ライフサイエンスコーパス: sentinel

1 k of macrophages that act as resident immune sentinels.

2 strategies can serve as a method to identify sentinels.

3 urther measurement, which could be done with Sentinel-1 and NASA's upcoming NISAR mission.

4 With Sentinel-1 continuity ensured until 2030 and likely beyo

5 Specifically, Copernicus Sentinel-1 images are used to detect the spatio-temporal

6 es and reanalysis data demonstrates that the Sentinel-1 retrievals capture the spatial variability be

7 Here, we show the ability of Sentinel-1 to map snow depth in the Northern Hemisphere

8 two time-series of descending and ascending Sentinel-1A acquisitions between 2014 and 2017.

9 COSMO-SkyMed and the European Space Agency's Sentinel-1A satellites.

10 Sentinel 2 imagery supported by two field campaigns reve

11 DC) light trap baited with CO(2), and the BG Sentinel 2 trap with BG-Lure and CO(2).

12 ouseholds throughout the communities with BG Sentinel 2 traps during a 12-week period.

13 ere suspected macroplastics were detected in Sentinel-2 Earth Observation data.

14 loating Debris Index (FDI) developed for the Sentinel-2 Multi-Spectral Instrument (MSI).

15 acquired by the European Space Agency (ESA) Sentinel-2 satellites and, furthermore, are distinguisha

16 The new method can be applied to Sentinel-3 Ocean Land Color Imager (OLCI) data for asses

17 hed imaging spectrometer TROPOMI onboard the Sentinel-5 Precursor satellite provides atmospheric colu

18 no populations, reinstating their anti-human sentinel [8].

19 foragers no longer responded differently to sentinel activity by former immigrants and residents.

20 an negatively alter population dynamics of a sentinel alpine species and provide insight into how dem

21 propose P. steinenii as an effective native sentinel and indicator species of climate change in the

22 e external world for unexpected events, as a sentinel, and when humans are engaged in high-level inte

23 Densely opaque axoplasmic sentinels are arranged along normoxic/hypoxic interfaces

24 ytosis ("Dragot" is a Greek surname meaning "sentinel"), as it represents sharing of a microbe betwee

25 e known role of gammadelta T cells as immune sentinels at barrier surfaces and their TCR-independent

26 We studied sentinel behaviour following immigration in a habituated

27 Mast cells (MCs) are immune sentinels, but whether they also function as antigen-pre

28 environment at the synthetic niche acts as a sentinel by reflecting both progression and regression o

29 , a laccase/tyrosinase-based biosensor and a sentinel carbon sensor, all located in the basolateral c

30 This sentinel case led the authors to hypothesize that the in

31 We report a sentinel case of methemoglobinemia that was associated w

32 macytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucl

33 We hypothesized that these sentinel cells can remember a previous contact with path

34 tion of high levels of cytokines by infected sentinel cells of the immune system, leading to endothel

35 represents sharing of a microbe between two sentinel cells of the innate immune system.

36 Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive

37 Mast cells are resident sentinel cells that come into contact with pathogens ear

38 and fibroblasts are among the most numerous sentinel cells that contribute to this production.

39 ve learned that inflammation is triggered by sentinel cells that monitor for tissue stress and malfun

40 Not surprisingly, mast cells act as sentinel cells that sense microbial attacks and initiate

41 ctions, we have compiled infection data from sentinel chickens, mosquito vectors, and human cases in

42 dy, we did two seroprevalence surveys in 133 sentinel cities in all Brazilian states.

43 These sentinels continually survey their environment and discr

44 nths after arrival, immigrants had increased sentinel contributions, and foragers no longer responded

45 Using electronic health data from the US Sentinel database (2001-2015), we identified live-birth

46 We find that the optimal selection of sentinels depends on both the network's temporal structu

47 The optimal choice of sentinels depends on the network structure.

48 ing in a live birth.Materials and MethodsThe Sentinel Distributed Database was used to retrospectivel

49 ryl-hydrocarbon receptor repressor (AHRR), a sentinel epigenetic biomarker of exposure to maternal sm

50 HIV-related deaths should be treated as sentinel events triggering epidemiological investigation

51 In cases without perinatal sentinel events, genomic alterations contributed substan

52 We show that the MAPKKK ZAK functions as the sentinel for ribosome collisions and is required for imm

53 chemosensory ion channel that functions as a sentinel for structurally diverse electrophilic irritant

54 nique micro anatomy, allows it to serve as a sentinel for the body's immune system.

55 ing ITx graft homeostasis and could serve as sentinels for early recognition of allograft rejection a

56 Beehive products are considered sentinels for environmental pollutants.

57 Dogs provide valuable insights as sentinels for exposure-related human disease because the

58 Travelers are sentinels for global Zika virus circulation and may faci

59 ) are critical effector cells and long-lived sentinels for immune memory.

60 tive to environmental agents, these would be sentinels for monitoring personal carcinogen exposure an

61 x (BMI) during childhood and adolescence are sentinels for the future population cardiovascular disea

62 As sentinels for the immune system, MG also detect "danger"

63 rine mammals are widely considered important sentinels for the implications of pollution for the mari

64 cohabit urban neighborhoods and may serve as sentinels for these contaminants.

65 ncluding the kidney, to perform an important sentinel function.

66 We review here sentinel functions of IELs in the maintenance of the muc

67 uenza surveillance is usually carried out by sentinel general practitioners (GPs) who compile weekly

68 Microglia, the brain's immune sentinels, have garnered much attention in recent years.

69 en aged 0-59 months with MSD seeking care at sentinel health centres were recruited along with one to

70 ence causal CRE variant for each of the five sentinel hits that could collectively predict SCN5A card

71 kely to have sought care before visiting the sentinel hospital (P = .009), visited any hospital for t

72 HIV/AIDS sentinel hospital had better retention, and substantiall

73 -59 months at each site who sought care at a sentinel hospital or health centre during a 12-month per

74 virus (HIV) statuses were available from 26 sentinel hospital sites.

75 and adults in Yangon, Myanmar, by combining sentinel hospital surveillance with a healthcare utiliza

76 ngococcus), and Haemophilus influenzae, at a sentinel hospital within the capital city, Lome, in the

77 h HIV who accessed services through HIV/AIDS sentinel hospital-based and ART service delivery in Chin

78 ervational database of 22 qualified HIV/AIDS sentinel hospital-based and two CDC-based drug delivery

79 tchment of malaria admission around the four sentinel hospitals although the extent varied.

80 2,966 individuals received ART from HIV/AIDS sentinel hospitals and 1,919 from DDFs, with linkage to

81 eillance systems: a Nationwide network at 10 sentinel hospitals and at the icddr,b hospital.

82 Retention rates were 94.1% and 84.0% in sentinel hospitals and DDFs, respectively (P < 0.01).

83 Between Nov 1, 2013, and April 30, 2014, 455 sentinel hospitals in 36 countries submitted 2703 clinic

84 from children <5 years of age, admitted to 5 sentinel hospitals in 5 Nigerian states.

85 bacterial meningitis (PBM) surveillance at 2 sentinel hospitals in Abidjan, targeting the main causes

86 mitted to Parakou, Natitingou, and Tanguieta sentinel hospitals with suspected meningitis.

87 n, we conducted longitudinal surveillance in sentinel hospitals within Nigeria to establish the burde

88 in patients receiving ART from the DDFs than sentinel hospitals, with an adjusted HR of 3.3 (95% CI:

89 ted cases of meningitis were admitted to the sentinel hospitals.

90 5 fold higher (95% CI: 6.3, 9.0) compared to sentinel hospitals.

91 We tested this by infecting sentinel host genotypes of Plantago lanceolata with stra

92 c type 2 responses by extrusion of activated sentinel ILC2s from tissue into the circulation.

93 al resident memory T (eT(RM)) cells serve as sentinels in barrier tissues to guard against previously

94 though airway epithelial cells are frontline sentinels in detecting pathogens, information on how the

95 R ligation, identifying MAIT cells as innate sentinels in inflammatory environments.

96 d susceptibility to mutation, and can act as sentinels indicating elevated mutation rates and increas

97 this national resource in collaboration with Sentinel investigators.

98 TCT daily for a year in 150 patients with a sentinel ischemic stroke or TIA event in the prior 6 mon

99 ory-confirmed pneumococcal isolates from ten sentinel laboratories, together representing 11 states i

100 Predation on sentinel larvae was much higher in urban gardens than in

101 gnal transduction system whereby cytoplasmic sentinel lectins detect membrane damage leading to ubiqu

102 heir prevalence in peripheral tissues, their sentinel-like phenotypes, and their unique antigen recog

103 These T cells act as sentinels, linking T cell receptor (TCR) recognition of

104 trial cancers; therefore, the exploration of sentinel LNs (SLNs) is highly important.

105 thus, only a picomolar dose is required for sentinel LNs detection.

106 coating are used to visualize cancer-invaded sentinel LNs in the NIR-IIb (>1500 nm) window.

107 ast cells (MCs) are granulated innate immune sentinels located perivascularly, including at the BBB.

108 lmanocept is a novel radiopharmaceutical for sentinel lymph node (SLN) biopsy in breast cancer.

109 ety of Surgical Oncology (SSO) guideline for sentinel lymph node (SLN) biopsy in melanoma.

110 Conclusion Women without sentinel lymph node (SLN) metastases should not receive

111 ned to identify 1,256 with metastases in the sentinel lymph node (SLN).

112 ammation; the results clearly identified the sentinel lymph node basin and delineated the lymphatic d

113 ial mastectomy (PM), partial mastectomy with sentinel lymph node biopsy (PM SLNB), laparoscopic chole

114 Observations: Sentinel lymph node biopsy (SLNB) after NAC in patients

115 oups according to axillary surgery approach: sentinel lymph node biopsy (SLNB) alone, SLNB+RLNR, axil

116 that disconcerting lymphedema rates in both sentinel lymph node biopsy (SLNB) and axillary lymph nod

117 TAD involves TLN biopsy (TLNB) and sentinel lymph node biopsy (SLNB) and was recently intro

118 ent as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in th

119 Several less invasive procedures, such as sentinel lymph node biopsy (SLNB), marking axillary lymp

120 ntigraphy (LSG) enhances staging accuracy of sentinel lymph node biopsy (SLNB).

121 Sentinel lymph node biopsy is a promising procedure in p

122 Sentinel lymph node biopsy was a possible option for 9/2

123 Sentinel lymph node biopsy was performed using an increa

124 Sentinel lymph node biopsy will not identify metastases

125 al hernia repair, partial mastectomy without sentinel lymph node biopsy, and partial mastectomy with

126 mph node biopsy, and partial mastectomy with sentinel lymph node biopsy.

127 s treated with breast-conserving therapy and sentinel lymph node dissection (SLND) alone without axil

128 r overall survival for patients treated with sentinel lymph node dissection alone was noninferior to

129 aspiration from the iliac crests and in vivo sentinel lymph node mapping were performed during open s

130 FAM-labeled UNO (FAM-UNO) homed to tumor and sentinel lymph node MEMs in different cancer models: 4T1

131 he 10-year overall survival of patients with sentinel lymph node metastases treated with breast-conse

132 However, sentinel lymph node removal does not necessarily extend

133 Patients who had mapping of at least one sentinel lymph node were included in the primary analysi

134 ignalling in the tumour microenvironment and sentinel lymph node, and convert immunosuppressive tumou

135 tastatic disease correctly identified in the sentinel lymph node.

136 ve nodes, 36 of whom had at least one mapped sentinel lymph node.

137 ients had successful mapping of at least one sentinel lymph node.

138 In cancer patients, metastasis of tumors to sentinel lymph nodes (LNs) predicts disease progression

139 detect the fluorescent signal emanating from sentinel lymph nodes (SLNs) approximately 2 d after inje

140 h cT1-2N0 breast cancers and 1 to 2 involved sentinel lymph nodes (SLNs) having breast-conserving the

141 SLNB correlates with the number of resected sentinel lymph nodes (SLNs), our primary end point was t

142 Association of SNTI in sentinel lymph nodes and BMM in patients with stage I to

143 isolated tumor cells and micrometastases) in sentinel lymph nodes and bone marrow micrometastases (BM

144 mors with RhoA knockdown efficiently invaded sentinel lymph nodes and significantly metastasized to l

145 t (CTCL, melanoma) and nonmalignant skin and sentinel lymph nodes but not in his prostate.

146 None of the three sentinel lymph nodes contained metastatic carcinoma.

147 no palpable axillary adenopathy, and 1 or 2 sentinel lymph nodes containing metastases, 10-year over

148 no palpable axillary adenopathy, and 1 or 2 sentinel lymph nodes containing metastases.

149 INTERPRETATION: Sentinel lymph nodes identified with indocyanine green h

150 Nodal metastases were identified in the sentinel lymph nodes of 35 (97%) of these 36 patients, y

151 showed significantly higher accumulation in sentinel lymph nodes than a control peptide.

152 All sentinel lymph nodes underwent multilevel sectioning and

153 Sentinel lymph nodes were successfully detected in all p

154 method on an open-source dataset of WSI from sentinel lymph nodes with breast cancer metastases, CAME

155 Despite frequent involvement of the sentinel lymph nodes, most cases have an uneventful clin

156 malignancy, and it is useful in identifying sentinel lymph nodes.

157 chnique's potential beyond merely localizing sentinel lymph nodes.

158 a was established, TIDC did not migrate into sentinel lymph nodes.

159 cans decreased by an average of 36%, whereas sentinel lymph-node procedures decreased by 45%, lung sc

160 ngoing clinical trials will evaluate whether sentinel-lymph-node biopsy can be avoided altogether in

161 section for staging has now been replaced by sentinel-lymph-node biopsy for patients with clinically

162 Sentinel-lymph-node biopsy is associated with increased

163 Refinement of the sentinel-lymph-node biopsy technique might overcome the

164 the study a ureteral injury incurred during sentinel-lymph-node dissection.

165 For selected patients with limited sentinel-lymph-node involvement, completion axillary-lym

166 sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold stand

167 cervical injection of indocyanine green and sentinel-lymph-node mapping followed by pelvic lymphaden

168 Sentinel-lymph-node mapping has been advocated as an alt

169 s with node-positive disease with successful sentinel-lymph-node mapping who had metastatic disease c

170 Sentinel-lymph-node mapping with complete pelvic lymphad

171 The primary endpoint, sensitivity of the sentinel-lymph-node-based detection of metastatic diseas

172 d murine leukemia virus (FrMLV) exploits the sentinel macrophages in the draining popliteal lymph nod

173 e 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.

174 n multiple tissues (P < 0.05), and show that sentinel methylation markers identify gene expression si

175 e metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of

176 Furthermore, the DMN is activated as a sentinel, monitoring the environment for unexpected even

177 genetic regulators, while also destabilizing sentinel mRNAs that are primed to activate rescue pathwa

178 n in Transcatheter Aortic Valve Replacement [SENTINEL]; NCT02214277).

179 use of VAS in the MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) app (Allergy Dia

180 The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Dia

181 MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-cen

182 and diagnoses among MSM attending a national sentinel network of 46 clinics in Australia between 2007

183 The EIN is a sentinel network of ID physicians who care for adult and

184 In MASK-air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for wor

185 National U.S. Food and Drug Administration Sentinel network.

186 -specific membrane antigen (PSMA) PET/CT and sentinel node (SN) biopsy in PSMA PET/CT-negative patien

187 Sentinel node (SN) biopsy is accurate in operable oral a

188 adio- and fluorescence image guidance during sentinel node (SN) biopsy procedures.

189 hat preoperative US could avoid the need for sentinel node (SN) biopsy, but in most single-institutio

190 with primary cutaneous melanoma, the risk of sentinel node (SN) metastasis varies according to severa

191 We aimed to identify determinants of sentinel node (SN) status for incorporation into an exte

192 Knowing that the hybrid sentinel node (SN) tracer indocyanine green (ICG)-(99m)T

193 diotherapy to the breast alone after BCS and sentinel node biopsy (Group 2) and nine healthy age-matc

194 rovide current recommendations on the use of sentinel node biopsy (SNB) for patients with early-stage

195 Regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic fa

196 The benefit of adding sentinel node biopsy (SNB) to extended pelvic lymph node

197 The patient underwent wide excision and sentinel node biopsy, which showed absence of residual m

198 ymph node dissection (CLND) after a positive sentinel node in patients with melanoma.

199 y, with partial axillary node dissection and sentinel node mapping.

200 lumpectomy and were found to have a positive sentinel node.

201 al trial, we randomly assigned patients with sentinel-node metastases detected by means of standard p

202 tion lymph-node dissection for patients with sentinel-node metastases is not clear.

203 ic survival among patients with melanoma and sentinel-node metastases.

204 o ovarian ligaments has been shown to detect sentinel nodes (SNs) in patients with ovarian cancer.

205 isualize the lymphatic drainage patterns and sentinel nodes (SNs) of individual prostate cancer patie

206 olloid to create a roadmap that depicted all sentinel nodes (SNs).

207 at SLNB after NAC is accurate when 3 or more sentinel nodes are obtained, but long-term outcomes are

208 isualize the lymphatic drainage patterns and sentinel nodes of individual prostate cancer patients.

209 We report a sentinel occurrence of an infection with an Enterobacter

210 teasome subunit suppression also serves as a sentinel of a more global remodeling of the transcriptom

211 Toll-like receptors (TLRs) are important sentinels of bacterial and viral infection and thus fulf

212 k/Stat pathway ligand Upd3, hemocytes act as sentinels of bacterial infection, inducing expression of

213 role of mountaintop aquatic invertebrates as sentinels of climate change in mid-latitude regions.

214 stem types or months; these species could be sentinels of community-wide responses to future shifts.

215 e been reported in polar regions, and act as sentinels of global pollution.

216 Inflammasomes are important sentinels of innate immune defence that are activated in

217 Microglia are the intrinsic immune sentinels of the central nervous system.

218 homeostasis and remodeling, as well as being sentinels of the innate immune system that can contribut

219 ut have also recently come into focus as key sentinels of tissue health and homeostasis.

220 embedded networks it is better to place the sentinels on nodes distributed across different regions.

221 during bioproduction, serve as environmental sentinels or guide living therapeutics.

222 e surveillance is to carefully select nodes (sentinels, or sensors) in the network to report outbreak

223 idney has been treated traditionally as the "sentinel" organ to biopsy, presumably representing the s

224 Escherichia coli, our sentinel organism, was cultured and a single isolate fro

225 ve samplers proved to be more sensitive than sentinel organisms for monitoring spatiotemporal changes

226 g the study period in the incidence rates of sentinel outcomes per 10,000 person-years were as follow

227 Three sentinel parameters of aerobic performance are the maxim

228 Ex-vivo growth of all sentinel pathogens was strongly associated with serum tr

229 n epidemics, we embedded multiple cohorts of sentinel plants, grown from seeds with and without a ver

230 osed of a glucose oxidase-based biosensor, a sentinel platinum sensor, a laccase/tyrosinase-based bio

231 d dendritic cells (DCs) are essential innate sentinels populating host-environment interfaces.

232 t of tissue-resident macrophages serves as a sentinel population against invading microorganisms whil

233 lowing PCV13 vaccination in the claims-based Sentinel/Postlicensure Rapid Immunization Safety Monitor

234 ere explored in the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) from 2

235 influenza vaccine are reported from Canada's Sentinel Practitioner Surveillance Network (SPSN).

236 ric datasets of the community-based Canadian Sentinel Practitioner Surveillance Network, spanning 201

237 m the Royal College of General Practitioners sentinel primary care network on consultations with pati

238 Using claims data of participating Sentinel/PRISM data-providing organizations, PCV13 vacci

239 This national, sentinel prospective study aimed to identify children wi

240 wild dwarf mongooses (Helogale parvula) [5]; sentinels (raised guards) use various vocalisations to p

241 Recent immigrants acted as sentinels rarely and significantly less often than resid

242 ed since the virus was first discovered in a sentinel rhesus macaque in Uganda in 1947.

243 idermal Langerhans cells (LCs), which play a sentinel role in the initiation of the immune responses

244 and associated lymphoid tissues that play a sentinel role.

245 Prospective active sentinel safety surveillance comparing the relative inci

246 with influenza-like illness (ILI) within the sentinel scheme run by the Royal College of General Prac

247 We examined quantities of sentinel services using an analogous approach.

248 We describe findings from sentinel site bacterial meningitis surveillance in child

249 ed bacterial meningitis were analyzed at the sentinel site laboratory (SSL) by microscopy, culture, a

250 imens were collected and tested first at the sentinel site laboratory with conventional microbiology

251 art of World Health Organization-coordinated sentinel site surveillance for pediatric bacterial menin

252 nt data from 2010 to 2016 collected at the 2 sentinel sites in Ghana.

253 served DBLalpha domain of var genes from six sentinel sites in Uganda we found that the parasites cau

254 This was a descriptive study with 28 sentinel sites reporting laboratory-confirmed CRS cases

255 culture-based febrile illness in 13 African sentinel sites with previous reports of typhoid fever: B

256 infection of less than 5% aggregated across sentinel sites, and the elimination target was defined a

257 y-intensity infection of less than 1% in all sentinel sites.

258 .192), meaning that 69% is missing, with the sentinel SNP of the largest eQTL explaining 87% (0.052/0

259 atistically significant associations between sentinel SNPs and case-control status have been replicat

260 One would like to choose sentinels so that they discover the outbreak as early as

261 rm supporting the contention of the dog as a sentinel species for human exposure.

262 As seabirds are sentinel species of marine ecosystem health, such declin

263 apex predators, predatory birds represent a sentinel species similar to humans.

264 Dragonflies are sentinel species that are key invertebrate predators in

265 cal prospective data from the United Kingdom Sentinel Stroke National Audit Programme (January 1, 201

266 4 other hospitals in England and Wales using Sentinel Stroke National Audit Programme data.

267 Controlling for patient characteristics and Sentinel Stroke National Audit Programme hospital score,

268 ESD service models (derived from Sentinel Stroke National Audit Programme postacute organ

269 alian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS) clinic network.

270 nza disease burden worldwide rely on passive sentinel surveillance at health clinics and hospitals th

271 ipliers to account for underascertainment in sentinel surveillance data.

272 e establishment of a continent-wide enhanced sentinel surveillance for carbapenemase-producing Entero

273 within 24 hours of hospital admission during sentinel surveillance for severe acute respiratory illne

274 of meningitis in children <5 years old from sentinel surveillance hospitals in 26 countries were cla

275 e Trust Clinical Research Programme has done sentinel surveillance of bacteraemia since 1998.

276 We document findings from hospital-based sentinel surveillance of bacterial meningitis among chil

277 ork (FluCAN) is an Australian hospital-based sentinel surveillance program.

278 about cholera outside of limited historical sentinel surveillance sites.

279 and adult (aged 18 years) CDI in a national sentinel surveillance study.

280 screening, HIV/STI bio-behavioural surveys, sentinel surveillance, and epidemiology studies.

281 The Sentinel System also offers enhanced capabilities, inclu

282 This review summarizes the Sentinel System and its ability to rapidly generate high

283 The Sentinel System is a national electronic postmarketing r

284 ge selection of flexible analytic tools, the Sentinel System permits rapid and secure analyses, while

285 man LL-37) and functions as an extracellular sentinel that activates the cell envelope stress respons

286 te lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection f

287 cells are ideally positioned as chemosensory sentinels that can detect and relay information from div

288 er these different constraints are therefore sentinels that can provide insight into the underlying h

289 Epithelial cells are primary airway sentinels that communicate with second-order P2RY1 neuro

290 ary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and couple

291 We deployed BG-Sentinel traps at heights of 0, 5, 10, and 15 m in trees

292 apenem-resistant Enterobacteriaceae (CRE) in sentinel US hospitals.

293 Here, we describe a concept of "Ocean Sentinel" using animals equipped with state-of-the-art l

294 of the causal candidates were nearest to the sentinel variant at the investigated molecular QTLs, ind

295 We identified a single sentinel variant in the GRK5 locus (rs10886430-G, p = 3.

296 based algorithm discerning eight independent sentinel variants, carrying considerable risk prediction

297 ulation we randomly selected two sets of ten sentinel villages for monitoring, one at baseline and th

298 onducted from May 2013 to December 2014 in 4 sentinel villages.

299 Ocean Sentinel was also able to provide unpreceded information

300 We consider the concept of FG sentinels, which signal to sleep-regulating circuits tha