ライフサイエンスコーパス: sequence variability

1 and in size, in accordance with the observed sequence variability.

2 directed evolutionary pressure that enhances sequence variability.

3 patibility complex (MHC) molecule of limited sequence variability.

4 viral titer, were consistent with increased sequence variability.

5 in the V3 loop regardless of the amino acid sequence variability.

6 raries for the study of pathogens with great sequence variability.

7 T will be an important tool to study protein sequence variability.

8 rentiate between certain microbes due to low sequence variability.

9 the recombination machinery show substantial sequence variability.

10 istics, offering more profound insights into sequence variability.

11 R and R-R junctions with modest inter-repeat sequence variability.

12 distance of plasmids, as they show large DNA sequence variability.

13 nce, while the remainder of the plasmids had sequence variability.

14 performed to assess the potential effect of sequence variability.

15 performed to assess the potential effect of sequence variability.

16 proteins imposes strong constraints on their sequence variability.

17 n had additional triple overlap with reduced sequence variability.

18 tional domains in the context of significant sequence variability.

19 (RAVV), is difficult because of substantial sequence variability.

20 ided into three variants based on amino acid sequence variability.

21 ble region and sequencing platform to reduce sequencing variability.

22 The gp120s also exhibited low amino acid sequence variability (12%) in V3 and high variability (3

23 residues, enabling broad recognition despite sequence variability; accordingly, SKT05 protected mice

24 binding domain (RBD) exhibits extremely high sequence variability across embecoviruses, and we found

25 variants (SVs) account for a large amount of sequence variability across genomes and play an importan

26 quantitate the fitness of HIV-1 Gag based on sequence variability across the protein.

27 Comparing sequence variability across viral genomes allows for the

28 Regardless of sequence variability, all tRNAs fold into a relatively r

29 logous Borrelia strains despite considerable sequence variability among DbpA in these strains.

30 protein which displays remarkable amino acid sequence variability among different CMV isolates, sugge

31 Here, we report the analysis of sequence variability among high and low affinity targets

32 The identification of a region of sequence variability among individual isolates of Bacill

33 Sequence variability among NWM glycoproteins (GP) poses

34 est that this mechanism is a major source of sequence variability among retrotransposed genetic eleme

35 A major challenge is the extreme viral sequence variability among strains.

36 We have examined the nature of V3 sequence variability among subtype C human immunodeficie

37 However, sequence variability among the class 5 adhesins may hind

38 The nucleocapsid protein amino acid sequence variability among the members of the Argentinia

39 High sequence variability among xrRNAs from distantly related

40 Sequence variability analysis indicated that both human

41 Gene distribution and sequence variability analysis showed that MC001 is prese

42 We discuss the relationship between sequence variability and "evolutionary opportunity" and

43 ropose that CDI systems exploit the inherent sequence variability and active-site plasticity of PD(D/

44 conservation was measured by the amino acid sequence variability and by the ratio of nonsynonymous-t

45 binant CAP256 gp120s displaying high protein sequence variability and changes in PNGS number and posi

46 Because of their extreme sequence variability and extensive domain shuffling, sig

47 We present evidence that sequence variability and functional diversity of a gene

48 These glycoproteins exhibit a high degree of sequence variability and glycosylation, which are used a

49 The intermediate domain contains the highest sequence variability and lacks homology to structural mo

50 ited effectiveness thus far, in part because sequence variability and other structural features of th

51 ld isolate strains for a correlation between sequence variability and sigma1 cleavage.

52 ously difficult to characterize due to their sequence variability and structural complexity.

53 ger fitness effects than those inferred from sequence variability and that contribute most of the sta

54 The effect of DNA sequence variability and the degree of cyclic AMP recept

55 s raises questions about how FoxP3 adapts to sequence variability and the potential role of nucleosom

56 estimation procedure that fully accounts for sequencing variability and show that it outperforms the

57 l as sets of spike-antibody complexes, spike sequence variability, and known polymorphisms.

58 their genomic origins, biogenesis pathways, sequence variability, and newly identified products such

59 tudies suggest that despite a high degree of sequence variability, antibody recognition sites or anti

60 Sequence variability associated with human immunodeficie

61 tive estimate of the correlation between the sequence variability at a position and the fractional ac

62 n concerned, and has the ability to generate sequence variability at both selected and neutral sites,

63 by providing evolution-based expectations of sequence variability at each genomic locus.

64 by using an HIV-1 database to determine the sequence variability at each position in all expressed H

65 Finally, the sequence variability at residue positions among function

66 mation through internal base pairing limited sequence variability at these sites, an algorithm was de

67 The effect of sequence variability between different types of hepatiti

68 g both epidemics, with no significant G gene sequence variability between samples.

69 Sequence variability between the N-terminal domains of t

70 ts, 19 showed no evidence of intrasubject K1 sequence variability, but, in 7 subjects, all of whom we

71 ctions, rapidly evolving pathogens with high sequence variability, complex viral antigens, and emergi

72 line-derived sequences and displayed a high sequence variability, confirming that these AHAs underwe

73 arity in structure and the low tolerance for sequence variability, coupled with the multiple critical

74 er, significantly influenced by assay target sequence variability due to natural diversity and rapid

75 dominant, focusing immune responses, despite sequence variability elsewhere.

76 conserved but retain a surprising degree of sequence variability, especially in the nonamer and spac

77 We conclude that sequence variability exists within all toxin serotypes,

78 ed that they would contain useful nucleotide sequence variability for epidemiologic studies.

79 Analysis of nucleotide sequence variability for these in conjunction with anoth

80 ine is that of contending with the extensive sequence variability found in circulating viruses.

81 Despite the enormous sequence variability found within sensor input domains,

82 Thus, sequence variability has a profound effect on the antige

83 Sequence variability has been analyzed in the context of

84 TL, we assessed the impact that intraepitope sequence variability has upon T-cell recognition.

85 Due to its extremely high sequence variability, HCV can readily escape the immune

86 rgence, and hybridization, combined with low sequence variability, however, have prevented phylogenet

87 re selected based on hydrophilicity and high sequence variability identified by sequence comparison w

88 The amount of DNA sequence variability in a genomic region is often positi

89 Rpt2-dependent resistance and Rps2 locus DNA sequence variability in a worldwide sample of 27 accessi

90 vity is sufficient to restore high levels of sequence variability in adult birds, suggesting that rec

91 turally conserved loop with a high degree of sequence variability in all classes of sortases.

92 utics have been limited in efficacy by viral sequence variability in emerging variants of concern (VO

93 Data on DNA sequence variability in human and plant populations are

94 Sequence variability in MHC class II molecules plays a m

95 arasitic nematode, we found a high degree of sequence variability in proteins predicted to be involve

96 The sequence variability in the ABCA4 locus is extensive and

97 Sequence variability in the amplified segment of the sec

98 cies encode functional CDI systems with high sequence variability in the CdiA-CT and CdiI coding regi

99 rientations that allow it to accommodate DNA sequence variability in the cognate binding sites.

100 (HIV) were studied with regard to nucleotide sequence variability in the E2/NS1 first hypervariable r

101 Because of the unusual sequence variability in the LRRs of this class of protei

102 While sequence variability in the N-terminal domain of differe

103 ly; however, the genetic mechanisms by which sequence variability in the penaeidin gene family is gen

104 ulosis clinical isolates revealed surprising sequence variability in the pks15/1 locus and substantia

105 arental lines allowing the quantification of sequence variability in the species.

106 not TMPRSS2 or Furin, has a higher level of sequence variability in the Spike protein interaction su

107 nfectious clones of noroviruses and the high sequence variability in their capsids, it has not been p

108 ved between species despite a high degree of sequence variability in their guanine nucleotide dissoci

109 as a conserved structural property; however, sequence variability in this region modulates kinase act

110 lusive splicing allows for the generation of sequence variability in three immunoglobulin ecto-domain

111 Sequence variability in V3 among the subtype C viruses w

112 Using DNA shuffling to introduce functional sequence variability into a protein of interest, we scre

113 Intrinsic sequencing variability introducing low-level expression

114 an immunodeficiency virus (HIV)'s tremendous sequence variability is a major obstacle for the develop

115 contrast to that for subtype B HIV-1, where sequence variability is associated with such substitutio

116 Sequence variability is high in all three satellite fami

117 IV-1 isolates in sub-Saharan Africa and that sequence variability is not a feature of the V3 region o

118 Interspecies sequence variability is observed in all functional class

119 e beta-arrestins throughout their N termini, sequence variability is present at a small number of res

120 ful to date, due in part to the virus's high sequence variability leading to immune escape.

121 Despite sequence variability, M proteins share coiled-coil struc

122 The sequence variability map of the hu4D5 binding site is co

123 We hypothesized that regions of amino acid sequence variability may contain signal motifs that dire

124 Such subtype sequence variability must be accounted for when generati

125 landscape helps us understand the effects of sequence variability observed in experimental data and p

126 hese species have 11 to 14 rRNA operons, and sequence variability occurs among the multiple 16S rRNA

127 Recently, it has been discovered that sequence variability occurs in BoNTs produced by serotyp

128 This study aimed at describing the sequence variability of Lassa virus across Nigeria and i

129 However, antigenic sequence variability of M proteins into >220 M types, as

130 has proved challenging due to high levels of sequence variability of non-canonical targeting signals,

131 C virus (HCV) persistence is related to the sequence variability of putative envelope genes.

132 As expected, sequence variability of the antigen-binding site is over

133 Here we analyzed the sequence variability of the assay target region from >2,

134 Here, we analyzed the sequence variability of the assay target regions from 1,

135 cal isolates, but nothing is known about the sequence variability of the gL and gO genes.

136 (emm typing) is effective for surveying the sequence variability of the M virulence protein, and com

137 In contrast to the sequence variability of the second SH3bm, tyrosine 89, w

138 The overall sequence variability of the subtype C V3 region was no g

139 We analysed the sequence variability of the third gene (MG192 or mgpC) o

140 s, along with the unexpectedly high level of sequence variability of the UL144 ORF, suggests that the

141 The extreme sequence variability of the virus resulting from error-p

142 eer and camel was carried out to investigate sequence variability of these genes among ruminants.

143 polymerases has been hampered by the extreme sequence variability of these sequences.

144 To examine the sequence variability of this nonanucleotide promoter mot

145 Recent findings of low sequence variability of Y chromosome genes has led to su

146 ical perspective to interpret the effects of sequence variability on protein families.

147 chored" in any individual genome to quantify sequence variability or conservation at a specific locus

148 Furthermore, sequence variability predicted from TERM data agrees clo

149 in genomic efforts to define and analyze the sequence variability present among individuals within a

150 dy strategies that cope with the viral spike sequence variability, prolonging vaccine efficacy, and u

151 dynamic and interactive viral ecosystem with sequence variability ranging over 2 orders of magnitude

152 he tolerance of this metal-free fold towards sequence variability, six additional peptides resulting

153 cular stability and lineage sharing of mtDNA sequence variability suggest that mutations arise in the

154 n is old, it will have an island of enhanced sequence variability surrounding it, which represents a

155 ients confirmed that there was extremely low sequence variability surrounding the PePHD.

156 sed vaccine strategies because it shows less sequence variability than other HIV-1 proteins.

157 osed modified classifiers are more robust to sequence variability than standard SVM classifiers, impr

158 ated class 5 pilins show much higher genetic sequence variability than the remainder of the pilin pro

159 -subunit rRNA genes demonstrate much greater sequence variability than the small-subunit rRNA sequenc

160 of beta-tubulin isotypes are regions of high sequence variability that bind to microtubule-associated

161 Whereas the S1 domain contains high sequence variability, the S2 domain is conserved and is

162 Despite extensive sequence variability, the two major domains of sigma(E)

163 es must take into account the extensive BoNT sequence variability; the seven BoNT serotypes differ by

164 Some species exhibit very high levels of DNA sequence variability; there is also evidence for the exi

165 ctural probing methods, we show that despite sequence variability they contain a common three-dimensi

166 We leveraged its remarkable sequence variability to align the repeat in 288 samples

167 cule conferred the ability to overcome viral sequence variability together with outstanding potency a

168 This limited sequence variability was also a feature of subtype B V3

169 Sequence variability was assessed by direct sequence ana

170 No sequence variability was detected in the distal portion

171 virus (HCV) envelope proteins, and envelope sequence variability was examined in chimpanzees.

172 nce at the four repeats, but some nucleotide sequence variability was observed at AUGC(865-868) if th

173 CDR (CDR-H3) presents significant length and sequence variability, we find a substantial contribution

174 By incorporating E2 sequence variability, we found a number of E2 polymorphi

175 was highly polymorphic and 22 "hot spots" of sequence variability were noted.

176 ositive clinical specimens and evaluated for sequence variability, which demonstrated transmission of

177 This pocket demonstrates considerable sequence variability, which has allowed species-specific

178 ular baseline of RSV strain distribution and sequence variability with which to track the emergence o

179 resent at this locus, there is unusually low sequence variability, with the mean number of nucleotide

180 onserved core domain mediates catalysis, and sequence variability within a structurally related N- an

181 Extensive sequence variability within and between RSV group A and

182 Against the background of ovulin's high sequence variability within and between species, we have

183 This contrasts markedly with the observed sequence variability within each serotype, which is conf

184 conditions, and provides insight into viral sequence variability within infected cells.

185 B molecules have significant strain-specific sequence variability within surface-exposed regions (loo

186 ndividuals, it was possible to quantify gene sequence variability within the population.

187 mRNA start sequence can tolerate significant sequence variability without affecting G protein product