ライフサイエンスコーパス: serine

1 and self-renewal require abundant exogenous serine.

2 the main pathway for neuronal reuptake of D-serine.

3 g the pK(a) of the nucleophilic alcohol of a serine.

4 es phosphorylation at a triplet of conserved serines.

5 meiosis, phosphorylates Katanin at multiple serines.

6 starting with phosphorylation of histone H3 serine 10 (H3S10ph), which signals the recruitment of ly

7 over, loss of this ADP-ribosylation enhances serine-139 phosphorylation of H2AX (gammaH2AX) upon oxid

8 DYRK1B-mediated phosphorylation at serine 185 of NKX3.1 leads to its polyubiquitination and

9 CDK11 phosphorylates serine 2 (Ser2) of the carboxy-terminal domain of RNA po

10 enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2), are modulated by IL-13.

11 in enhanced occupancy of NF-kB, P-TEFb, and serine 2 phosphorylated RNA Polymerase II on the HEXIM1

12 zyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells.

13 letion of SET1 or SET2 causes an increase in serine-2 phosphorylation within the C-terminal domain of

14 atase calcineurin dephosphorylates Hoxb13 at serine-204, resulting in its nuclear localization and ce

15 y, and further identified phosphorylation of serine 240 on p115 RhoGEF by PKC to be the mechanistic l

16 nase 5-mediated phosphorylation of PPARgamma serine 273.

17 this is indeed the case: phosphorylation of serine 298 decreased the binding affinity for MUPP1, a k

18 lular kinase CK1alpha phosphorylates NSP2 on serine 313, triggering the localization of vNSP2 to site

19 ommon mutation is a missense substitution of serine-34 to phenylalanine (S34F).

20 To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of STING

21 Phosphorylation of AID at serine 38 was previously hypothesized to regulate BER du

22 irected mutagenesis of the key CcmK2 residue Serine 39.

23 ne-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS), and reveal an increase of neu

24 re overexpressed in adult rat VMs, revealing serine-465 as the site that elicits PKA-dependent phosph

25 onferred by PKA-dependent phosphorylation at serine-465.

26 upregulation of Akt1/PKB phosphorylation at serine 473, with the orientation of the 20 carbon epimer

27 the Kin28/Cdk7 kinase, which phosphorylates Serine 5 of heptapeptide repeats on the carboxy-terminal

28 N-AS then acetylates serine 565 (S565) of COX2, and the N-AS-acetylated COX2

29 resent genetic and biochemical evidence that serine 57 (Ser57) phosphorylation of ubiquitin functions

30 iac Na channel phosphorylation (Na(V)1.5, at serine 571, Western blotting).

31 The mutant P0S63del (deletion of serine 63 in the extracellular domain of P0), that cause

32 YD1] in which the 3 phosphorylation sites on serines 63, 68, and 69 are mutated to alanines), in whic

33 Meiob mutagenesis identifies serine 67 as a critical residue for MEIOB.

34 AURKB directly phosphorylates MYC at serine 67, counteracting GSK3beta-directed threonine 58

35 Bcl-2 phosphorylation at serine-70 (S70pBcl2) confers resistance against drug-ind

36 by demonstrating that its phosphorylation at serine-70 functions as a redox sensor to prevent drug-in

37 ppaB kinase epsilon (IKKepsilon) on the same serine-72 (S72) site.

38 anistically, we find that phosphorylation of serine-880 of the GluA2 AMPAR subunit (GluA2-S880) is de

39 RP1 and PARP2 from aspartate or glutamate to serine(9,10).

40 stronger affinity for its natural inhibitor, serine acetyltransferase (SAT), as compared with its aff

41 These results support an autocrine mode of d-serine action at synapses.

42 and suggests a possible autocrine mode of d-serine action.SIGNIFICANCE STATEMENT NMDARs are key regu

43 Serine active-site beta-lactamases hydrolyze beta-lactam

44 guration and seryl-adenylate supplied by the serine adenylation activity of AbmK.

45 h reprogrammes a metabolic network involving serine, alanine and pyruvate that drives the endogenous

46 Instead, serine alters E. coli's 1C-metabolism, reduces the provi

47 ties, and are well tolerated by the brain, D-serine, an endogenous amino acid, offers new hope as a t

48 be critical for the attractant response to L-serine and DHMA.

49 , proline (PRO), tryptophan (TRP), tyrosine, serine and GABA were quantified by gas-chromatography-ma

50 rs metabolic gene expression with consequent serine and glycine elevation in the brain.

51 The promiscuity of SPT therefore links serine and mitochondrial alanine metabolism to membrane

52 t is normally formed by the conjugation of l-serine and palmitoyl-CoA.

53 ion depends on a unique motif with conserved serine and threonine (S/T) residues that have a high cap

54 Both of these events leave behind deaminated serine and threonine and thus can lead to ambiguous stru

55 ransfer of N-acetylglucosamine (O-GlcNAc) to serine and threonine hydroxyls.

56 that these strong H-bonds serve to stabilize serine and threonine residues in hydrophobic environment

57 tructured, N-terminal region that is rich in serine and threonine residues, several of which are repo

58 also led to differential phosphorylation of serine and threonine sites within proteins regulating T

59 nylprop-2-yn-1-yl)-sulfonamides derived from serine and threonine were synthesized using solid-phase

60 In the brain, glutamate, serine, and N-acetylaspartate (NAA) were reduced after L

61 y found in the LFM composition-oleic acid, l-serine, and squalene.

62 R1 alternative splicing is pronounced in the serine- and arginine-rich intrinsically disordered domai

63 We show that PEs in serine-arginine-rich (SR) proteins, a family of 14 essen

64 ically encoded 4,5-dimethoxy-2-nitrobenzyl-l-serine as a transient active-site block, and its subsequ

65 id and palmitoleic acid were increased while serine, asparagine and arachidonic acid and its derivati

66 ement for binding of a coagonist, which is d-serine at most forebrain synapses.

67 nally requiring gluten epitopes possessing a serine at the P3 position of the peptide.

68 We find that oncogenic EpdSCs are serine auxotrophs whose growth and self-renewal require

69 ding of the mechanisms regulating synaptic d-serine availability remains limited.

70 media (CRCM) as functional molecules, with L-serine being a particularly strong candidate.

71 Class A serine beta-lactamases (SBLs) are key antibiotic resista

72 ts, the reaction of the class D nucleophilic serine beta-lactamases (SBLs) with carbapenems also prod

73 spectrum activity against class A, C, and D serine beta-lactamases.

74 expression of Pck2 and genes associated with serine biosynthesis (Phosphoglycerate dehydrogenase, Phg

75 on pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide

76 Consequently, expression of the serine biosynthesis enzyme PHGDH was required for sensit

77 corresponding primary breast tumors, use the serine biosynthesis pathway to support mTORC1 growth sig

78 h Mct2 supported mTORC1 signaling by fueling serine biosynthesis-derived alpha-ketoglutarate producti

79 ensitive mutant in which C674 is replaced by serine (C674S) were exposed to H(2)O(2) (100 umol/Lmu).

80 inguishes between metallo-beta-lactamase and serine-carbapenemase production in P. aeruginosa The mCI

81 However, L-serine catabolism has a minimal effect on its fitness in

82 , and glycine, with decreases in total and D-serine, cholesterol esters, diacylglycerides, triacylgly

83 by decreased phosphorylation of a C-terminal serine cluster involved in mRNA target release, increase

84 er its gentle ionization), while the smaller serine clusters are achiral.

85 en suggested that BMAA is misincorporated at serine codons during protein synthesis, but direct evide

86 A's previously predicted misincorporation at serine codons, following a screen for amino acid activat

87 er sex, while increasing the extracellular D-serine concentration in slices and in vivo by microdialy

88 d suppressor mutants that can tolerate toxic serine concentrations by three targeted and non-targeted

89 binding similarly to PKM2, how cysteine and serine differentially regulate this enzyme remains elusi

90 By contrast, serine does not alter FUdR metabolism.

91 APA), (2S,3R)-diaminobutyric acid (DABA), or serine, effectively replacing the ring-closing ester bon

92 lectrospray droplet, but <=5.6% and ~0.6% of serine exists as an octamer complex in 10 mM and 100 muM

93 Endogenous serine flow was similar (P > 0.05) for diets C, HC, and

94 mine-148->histidine (Q148H) and glycine-140->serine (G140S) amino acid substitutions in integrase tha

95 stages of its sublimation, nonracemic solid serine generates a neutral serine monomer as the princip

96 used to append nearly any kind of cargo onto serine, generating a stable, benign, and hydrophilic pho

97 The serine-glycine dipeptide lipid classes, including lipid

98 ipid classes are structurally related to the serine-glycine dipeptide lipids.

99 Both serine-glycine lipid classes were previously shown to en

100 for example UDP-glucoronosyltransferase and Serine-glyoxylate transferase, were downregulated.

101 polymorphisms in the region of the trimeric serine hydrolase high-temperature requirement 1 (HTRA1)

102 versibly inhibited a cysteine protease and a serine hydrolase with nanomolar potency and exceptional

103 Serine hydrolases (SHs) are a large, diverse family of e

104 than 1000-fold selectivity relative to other serine hydrolases.

105 n act as hydrogen bond acceptor sites to the serine hydroxyl.

106 nal lethality of the yggS and glyA (encoding serine hydroxymethyltransferase) has been described, but

107 e mutant phenotype, which encodes a putative serine hydroxymethyltransferase.

108 ic and postsynaptic localization of SR and d-serine in CA1 pyramidal neurons.

109 tion of the system A reduced the uptake of D-serine in synaptosomes and neuronal cultures of mice of

110 MacTel, and showed low levels of glycine and serine in the serum of MacTel patients.

111 d that avibactam is bound to the active-site serine in two orientations ~180 degrees to each other.

112 An additional layer comprising two serines in human TMEM175 increases selectivity further a

113 Thus, the ability to catabolize L-serine increases bacterial fitness and provides Enteroba

114 However, excess serine inhibits the growth of B. subtilis.

115 er, these findings reveal that extracellular serine is a critical determinant of EpdSC fate and provi

116 The concentration of luminal L-serine is largely dependent on dietary intake.

117 When extracellular serine is limited, EpdSCs activate de novo serine synthe

118 preferentially to iron and that a conserved serine is required for this specificity.

119 rther modified with l-cysteine (l-Cys) and l-serine (l-Ser).

120 Directed evolution of a serine-ligated P450 variant, P411-C10, yielded a lineage

121 gion was substituted with a flexible glycine-serine linker of the same length underwent efficient S-a

122 ommunication pathway between Arg-293 and the serine loop by reducing its dynamicity.

123 nd variants in genes associated with glycine-serine metabolism (PSPH, PHGDH and CPS1) to be associate

124 that defects in the urea cycle, glycine, and serine metabolism may be underrecognized in the progress

125 are directly or indirectly linked to glycine-serine metabolism, further validating our previous genet

126 nonracemic solid serine generates a neutral serine monomer as the principal species in the vapor pha

127 The serine monomer, when the flux is sufficient, assembles i

128 BARD1 BRCT domains via a C-terminal phospho-serine motif.

129 am-positive bacterium Bacillus subtilis uses serine not only as a building block for proteins but als

130 ase (CS), synthesizes cysteine from O-acetyl serine (OAS) and sulfur in bacteria and plants.

131 , the population abundance of the protonated serine octamer decreases from 1% to 0.6% from the larges

132 The spectrum confirms that the collected serine octamer has undergone chiral enrichment relative

133 leic acid, pyruvic acid, palmitoleic acid, L-serine, oleic acid, myo-inositol, dodecanoic acid, L-met

134 t least one non-canonical H-bond formed by a serine or threonine residue whose hydroxyl side chain H-

135 y-glutamine in the peptide core instead of a serine or threonine residue, the inclusion of a non-heme

136 dition of GalNAc onto the hydroxyl groups of serines or threonines in protein substrates.

137 (PG1780 in strain W83) predicted to encode a serine palmitoyl transferase (SPT)-the enzyme that catal

138 Serine palmitoyltransferase (SPT) catalyses the de novo

139 rate peptidoglycan cross-bridges with unique serine patterns that provide protection from endogenous

140 g association between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concen

141 The endothelial lipase LIPG possesses serine phospholipase activity and is involved in lipopro

142 Analyses of the transport cycle show that serine phosphorylation abolishes the K(+)-dependence of

143 nvestigated the role of direct AMPK-mediated serine phosphorylation of RAPTOR in a new Raptor (AA) mo

144 , we investigate an evolutionarily conserved serine phosphorylation that occurs at the site of commun

145 ced adhesion turnover downstream of paxillin serine phosphorylation, which is rescued by addition of

146 but the abundance decreases from 10% of the serine population at the largest tip size to ~5.6% for t

147 The type II transmembrane serine protease (TTSP) family encompasses several protea

148 Mutations in the human serine protease 1 gene (PRSS1), which encodes cationic t

149 ous studies have reported that transmembrane serine protease 2 (TMPRSS2) is essential for activation

150 th host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry.

151 databases within ACE2/SLC6A19/transmembrane serine protease 2 (TMPRSS2), warranting genomic enrichme

152 converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2).

153 this 24-week trial, reduction of neutrophil serine protease activity with brensocatib in patients wi

154 mals had non-inflammatory CHS with increased serine protease activity.

155 streptokinase are strictly attributed to the serine protease domain (residues 562-791) of hPg.

156 CORIN is a transmembrane type II serine protease expressed in cardiomyocytes that convert

157 ften leads to overexpression of the membrane serine protease fibroblast-activating protein (FAP).

158 m of the study was to investigate the use of serine protease from Yarrowia lipolytica yeast for reduc

159 virulence factors produced by EAEC, the Pic serine protease has been implicated in bacterial coloniz

160 ymph serine proteases (HPs) and noncatalytic serine protease homologs (SPHs) and inhibited by serpins

161 a higher percentage of cells expressing the serine protease HtrA1.

162 storation of the deleted C12L gene, encoding serine protease inhibitor 1, enhances replication of MVA

163 ng PDAC progression, AGRN (agrin), SERPINB5 (serine protease inhibitor B5), and CSTB (cystatin B).

164 Degradation of the protective serine protease inhibitor Kazal type 1 (SPINK1) by mesot

165 Genetic ablation of serine protease inhibitor SerpinB9 (Sb9) results in the

166 ctor 15 (GDF15), stanniocalcin 1 (STC1), and serine protease inhibitors (SERPINs), which significantl

167 dentified from a diverse library of internal serine protease inhibitors, was originally designed as a

168 A serine protease physiologically often comes together wit

169 Chymase is a serine protease that is predominantly expressed by mast

170 , encoded by TMPRSS6, is a membrane-anchored serine protease that plays a key role in suppressing hep

171 s by NMDA agonists (NMDA or glycine) and the serine protease tissue plasminogen activator, previously

172 xceptional, however, as it also inhibits the serine protease trypsin due to replacement of the P1 Leu

173 Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective f

174 2 depend on angiotensin-converting enzyme 2, serine protease, virus replication, and PAD-4.

175 broad spectrum of plasma proteins including serine protease/endopeptidase inhibitors, coagulation fa

176 nsects is mediated by a network of hemolymph serine proteases (HPs) and noncatalytic serine protease

177 ion proteins potently inhibit the neutrophil serine proteases (NSPs) neutrophil elastase, cathepsin-G

178 The FhKT1 inhibitors do not inhibit serine proteases but are potent inhibitors of parasite c

179 we provide evidence for a potential role of serine proteases in CD44-mediated necroptotic death of G

180 detect the activities of flavivirus NS2B-NS3 serine proteases in living cells.

181 Skin desquamation is facilitated by serine proteases KLK5 and KLK7, which are tightly regula

182 how that two 20E-regulated chymotrypsin-like serine proteases specifically expressed in the reproduct

183 ition to NE, neutrophils contain three other serine proteases that could compensate if the activity o

184 s balance is not yet defined for some of the serine proteases that serve as coagulation factors.

185 Kallikreins (KLK), a family of serine proteases with a diverse array of homeostatic fun

186 thought to involve off-target inhibition of serine proteases, although the precise molecular details

187 ll-based assays, are selective against other serine proteases, and do not show relevant cytotoxicity.

188 The activity and quantity of neutrophil serine proteases, including neutrophil elastase, are inc

189 m a family of nine secretory subtilisin-like serine proteases, seven of which cleave at specific basi

190 ptidyl arginine deiminase 4, or digestion by serine proteases.

191 responsible for the activation of neutrophil serine proteases.

192 this family that is cleaved and activated by serine proteinases such as thrombin, trypsin, and cathep

193 om astrocytes would increase extracellular D-serine, providing a feedforward mechanism to increase sy

194 Additionally, treatment with D-serine reduces astrocyte counts in the MEA, alters their

195 ms regulating the availability of synaptic d-serine remains limited.

196 Insertion of additional flexible glycine-serine repeats had no effect on S-acylation, but extende

197 Budding yeast SER3 is repressed under serine-replete conditions by transcription of an upstrea

198 d an ester bond formed between a thermolysin serine residue and the A2ML1 thiol ester.

199 and also SrtB from Staphylococcus aureus The serine residue indispensable for SrtB activity may be in

200 e report the first evidence that a conserved serine residue near the active site participates in the

201 lysine substrate, also involving two nearby serine residues - S566 and S527- that possess a proton r

202 Occasionally, serine residues are also incorporated into the cross-bri

203 FmhA incorporates serine residues at positions 3 and 5 of the cross-bridge

204 ers with a phosphorylation pocket flanked by serine residues between their N-terminal domains.

205 nM, can covalently transacylate arginine and serine residues in GSTP and cross-link them to adjacent

206 oselective, and modular functionalization of serine residues in native polypeptides, which uses a rea

207 t AvrPtoB phosphorylation occurs at multiple serine residues in planta, with S258 phosphorylation sig

208 PKA preferentially targeted two serine residues in TOMM34: Ser(93) and Ser(160), located

209 Mutations of cyclin L2 at serine residues preceding proline significantly stabiliz

210 rylation patterns across the four implicated serine residues was observed.

211 ational modification occurs predominantly on serine residues(6-8) and requires HPF1, an accessory fac

212 Moreover, a lack of serine results in the initiation of biofilm formation.

213 plasma membrane transporters that mediate D-serine reuptake has remained elusive.

214 f either sex further support its role as a D-serine reuptake system.

215 we report that allosteric regulation of the serine-rich loop is mediated by Arg-293 of CRY1, identif

216 ry, we found that ACTN4 is phosphorylated at serine (S) 159 in human podocytes.

217 ino acid variants (leucine [L], proline [P], serine [S], and threonine [T]).

218 another host protein, transmembrane protease serine S1 member 2.

219 We found that peripheral axons release serine (Ser) to support the growth of exogenous Ser (exS

220 e of them-leucine (Leu), arginine (Arg), and serine (Ser)-are encoded by six different codons.

221 These amino alcohols are based on serine (seramox) or isoserine (isoseramox) and can be in

222 Mutations of Cys69 with alanine or serine show 5hmC-specificity that mirrors the hydrogen b

223 o and provide an unexpected link between the serine shuttle pathway, responsible for regulating D-ser

224 The dissolved chemoattractant (l-serine) significantly increases the accumulation and cap

225 ptor (AA) mouse model, in which AMPK phospho-serine sites Ser722 and Ser792 of RAPTOR were mutated to

226 er was observed for all tip sizes with 10 mM serine solution, but the abundance decreases from 10% of

227 Accordingly, serine starvation or enforced alpha-ketoglutarate produc

228 ing enzyme (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS2), their expression sh

229 s scored as R3 or R4 had the same proline-to-serine substitution at p106.

230 ation in the Ins2 gene, causing a glycine-to-serine substitution at position 32 on the B chain of the

231 egulated synthesis of O-linked (threonine or serine) sugars occurs in many cancers, and that this can

232 O-acetyl serine sulfhydrylase (OASS), referred to as cysteine syn

233 huttle pathway, responsible for regulating D-serine synaptic turnover, and the glutamine-glutamate cy

234 ults offer a new link between Parkin and the serine synthesis pathway, and they bear translational po

235 PHGDH overexpression activates serine synthesis to promote cancer progression.

236 e (PHGDH), the first rate-limiting enzyme of serine synthesis, is frequently overexpressed in human c

237 r serine is limited, EpdSCs activate de novo serine synthesis, which in turn stimulates alpha-ketoglu

238 30, leading to PHGDH degradation to suppress serine synthesis.

239 ina of Muller glial cells and the amino acid serine, synthesized by the Muller cells.

240 unchanged in levels, except for glycine and serine that increased as a percentage of all amino acids

241 by inducing a distinct activation of Akt, a serine/theonine protein kinase.

242 like kinase 1 (DCLK1), a microtubule binding serine threonine kinase, emerged as a promising target d

243 beling on the off-target amino acid residues serine, threonine, and tyrosine was observed to pose a c

244 LAK cell-originated protein kinase (TOPK), a serine-threonine kinase is activated by SUV irradiation

245 The serine-threonine kinase PINK1 is responsible for recruit

246 d may be a curative option for other proline-serine-threonine phosphatase-interacting protein 1-assoc

247 Proline-serine-threonine phosphatase-interacting protein 1-assoc

248 ich carry a missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstp

249 PI3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to th

250 ar, cytosolic, and mitochondrial proteins on serine/threonine amino acid residues, a process termed p

251 Here, we identify that mutation in dual serine/threonine and tyrosine protein kinase (dstyk) lea

252 PPPs perform much of the serine/threonine dephosphorylation in eukaryotic cells a

253 This results in AKT serine/threonine kinase (Akt) activation, membrane focal

254 tivated phosphoinositide 3-kinase (PI3K)/Akt serine/threonine kinase (Akt) and mitogen-activated prot

255 lator phenotype (CIMP), B-Raf proto-oncogene serine/threonine kinase (BRAF) mutation, and Kirsten rat

256 Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11) is the major energy s

257 monstrated that IkappaB kinase beta is a key serine/threonine kinase activated by autophagy stimuli a

258 oral inhibitor of all three isoforms of the serine/threonine kinase AKT.

259 disease has led to the identification of the serine/threonine kinase ALK2 as a potential target for t

260 ke kinase (NLK) is an evolutionary conserved serine/threonine kinase and a negative regulator of the

261 induce downstream signaling through the ERK serine/threonine kinase and the Fos transcription factor

262 UHMK1 is a nuclear serine/threonine kinase recently implicated in carcinoge

263 The serine/threonine kinase TBK1 (TANK-binding kinase 1) and

264 or-interacting protein kinase 1 (RIPK1) is a serine/threonine kinase that dictates whether cells surv

265 The HipA toxin functions as a serine/threonine kinase that inhibits cell growth, while

266 n kinase (AMPK) is an evolutionary conserved serine/threonine kinase that integrates cellular energy

267 Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that is overexpressed in gastroi

268 e screens was GSG2 (also known as Haspin), a serine/threonine kinase that phosphorylates histone H3 a

269 (384) by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is req

270 that the 7-amino acid truncation in NUAK2, a serine/threonine kinase, completely abrogated its cataly

271 Aurora kinases are a family of serine/threonine kinases vital for cell division.

272 PGAM5 is a mitochondrial serine/threonine phosphatase that regulates multiple met

273 uppressor protein phosphatase 2A (PP2A) is a serine/threonine phosphatase whose activity is inhibited

274 Knockdown of Nqo1 enhanced activity of the serine/threonine phosphatase, protein phosphatase 2A, wh

275 Members of the PP2A family of serine/threonine phosphatases are important human tumor

276 The Akt serine/threonine protein kinase family is linked to main

277 ycle, in a process that is controlled by the serine/threonine protein kinase PLK4 (refs.

278 ATM is a serine/threonine protein kinase that is recruited and ac

279 The serine/threonine protein kinase v-AKT homologs (AKTs), a

280 upon PASTA-domain containing eukaryotic-like serine/threonine protein kinases (PASTA-eSTK) that sense

281 The characterization of prokaryotic serine/threonine protein kinases in bacterial pathogens

282 and PRK2 are two closely related AGC-family serine/threonine protein kinases.

283 The serine/threonine Protein Phosphatase 2A (PP2A) functions

284 protein 51 (FKBP51), in conjunction with the serine/threonine protein phosphatase 5C (PPP5C), inhibit

285 ts unstructured N- and C-terminal regions at Serine/Threonine-Glutamine (SQ) motifs.

286 c machinery lies RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a mast

287 dence of caspase-8- and receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated infla

288 RNA virus that triggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathw

289 c plaque undergo RIPK3 (receptor-interacting serine/threonine-protein kinase 3)-MLKL (mixed lineage k

290 While targeted serine/threonine-protein kinase B-Raf (BRAF) and immune

291 es on the structure of the CTD showed that a serine/threonine-rich stretch causes a backbone twist in

292 a conserved acidic residue is replaced by a serine/threonine.

293 Focal administration of D-serine to the MEA attenuates neuronal loss in this regio

294 ypothesized that hypophosphorylation of Cx43 serine-triplet triggers pathological Cx43 redistribution

295 s TNPO3 recognizes a region rich in arginine-serine-tyrosine (RSY) residues.

296 zes non-canonical phosphoribosyl-linked (PR) serine ubiquitination and promotes infectivity of Legion

297 Spraying solutions of serine under a wide variety of conditions results in unu

298 ree transporters was able to tolerate 100 mM serine whereas the wild type strain was already inhibite

299 on that the substitution of the PKA-targeted serine with a negatively charged residue within the ICD

300 The ubiquitous mutation from serine (WT) to asparagine at residue 31 (S31N) in the in