ライフサイエンスコーパス: sequential activation

1 ial lipid raft localization, and may undergo sequential activation.

2 caspase-3 cleavage product (p20), suggesting sequential activation.

3 by phosphorylation events that lead to their sequential activation.

4 y limits between traveling waves and modular sequential activations.

5 earer distinction between co-activations and sequential activations.

6 Thus, simultaneous input led to sequential activation across cortical retinotopy.

7 After this sequential activation, all four regions were simultaneou

8 ients had a single early site with focal and sequential activation along the tendon of Todaro.

9 ons of the mechanism are consistent with the sequential activation and 1,2-addition of hydrosilane ac

10 The sequential activation and destruction of CDK-cyclin acti

11 these data suggest a molecular basis for the sequential activation and inactivation of CaMKIV.

12 h the cell cycle is regulated in part by the sequential activation and inactivation of cyclin-depende

13 f eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-depende

14 nt of sporulating Bacillus subtilis involves sequential activation and inactivation of several transc

15 At later stages, including adulthood, sequential activation and inhibition of Wnt activity is

16 o super-resolution fluorescence imaging uses sequential activation and localization of individual flu

17 gh the germinal center (GC) is controlled by sequential activation and repression of key transcriptio

18 ession known as "switching" involve both the sequential activation and silencing of the individual gl

19 The sequential activation and summation of these units resul

20 le that of the mammalian type II enzyme with sequential activation by Galpha followed by Gbetagamma.

21 Sequential activation by way of alkylation of the imidaz

22 stress-triggered condensation, which we term sequential activation (Fig.

23 , the voltage-sensing domain (VSD) undergoes sequential activation from the resting state to the inte

24 A sequential activation, hydrogen-atom transfer, and halog

25 We propose a Sequential Activation Hypothesis where initial abnormal

26 er 2 and/or 3 pyramidal neurons (PNs) showed sequential activation in the mouse primary motor cortex

27 reaction through an iminium-enamine-iminium sequential activation initiated by a hetero-Michael addi

28 We present evidence of a sequential activation mechanism in the STIM1 cytosolic d

29 Kinetic analysis supports a sequential activation mechanism in which individual Btk

30 s two possible activation pathways (parallel-sequential activation model).

31 pled receptor signaling does not result from sequential activation of a linear pathway of proteins/en

32 ze target recognition and eradication by the sequential activation of a reconstituted immune system,

33 is is a cellular death process involving the sequential activation of a series of caspases, endonucle

34 t Rab along the pathway, can account for the sequential activation of a series of Rabs, but it does n

35 -dependent NF-kappaB activation involves the sequential activation of a serine kinase cascade involvi

36 erm-egg interaction causes egg activation by sequential activation of a Src-like kinase and phospholi

37 The sequential activation of a transient FPRL1 ligand and a

38 A) node is usually thought to arise from the sequential activation of a variety of ionic currents in

39 res the accumulation of arachidonic acid and sequential activation of acid sphingomyelinase for the g

40 ained, as in other hair-cell systems, by the sequential activation of alpha9/alpha10 and SK channels.

41 he PKA-I isozyme in primary T lymphocytes by sequential activation of an intracellular pathway compri

42 namics of Lgr5(+) stem cells and demonstrate sequential activation of an oncogene in established colo

43 Thus, a common toxicity of mutant SOD1 is a sequential activation of at least two caspases, caspase-

44 orm into mammary-specific mesenchyme via the sequential activation of Bone Morphogenetic Protein 4 (B

45 ry that orchestrates the innate response via sequential activation of both cell surface and endocytic

46 a pericentrin-dependent manner, and promotes sequential activation of both kinases via T-loop phospho

47 he conditions studied here, simultaneous and sequential activation of both the D and I pathways cause

48 me that EGF enhances expression of PAI-1 via sequential activation of c-Src, protein kinase C delta (

49 emma ("coupled" Ca(2+) sparks) revealing the sequential activation of Ca(2+) release sites of the j-S

50 iated store-operated Ca(2+) entry (SOCE) and sequential activation of Ca(2+)/calmodulin-dependent pro

51 en together, these results indicate that the sequential activation of caspase 3 and c-Jun participate

52 In this study, we investigated the sequential activation of caspase family members, to gain

53 of the death receptor family is promoted by sequential activation of caspase zymogens.

54 the IRF-1 promoter, induction of IRF-1, and sequential activation of caspase-1 and -3.

55 of transgenic mSOD1 mice is the site of the sequential activation of caspase-1 and caspase-3.

56 pase activation and kinetic studies show the sequential activation of caspase-8, caspase-9, and caspa

57 se in mitochondrial transmembrane potential, sequential activation of caspase-9 and -3, and a 90% dec

58 d that apoptosis in MCF-7 cells proceeds via sequential activation of caspases 9, 7 and 6.

59 Here we show the sequential activation of caspases and calpain during dru

60 optosis by thrombospondin-1 all required the sequential activation of CD36, p59fyn, caspase-3 like pr

61 llow stimulus-selective, temporally-extended sequential activation of cell assemblies.

62 er extravascular cells is exposed to plasma, sequential activation of coagulation proteases coordinat

63 Together, the results indicate that sequential activation of complement on neutrophils cruci

64 The open state then triggers the sequential activation of confined downstream signaling m

65 Pharmacological studies determined that sequential activation of CXCR4, the IL-1beta receptor, a

66 m G(1) to S phase in the cell cycle requires sequential activation of cyclin-dependent kinase 4 (cdk4

67 specific developmental stages including the sequential activation of different classes of MIKC-MADS

68 asymmetrical strengths, which also explains sequential activation of different fates.

69 ion was associated with synaptic remodeling, sequential activation of different glial cell types, lip

70 erentiation and survival are associated with sequential activation of different Notch pathway compone

71 Microendoscopic calcium imaging reveals sequential activation of distinct corticofugal neuronal

72 The sequential activation of distinct developmental gene net

73 From these results, we propose a sequential activation of DNA-PK and PARP-1 in cells arre

74 activation in Jurkat leukemia cells induced sequential activation of downstream kinases including p3

75 t greater Ca2+ influx, the delay between the sequential activation of eager sites was reduced.

76 novel signal transduction pathway involving sequential activation of Epac, PLCepsilon, PKCepsilon, a

77 The sequential activation of ERK and Rsk2 by Ca2+ leads to t

78 h which receptor-activated G(q) leads to the sequential activation of ERK1/2 and IRS2 signaling, thus

79 ible renal medullary gene expression wherein sequential activation of ERKs and Elk-1 results in incre

80 iver regeneration requires the organized and sequential activation of events that lead to restoration

81 Peroxynitrite caused the sequential activation of extracellular signal-regulated

82 esolution microscopy techniques based on the sequential activation of fluorophores can achieve image

83 Acute stress leads to sequential activation of functional brain networks.

84 protein-coupled receptor (PAR1) leads to the sequential activation of G alpha(q), Rac, Rho, and PIP5K

85 y G(q/13)-coupled receptors are initiated by sequential activation of Galpha(q)/alpha13, RhoGEF, and

86 initiated by G(i)-coupled receptors involve sequential activation of Gbetagamma(i), PI 3-kinase, and

87 sters from 3'to 5', which contributes to the sequential activation of gene expression.

88 known to be transcriptionally controlled via sequential activation of gene regulatory networks (GRNs)

89 a complex developmental event requiring the sequential activation of genes encoding the component pa

90 thelium during pregnancy is characterized by sequential activation of genes over several orders of ma

91 We conclude that sequential activation of Gs and Gi, mediated by cAMP-dep

92 Whether the pace of sequential activation of HOX genes, the 'HOX clock', is

93 First, the sequential activation of Hoxb genes controls the relativ

94 yocardium, the heartbeat originates from the sequential activation of ionic currents in pacemaker cel

95 These events lead to sequential activation of JNK and multiple BH3-only prote

96 These results highlight the sequential activation of keratinocytes, fibroblasts, end

97 According to a model of sequential activation of kinases, Syk acts downstream of

98 ed that CTGF production was mediated through sequential activation of MAPkinase and Smad-dependent pa

99 The sequential activation of master regulatory basic-helix-l

100 tream of, and that ALG-3 interferes with the sequential activation of members of the ICE family prote

101 ulated maturation process characterized by a sequential activation of Merkel cell-specific genes.

102 A two-step sequential activation of MT1-MMP is likely to include th

103 n proves that this improvement is due to the sequential activation of multiple deformation mechanisms

104 These differences suggested a sequential activation of multiple EMT molecular programs

105 wn as central pattern generators produce the sequential activation of muscles needed for locomotion.

106 c triggers microglial activation through the sequential activation of NADPH oxidase, PARP-1, and NF-k

107 Sequential activation of neurons has been observed durin

108 The sequential activation of neurons has been observed in va

109 Sequential activation of neurons is a common feature of

110 This would allow sequential activation of neutrophil degranulation in the

111 xes are essential initiators of arthritis by sequential activation of neutrophils and mast cells to a

112 Sequential activation of NF-kappaB and an increased Gata

113 estration of an immune cascade involving the sequential activation of NK cells, cDCs, and CD8(+) T ce

114 nsient subsecond firing responses in CINs by sequential activation of NMDA, D2-type, and D1-type rece

115 and postsynaptic spikes instead requires the sequential activation of NMDARs followed by voltage-sens

116 of excess electron transport, we uncover the sequential activation of non-radiative energy dissipatio

117 depend on an increase in cytosolic Ca2+ and sequential activation of NOX5-S and NF-kappaB in SEG1 ce

118 s under anesthesia, we identified a reliable sequential activation of NR neurons at the beginning of

119 Breathing, for example, involves the sequential activation of numerous muscles hypothesized t

120 redox cycling at the metal center to effect sequential activation of O(2) and the substrate.

121 type of pancreatic malignancy, involves the sequential activation of oncogenes and inactivation of t

122 d prolonged phosphorylation of ERK1/2 led to sequential activation of p90RSK and CREB, which conseque

123 an indomethacin-sensitive pathway involving sequential activation of phospholipase C, mobilization o

124 ression and cell proliferation may depend on sequential activation of PI-PLCgamma2 and ERK2 MAP kinas

125 ing from Ras to Tsp-1 repression induces the sequential activation of PI3 kinase, Rho and ROCK, leadi

126 novel platelet activation pathway involving sequential activation of PI3K, Akt, nitric-oxide synthas

127 betaPMA exerts its effects on HCN gating via sequential activation of PKC and diacylglycerol kinase (

128 ulate cPLA2-mediated AA release only through sequential activation of PKC and MAP kinase.

129 iments provided additional evidence that the sequential activation of PKCepsilon, mitogen-activated p

130 Sequential activation of place cells was not required fo

131 e and maintain synaptic plasticity-dependent sequential activation of PNs during motor skill learning

132 ermore, the control of SST interneurons over sequential activation of PNs required CaMKII-dependent s

133 ts recapitulated apoptotic events, including sequential activation of procaspase-9 and procaspase-3 a

134 orage proteins in the MVBs may allow for the sequential activation of processing proteases as the MVB

135 n wavelengths (365, 405, and 760 nm) for the sequential activation of protein function in live cells.

136 nts of signal transduction cascades in which sequential activation of protein kinases culminates in t

137 ar tyrosine kinase cascade that involves the sequential activation of PYK2 and Src.

138 motes tumor metastasis in prostate cancer by sequential activation of Pyk2, FAK, MAPK, and Akt follow

139 The addition of agrin induces the sequential activation of Rac and Rho in C2 muscle cells.

140 t the CB1R, through G alpha(o), mediates the sequential activation of Rap1 to Ral to Src to Stat3 in

141 in complex including Shc, Grb2, and Sos, and sequential activation of Ras, Raf, and MEK.

142 vior lordosis, a behavior dependent upon the sequential activation of receptors for the ovarian stero

143 actin cytoskeleton are closely linked to the sequential activation of Rho GTPases through PI 3-kinase

144 This analysis reveals how sequential activation of sets of transcription factors s

145 Inflammation involves the sequential activation of signaling pathways leading to t

146 For example, during planning, sequential activation of spatial cells may enable simula

147 Lastly, after arrival at the goal, sequential activation of spatial cells may represent the

148 programmed cell death in many cells involves sequential activation of specific caspases, we tested th

149 Skeletal development is programmed by the sequential activation of specific genetic pathways that

150 king of GPVI mediates activation through the sequential activation of Src and Syk family kinases and

151 at platelet spreading on fibrinogen requires sequential activation of Src and Syk in proximity to alp

152 n matrix assembly through the uPAR-dependent sequential activation of Src kinase, EGFR, and beta1 int

153 Sequential activation of Src, mitogen-activated protein

154 ditional inhibitor studies revealed that the sequential activation of Src, p38 MAPK, EGFR, and p38 MA

155 esults in JNK activation, which requires the sequential activation of Src, Rac1, and JNK.

156 veal a regeneration program characterized by sequential activation of stage-specific pathways, regula

157 Therefore, nonoverlapping, sequential activation of STAT3 and STAT5, achievable by

158 sm of two beta-arrestins is mediated through sequential activation of sterile alpha motif domain cont

159 osensory evoked potential primarily reflects sequential activation of supragranular and infragranular

160 e for discrete medullary pathways subserving sequential activation of swallowing reflexes.

161 Thus, sequential activation of synaptic then extrasynaptic NMD

162 oth muscle following vagotomy is mediated by sequential activation of tachykinin-containing spinal af

163 Cortical current densities revealed the sequential activation of temporal regions, from the occi

164 The salient feature of the strategy involves sequential activation of terminal and internal alkynes l

165 GF in the parietal cells are mediated by the sequential activation of the Akt and the Shh signal tran

166 case of the soft selenium Lewis acid PhSeCl, sequential activation of the alkyne bonds leads initiall

167 itor MAD2L2 also contributes to ensuring the sequential activation of the APC/C by CDC20 and CDH1.

168 We have previously demonstrated that sequential activation of the bacterial ilvIH-leuO-leuABC

169 These signals cause the selective, sequential activation of the calcium-dependent, proline-

170 , interestingly, dependent on the apparently sequential activation of the dantrolene-sensitive, nonre

171 pe 1 TNF-alpha receptor tail, leading to the sequential activation of the downstream NF-kappaB-induci

172 beta-cell proliferation and survival through sequential activation of the epidermal growth factor rec

173 Activation of Ras, in turn, leads to sequential activation of the following three serine-thre

174 Sequential activation of the inducing factors NGN3 and P

175 on of the catalytic domain of the kinase and sequential activation of the MAPK-activated protein kina

176 We found that interfering with the sequential activation of the microtubule assembly pathwa

177 Both ATM and DNA-PK promote sequential activation of the mitogen-activated protein k

178 own to be activated by mIgM, consists of the sequential activation of the mitogen-activated protein k

179 h human H2009 lung cancer cells demonstrated sequential activation of the nanoparticles inside endocy

180 hibition and resulted from a coordinated and sequential activation of the Npas4 and Bdnf gene program

181 etion of ATP by infected macrophages and the sequential activation of the P2X7 purinergic receptor an

182 hat cadmium induces ho-1 gene expression via sequential activation of the p38 kinase pathway and Nrf2

183 GF-1, can regulate RUNX2 DNA binding through sequential activation of the PI3K/Pak1 and ERK1/2 signal

184 This rapid sequential activation of the relevant and irrelevant fea

185 nd this process required an MT1-MMP-mediated sequential activation of the Src and JAK/STAT pathways.

186 antigen receptor (TCR) engagement results in sequential activation of the Src protein tyrosine kinase

187 we show that sonic hedgehog (SHH)-dependent sequential activation of the transcription factors OLIG2

188 l of Fc epsilon RI engagement leading to the sequential activation of the tyrosine kinases Lyn and th

189 port the hypothesis that there is three-step sequential activation of the vir regulon.

190 t this connectivity scheme may determine the sequential activation of these cell types during large n

191 g of intracellular calcium dynamics revealed sequential activation of these ensembles after ETH actio

192 Maf, and Rorc knockout mice, we demonstrate sequential activation of these factors during IL-17-prod

193 The sequential activation of these global regulators is also

194 To test whether the sequential activation of these microtubule assembly path

195 se activation was dependent on Syk, and that sequential activation of these molecules was required fo

196 Taken together, these data suggest that the sequential activation of these two quorum-sensing system

197 Such a 'switchable' GEF could ensure sequential activation of these Ypts, thereby coordinatin

198 We propose a model where the sequential activation of TLRs tailors the immune respons

199 generated in macrophages as a consequence of sequential activation of toll-like receptor 4 (TLR4), a

200 CSN activity during performance revealed the sequential activation of topographically ordered functio

201 these studies provide an example of how the sequential activation of transcription factors can deter

202 The sequential activation of transcription factors in time i

203 This indicates that sequential activation of trophically organized SDASs by

204 N-type ICa,V by bradykinin (BK) requires the sequential activation of two G-proteins, heterotrimeric

205 tion of foreign targets by antibodies drives sequential activation of two serine proteases, C1r and C

206 It signals through the sequential activation of two serine/threonine kinase rec

207 irus (EBV) infection of B cells leads to the sequential activation of two viral promoters, Wp and Cp,

208 nsforming infection are characterized by the sequential activation of two viral promoters, Wp and Cp,

209 ion of protein trimers via a charge-directed sequential activation of tyrosine residues (CDSAT).

210 Most action potentials are produced by the sequential activation of voltage-gated sodium (Nav) and

211 cursors' design rely on highly selective and sequential activations of carbon-bromine (C-Br) and carb

212 synergies could be readily reconstructed as sequential activations of spatial synergies (a subset of

213 aling involves PIP(3) generation through the sequential activations of the p110 PI3-kinases and IPMK.

214 Here we demonstrate how the sequential activation or deactivation of distinct DNA bu

215 mation, such as object distance, it is their sequential activation over longer timescales that track

216 ling its substrate binding specificity and a sequential activation process by cOAs.

217 Skeletal myogenesis involves sequential activation, proliferation, self-renewal/diffe

218 Sequential activation with the cytokines IFN-gamma and e

219 chainment selectivity (up to 7.2 mol%) after sequential activation with trimethylaluminum, then Ph(3)