ライフサイエンスコーパス: sequence conservation

1 ent studies, would then be less dominated by sequence conservation.

2 rising homology to MMACHC despite their poor sequence conservation.

3 ytosolic domain is conserved despite limited sequence conservation.

4 NP proteins share a relatively high level of sequence conservation.

5 ponses not elicited by VACV despite complete sequence conservation.

6 ities to bind and activate each other and on sequence conservation.

7 t function, when combined independently with sequence conservation.

8 n-single-copy genes, and they exhibit higher sequence conservation.

9 the use of relative entropy as a measure of sequence conservation.

10 ructure across species despite low levels of sequence conservation.

11 onarily conserved, despite a lack of overall sequence conservation.

12 amework can identify ncRNAs that lack strong sequence conservation.

13 r of domains comprising a var gene and their sequence conservation.

14 f <1, which is indicative of high amino acid sequence conservation.

15 nserved genomic locations without detectable sequence conservation.

16 with functionality conserved despite limited sequence conservation.

17 r/enhancer region by examining cross-species sequence conservation.

18 f race and ethnicity, mutation location, and sequence conservation.

19 d genes, however, Nanog shows relatively low sequence conservation.

20 we reasoned that this would be reflected in sequence conservation.

21 cation from genomic sites that lack apparent sequence conservation.

22 vast fungal lineage, with a 300aa region of sequence conservation.

23 conformational flexibility, and evolutionary sequence conservation.

24 virus, but they do not share any substantial sequence conservation.

25 omplexes with DNA segments that share little sequence conservation.

26 and two internal helices with high codon and sequence conservation.

27 spatial orientation of residues that drives sequence conservation.

28 f the GRD that displays the highest level of sequence conservation.

29 nserved nested double-pseudoknot and minimal sequence conservation.

30 o regions of DNA that are AT-rich, with poor sequence conservation.

31 ound fatty acid desaturases based on overall sequence conservation.

32 modeling variant effects, often emphasizing sequence conservation.

33 ne design but are not reliably identified by sequence conservation.

34 oth protein sequence and corresponding crRNA sequence conservation.

35 ha for 14 substrates with varying degrees of sequence conservation.

36 stinct NP binding profiles despite extensive sequence conservation.

37 may be placed on RNA structure more so than sequence conservation.

38 conserved secondary structures, rather than sequence conservation.

39 for enhancer activity without assumptions on sequence conservation.

40 reactivity and influenced by T cell epitope sequence conservation.

41 h these N-terminal regions have only limited sequence conservation.

42 ed by combining correlation information with sequence conservation.

43 enerally exhibited more-stringent amino acid sequence conservation (2 substitutions identified) than

44 re highly syntenic and show a high degree of sequence conservation (20 nucleotide substitutions per k

45 Analysis of the similarity in patterns of sequence conservation across a large set of eukaryotes c

46 Rep N terminus that displays high amino acid sequence conservation across all geminivirus genera.

47 omeric structure in mature virions with high sequence conservation across different IAV subtypes, whi

48 ntal conditions can show similar patterns of sequence conservation across phylogenetic clades.

49 Sequence conservation across species and a higher abunda

50 ination consistent with the relative lack of sequence conservation across species within the CD86 cyt

51 d adult human retinal neurons based on their sequence conservation across species.

52 Examination of the sequence conservation across vertebrate and invertebrate

53 hese sites in multiple species indicate that sequence conservation alone is insufficient to identify

54 Sequence conservation also indicates highly conserved su

55 Absolute sequence conservation among 28 orthologs of residues at

56 Extensive sequence conservation among carrier proteins suggests th

57 r therapeutic/vaccine design due to its high sequence conservation among ebolaviruses.

58 Given the high degree of sequence conservation among GP of Ebola viruses, it woul

59 ls in heterosubtypic protection, despite low sequence conservation among known MHC-II restricted epit

60 There is strong sequence conservation among most of the put sequences, b

61 ral proteins are often assessed by examining sequence conservation among natural strains, but this ap

62 We show that lack of sequence conservation among orthologs of CG15460 and CG1

63 ibed region of APeg3 displays high levels of sequence conservation among placental mammals, but witho

64 Despite low primary sequence conservation among the archaeal Nop56/58 homolo

65 f pathogenic SFG rickettsiae and, due to its sequence conservation among these species, we predict th

66 ed human micro-exons exhibit a high level of sequence conservation, an indicator of functionality.

67 Sequence conservation analysis confirms the importance o

68 data, free energy minimization and structure-sequence conservation analysis for type A influenza.

69 Structure-based sequence conservation analysis reveals a conserved hydro

70 These data combined with sequence conservation analysis suggest that Glu-292 is t

71 Sequence conservation analysis suggested that this regio

72 e several features of active miRNAs, such as sequence conservation and AGO1 association.

73 an algorithm for the detection of regulatory sequence conservation and applied it to phytohormone REs

74 Sequence conservation and co-variation of base pairs are

75 dozen subfamilies, of which we profile both sequence conservation and composition.

76 imensional structure and the other utilizing sequence conservation and detecting all types of effects

77 zation of these 44 strains demonstrated both sequence conservation and diversity among simian PBVs an

78 aches are revealing the relationship between sequence conservation and functional use of cis-regulato

79 hese findings identify a direct link between sequence conservation and genomic function of regulatory

80 Sequence conservation and homology modeling suggested th

81 ancers is of greater importance than overall sequence conservation and is indicative of enhancer func

82 identified lincRNAs showed little signal for sequence conservation and mapped antisense to clusters o

83 The high degree of sequence conservation and mapped disease-associated muta

84 and two tolerant species, revealed extensive sequence conservation and microcolinearity, but grouping

85 Incorporating sequence conservation and network-level features, we hav

86 subject to skipping in S. pombe reveals high sequence conservation and perfect length conservation wi

87 (rtCD80/86) that shows the highest degree of sequence conservation and phylogenetic relationship with

88 cessary to truncate both constructs based on sequence conservation and predicted secondary structural

89 ferences in gene neighborhood and amino acid sequence conservation and present the crystal structures

90 e was no overall strong relationship between sequence conservation and replicative capacity.

91 We used sequence conservation and ribosome binding site models t

92 mplete sequences under a model using primary sequence conservation and secondary structure informatio

93 opensity for disorder, sequence composition, sequence conservation and selected putative structural p

94 Seed enhancers have increased sequence conservation and show preferential usage in dow

95 et genes they control, even though they lack sequence conservation and sometimes produce divergent pa

96 l tools are usually based on the analysis of sequence conservation and structural properties of the m

97 Despite high sequence conservation and structural similarity in the N

98 al implications for the relationship between sequence conservation and structural similarity.

99 However, some types of ncRNA lack strong sequence conservation and tend to be missed or mis-align

100 ulence is surprising given the high level of sequence conservation and the wide range of phenotypic t

101 RNAs are more highly expressed, have greater sequence conservation, and are more likely to drive canc

102 They lack ribosome occupancy, sequence conservation, and known localization signals, a

103 , frequency, location, statistical strength, sequence conservation, and other properties offers a uni

104 ding: short sequence length, lack of primary sequence conservation, and the importance of secondary s

105 Sequence conservation, animal models, and protein struct

106 proteins (NgTet1), which shares significant sequence conservation (approximately 14% identity or 39%

107 ecause of their repeat structure and lack of sequence conservation, are difficult to assemble and com

108 stinctive structural features that, based on sequence conservation, are likely to be characteristic o

109 Using phylogenetic sequence conservation as a guide, we have identified sev

110 These observations have led to the use of sequence conservation as a proxy for functional conserva

111 Synteny and sequence conservation, as well as deletions and insertio

112 and ETV4, that are highly prevalent and show sequence conservation at HOT loci.

113 and G3) exist according to the extent of DNA sequence conservation at the 3' end of the leader.

114 Given the high degree of sequence conservation at the interaction interface, we t

115 Despite only moderate sequence conservation at the protein level, key features

116 However, sequence conservation based approaches have limited abil

117 Consistent with sequence conservation-based predictions, we show that SA

118 Remarkably, despite the high degree of sequence conservation between actn2 and actn3, the pheno

119 Additionally, there is no sequence conservation between BV- and HSV-encoded miRNAs

120 Here, we report that, despite extensive sequence conservation between Cdk4/cyclin D1 (hereafter

121 Until recently, the high sequence conservation between homoeologous genes, togeth

122 Although there is no sequence conservation between human and zebrafish RPT, a

123 The sequence conservation between NgTet1 and mammalian Tet1,

124 Relatively high sequence conservation between plant CESAs allowed mappin

125 Differences in sequence conservation between plants and animals are lik

126 s not expected given the very high degree of sequence conservation between promoters.

127 distribution, tissue-specific regulation and sequence conservation between species, as well as to pre

128 human and 804 mouse miRNAs and showed strong sequence conservation between species.

129 st conformational flexibility show the least sequence conservation between TEG sulfotransferases.

130 On the basis of the sequence conservation between the C-terminal half of Opi

131 In spite of the high degree of amino acid sequence conservation between TraM proteins, many of the

132 Due to their short lengths and low sequence conservation, BH3 motifs are not detected using

133 in architecture resembles, despite a lack of sequence conservation, both trigger factor, a ribosome-b

134 Most prediction methods exploit evolutionary sequence conservation but do not consider the interdepen

135 wide spectrum of protein features that lack sequence conservation but have similar amino acid charac

136 Mononegavirales phosphoproteins lack sequence conservation, but contain all large disordered

137 However, despite genomic sequence conservation, changes in protein interactions c

138 (a PSSM or HMM) that captures the pattern of sequence conservation characteristic to a protein family

139 of 17 sequence hexamers exhibiting increased sequence conservation combined with evidence of position

140 location, gene expression, and evolutionary sequence conservation data to score putative gene neighb

141 also revealed that ComGC displays extensive sequence conservation, defining a monophyletic group amo

142 ultiple criteria including motif enrichment, sequence conservation, direct sequence pileup, nucleosom

143 se data provide a clear case where a lack of sequence conservation does not imply a lack of conservat

144 D1 protein and reveals that species-specific sequence conservation does not necessarily predict patho

145 cal role in neuronal firing and their strong sequence conservation during evolution, it is not surpri

146 Despite extensive sequence conservation, each leukotoxin has unique proper

147 to detect from sequence data because of low sequence conservation, few known conserved catalytic sit

148 the limitations inherent in the use of deep sequence conservation for identifying functional sequenc

149 othesis in Salmonidae, which predicts higher sequence conservation for mORs than ora.

150 The graphic output shows the profile of sequence conservation for the query and the most similar

151 Although these sites rarely showed sequence conservation from fish to mammals, surprisingly

152 differ in expression level, 3'UTR length and sequence conservation from unlocalized mRNAs.

153 tructure, and we found that, on the basis of sequence conservation, functionally important residues m

154 The observed associations between sequence conservation, gene architecture and repertoire

155 Integrating sequence conservation, gene expression data, gene functi

156 As predicted by polypeptide sequence conservation, Gon4l interacted and co-localized

157 contain this domain, but their generally low sequence conservation has made functional classification

158 Extreme noncoding-sequence conservation has successfully predicted enhance

159 de composition of 3' UTR sequences and their sequence conservation have been appreciated since mammal

160 A study of D1 protein sequence conservation highlighted features shared with m

161 tes has been suggested to lie behind loss of sequence conservation; however this has not been experim

162 in accessibility, histone modifications, and sequence conservation identified regions within the firs

163 Structure and sequence conservation imply that other paramyxovirus mat

164 or sRNA-induced growth inhibition along with sequence conservation in a related Caulobacter species l

165 High levels of sequence conservation in ACDs from mammalian sHSPs sugge

166 surface loops on BirA, two of which exhibit sequence conservation in all biotin protein ligases and

167 tagenesis results versus those inferred from sequence conservation in an alignment of 156 class A bet

168 RtcB sequence conservation in archaea and in eukaryotes impli

169 nding sites, coinciding with regions of high sequence conservation in beta-trefoil domains 1 and 3.

170 ation and helps explain the apparent lack of sequence conservation in chloroplast TPs.

171 ovide surprising evidence that, despite deep sequence conservation in DNA-binding domains, the functi

172 roperties were suggested by a high degree of sequence conservation in functionally important regions

173 es: amino acid type, catalytic function, and sequence conservation in homologous proteins.

174 Strong protein sequence conservation in mammalian lineages, particularl

175 s that not all sites in M1 that exhibit high sequence conservation in nature are under strong constra

176 This pattern corresponded to sequence conservation in nontuberculous mycobacteria (NT

177 correlation with serological reactivity and sequence conservation in other allergens.

178 Overall, our results show that sequence conservation in Ras depends strongly on the bio

179 These data, as well as sequence conservation in SpoIIID binding sites, were use

180 so have used RNA-Seq to assess the degree of sequence conservation in tandem array genes and found th

181 lindromic repeats play a role in maintaining sequence conservation in the absence of homologous recom

182 In contrast to complete amino acid sequence conservation in the AR DNA and ligand binding d

183 l developmental gene, even in the absence of sequence conservation in the fish genome.

184 Judged from sequence conservation in the known GatCAB sequences, the

185 s the extent of loop nucleotide evolutionary sequence conservation in the Psi-modified P6.1 structure

186 Based upon the sequence conservation in the rescuing homologs, a minima

187 Next we investigate sequence conservation in the vicinity of editing sites b

188 psid proteins, and similar organizations and sequence conservation in their DNA packaging machinery a

189 alian-expressed lincRNAs show higher primary sequence conservation in their promoters and exons, incr

190 issues in basic transcription mechanisms and sequence conservation in these algae.

191 ozygous cell lines, we demonstrate extensive sequence conservation in two common Asian MHC haplotypes

192 Sequence conservation indicates that these structural fe

193 Sequence conservation indicates that this domain is an i

194 Sequence conservation indicates this rotary mechanism is

195 egrating both evolutionary coupling (EC) and sequence conservation information through an ultra-deep

196 T structures based on fold stability, pocket sequence conservation is coincident to native.

197 Although sequence conservation is commonly used to decipher gene

198 PEP mutase sequence conservation is strongly correlated with conser

199 We show that in this case sequence conservation is the dominating factor in SCA, a

200 We reveal that loss of sequence conservation is the result of relaxed selection

201 ins, MYC proteins carry five regions of high sequence conservation known as Myc boxes (Mb).

202 exons, transposable element composition, and sequence conservation level across legume species.

203 Based on sequence conservation, MAF, and location on a complete m

204 Sequence conservation mapping to the surface of the stru

205 Sequence conservation near the TMD of IFNAR1 is low, sug

206 Herein, we examined the sequence conservation of ANTAR domains to find residues

207 evolutionary assessments reveal a remarkable sequence conservation of delta-HXTXs despite their deep

208 The high sequence conservation of druggable pockets of closely re

209 We examine sequence conservation of EO053 within the Schizophora, a

210 dies, as well as studies on the evolutionary sequence conservation of eRF1.

211 Spatial and sequence conservation of key residues indicates that thi

212 s of cleavage are species-specific, with low sequence conservation of PmpD across the genus.

213 DNA search for clusters of short motifs and sequence conservation of the -2 kb promoter region of pa

214 The high sequence conservation of the 120 human SH2 domains poses

215 The unique structure and high sequence conservation of the 5' UTR render the IRES RNA

216 Compared to avi- and orthohepadnaviruses, sequence conservation of the core, polymerase, and surfa

217 curacy was found to correlate inversely with sequence conservation of the epitope.

218 Based on the high sequence conservation of the loop-helix domain, our arti

219 functional elements, explaining the minimal sequence conservation of the NTDs in the Ulp2/SENP6 fami

220 The high sequence conservation of the residues coordinated to Fe1

221 B-block histidine and for the near absolute sequence conservation of this residue.

222 ic analysis shows a correlation between high sequence conservation of TMDs of cytokine receptors and

223 ard approaches, we could previously identify sequence conservation only in some Paramyxovirinae.

224 Several rules based on sequence conservation or location, relative to a transcr

225 contain multiple SAMP repeats that lack high sequence conservation outside of the Axin-binding motif.

226 member by virtue of its cysteine spacing and sequence conservation over functionally important residu

227 Sequence conservation patterns confirm the importance of

228 The analysis of sequence conservation patterns has been widely utilized

229 s chosen based on structural information and sequence conservation patterns observed among members of

230 e search algorithm was based on evolutionary sequence conservation patterns observed for yeast prion

231 eted a detailed quantitative analysis on the sequence conservation patterns of subdomains of KCNQ1 an

232 at intergenic lncRNA have substantially less sequence conservation patterns than protein-coding genes

233 known Tpx crystal structures and analyze the sequence-conservation patterns among nearly 300 Tpx sequ

234 rium of variants with known GWAS signals and sequence conservation (phastCons), the proposed method p

235 In addition to low sequence conservation, poor understanding of structural

236 Understanding how the sequence conservation profile relates in space requires

237 lassifications of proteins, based on primary sequence conservation, protein size, and domain architec

238 an be readily produced as a result of strong sequence conservation, providing new insights into the d

239 Conserved CRE function is associated with sequence conservation, proximity to coding genes, cell-t

240 r with their lack of fixed structure and low sequence conservation raise a question about the impact

241 sperm, involving several processes including sequence conservation, rapid turnover, stochastic losses

242 important for their degradation despite poor sequence conservation, redefining the D-box as a 12-amin

243 ses of these genomes demonstrated remarkable sequence conservation, regardless of geographic origin,

244 study was designed to examine in detail CTT sequence conservation relative to gp120 and the gp41 ect

245 About half of the proteins display sequence conservation relative to other Diptera, and low

246 across taxonomic orders due to their lack of sequence conservation relative to protein coding genes.

247 Meanwhile sequence conservation remains by far the most influentia

248 is of position, frequency of occurrence, and sequence conservation revealed significant enrichment an

249 regulatory function in the absence of overt sequence conservation, revealing an entire class of func

250 Therefore, despite the lack of sequence conservation, Schizosaccharomyces centromere DN

251 Analysis of sequence conservation showed that nsSNP at highly conser

252 and by >or=50% over methods that make use of sequence conservation signal only.

253 in fidelity regulation and that, despite low sequence conservation, some determinants of RdRp nucleot

254 or binding Gbetagamma but not Galphaq, Using sequence conservation, structural analyses, and mutagene

255 Such universal distribution and sequence conservation suggest an essential cellular role

256 Molecular dynamics simulations and primary sequence conservation suggest that the sorting signal-st

257 A IRES also lack extensive RNA structures or sequence conservation, suggesting that this viral IRES a

258 teractions are oppositely charged, and their sequence conservation suggests that IHM is present acros

259 Sequence conservation suggests that the principles of PA

260 Sequence conservation suggests that the SH4 domain regul

261 ignificantly higher mutation rates and lower sequence conservation than disease-susceptible proteins

262 in proteins contain a central region of high sequence conservation that is required for catalytic act

263 tuated with small segments of order and high sequence conservation that serve as substrate-recognitio

264 We find that despite low sequence conservation, the basic Ig fold of modern antib

265 Despite low sequence conservation, the Hp53 and Dmp53 proteins had a

266 ignored and distinguished by lack of primary sequence conservation, the linker is presumed to be intr

267 Despite low sequence conservation, the overall structure of the GRD

268 A high degree of sequence conservation, the presence of unusual tRNAs, an

269 Despite the lack of appreciable sequence conservation, the structure and beta-eliminatio

270 Despite sequence conservation, there are significant structural

271 Although Gcsfa and Gcsfb share low sequence conservation, they share significant similarity

272 n different Drosophila species using overall sequence conservation, this approach has not proven suff

273 across the non-recombining region that show sequence conservation through gene conversion and contai

274 Here, we have integrated multispecies sequence conservation, tissue-specific chromatin, in vit

275 ce analysis revealed a site of GII norovirus sequence conservation to reside under the critical alpha

276 ation via immune libraries fails due to high sequence conservation, toxicity or insufficient stabilit

277 y of features including duplication pattern, sequence conservation, transcription, protein domain con

278 able chemical modification patterns, natural sequence conservation/variations in PSTVd isolates and r

279 onserved between RFHVMn and KSHV, and strong sequence conservation was noted in specific promoters an

280 es, coevolution-based contact prediction and sequence conservation, we first identified the INTU/FUZ

281 Based on sequence conservation, we propose that Apc7 forms a homo

282 ent insecticidal effects, and high levels of sequence conservation, we propose that the delta-HXTXs w

283 rected mutagenesis, charge distribution, and sequence conservation, we propose that the HhH domain of

284 For pallilysin, lower levels of sequence conservation were observed between this protein

285 ormations across all conformations increased sequence conservation when compared to single-state desi

286 MCC has strong sequence conservation with propionyl-CoA carboxylase (PC

287 aminergic neurons, although it did not share sequence conservation with regulatory regions of otpa or

288 tone H1.0, whose globular domain shares high sequence conservation with the corresponding globular do

289 Correlating sequence conservation with the effects of mutations in E

290 n the 40S-binding domain display significant sequence conservation with the HCV IRES.

291 yeast PRELID1 homolog, Ups2p, which contains sequence conservation with the LEA domain of human PRELI

292 e same domain organization and shares strong sequence conservation with the related biotin-dependent

293 mployed a strategy that combines gnathostome sequence conservation with transgenic mouse and zebrafis

294 CNEs exhibit unexplained extreme levels of sequence conservation, with many acting as developmental

295 Analysis of sequence conservation within family GH130, mapped on a t

296 eae species, revealed a high level of global sequence conservation within the family.

297 e characterized to date solely by their high sequence conservation within the GATA DNA-binding domain

298 Sequence conservation within these regions is taken as e

299 Despite relatively little sequence conservation within this domain, ZLD orthologs

300 nstituent proteins exhibiting relatively low sequence conservation; yet the NPC as a whole retains it