells of the inner ear, are essential to th

221 In sensory hair cells of the inner ear, mechanical amplific

222 alysis showed that Cdh23 is expressed in the sensory hair cells of the inner ear, where it has been s

223 this phenotype, COMT2 is highly expressed in sensory hair cells of the inner ear.

224 key player in mechanical transduction by the sensory hair cells of the inner ear.

225 hanism linked to the CLRN1(N48K) mutation in sensory hair cells of the inner ear.

226 Sensory hair cells of the mammalian organ of Corti in th

227 aracteristic frequency maximally excites the sensory hair cells of the organ of Corti, which transduc

228 eurons project from the brainstem to inhibit sensory hair cells of the vertebrate inner ear.

229 is often associated with defects in cochlea sensory hair cells, opening an avenue to systematically

230 epithelial cells and fibrocytes, but not by sensory hair cells or neurons.

231 essential for the generation of the auditory sensory hair cells or the spiral ganglion (SG) neurons t

232 rimordium deposits seven to nine clusters of sensory hair cells, or neuromasts, at intervals along th

233 ffness and numerous individual gradations in sensory hair cell phenotypes, but it is unknown what pat

234 Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly specia

235 studies reveal a role for glia in regulating sensory hair cell precursors.

236 of Jag2 results in a significant increase in sensory hair cells, presumably as a result of a decrease

237 In the developing mammalian cochlea, the sensory hair cells receive efferent innervation originat

238 Sensory hair cells receive near constant stimulation by

239 maintain the local ionic environment of the sensory hair cells reflected in a reduced endocochlear p

240 ctional involvement of JAK/STAT signaling in sensory hair cell regeneration.

241 Sensory hair cells rely on otoferlin as the calcium sens

242 IGNIFICANCE STATEMENT Mechanotransduction by sensory hair cells represents a key first step for the s

243 Sensory hair cells require control of physical propertie

244 ased mechanosensory protrusions of inner ear sensory hair cells, require precise dimensional control

245 of the mechanically sensitive hair bundle of sensory hair cells requires growth and reorganization of

246 Excess noise damages sensory hair cells, resulting in loss of synaptic connec

247 Sensory hair cell ribbon synapses respond to graded stim

248 ode proteins located in the hair bundle, the sensory hair cell's mechanoreceptive organelle.

249 into a stereotyped array of inner and outer sensory hair cells separated from each other by non-sens

250 ity.SIGNIFICANCE STATEMENT In the inner ear, sensory hair cells signal reception of sound.

251 In sensory hair cells, sound and movement are transduced by

252 ticular emphasis on early patterning events, sensory hair cell specification and planar cell polarity

253 The maintenance of sensory hair cell stereocilia is critical for lifelong h

254 In developing and mature sensory hair cells, stereocilia are connected to each ot

255 Jxc1 mRNA was detected in inner ear sensory hair cells, supporting cells, and the acoustic g

256 ent of tight junctions that is necessary for sensory hair cell survival and inner ear homeostasis.

257 ein otoferlin plays an essential role at the sensory hair cell synapse.

258 Generating sensory hair cells takes about 40 d, and cultures can be

259 This manipulation increased one type of sensory hair cell (tall HCs) at the expense of another (

260 ilia are actin-based protrusions on auditory sensory hair cells that are deflected by sound waves to

261 The patches of sensory hair cells that eventually develop are few and s

262 Sensory hair cells, the mechanoreceptors of the auditory

263 port the hypothesis that pulsed IR activates sensory hair cells, thus leading to modulation of synapt

264 Localization of mechanotransduction in sensory hair cells to hair bundles requires selective ta

265 primary conveyor of hearing information from sensory hair cells to the brain.

266 resholds correlate with synaptic position on sensory hair cells, we combined patch clamping with fibe

267 in shear modulus in the neighborhood of the sensory hair cells; we argue that this inhomogeneity of

268 the cochlea by vibration of hair bundles on sensory hair cells, which activates mechanotransducer io

269 irds, and mammals possess Type I and Type II sensory hair cells, which have distinct morphologies, ph

270 hearing and balance require intact inner ear sensory hair cells, which transduce mechanical stimuli i

271 nt study links the mechanical stimulation of sensory hair cells with short- and long-term signalling

272 nsory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia o

273 type producing a fine mosaic of two types of sensory hair cells within inner ear epithelia of hemizyg

274 Mechano-sensory hair cells within the inner ear cochlea are esse