ライフサイエンスコーパス: sequence diversity

1 oint mutations outside these regions of high sequence diversity.

2 hape and bonding potential, despite dramatic sequence diversity.

3 HIV-1 pathogenesis but is hampered by viral sequence diversity.

4 the TPS domains of all TpsAs, despite their sequence diversity.

5 st (e.g., A3G) factors can contribute to HIV sequence diversity.

6 RNA and Cas9 in bacteria produced remarkable sequence diversity.

7 ecretion by human plasma cells regardless of sequence diversity.

8 geographic location in order to reveal their sequence diversity.

9 n protein function while generating enormous sequence diversity.

10 merous host ligands that exhibit significant sequence diversity.

11 membrane domain, their small size, and their sequence diversity.

12 ral-like catalytic function with substantial sequence diversity.

13 methods to make accurate predictions of the sequence diversity.

14 veloping customizable DNA standards of known sequence diversity.

15 ellular immunologic coverage of global HIV-1 sequence diversity.

16 MHC molecules, CD1 proteins exhibit limited sequence diversity.

17 cal function that depends on MSA lengths and sequence diversity.

18 hat is strongly influenced by the underlying sequence diversity.

19 avoidance are the ones that display the most sequence diversity.

20 dies require the measurement of nucleic acid sequence diversity.

21 specially selected from CATH v.2.4 to ensure sequence diversity.

22 adoceran crustacean Daphnia and examined DNA sequence diversity.

23 , and its encoding gene region exhibits high sequence diversity.

24 full coverage of, and scale well with, known sequence diversity.

25 d composition compared to typically observed sequence diversity.

26 and for quantitating other viruses with high sequence diversity.

27 ce of genome damage and a means for creating sequence diversity.

28 imens in this region, revealing whole-genome sequence diversity.

29 alysis of mammalian tRNAs due to their large sequence diversity.

30 wed by next-generation sequencing, to reveal sequence diversity.

31 dulator, albeit less frequently than genomic sequence diversity.

32 nsight into epitranscriptional regulation of sequence diversity.

33 isease and correlate these with evolutionary sequence diversity.

34 Surprisingly, however, the greatest sequence diversity (79% identity) was in the less-studie

35 Sequence diversity accumulated subsequently, with the 5'

36 ized to seven variable (V) regions, and tprK sequence diversity accumulates with serial passage in na

37 ithin Stevor and Pfmc-2TM proteins possesses sequence diversity across isolate boundaries.

38 f which each possesses a region of extensive sequence diversity across paralogs and between isolates

39 FV, Nairoviridae) exhibits extensive genomic sequence diversity across strains (Deyde et al., 2006; S

40 We hypothesize that sequence diversity affects the emergence of viable recom

41 ade of ligand binding, is maintained despite sequence diversity, allowing escape from blockade antibo

42 Therefore, the existence of sequence diversity among 14-3-3s within a single organis

43 An analysis of whole genome sequence diversity among 153 A:cc5 isolates identified e

44 Sequence diversity among 2A(pro) proteases from differen

45 al similarity, helps calibrate the limits of sequence diversity among CDRs that might have a common m

46 Despite the wide range of sequence diversity among chemokines, their tertiary stru

47 In conclusion, much greater sequence diversity among EBV isolates derived from NPC b

48 The extent of sequence diversity among functional terminators and the

49 Whether sequence diversity among isodecoder tRNA genes reflects

50 es were chosen because they exhibit very low sequence diversity among maize inbreds and have sequence

51 r potential function (but also with very low sequence diversity among maize inbreds) provided some we

52 tion, despite having extremely low levels of sequence diversity among natural influenza virus strains

53 Despite the immense sequence diversity among OSS cell piRNAs, our analysis i

54 The nuclear DNA sequence diversity among the three Denisovans is compara

55 The structural and sequence diversity among these domains may be important

56 The sequence diversity among these wild mouse isolates helps

57 0 copies RNA/mL) and in the context of viral sequence diversity analysis in the plasma of viremic con

58 hese data further the understanding of viral sequence diversity and allow for high throughput documen

59 Our results give an insight into sequence diversity and categories of PQ sequences which

60 o these expression patterns, exhibiting both sequence diversity and cell type specificity.

61 y expands the boundary of known Cryptomycota sequence diversity and characterizes the phylogenetic di

62 teriocins, this is because of high levels of sequence diversity and difficulties in distinguishing th

63 Here, we report the estimates of DNA sequence diversity and divergence in a newly isolated nu

64 ine performance against the backdrop of DENV sequence diversity and evolution.

65 als, the tapasin gene appears to have little sequence diversity and few alleles and is located distal

66 a four-stranded beta-sheet domain, in which sequence diversity and glycosylation are largely segrega

67 Clone members showed high intraclonal sequence diversity and high intraclonal versatility in I

68 current vaccines are not easily adaptable to sequence diversity and immune evasion.

69 and close-to-capping units tend to have more sequence diversity and more conformational variation, it

70 Due to the high sequence diversity and mutation rate of HIV-1, viral iso

71 nd are themselves protected by extraordinary sequence diversity and N-linked glycosylation.

72 virus content, (ii) infectious titer, (iii) sequence diversity and polymorphism frequency by single-

73 The high levels of sequence diversity and rapid rates of evolution of HIV-1

74 Extraordinary viral sequence diversity and rapid viral genetic evolution are

75 sion in adult LMAN induced increases in song sequence diversity and slower song tempo more similar to

76 optimized and driven to apparent completion, sequence diversity and species abundance in the input sa

77 eriophage parABS cassettes span considerable sequence diversity and specificity, providing a suite of

78 ke vaccine design problematic, including the sequence diversity and structural variability of the sur

79 However, due to sequence diversity and the dynamics of influenza virus e

80 m flagellin proteins display a high level of sequence diversity and the flagellin produced by MRx0518

81 HIV sequence diversity and the propensity of eliciting immun

82 One strategy to address such sequence diversity and to improve the magnitude of neutr

83 The sequence diversity and variation in element patterns led

84 d from individuals with greater intrapatient sequence diversity and were associated with changes in p

85 , even though all tested variants had low V3 sequence diversity and were measurably bound by these nA

86 ribution among bacterial species, amino acid sequence diversity, and features indicative of horizonta

87 These genes were analyzed for functional and sequence diversity, and good indications that natural al

88 herently applicable to antigens that exhibit sequence diversity, and its accuracy was found to correl

89 The designs vary in parent scaffold, sequence diversity, and orientation of docked ligand, su

90 distances (p-distances) based on nucleotide sequence diversity, and plotted the median p-distance fo

91 ising from their remarkable stability, broad sequence diversity, and range of bioactivities.

92 positive selection for increased amino acid sequence diversity, and surprisingly, so does Cmicro2.

93 his diversity can be modulated by tuning the sequence diversity, and that this method compares favora

94 netic analysis of env clones revealed little sequence diversity, and weak HIV-1-specific CD8(+) T cel

95 nd structural properties despite substantial sequence diversity, apparently indicating a delicate bal

96 the efficiency of natural selection and DNA sequence diversity are expected to depend upon the effec

97 Rapid evolution and high intrahost sequence diversity are hallmarks of human and simian imm

98 nt of mechanistic variation as a function of sequence diversity are largely unknown.

99 Sequence diversity around these residues modulates TCR l

100 14 inbred lines and chose 35 genes with zero sequence diversity as potential targets of selection.

101 es indicated that HSV-1 genomes exhibit more sequence diversity, as well as geographical clustering.

102 NS5B sequence diversity assessed by deep sequencing can diffe

103 sminogen activation and contains a region of sequence diversity associated with infection and disease

104 To assess their variability, we examined sequence diversity at 11 H. ducreyi loci, including viru

105 ns were highly positional and independent of sequence diversity at other positions.

106 ne annotation and allow in-depth analysis of sequence diversity at the 5' regions of mRNA transcripts

107 At the same time the sequence diversity at the common footprints allows for b

108 he tooth, we investigated the association of sequence diversity at the SAG-binding gene of S. mutans,

109 The sequence diversity between genomes within a cluster vari

110 have previously published data demonstrating sequence diversity between hosts.

111 Despite high sequence diversity between the different genera, most pa

112 tural groups with a high level of amino acid sequence diversity between them.

113 Sequence diversity between VSGs facilitates escape of a

114 First, libraries with the same sequence diversity but built around different "framework

115 functional rationale for this long-observed sequence diversity by demonstrating that differences amo

116 with significantly increased coverage of HIV sequence diversity by including alternative amino acids

117 agenic recombination rapidly creates protein sequence diversity compared with random mutation, but li

118 ng the distal breakpoint exhibit patterns of sequence diversity consistent with neutral evolution, ye

119 ongly responsive ORs spread widely across OR sequence diversity, consistent with most other combinato

120 While much is understood about how sequence diversity contributes to this remarkable feat o

121 Examination of sequence diversity demonstrated a significant positive a

122 Patterns of sequence diversity differed between naive and vaccinated

123 idated thermostable CBH II enzymes have high sequence diversity, differing from their closest natural

124 general method for assessing human antibody sequence diversity displayed on phage using massively pa

125 We have estimated the sequence diversity due to substitutions and insertions/d

126 sequences revealed nonlinear accumulation of sequence diversity during the course of infection.

127 We show that sequence diversity exists across the entire variable reg

128 roughout a protein family to explore natural sequence diversity for desirable biocatalytic transforma

129 le novel mutagenesis strategies to introduce sequence diversity for engineering and discovery.

130 teins between sets yet maintains the maximum sequence diversity for training.

131 ophila melanogaster, the ratio of silent DNA sequence diversity for X-linked loci to that for autosom

132 s circularly permuted proteins with distinct sequence diversity from existing methods.

133 CRISPR/Cas gRNA reagents and that uncouples sequence diversity from sequence distribution.

134 The ability to study sequence diversity from world populations has allowed ex

135 nvolved in AGP biosynthesis by examining its sequence diversity, genetic architecture, phylogenetic a

136 dscape irrespective of transcript length and sequence diversity, Grad-seq promises to define function

137 etween various physical characteristics: DNA sequence diversity, hair-wavelength-specific reflectance

138 s) is a challenging task because of the high sequence diversity, heavy glycosylation, and inherent me

139 The pattern of sequence diversity here does not support a model of stro

140 from the United Kingdom, revealed amino acid sequence diversity higher than that of any protein codin

141 To fully capture this sequence diversity, however, libraries containing millio

142 cular recognition, little is known about how sequence diversity impacts antibody dynamics, which is a

143 lts show that (i) EV-A71 strain type and RNA sequence diversity impacts recombination frequency in a

144 phages and their phylogeny, distribution and sequence diversity imply lateral transfers between bacte

145 Sequence diversities in the G protein second hypervariab

146 Analysis of sequence diversity in 10.9 kb covering the complete codi

147 By studying SIV sequence diversity in 44 MHC-typed SIV-infected pigtail

148 We describe patterns of DNA sequence diversity in a newly identified sex-linked gene

149 crossover role for MSH2 in regions of higher sequence diversity in A. thaliana.

150 The most commonly reported estimates of DNA sequence diversity in animal populations are haplotype d

151 play, libraries can be designed that present sequence diversity in architecturally distinct, biologic

152 struction suggested relatively low bacterial sequence diversity in both ice samples, metagenomic anal

153 solates were due to introgression in mapA or sequence diversity in ceuE The results of this study ill

154 crease in human immunodeficiency virus (HIV) sequence diversity in drug resistance surveillance speci

155 describe contrasting levels and patterns of sequence diversity in genes encoding three MSP-1-associa

156 ealogies, but the extremely low Y chromosome sequence diversity in horses has prevented the reconstru

157 rison of these sequences revealed amino acid sequence diversity in MAP1 (89% identity), which is know

158 by these enzymes and also correlate with P5' sequence diversity in naturally occurring Bowman-Birk in

159 model enables an assessment of the expected sequence diversity in new HIV-1 infections originating f

160 The findings suggest that sequence diversity in Pfhrp2 and Pfhrp3 genes in Indian

161 ltiple different ancestral origins increases sequence diversity in plasma for reasonable fitness land

162 puleucel-T treatment resulted in greater TCR sequence diversity in resected prostate tissue in sipule

163 genomic analysis, we found higher within-ST sequence diversity in ST615 compared with ST306 and dete

164 uence (CDS), indicating the presence of high sequence diversity in the 3'UTRs of orthologous genes.

165 classification and fine characterization of sequence diversity in the 6 CDRs are presented.

166 tudy, e.g. 25% of the core genes with higher sequence diversity in the Campylobacter jejuni and Neiss

167 ese genes showed very low degrees of allelic sequence diversity in the coding regions, introns, and f

168 Tracing sequence diversity in the gene encoding domain 1 of the

169 ssaging, and the results showed that overall sequence diversity in the IBV population increased but t

170 We also compared mitochondrial sequence diversity in the Malagasy with a manually curat

171 uced vlhA allele switching indirectly drives sequence diversity in the passenger sialidase gene of M.

172 However, functional sequence diversity in the RBS has not been fully explore

173 io of full-length versus partial-length (V4) sequence diversity in the SILVA sequence database, we fu

174 them vulnerable to false negatives caused by sequence diversity in the template.

175 f gastroenteritis is hampered by the lack of sequence diversity in those regions of the genome chosen

176 (d)/AH1-specific T cells and an expansion of sequence diversity in treated mice.

177 represent a novel mechanism contributing to sequence diversity independently of DNA mutations.

178 g a toggle-peptide approach, which takes HIV sequence diversity into account, and a novel, boosted cy

179 troelements (DGRs) introduce vast amounts of sequence diversity into target genes.

180 The sequence diversity introduced through shuffling efficien

181 HIV-1 sequence diversity is a major barrier limiting the capab

182 HIV-1 sequence diversity is affected by selection pressures ar

183 ance and an overwhelming amount of small RNA sequence diversity is contributed by distinct classes of

184 It is thus of interest to test whether Aly8 sequence diversity is elevated due to close linkage to t

185 B cell receptor sequence diversity is generated by a random recombinatio

186 s that bind the desired class of ligands and sequence diversity is introduced at residues typically i

187 Sequence diversity is lowest in a 2-kb portion of intron

188 This functional sequence diversity is made possible by pervasive epistas

189 We show here that mitochondrial DNA sequence diversity is reduced in non-ratite birds compar

190 Together, the data suggest that ITAM sequence diversity is required for optimal TCR signal tr

191 ades of independent passage, only minor tprK sequence diversity is seen among the Nichols strains fro

192 osely related prokaryotic groups reveal that sequence diversity is typically organized into distinct

193 ith complementarity-determining region (CDR) sequence diversity, length variability, and main-chain c

194 the footprints of SA polymorphisms, based on sequence diversity levels in S. latifolia PAR genes iden

195 othesized that viral characteristics such as sequence diversity may play a role in driving HIV-associ

196 improve the accuracy and reproducibility of sequence diversity measurements.

197 tion.IMPORTANCE HIV-1 has exceptionally high sequence diversity, much of which is found within CD8 ep

198 ate receptors, ligands, and catalysts having sequence diversities nearer to that displayed by protein

199 The sequence diversity necessary for WC1 genes to function a

200 Furthermore, increasing gRNA sequence diversity negatively affects gRNA distribution,

201 substitutions, contrary to the extremely low sequence diversity observed across naturally occurring M

202 ration dynamics can help explain the low DNA sequence diversity observed among isolates of M. tubercu

203 persistent problem, due to the high level of sequence diversity observed in human variable domains an

204 ies S. dioica as an explanation for the high sequence diversity observed.

205 We compared sequence diversity of 30 candidate selected and 15 refer

206 sembly cannot capture the full complement of sequence diversity of a crop species (known as the 'pan-

207 The sequence diversity of a sample is proportional to the pr

208 The sequence diversity of all CDRs was determined from 143 r

209 This method measures the sequence diversity of all clades, classifies genomes fro

210 The sequence diversity of an RNA virus population contribute

211 we review recent evidence that the enormous sequence diversity of both passenger and beta domains be

212 Sequence diversity of diploid and tetraploid Stuberosum

213 The extensive intergenotypic sequence diversity of envelope proteins E1 and E2 of HCV

214 Testing this hypothesis, we compared the TCR sequence diversity of gamma(9)delta(2) T cells expanded

215 High sequence diversity of HCV and inadequate drug exposure d

216 ned influence of multiple forces shaping the sequence diversity of HCV and other highly variable path

217 The sequence diversity of HIV-1 presents a challenge for the

218 However, the sequence diversity of HRV genotypes poses challenges for

219 The sequence diversity of human immunodeficiency virus type

220 The sequence diversity of human immunodeficiency virus type

221 proaches for accommodating the extraordinary sequence diversity of immune receptors and widely used m

222 ormed the basis of exploration of length and sequence diversity of novel insertions by insertional-sc

223 a method, called AmpliCot, that measures the sequence diversity of PCR products on the basis of DNA h

224 Methods to measure the sequence diversity of polymerase chain reaction (PCR)-am

225 olecular function often use the evolutionary sequence diversity of protein homologs to rationally gui

226 A binding preferences has been driven by the sequence diversity of short segments of relevant pathoge

227 Sequence diversity of the enhancer is significantly high

228 ntibody (bnAb) response against the enormous sequence diversity of the HIV-1 envelope glycoprotein (E

229 tator Superfamily (MFS) because of the broad sequence diversity of the members.

230 action with the exit tunnel and maximize the sequence diversity of the proteome, although allowing so

231 TCR V segment utilization, CDR3 length, and sequence diversity of the response to natural HSV-1 infe

232 cleotides either overall or according to the sequence diversity of the resulting chimeras.

233 r immune response to HIV despite significant sequence diversity of the strains of the Env immunogens

234 The size and sequence diversity of these structure-based binding land

235 from women in Malawi and Benin, we assessed sequence diversity of VAR2CSA's ID1-DBL2x region, contai

236 rimary NPC biopsy specimens and revealed the sequence diversity on a whole-genome level among these E

237 ls of viral isolates to assess the impact of sequence diversity on detection as well as quantificatio

238 y understand the role of viral evolution and sequence diversity on KSHV gene functions and pathogenes

239 We detect changes in CRISPR spacer sequence diversity over time that may be attributable to

240 m mechanism of action and enormous potential sequence diversity, peptides that inhibit virus entry co

241 Engineered antibody paratopes with limited sequence diversity permit assessment of the roles played

242 at modern cultivars have retained 72% of the sequence diversity present in the Asian landraces but lo

243 most impact was domestication; when the low sequence diversity present in the wild species was halve

244 he MgpB adhesin and the accumulation of mgpB sequence diversity previously observed in persistent hum

245 t share a basic gene structure but show high sequence diversity, primarily due to the mosaic appearan

246 motifs, recent genomic surveys reveal great sequence diversity, questioning how SD functions.

247 esviruses through genome-wide comparisons of sequence diversity, recombination, allele frequency, and

248 Among healthy donors, circulating TCR sequence diversity remained unchanged over the same time

249 e two pools starting from a low (5 x 10(12)) sequence diversity revealed that the phenotypic potentia

250 Alignment of LMW SLPs, which exhibit high sequence diversity, reveals a core of conserved residues

251 imilar conserved syntenic gene content, gene sequence diversity signatures, and phylogenetic networks

252 r peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the

253 les over others in hybrid mice and increases sequence diversity specifically at hot spots that become

254 bination events as well as to detect complex sequence diversity, such as that seen in variable multig

255 LLV displays up to 25% interclade sequence diversity, suggesting that it has been in the l

256 st 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably li

257 Molecular dating based on sequence diversity suggests an early age, of 175 Mya, fo

258 Analysis of the underlying sequence diversity suggests the presence of at least two

259 ults uncover remarkable depths in retroviral sequence diversity, supported within a phylogenetic cont

260 RBS can accommodate a much greater range of sequence diversity than previously thought, which has si

261 b(5) cytochromes exhibit greater amino acid sequence diversity than their type A (microsomal) counte

262 To illustrate the varying degree of sequence diversity that exists within cytoskeletal gene

263 s endothelial adhesion, and displays extreme sequence diversity that underpins antigenic variation.

264 ur crystal structure rationalize the binding sequence diversity that was uncovered during ChIP-chip a

265 Because of HIV's vast sequence diversity, the ability of the CD8 T-cell respon

266 However, the effectors display high level of sequence diversity, therefore making the identification

267 Despite such sequence diversity, these signals are all recognized and

268 downstream expression, that have sufficient sequence diversity to reduce homologous recombination wh

269 ary piRNAs from cleaved transposon RNAs adds sequence diversity to the piRNA pool, allowing adaptatio

270 Although the contribution of sequence diversity to this molecular recognition has bee

271 cks of SIVmac251 or SIVsmE660 that exhibited sequence diversity typical of early-chronic HIV-1 infect

272 With their sequence diversity, ultra-stable core structural motif,

273 te that the modular genetic architecture and sequence diversity underlying var-mediated host-parasite

274 RRE sequence diversity varied over the course of infection,

275 puleucel-T treatment reduced circulating TCR sequence diversity versus baseline as measured by the Sh

276 Higher sequence diversity was correlated with areas with increa

277 olecular typing method based on the 16S rRNA sequence diversity was developed for Haemophilus influen

278 Sequence diversity was high with a mean single nucleotid

279 The sequence diversity was introduced into 3-23 (V(H)) only,

280 gether by phylogenetic analysis, significant sequence diversity was observed in the VP1 gene (66.9%-1

281 ERV-DC sequence diversity was present across wild and domestic

282 Nucleotide sequence diversity was uniformly low and did not change

283 ol of viral replication and the evolution of sequence diversity, we measured EBV gp350-specific antib

284 Genotypes and sequence diversity were evaluated.

285 ma has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing

286 e's activation rate is positively associated sequence diversity, which could offer important new insi

287 We conclude that PolA1 promotes genome sequence diversity while playing an essential role in ox

288 The ability to effectively cull sequence diversity while still generating the functional

289 genotypes and (ii) correlate intergenotypic sequence diversity with functional VP1-VP2 interaction(s

290 have struggled to reconcile their limitless sequence diversity with their binding to relatively few

291 CR sequences organize into networks based on sequence diversity, with differences in network connecti

292 By examining the patterns of sequence diversity within field isolates, we have identi

293 Overall, we found less glycoprotein sequence diversity within HSV-2 than within the HSV-1 st

294 t therefore exist to differentially generate sequence diversity within select genes, as well as withi

295 en recombination rates and intron nucleotide sequence diversity within species, but no relationship b

296 To define the mechanistic implications of sequence diversity within the ETS family, we characteriz

297 DNA sequence diversity within the human genome may be more g

298 of events that may have led to the enormous sequence diversity within the MFS.

299 le-profile comparison made by COMPASS on the sequence diversity within these alignments.

300 mechanisms responsible for the generation of sequence diversity within these gene families, a charact