ライフサイエンスコーパス: sequential mechanism

1 MEK operates through a bi-bi random-ordered sequential mechanism.

2 tic constants for the reaction and suggest a sequential mechanism.

3 tabilize the phosphorane intermediate in the sequential mechanism.

4 of the initial velocity patterns indicated a sequential mechanism.

5 catalyzed by Hhat proceeds through a random sequential mechanism.

6 ajor hurdle for physical implementation of a sequential mechanism.

7 at the transglycosylation reaction follows a sequential mechanism.

8 The simulations support a sequential mechanism.

9 s demonstrate that APH(2'')-Ib operates by a sequential mechanism.

10 , and (3) the reaction proceeds via a random sequential mechanism.

11 nal domains, insertion no longer occurs by a sequential mechanism.

12 lysis based on a conventional unidirectional sequential mechanism.

13 how that the streptococcal enzyme utilizes a sequential mechanism.

14 teady-state turnover cycle involves a random sequential mechanism.

15 d by prenylcysteine lyase proceeds through a sequential mechanism.

16 ction, and Lineweaver-Burk plots indicated a sequential mechanism.

17 ndicated that the reaction followed a random sequential mechanism.

18 d the two electron transfer reactions in the sequential mechanisms.

19 The model consists of two sequential mechanisms.

20 suggest that both ARD and ARD' have ordered sequential mechanisms.

21 rmation of N-acetylagmatine using an ordered sequential mechanism; acetyl-CoA binds prior to agmatine

22 hod correctly identified the enzyme's random sequential mechanism and allosteric catalytic suppressio

23 usly eliminate the possibility of an ordered sequential mechanism and demonstrate that both kinases h

24 w that c-di-GMP binds BldD using an ordered, sequential mechanism and that BldD function necessitates

25 The methylation reaction proceeds by a sequential mechanism, and either substrate (S-adenosyl-l

26 gave initial velocity patterns indicating a sequential mechanism, and provided the following kinetic

27 hydrolyzable ATP analogue AMPPNP, indicate a sequential mechanism, and the k(cat) of the reaction was

28 o 2'-fucosyl lactose are characteristic of a sequential mechanism, as observed previously for this fa

29 At higher pH, a sequential mechanism becomes dominant with rate-limiting

30 cis spore germination revealed synergy and a sequential mechanism between inosine and alanine binding

31 vel ubiquitin ligase domain and identify two sequential mechanisms by which A20 downregulates NF-kapp

32 diates asymmetric division via two distinct, sequential mechanisms: by promoting the asymmetric local

33 exes of different lengths, L, using "n-step" sequential mechanisms, can reveal information about the

34 e binding prior to reaction with O(2)) and a sequential mechanism (cofactor binding and reaction with

35 oribosyltransfer proceeds through an ordered sequential mechanism common to many related purine phosp

36 the basis of the combined data, we propose a sequential mechanism comprising molecular, colloidal, an

37 The simple sequential mechanism deduced for sIGPS reflects the domi

38 l domain in the full-length CyoA occurs by a sequential mechanism even when the CyoA amino and carbox

39 eNOS oxygenase domain (eNOS(ox)) followed a sequential mechanism: Fe(II) <--> Fe(II)O(2) --> Fe(III)

40 ity of RAX to activate PKR is regulated by a sequential mechanism featuring RAX association with PKR,

41 We favor a sequential mechanism for actomyosin V dissociation with

42 A sequential mechanism for ATP binding or hydrolysis that

43 e other show intersecting lines indicating a sequential mechanism for both the forward and the revers

44 tional data, an IL-13/IL-4Ralpha model and a sequential mechanism for forming the signaling heterodim

45 8 inhibitors were consistent with an ordered sequential mechanism for p38 with protein substrate, glu

46 These results suggest an ordered sequential mechanism for substrate binding.

47 The results allow us to propose a sequential mechanism for the (un)binding of Amt to the w

48 ad-end inhibition studies support an ordered sequential mechanism for the enzyme(s).

49 nhibition kinetic studies support an ordered sequential mechanism for the enzyme, and we propose that

50 city and inhibition studies support a random sequential mechanism for the enzyme.

51 ength data does not support the conventional sequential mechanism for the reduction of dioxygen to wa

52 The sequential mechanism for the release of fibrinopeptides

53 This study thus reveals two sequential mechanisms for translocating anastral spindle

54 JNK1beta1 followed a random sequential mechanism forming a ternary complex between J

55 linear least-squares analysis using "n-step" sequential mechanisms has previously been limited by an

56 lows a ping-pong mechanism but switches to a sequential mechanism in the luciferase-coupled reaction.

57 Together, these data support a sequential mechanism in which AcCoA and H3 bind to the R

58 constant suggests that folding occurs via a sequential mechanism in which an on-pathway intermediate

59 Our results reveal a sequential mechanism in which hypoxia (<5% O2) first inh

60 We propose a sequential mechanism in which initial axon extension in

61 s using its single RuvC nuclease domain by a sequential mechanism in which initial cleavage of the no

62 A kinetic analysis reveals a sequential mechanism in which O(2) binding to heme a(3)

63 ctroscopy, it is shown that this occurs by a sequential mechanism in which oxidation to an imine (N-q

64 These observations support a sequential mechanism in which PD-associated stresses ind

65 ies indicated that LdAPRT follows an ordered sequential mechanism in which PRPP is the first substrat

66 Apomyoglobin folds by a sequential mechanism in which the A, G, and H helix regi

67 n DeltaG(I) degrees of 2 eV, compared to the sequential mechanism in which the rate can change over 1

68 Single-molecule experiments have suggested a sequential mechanism, in which the ORC-dependent loading

69 The fast bimolecular step and the sequential mechanism indicate that the site is easily ac

70 This study dissected sequential mechanisms involved in nanoparticle transcyto

71 anine being the third substrate to bind in a sequential mechanism involving a putative acyl-phosphate

72 Gcn5-like HATs utilize an ordered sequential mechanism involving direct nucleophilic attac

73 e that solvent-assisted PT takes place via a sequential mechanism involving first deprotonation of th

74 LHMDS or LDA (2.4 equiv, THF) proceeds via a sequential mechanism involving monometalation-monoalkyla

75 Cytosine deamination proceeds via a sequential mechanism involving the protonation of N(3),

76 rescence anisotropy measurements, supports a sequential mechanism involving the unfolded monomer, a f

77 The sequential mechanism is also corroborated by dead-end in

78 This sequential mechanism is consistent with experimental cha

79 This sequential mechanism is consistent with the requirement

80 The few-state sequential mechanism is likely to enhance the efficiency

81 tained from experiment for this or any other sequential mechanism of any number of steps.

82 DNA topoisomerase II uses a complex, sequential mechanism of ATP hydrolysis to catalyze the t

83 ClpB subunit blocked activity, supporting a sequential mechanism of ATP utilization.

84 In contrast with the sequential mechanism of binding and stabilization afford

85 e mitoribosome and its ligands, suggesting a sequential mechanism of conformational changes.

86 d prior serine phosphorylation, suggesting a sequential mechanism of endoglin phosphorylation.

87 The sequential mechanism of formation of actomyosin interfac

88 A pathological, sequential mechanism of gelation, syneresis, and fibrill

89 Both AT and AR reactions used a sequential mechanism of rapid equilibrium random binding

90 These studies indicate a four-step sequential mechanism of RNA binding and reveal the respe

91 Concerted, stochastic and sequential mechanisms of action have been proposed for d

92 Random and sequential mechanisms of hydrolysis are compared, and it

93 These two sequential mechanisms, one occurring before stalk format

94 entation of certain V genes could arise from sequential mechanisms operating at both early and later

95 olecular machines operate by a stochastic or sequential mechanism or how power strokes relate to the

96 According to a proposed sequential mechanism, partial release of secondary struc

97 il of the A(3)AR in situ appears to follow a sequential mechanism, perhaps involving receptor depalmi

98 16) formation occurs by a minimum four-step, sequential mechanism: (reaction: see text).

99 cause it serves as a bridge between ordered (sequential) mechanisms (representing one type of orderin

100 The sequential mechanism shows only absorptive features in t

101 st that wild-type IDH1 goes through a random sequential mechanism, similar to previous reports on rel

102 he CKI, p27, binds to Cdk2/cyclin A though a sequential mechanism that involves folding-on-binding.

103 Escherichia coli sliding clamp occurs via a sequential mechanism that involves two subsites (I and I

104 In such a sequential mechanism, the number of steps is a key deter

105 ce anticipated muscle fibrosis through these sequential mechanisms: the alteration of collagen metabo

106 and Cdc42, demonstrates that VopS utilizes a sequential mechanism to AMPylate Rho GTPases.

107 Together, our results lead to a proposed sequential mechanism to describe the activation pathway

108 Diverse sequential mechanisms underpin the highly heterogeneous

109 Kinetic data were in agreement with a sequential mechanism via a ternary complex.

110 A sequential mechanism was also followed when 3-PGA was ab

111 teady-state kinetic data are indicative of a sequential mechanism where oxygen reacts with a reduced

112 nalysis indicates that Sir2 enzymes follow a sequential mechanism, where both the acetylated substrat

113 s revealed that PP2Calpha employs an ordered sequential mechanism, where the metal cations bind befor

114 Our findings support a sequential mechanism whereby TNF-alpha leads to stabiliz

115 cate that the oxygenase reaction occurs by a sequential mechanism which most likely involves reversib

116 large, but at small DeltaG(I) degrees , the sequential mechanism will dominate.

117 ses catalyzes reactions via an Ordered Bi Bi sequential mechanism with ATP binding to the enzyme prio

118 y characterized and found to follow a random sequential mechanism with kinetic parameters K(m,epoxypr

119 lished that the reaction involves an ordered sequential mechanism with mandatory initial binding of C

120 esults suggest that Pol X prefers an ordered sequential mechanism with Mg (2+).dNTP as the first subs

121 ct inhibition by NAD(+) indicated an ordered sequential mechanism with NADH as the first binding subs

122 haromyces cerevisiae at pH 7.0, suggesting a sequential mechanism with ordered addition of reduced ni

123 eaction, the enzyme follows an Ordered Bi Bi sequential mechanism with poly(P) binding to the enzyme

124 , is shown to proceed via a hybrid ping-pong/sequential mechanism with pronounced (> or = 40-fold) su

125 An ordered sequential mechanism with protein substrate binding firs

126 ta are also consistent with an Ordered Bi Bi sequential mechanism, with ATP binding to the enzyme fir

127 dF catalyzes flavin reduction via an ordered sequential mechanism, with FAD being bound first and FAD

128 of IDH1 are more consistent with an ordered sequential mechanism, with NADPH binding before alphaKG.

129 ghly unusual that a flavin reductase using a sequential mechanism would require a flavin cofactor to