ライフサイエンスコーパス: sensory nerve

1 ., with the sympathetic, parasympathetic, or sensory nerves).

2 tralateral supratrochlear nerve as the donor sensory nerve.

3 a collective dendrite extension to form the sensory nerve.

4 of these cation channels expressed in airway sensory nerves.

5 nding the brain and is heavily innervated by sensory nerves.

6 trical and involves activation of peripheral sensory nerves.

7 central nervous systems, including in airway sensory nerves.

8 ithin developing eyefronts and on trigeminal sensory nerves.

9 ptor potential vanilloid 1 (TRPV1) on airway sensory nerves.

10 release of mediators that sensitize primary sensory nerves.

11 tenuation of sympathetic vasoconstriction by sensory nerves.

12 are significantly reduced after depletion of sensory nerves.

13 ctively, in response to brief stimulation of sensory nerves.

14 ex resulting from activation of these airway sensory nerves.

15 y coaptation of all main available motor and sensory nerves.

16 c pain is the result of abnormal activity in sensory nerves.

17 cells and their invasion of intrapancreatic sensory nerves.

18 flex, which is dependent on intact cutaneous sensory nerves.

19 ed with symptoms attributed to activation of sensory nerves.

20 y and mechanosensitivity of gastrointestinal sensory nerves.

21 bs are differentially expressed in motor and sensory nerves.

22 om an increased expression of TRPV1 in these sensory nerves.

23 gery is known to cause damage to the corneal sensory nerves.

24 disorder affecting long peripheral motor and sensory nerves.

25 els, thereby impairing impulse conduction in sensory nerves.

26 d plays a role in regulating the function of sensory nerves.

27 n promoted reinnervation of HSK corneas with sensory nerves.

28 ated peptide (CGRP), a marker of nociceptive sensory nerves.

29 ctural and functional correlation of DCs and sensory nerves.

30 ated both ASICs and TRPV1 expressed in these sensory nerves.

31 These functional effects were retained after sensory nerve ablation, indicating specific signalling b

32 showed a significant decrease of the caudal sensory nerve action potential amplitude for all cytosta

33 tabolic syndrome associated with lower sural sensory nerve action potential amplitudes.

34 ld be measured in all patients compared with sensory nerve action potentials (11 patients [73%; 95% C

35 The sensory nerve action potentials (SNAPs) remained dispers

36 Patients with altered sensory nerve action potentials and intraepidermal nerve

37 nated and small unmyelinated axons, although sensory nerve action potentials were not significantly d

38 Sensory nerve action potentials were reduced in nearly a

39 Sensory nerves activate Hedgehog signaling in normal tou

40 -705498 were profiled against capsaicin in a sensory nerve activation assay and in vivo potency estab

41 to investigate a role for TRPV4 in mediating sensory nerve activation in vagal afferents and the poss

42 we demonstrate its effectiveness in imaging sensory nerve activation in vivo in the human median ner

43 el that assesses depolarization (a marker of sensory nerve activation) of human vagus.

44 inhibitory activity of theophylline on vagal sensory nerve activity and the cough reflex.

45 ther tiotropium can directly modulate airway sensory nerve activity and thereby the cough reflex.

46 f theophylline on human and guinea pig vagal sensory nerve activity in vitro and on the cough reflex

47 Afferent sensory nerve activity was recorded during fin ray bendi

48 In vivo natural voiding behaviour, sensory nerve activity, urothelial cell function, muscle

49 ng evidence exists for a neuropathy of vagal sensory nerves after upper-respiratory viral infections

50 of erythropoietin prevented the reduction in sensory nerve amplitude characteristic of diabetic neuro

51 uditory prostheses, both at the level of the sensory nerve and at the brainstem, can restore patterns

52 s cough model in guinea pigs, isolated vagal sensory nerve and isolated airway neuron tissue- and cel

53 type 2 diabetic GK rats, and defects in the sensory nerve and/or tear film may contribute to diabeti

54 ion channel receptor primarily localized on sensory nerves and activated by specific stimuli to init

55 These data suggest (1) sensory nerves and BKCa channels play major roles in the

56 individual and combined contributions of (1) sensory nerves and large-conductance calcium activated p

57 otential analgesic and/or counterirritant at sensory nerves and may also influence nicotine's actions

58 Our data suggest that sensory nerves and neovessels inhibit each other in the

59 he paraneoplastic disorders of the motor and sensory nerves and neurons, and their immunologic associ

60 or and cannabinoid CB2 receptors can inhibit sensory nerves and prevent cough.

61 volving peripheral neural elements, visceral sensory nerves and rapid neural transmission.

62 of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with symp

63 mitochondria at the peripheral terminals of sensory nerves and the sensitivity of transient receptor

64 The sensory nerves are all derived as branches of the trigem

65 Peripheral terminals of sensory nerves are densely packed with mitochondria; thu

66 Taken together, our data show that DCs and sensory nerves are located in close proximity.

67 ting in leakage and activation of underlying sensory nerves are potential causative factors of bladde

68 t that purinergic P2 receptors on thin fibre sensory nerves are stimulated and evoke this reflex, hum

69 of the capsaicin receptor, TRPV1, outside of sensory nerves are unclear.

70 tress fracture repair and implicate skeletal sensory nerves as an important upstream mediator of this

71 Ultrastructural studies were performed on sensory nerve biopsies from 2 affected family members.

72 In the sensory nerve/BKCa protocol: (1) EMLA cream (EMLA, appli

73 urposes, are known to excite and desensitize sensory nerves by acting on two members of transient rec

74 ase ECE-1 as a negative regulator of itch on sensory nerves by directly regulating ET-1-induced pruri

75 TRPV1 was detected in extracts of peripheral sensory nerves by Western blotting.

76 Whether sensory nerve can sense bone density or metabolic activi

77 uring an allergic reaction can interact with sensory nerves, change processing in the central nervous

78 nsistent with phenotypic switching in airway sensory nerves comparable with the cough responses obser

79 Treatment also restored the duration of sensory nerve compound potentials.

80 ssentially corrected thermal hypoalgesia and sensory nerve conduction deficit without affecting motor

81 They also had motor and sensory nerve conduction deficits, tactile allodynia, an

82 tcomes, both local to the wrist (i.e. median sensory nerve conduction latency) and in the brain (i.e.

83 st and large fiber sensory polyneuropathy on sensory nerve conduction studies in all patients associa

84 functional recovery as assessed by motor and sensory nerve conduction velocities and sciatic function

85 METHODS AND We found that motor and sensory nerve conduction velocities, blood flow, and cap

86 cterized by significant slowing of motor and sensory nerve conduction velocities.

87 uction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits, therm

88 pairments accompanied by decreased motor and sensory nerve conduction velocity and reduced compound m

89 al hypoalgesia, tactile allodynia, motor and sensory nerve conduction velocity deficits, and reductio

90 l tunnel syndrome, but not healthy controls, sensory nerve conduction velocity for Digits 2 and 3 was

91 nerve conduction velocity, hindlimb digital sensory nerve conduction velocity, and sciatic nerve con

92 uropathy as determined by abnormal motor and sensory nerve conduction velocity, mechanical allodynia,

93 blood flow, significantly improved motor and sensory nerve conduction velocity, prevented the develop

94 Peripheral motor and sensory nerve conduction, central motor conduction, a cl

95 eting, we uncovered a central role for C3 in sensory nerve damage at the morphological and functional

96 is same C3/CD4 T cell axis triggered corneal sensory nerve damage in a mouse model of ocular graft-ve

97 mouse model of ocular HSV-1 infection, where sensory nerve damage is a common clinical problem.

98 tivity to spared peripheral inputs following sensory nerve damage.

99 he CNTF-specific receptor CNTFRalpha induced sensory nerve degeneration and retarded regeneration in

100 a stage-dependent progression pattern, with sensory nerve degeneration as the early skin nerve patho

101 c mice, there was a substantial reduction in sensory nerve density and the number of intraepithelial

102 In Old MAs, sensory nerve density was reduced and RAMP1 (CGRP recept

103 endent on TRPA1 activation being mediated by sensory nerve-derived dilator neuropeptides CGRP and sub

104 These data demonstrate that sensory nerve-derived peptides mediate psoriasiform dend

105 Sensory nerves detect an extensive array of somatosensor

106 The lateral line and its associated sensory nerves develop from cephalic epithelial thickeni

107 Notably, ablation of sensory nerves did not affect the responses to capsaicin

108 to hypoxia evokes long term facilitation of sensory nerve discharge (sLTF) of the carotid body in ro

109 It is well recognized that this sensory nerve dysfunction can be caused by traumatic, to

110 ve demyelination, axonal loss, and motor and sensory nerve dysfunction.

111 progressive axon degeneration and motor and sensory nerve dysfunction.

112 Sensory nerves emanating from the dorsal root extensivel

113 mily of ion channels, which are expressed in sensory nerve endings and in skin, respond to distinct t

114 estored the branching of diabetes-suppressed sensory nerve endings and regeneration in the diabetic c

115 This depolarizes the sensory nerve endings by simultaneously closing M-type p

116 TRPM3, and indicate that TRPM3 activation in sensory nerve endings can contribute to neurogenic infla

117 alpha-motor axons in SOD1(G93A) mice, Ia/II sensory nerve endings degenerate in the absence of obvio

118 nates following the activation of peripheral sensory nerve endings following damage or exposure to in

119 Our aim was to identify the sensory nerve endings in the colon that arise from singl

120 ation results from the excitation of primary sensory nerve endings in the skin, but the underlying mo

121 ver, the way in which it excites nociceptive sensory nerve endings is still unclear.

122 ent strategies that target TRPA1 channels on sensory nerve endings to achieve chemical deterrence.

123 dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivatio

124 nociceptive effect starts after entering the sensory nerve endings, where these agents are axonally t

125 s and modulate their sensitivity directly in sensory nerve endings.

126 ng at CB1 cannabinoid receptors localized on sensory nerve endings.

127 ds, arrector pili muscles, Merkel cells, and sensory nerve endings.

128 tivating TRPA1, an excitatory ion channel on sensory nerve endings.

129 activating capsaicin-sensitive perivascular sensory nerve endings.

130 detector of environmental cold in mammalian sensory nerve endings.

131 hnique to selectively label spinal afferent (sensory) nerve endings that innervate the periosteum and

132 Capsaicin (10 mum; to inhibit sensory nerves) enhanced MA constriction to PNS (P 0.05)

133 Ablation of sensory nerves erodes the skeletal integrity.

134 Airway sensory nerve excitability is a key determinant of respi

135 terminal mitochondrial dysfunction on airway sensory nerve excitability.

136 he ion channels that underpin the changes in sensory nerve excitability.

137 hannel, since Cav3.2 plays a central role in sensory nerve excitability.

138 ated prototypical Th2 cytokines which elicit sensory nerve excitation.

139 f large myelinated fibers, its role in small sensory nerve fiber degeneration and neuritic dystrophy

140 ions in sudomotor, vasomotor, pilomotor, and sensory nerve fiber densities in capsaicin-treated subje

141 ns and to investigate whether IL-31 promotes sensory nerve fiber outgrowth.

142 intimate association between mast cells and sensory nerve fibers allows bidirectional communication,

143 ut to the central nervous system (CNS) along sensory nerve fibers and initially entered the simian CN

144 anilloid 1 (TRPV1) is primarily localized to sensory nerve fibers and is associated with the stimulat

145 that abnormalities in communication between sensory nerve fibers and SCs may result in pain states.

146 Sensory nerve fibers differ not only with respect to the

147 They are approached by sensory nerve fibers expressing nicotinic acetylcholine

148 Embryonic corneal keratocytes and sensory nerve fibers grow and differentiate according to

149 n epithelium innervation by accompanying the sensory nerve fibers in crossing the basement membrane a

150 lamina propria, where it was associated with sensory nerve fibers in the core of the lingual papillae

151 eriosteum, while it occasionally reaches the sensory nerve fibers in the mouse footpad.

152 herapies that prevent this reorganization of sensory nerve fibers may provide insight into the evolvi

153 This ectopic sprouting occurs in sensory nerve fibers that are in close proximity to colo

154 he hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing ti

155 Nearly all sensory nerve fibers that undergo sprouting also coexpre

156 erve damage may differ between autonomic and sensory nerve fibers treated with capsaicin and enhances

157 Dispersed maturation of sensory nerve fibers with desynchronized inputs to the C

158 Sprouting and arborization of CGRP+TrkA+ sensory nerve fibers within the reactive periosteum in N

159 nerve fibers), neurofilament 200 kd (NF200; sensory nerve fibers), growth-associated protein 43 (GAP

160 ainst calcitonin gene-related peptide (CGRP; sensory nerve fibers), neurofilament 200 kd (NF200; sens

161 s and enhanced expression of TRPA1 in dermal sensory nerve fibers, their dorsal root ganglia, and mas

162 ceptor kinase A-expressing (TrKa-expressing) sensory nerve fibers, which are required for osteochondr

163 ation of the neuronal cell bodies of corneal sensory nerve fibers.

164 n requiring ATP as a transmitter to activate sensory nerve fibers.

165 he JAM-C SC KO animals, on finely myelinated sensory nerve fibers.

166 on contributes to the distal degeneration of sensory nerve fibers.

167 ute to neuropathic dysfunction in peripheral sensory nerve fibers.

168 GRP(+)) and neurofilament 200 kDa (NF200(+)) sensory nerve fibers.

169 athological reorganization of nearby TrkA(+) sensory nerve fibers.

170 Sensory nerve fibres can detect changes in temperature o

171 how that cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice exhibit p

172 ich suggests that adipocytes signal to local sensory nerve fibres in response to perturbations in lip

173 tify TRPA1 channels as infrared receptors on sensory nerve fibres that innervate the pit organ.

174 1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain.

175 vert predators by activating TRP channels on sensory nerve fibres to elicit pain and inflammation.

176 ndothelin excites cutaneous group III and IV sensory nerve fibres.

177 electrical activation of nociceptive primary sensory nerve fibres.

178 currents have been documented in lung vagal sensory nerves fibres, a rigorous comparison of their ex

179 tical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itc

180 This technique allows some sensory nerves from the amputated limb to reinnervate ov

181 approach and consists of rerouting motor and sensory nerves from the residual limb towards intact mus

182 tudy, we comprehensively evaluated motor and sensory nerve function 2-24 weeks after injection of ret

183 With advanced age, the loss of sensory nerve function and diminished effectiveness of C

184 We found that motor and sensory nerve functions were completely recovered by 24

185 s simplex virus (HSV) establishes latency in sensory nerve ganglia during acute infection and may lat

186 the percentages and types of cells in human sensory nerve ganglia that harbor latent herpes simplex

187 causes varicella and establishes latency in sensory nerve ganglia, but the characteristics of VZV la

188 The effect of motor versus sensory nerve grafting after facial nerve injury has not

189 onstructing nerve gap injuries involve using sensory nerve grafts to bridge the nerve defect.

190 Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through th

191 itro, VEGF-A from infected corneas repressed sensory nerve growth and promoted sympathetic nerve grow

192 nergic systems in adult mammalian peripheral sensory nerves has not been established.

193 es are associated with dysfunction of airway sensory nerves has the potential to identify novel thera

194 he specific interaction of ozone with airway sensory nerves has yet to be elucidated.

195 in-predominant symptoms were consistent with sensory nerve hyperexcitability.

196 Destroying visceral sensory nerves impacts pancreatic islet function, glucos

197 e examined the regulation of angiogenesis by sensory nerves in response to inflammation using the cor

198 he missing limb via direct activation of the sensory nerves in the residuum would improve the standin

199 ng of the morphology and distribution of the sensory nerves in the skin has considerably progressed o

200 However, the role of sensory nerves in this phenomenon has received scant att

201 Motor and/or sensory nerve injuries occurred after seven procedures (

202 -gated calcium channels is upregulated after sensory nerve injury and is also the therapeutic target

203 this treatment is beneficial in humans with sensory nerve injury has not been tested.

204 Peripheral sensory nerve injury results in the up-regulation of alp

205 Vagal sensory nerves innervate the majority of visceral organs

206 a useful gene delivery vector to target the sensory nerves innervating bone.

207 Sensory nerves innervating the airways play an important

208 TRPA1, but not TRPM8, is expressed in vagal sensory nerves innervating the airways.

209 Sensory nerves innervating the mucosa of the airways mon

210 Collectively, our data show that DCs mediate sensory nerve innervation and regeneration through CNTF

211 as, resulting in decreased CNTF and impaired sensory nerve innervation and regeneration.

212 tous responses and remodeling events such as sensory nerve innervation of the skin and induced pathop

213 s related genes may participate in mast cell sensory nerve interactions.

214 There is no evidence of sensory nerve involvement.

215 TRPV1 and TRPM8 are sensory nerve ion channels activated by heating and cool

216 we show that NGF-TrkA signaling in skeletal sensory nerves is an early response to mechanical loadin

217 stimulatory effect of hydrogen ion on these sensory nerves is generated by activation of two major t

218 e are elevated levels of PGE2 which activate sensory nerves, leading to sodium influx through Na(v) 1

219 Peripheral injury to other sensory nerves leads to glial responses at central termi

220 ory signalling mediated through perivascular sensory nerves may compromise perfusion of visceral orga

221 htened stimulatory effects of acid on airway sensory nerves may play a part in the manifestation of a

222 n developing eyefronts and on the surface of sensory nerves, may provide guidance cues to nerves duri

223 Sensory nerves mediate spontaneous behaviors in addition

224 e, we aimed to understand the involvement of sensory nerve mediators with a murine model of psoriasis

225 potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling.

226 ical or surgical depletion of small-diameter sensory nerves/nociceptors benefits the condition, but t

227 pinal neurons activated with either pudendal sensory nerve or pelvic nerve stimulation was examined i

228 n the affected neurons: peripheral motor and sensory nerves or central nervous system axons of the co

229 pecifically, knockout of the EP4 gene in the sensory nerves or cyclooxygenase-2 (COX2) in the osteobl

230 of the periosteum, capsaicin denervation of sensory nerves or knockdown in vivo of the CGRP-receptor

231 channel agonist retigabine nearly abolished sensory nerve outflow from the urinary bladder during bl

232 smooth muscle excitability, or by decreasing sensory nerve outflow.

233 The major sensory nerve pathway between the colon and central nerv

234 Until recently, sensory nerve pathways from the stomach to the brain wer

235 y population High-threshold gastrointestinal sensory nerves play a key role in signalling distressing

236 e mitochondrial dysfunction activates airway sensory nerves preferentially via TRPA1 through the acti

237 e further indicates an involvement of airway sensory nerves, presumably the thermosensitive C-fiber a

238 We addressed the hypothesis that mouse vagal sensory nerves projecting to the airways express TRPA1 a

239 r pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SA

240 gents are also known to stimulate peripheral sensory nerves, raising the possibility that they may ex

241 a key osmosensing pathway involved in airway sensory nerve reflexes.

242 n wounded corneas, diabetes markedly delayed sensory nerve regeneration and reduced the number of inf

243 to test the hypothesis that ES would enhance sensory nerve regeneration following digital nerve trans

244 The contribution of acute inflammation to sensory nerve regeneration was investigated in the murin

245 inhibited sympathetic innervation, promoted sensory nerve regeneration, and alleviated disease.

246 an interesting therapeutic target for human sensory nerve regeneration.

247 rves generally regenerated more rapidly than sensory nerves, requiring 40-50 days to return to baseli

248 procedure involving the division of selected sensory nerve roots, followed by intensive physiotherapy

249 We found that NVB sensory nerves secrete Shh protein, which activates Gli1

250 TRPV1, a cation channel on sensory nerves sensitive to heat and capsaicin, plays an

251 m channel blocker CDA54 selectively inhibits sensory nerve signaling associated with neuropathic pain

252 We show that knockout of PGE2 receptor 4 in sensory nerves significantly reduces spinal hypersensiti

253 port the hypothesis that agonists of certain sensory nerve specific receptors or mas related genes ma

254 y discovered orphan receptors referred to as sensory nerve specific receptors or products of mas rela

255 Thus, bile acids activate TGR5 on sensory nerves, stimulating the release of neuropeptides

256 Pudendal sensory nerve stimulation resulted in a significant incr

257 With perivascular sensory nerve stimulation, dilatation and inhibition of

258 rdings has allowed direct comparison between sensory nerve studies in animals and human, as well as i

259 TMA contact toxicant reactions increase skin sensory nerve substance P and, in turn, increase itching

260 More than one sensory nerve subtype is thought to subserve pruriceptiv

261 of adenosine on the nerve terminals of vagal sensory nerve subtypes was evaluated in an ex vivo perfu

262 timulator to surgically redirected cutaneous sensory nerves (targeted reinnervation) that once served

263 This approach to selective labeling of sensory nerve terminal endings will help to better ident

264 The data support the hypothesis that the sensory nerve terminal is able to release vesicles to fi

265 smitters and trophic factors from peripheral sensory nerve terminals (PSNTs), yet Ca2+ regulation in

266 calcitonin gene-related peptide (CGRP) from sensory nerve terminals and insulin from isolated pancre

267 among glomeruli, releasing GABA and DA onto sensory nerve terminals and postsynaptic neurons.

268 The ion channels expressed within the sensory nerve terminals play an essential role in the ab

269 peripheral neuropathy, such as depletion of sensory nerve terminals, thermal hypoalgesia, and nerve

270 of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli

271 and due to a dramatic retraction of corneal sensory nerve termini in the epithelium and the nerve pl

272 at had been treated to expose the underlying sensory nerve termini.

273 nerve tropism, whether AAV can distribute to sensory nerves that innervate the bone or skeletal tissu

274 ting of non-glabrous skin by sensitizing the sensory nerves that mediate the axon reflex associated w

275 Although mainly studied in sensory nerves, there are reports of TRPV1 expression in

276 conditions by decreasing the excitability of sensory nerves through activation of small- and intermed

277 ic transdifferentiation of tumour-associated sensory nerves through loss of the microRNA miR-34a.

278 e that communication between osteoblasts and sensory nerves through NGF-TrkA signaling is essential f

279 ate stretch-activated mechanotransduction in sensory nerves through subcellular stimulation.

280 the CSF outflow pathway along the olfactory sensory nerves through the cribriform plate, and into th

281 Thus, we show that PGE2 mediates sensory nerve to control bone homeostasis and promote re

282 pofol) general anesthetics excite peripheral sensory nerves to cause pain and irritation upon adminis

283 tic cells activates PGE2 receptor 4 (EP4) in sensory nerves to regulate bone formation by inhibiting

284 of pain-related signals from the peripheral sensory nerves to the CNS.

285 of Schwann cell activity following cutaneous sensory nerve transection in melanoma orthotopic models

286 This representation persists after sensory nerve transection, indicating an efferent source

287 Moreover, unlike in sensory nerves, TRPV1 function in arteries was resistant

288 In ex vivo motor and sensory nerve trunk preparations, antibody deposits are

289 deeper fibrous layer that contains the main sensory nerve trunks that give rise to numerous branches

290 olimbal epithelial progenitor/stem cells and sensory nerves using a denervated mouse model of NK.

291 1.47 to 2.17), and there were no effects on sensory nerves velocity (ES = 0.01, 95% CI = - 0.79 to 0

292 landin E2 and bradykinin can activate airway sensory nerves via EP3 and B2 receptors receptively and

293 ion (DRG) neurons following direct injury of sensory nerves, we asked whether such a dysregulation al

294 Two sensory nerves were cut and the distal ends were anastom

295 cularly with regard to the activation of the sensory nerves which relay pain from the gut to the brai

296 leads to activation of guinea pig and human sensory nerves, which are responsible for respiratory sy

297 affect the function of enteric and extrinsic sensory nerves, which can contribute to the development

298 ure activates vagal bronchopulmonary C-fiber sensory nerves, which upon activation can elicit reflex

299 helium and approximately 19% regeneration of sensory nerves within 96 hours.

300 nels, which are putative channels located on sensory nerves, would attenuate the skin blood flow resp