ライフサイエンスコーパス: serine proteinase

1 that NS4A forms an integral part of the NS3 serine proteinase.

2 uncontrolled activation of a specific plasma serine proteinase.

3 t both papain-like cysteine and trypsin-like serine proteinases.

4 was an inhibitor of the S1 clan SA family of serine proteinases.

5 a major physiological inhibitor of multiple serine proteinases.

6 appeared to be an inhibitor of trypsin-like serine proteinases.

7 x that is the basis for serpin inhibition of serine proteinases.

8 rg, since P1 Arg also inhibits several other serine proteinases.

9 mited to the inhibition of chymotrypsin-like serine proteinases.

10 d mechanism, canonical protein inhibitors of serine proteinases.

11 eutrophil elastase, but not a range of other serine proteinases.

12 trypsin, thrombin, and several fibrinolytic serine proteinases.

13 n-coupled receptor activated by trypsin-like serine proteinases.

14 s show that SCCA2 inhibits chymotrypsin-like serine proteinases.

15 physiologically important chymotrypsin-like serine proteinases.

16 bitor family, interacting with six different serine proteinases.

17 rophosphate, indicated that they were active serine proteinases.

18 is a G protein-coupled receptor activated by serine proteinases.

19 activation of plasminogen and other complex serine proteinases.

20 Enamel matrix serine proteinase 1 (EMSP1) is a proteolytic enzyme that

21 has been variously designated enamel matrix serine proteinase 1 (EMSP1), prostase, KLK4, and KLK-L1.

22 We designate this protein enamel matrix serine proteinase 1 or EMSP1.

23 78% identity with the porcine enamel matrix serine proteinase 1, an enzyme involved in enamel matrix

24 Mannan-binding lectin-associated serine proteinase 2 (MASP-2) is essential for LP activat

25 l as induce collagenase expression make this serine proteinase a key initiator and inducer of cartila

26 Serine proteinases activate the G protein-coupled recept

27 Of the serine proteinase activities detected, an enzyme of appr

28 MBP possesses endogenous serine proteinase activity and can undergo autocatalytic

29 Serine proteinase activity in liquid cultures was reduce

30 Each of the three serine proteinase activity-based probe-labelled enzymes

31 Transmural inflammation was associated with serine proteinase and MMP activity in overlying epitheli

32 eptides, phospholipase A(2), C-type lectins, serine proteinases and l-amino oxidases.

33 There is also a search for inhibitors of serine proteinases and matrix metalloproteinases to prev

34 ry activity toward PAPP-A2, but not selected serine proteinases and metalloproteinases.

35 ade activates latent MMP-1 and involves both serine proteinases and MMPs, particularly stromelysin 1

36 ns are structural modules found in arthropod serine proteinases and some proteolytically inactive hom

37 te the response, a cascade of mostly unknown serine proteinases, and phenoloxidase.

38 roteins (disintegrins, phospholipase A(2)'s, serine proteinases, and snake venom metalloproteases).

39 required for effective peptide inhibitors of serine proteinases, and will assist in the further desig

40 dopeptidases (thiorphan and phosphoramidon), serine proteinases (aprotinin), cysteine proteinases (le

41 This suggests that serine proteinases are involved in the activation cascad

42 Tests included cysteine proteinases, serine proteinases, aspartic proteinases, metallo protei

43 Standard mechanism protein inhibitors of serine proteinases bind as substrates and are cleaved by

44 ts that similar active site modifications of serine proteinases block the ability of serpins to form

45 specific labeling of the catalytic sites of serine proteinases but have not been widely used as prob

46 vity against any of the more common types of serine proteinases but is a potent cross-class inhibitor

47 ealed that SCCA2 inhibited chymotrypsin-like serine proteinases, but not papain-like cysteine protein

48 tive inhibitor of plasmin than several other serine proteinases, but the molecular basis for this spe

49 by thrombin or other heparin binding plasma serine proteinases by a similar mechanism.

50 ortance of this residue in the inhibition of serine proteinases by KD1.

51 Herpesviruses encode an essential serine proteinase called assemblin that is responsible f

52 A serine proteinase cascade in insect hemolymph mediates p

53 molymph phenoloxidase, a pathway involving a serine proteinase cascade.

54 and Toll pathway initiation) are mediated by serine proteinase cascades and regulated by serpins in h

55 in vertebrates and invertebrates to regulate serine proteinase cascades that mediate the host defense

56 K; and SCCA2 inhibits the chymotrypsin-like serine proteinases, catG and human mast cell chymase.

57 tored in azurophil granules along with other serine proteinases (cathepsin G, proteinase 3 and azuroc

58 in antichymotrypsin (ACT, I) reacts with the serine proteinase chymotrypsin (Chtr, E) to form an E*I*

59 alysis of the interactions between the human serine proteinases, chymotrypsin, cathepsin G, and elast

60 Several serine proteinases clearly influence vascular remodellin

61 we show that both human and mouse neutrophil serine proteinases cleave flagellin from Pseudomonas aer

62 er, our data suggest that neutrophil-derived serine proteinases cleave SP-D at sites of inflammation

63 in G, a member of the chymotrypsin family of serine proteinases, consistent with serpin activity.

64 PAP belongs to a family of arthropod serine proteinases containing a carboxyl-terminal protei

65 tion by elastolytic enzymes belonging to the serine proteinase, cysteine proteinase, and metallo-prot

66 d VLA-5 expression, and did so by inducing a serine proteinase-dependent proteolysis of this beta(1)

67 of West Nile virus (WNV) with an N-terminal serine proteinase domain and an RNA triphosphatase, an N

68 o terminus, a linker region, and a catalytic serine proteinase domain at the carboxyl terminus.

69 Molecular modeling of the serine proteinase domain of macrophage stimulating prote

70 n, whereas the 30-kDa light chain contains a serine proteinase domain, which was labeled by [(3)H]dii

71 respectively) and a lesser reduction of the serine proteinase, elastase (46%).

72 sion in macrophages that increased following serine proteinase exposure.

73 minogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events tha

74 riety of molecules, including the neutrophil serine proteinases, extracellularly.

75 findings represent a novel mechanism whereby serine proteinases facilitate epithelial cell survival a

76 rombinase, an enzyme complex composed of the serine proteinase factor Xa and a cofactor protein, fact

77 complex (Xase) composed of the trypsin-like serine proteinase, factor VIIa, bound to tissue factor (

78 novel two-component viral proteinase of the serine proteinase family, NS2B/NS3(Pro), in the endoplas

79 e secretion of matrix metalloproteinases and serine proteinases for the extracellular degradation of

80 Tissue-type plasminogen activator (tPA) is a serine proteinase found in the intravascular space and t

81 As an example, we found that the serine proteinase from Staphylococcus aureus (SSP) had v

82 We have identified three different serine proteinases from the German cockroach that may, v

83 haracterization of TgSUB2, a subtilisin-like serine proteinase, from T. gondii.

84 Serine proteinase gene expression in femoral head cartil

85 mbled CrmA in that a stable complex with the serine proteinase granzyme B was detectable after sodium

86 ith selectivity against structurally related serine proteinases (>1000 times).

87 es of many protein inhibitors complexed with serine proteinases have revealed that the amide NH group

88 itional MC/B mediators or receptors, such as serine proteinases, histamine 4-receptor, 5-lipoxygenase

89 o prevented processing of pro-phenoloxidase, serine proteinase homolog (SPH) 1, and SPH2.

90 The serine proteinase homologs associate with a bacteria-bin

91 However, in the presence of two serine proteinase homologs, active phenoloxidase was gen

92 Furthermore, immulectin-2, serine proteinase homologs, proPO, PO, attacin-2, and a

93 the four kringle domains (K1 to K4) and the serine proteinase homology domain (SP) of HGF/SF individ

94 -strands b-c and d-a, whereas the C-terminal serine proteinase homology domain binds the opposite "b"

95 forms of the previously identified hemolymph serine proteinase, HP21.

96 tested whether neutrophil azurophil granule serine proteinases, human neutrophil elastase (NE), cath

97 We have identified more than 20 serine proteinases in hemolymph of the tobacco hornworm,

98 in regulating both exogenous and endogenous serine proteinases in hemolymph.

99 a central coordinator for activation of many serine proteinases in immune/inflammatory cells.

100 Serine proteinases in insect plasma have been implicated

101 evolutionary pathway of the dual clip-domain serine proteinases in M. sexta.

102 Increasing evidence implicates serine proteinases in pathologic tissue turnover.

103 Increasing evidence implicates serine proteinases in the proteolytic cascades leading t

104 inalis is a potent protein inhibitor of many serine proteinases including chymotrypsin and subtilisin

105 iants were active as inhibitors of microbial serine proteinases, including subtilisin Carlsberg, prot

106 oforms of AbetaPP that contain a Kunitz-type serine proteinase inhibitor (KPI) domain are expressed i

107 therton disease (SPINK5) encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed i

108 ane and thus was named myoepithelium-derived serine proteinase inhibitor (MEPI).

109 Serine proteinase inhibitor (PI)-9 with a reactive cente

110 d efficacy of a novel nontoxic viral-derived serine proteinase inhibitor (SERP-1) in preventing posta

111 en (PSA) and its SDS-stable complex with the serine proteinase inhibitor (serpin) alpha(1)-antichymot

112 Kallistatin is a unique serine proteinase inhibitor (serpin) and a heparin-bindi

113 rch showed that GCET1 has a highly conserved serine proteinase inhibitor (SERPIN) domain and is locat

114 Members of the serine proteinase inhibitor (serpin) family play importa

115 C1 inhibitor (C1INH), a member of the serine proteinase inhibitor (serpin) family, is an inhib

116 a(1)-antichymotrypsin (ACT), a member of the serine proteinase inhibitor (serpin) family.

117 ibitory members of the high-molecular-weight serine proteinase inhibitor (serpin) family.

118 We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for t

119 The activity of the serine proteinase inhibitor (serpin) plasminogen activat

120 ation levels of kallistatin, a member of the serine proteinase inhibitor (SERPIN) superfamily with an

121 metazoan member of the high molecular weight serine proteinase inhibitor (serpin) superfamily, we ini

122 Kallistatin is a serine proteinase inhibitor (serpin) that specifically i

123 Headpin is a novel serine proteinase inhibitor (serpin) with constitutive m

124 An amyloid-associated serine proteinase inhibitor (serpin), alpha(1)-antichymo

125 Kallistatin, a serine proteinase inhibitor (serpin), is expressed in th

126 A cDNA clone for the serine proteinase inhibitor (serpin), neuroserpin, was i

127 Kallistatin is a heparin-binding serine proteinase inhibitor (serpin), which specifically

128 nd hence named trespin (TGF-beta-repressible serine proteinase inhibitor (trespin).

129 nhibitor 9 (PI-9), or the murine orthologue, serine proteinase inhibitor 6 (SPI-6), confers resistanc

130 r 9 (PI-9/serpinB9) and the murine ortholog, serine proteinase inhibitor 6 (SPI-6/serpinb9) are membe

131 have demonstrated that administration of the serine proteinase inhibitor alpha1-antitrypsin (AAT) pre

132 trix of type I collagen and the ability of a serine proteinase inhibitor and all-trans-retinoic acid

133 uman LEKTI gene encodes a putative 15-domain serine proteinase inhibitor and has been linked to the i

134 es in, and the functional activation of, the serine proteinase inhibitor antithrombin.

135 lular matrix, is composed of the light-chain serine proteinase inhibitor bikunin and two homologous h

136 icating that the RRHR motif is not a general serine proteinase inhibitor binding site.

137 ed peptidylarginine deiminases, kallikreins, serine proteinase inhibitor family members, Kruppel-like

138 adly expressed multifunctional member of the serine proteinase inhibitor family.

139 Inter-alpha-inhibitor (IalphaI) is a serine proteinase inhibitor found in high concentrations

140 A Beta vulgaris serine proteinase inhibitor gene (BvSTI) was fused to th

141 The abundant serine proteinase inhibitor heparin cofactor II (HCII) h

142 vator inhibitor type 2 (PAI-2) is an unusual serine proteinase inhibitor in that it is largely retain

143 The sugar beet serine proteinase inhibitor may be more effective for in

144 sue-type plasminogen activator (tPA) and the serine proteinase inhibitor neuroserpin are both express

145 -Antitrypsin is the archetypal member of the serine proteinase inhibitor or serpin superfamily.

146 ent study was to investigate the role of the serine proteinase inhibitor plasminogen activator inhibi

147 ve "canonical conformation" typical of small serine proteinase inhibitor proteins, which explains why

148 le the interaction with other members of the serine proteinase inhibitor superfamily, protein nexin 1

149 or pathway inhibitor (TFPI) is a Kunitz-type serine proteinase inhibitor that down-regulates tissue f

150 ima phloem serpin-1 (CmPS-1), a novel 42-kDa serine proteinase inhibitor that is developmentally regu

151 (TFPI-2), which encodes for a broad-spectrum serine proteinase inhibitor that negatively regulates th

152 We report here that the serine proteinase inhibitor tissue factor pathway inhibi

153 Kallistatin is a serine proteinase inhibitor which binds to tissue kallik

154 e inhibitor of the Wnt pathway, SERPINA3K, a serine proteinase inhibitor with anti-inflammatory and a

155 igment epithelium-derived factor (PEDF) is a serine proteinase inhibitor with antiangiogenic activiti

156 Members of the serpin (serine proteinase inhibitor) superfamily play a central

157 ocyte proteinase inhibitor (SLPI) is a major serine proteinase inhibitor, a potent antibiotic, and th

158 SERPINA3K is a serine proteinase inhibitor, and its levels were decreas

159 ve shown that retinal levels of SERPINA3K, a serine proteinase inhibitor, are decreased in an animal

160 Serine proteinase inhibitor, clade E, member 2 (SERPINE2

161 Labeling of these polypeptides with a serine proteinase inhibitor, diisopropyl fluorophosphate

162 nes including DEFB4 (defensin B4), SERPINB3 (serine proteinase inhibitor, member 3), STAT1 (signal tr

163 alpha(1)-Antichymotrypsin is a member of the serine proteinase inhibitor, or serpin, family that typi

164 Addition of the broad-spectrum serine proteinase inhibitor, p-aminobenzamidine, or the

165 show that sodium dodecyl sulfate induces the serine proteinase inhibitor, plasminogen activator inhib

166 The serine proteinase inhibitor, plasminogen activator inhib

167 s, whereas levels of mRNA encoding a related serine proteinase inhibitor, proteinase inhibitor 8, wer

168 op-active site interaction characteristic of serine proteinase inhibitor-serine proteinase pairs.

169 is a secreted myxoma virus anti-inflammatory serine proteinase inhibitor.

170 ium-derived factor (PEDF), a multifunctional serine proteinase inhibitor.

171 In addition, CPAMD8 has a Kazal-type serine proteinase inhibitor/follistatin-like domain at t

172 ecular mechanism of action of this family of serine proteinase inhibitors (I77).

173 The high-molecular-weight serine proteinase inhibitors (serpins) are restricted, g

174 Serine proteinase inhibitors (serpins) form enzymaticall

175 Serine proteinase inhibitors (serpins) play a vital regu

176 High-molecular-weight serine proteinase inhibitors (serpins) regulate a divers

177 Serine proteinase inhibitors (serpins), typically fold t

178 a distinct substrate specificity, targeting serine proteinase inhibitors (serpins), which regulate c

179 kin-18-binding protein, semaphorin, and five serine proteinase inhibitors (serpins).

180 protein polymerization in the superfamily of serine proteinase inhibitors (serpins).

181 genes that encode two high-molecular-weight serine proteinase inhibitors (serpins).

182 b9) are members of a family of intracellular serine proteinase inhibitors (serpins).

183 rypsin inhibitor-like (TIL) domains of small serine proteinase inhibitors (smapins).

184 Pretreatment of CM with serine proteinase inhibitors 4-(2-aminoethyl)benzenesulf

185 ents but was inhibited by specific synthetic serine proteinase inhibitors and the aminopeptidase inhi

186 Proteinaceous serine proteinase inhibitors are widespread throughout t

187 ) is distinct from those of other classes of serine proteinase inhibitors except in the inhibitor loo

188 The serpin-type serine proteinase inhibitors have a flexible reactive si

189 Serine proteinase inhibitors have been reported to block

190 The serpin family of serine proteinase inhibitors is a mechanistically unique

191 Many serine proteinase inhibitors of the serpin superfamily h

192 Serpins are a superfamily of serine proteinase inhibitors which function to regulate

193 The serpins (SERine Proteinase INhibitors) are a family of proteins w

194 ration/spermiogenesis (metalloproteinase and serine proteinase inhibitors), and steroidogenesis (CYP2

195 Serpins, serine proteinase inhibitors, form enzymatically inactiv

196 Serine proteinase inhibitors, including plasminogen acti

197 de precursors is believed to be regulated by serine proteinase inhibitors, or serpins.

198 a-lytic proteinase by two standard mechanism serine proteinase inhibitors, turkey ovomucoid third dom

199 05 that members of the serpin superfamily of serine proteinase inhibitors, which are best recognized

200 PI) is a member of the serpin superfamily of serine proteinase inhibitors, which function in maintain

201 age was inhibited with synthetic and natural serine proteinase inhibitors.

202 upplemented with any one or all of the above serine proteinase inhibitors.

203 n-reactive loop of the Bowman-Birk family of serine proteinase inhibitors.

204 high molecular weight serpin superfamily of serine proteinase inhibitors.

205 n vitro evolution of two unrelated canonical serine proteinase inhibitors.

206 P-mediated Abeta degradation is inhibited by serine proteinase inhibitors.

207 r bracovirus encodes the Egf family of small serine proteinase inhibitors.

208 rd mechanism canonical protein inhibitors of serine proteinases, inserts into the S1 primary specific

209 SDS-resistant ACT complex, suggesting an ACT-serine proteinase interaction.

210 a manner similar to that observed for serpin-serine proteinase interactions.

211 similar to that observed for typical serpin-serine proteinase interactions.

212 einase inhibitor that regulates a variety of serine proteinases involved in coagulation and fibrinoly

213 demonstrate that a catalytically active NS3 serine proteinase is essential for pestivirus replicatio

214 mily of protein inhibitors with six selected serine proteinases is described.

215 in-cleaving enzyme (APCE), a prolyl-specific serine proteinase, is essentially identical to membrane-

216 n-coupled receptor activated by trypsin-like serine proteinases, is expressed on intestinal epithelia

217 , a G-protein-coupled Receptor, activated by serine proteinases, is reported to have both protective

218 ously reported that expression of a panel of serine proteinase kallikreins (KLK 5, 7, 8, and 10) is c

219 Serine proteinase levels increased in colitic tissue, wi

220 hypothesize that several membrane-associated serine proteinases (MASPs), in synergy with or in place

221 was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in

222 Most importantly, we show that serine proteinase MMP-12 regulation in macrophages occur

223 d to form SDS-stable complexes with inactive serine proteinases modified at the catalytic serine with

224 Serine proteinases modulate the interaction of tumor cel

225 tructures confirms the "universality" of the serine proteinase motif and reveals a difference at resi

226 bond in the complexes of OMTKY3 with several serine proteinases, native chemical ligation was used fo

227 of P. aeruginosa flagellin by the neutrophil serine proteinases neutrophil elastase and cathepsin G r

228 FNf also induced monocytes to release a serine proteinase, nominally identified as proteinase-3,

229 d the hypothesis that the neutrophil-derived serine proteinases (NSPs): neutrophil elastase, proteina

230 Because the serine proteinase of the natural anticoagulant pathway,

231 the reagents can be employed for labeling of serine proteinases of diverse substrate specificity.

232 ence showed significant identity with fungal serine proteinases of the subtilisin family, indicating

233 lt of nucleophilic attack by Ser(195) of the serine proteinase on the P1 residue within the RCL of th

234 The specific action of serine proteinases on protein substrates is a hallmark o

235 operative aprotinin, an inhibitor of several serine proteinases, or placebo.

236 elevant results from studies of other serpin-serine proteinase pairs.

237 haracteristic of serine proteinase inhibitor-serine proteinase pairs.

238 A serine proteinase pathway in insect hemolymph leads to p

239 l point in cartilage collagen breakdown, and serine proteinase pathways activate MMPs.

240 We examined the role of the serine proteinase plasmin in regulating fibroblast-media

241 The serine proteinases plasmin and thrombin convert proenzym

242 rLEKTI inhibited the serine proteinases plasmin, subtilisin A, cathepsin G, h

243 onfirm the identity of, and to quantify, the serine proteinase, plasmin.

244 Although the VSMC-derived serine proteinases, plasminogen activator and plasminoge

245 suited to bind high concentrations of active serine proteinases released from degranulating PMN.

246 d the secretion of the metalloproteinase and serine proteinases, respectively.

247 n of the NS3 protein, is a chymotrypsin-like serine proteinase responsible for processing of the nons

248 The prohormone convertases (PCs) are serine proteinases responsible for the processing of sec

249 teraction of this class of inhibitors with a serine proteinase results in the formation of a stable a

250 in, SCCA2 (an inhibitor of chymotrypsin-like serine proteinases), reversed their target specificities

251 Chymases are chymotrypsin-like serine proteinases secreted by mast cells.

252 istic of the prolyl oligopeptidase family of serine proteinases (Ser-Asp-His).

253 or (BPTI), a well-known inhibitor of various serine proteinase (SerP) enzymes.

254 Standard mechanism protein inhibitors of serine proteinases share a common mechanism of interacti

255 eveloped for immobilizing thrombin and other serine proteinases specifically (>/=92%) through their a

256 The A. bisporus serine proteinase SPR1 is induced by humic acids and is

257 The propeptides of subtilisin-like serine proteinases (subtilases, SBTs) serve dual functio

258 this family that is cleaved and activated by serine proteinases such as thrombin, trypsin, and cathep

259 Transforming growth factor-beta (TGF-beta), serine proteinases such as trypsin, and proteinase-activ

260 plasminogen activator inhibitor-1 (PAI-1) to serine proteinases, such as tissue-type plasminogen acti

261 contained increased levels of several active serine proteinases, suggesting that MP24.15 activates on

262 lin is susceptible to cleavage by neutrophil serine proteinases suggests a novel role for these enzym

263 Members of the Flaviviridae encode a serine proteinase termed NS3 that is responsible for pro

264 Although 12 of the 13 serine proteinases tested in our laboratory for inhibiti

265 d two complementary approaches to identify a serine proteinase that activates proPAP3.

266 from the tobacco hornworm, Manduca sexta, a serine proteinase that activates proPO, and have cloned

267 f the tobacco hornworm, Manduca sexta, a new serine proteinase that cleaves prophenoloxidase.

268 Tissue-type plasminogen activator (tPA) is a serine proteinase that is found in the intravascular spa

269 autoantigen in Wegener's granulomatosis is a serine proteinase that is normally stored intracellularl

270 kinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-typ

271 kinase-type plasminogen activator (uPA) is a serine proteinase that, upon binding to its receptor (uP

272 kinase-type plasminogen activator (uPA) is a serine proteinase that, upon binding to its receptor (uP

273 a-defensins are converted to active forms by serine proteinases that co-localize in azurophil granule

274 rypsin-like elastases (CELAs) are pancreatic serine proteinases that digest dietary proteins.

275 terocyclic mechanism-based inhibitors of the serine proteinases that embody in their structure a nove

276 ite loop (RSL) to bait and trap their target serine proteinases, the mechanism by which they inactiva

277 molecules inhibit the central blood-clotting serine proteinase thrombin that is also the target of se

278 sumed to be a physiological inhibitor of the serine proteinase thrombin.

279 The serine proteinase tissue kallikrein has been previously

280 The serine proteinase tissue-type plasminogen activator (tPA

281 Type II transmembrane serine proteinase (TMPRSS6) antagonizes hepcidin inducti

282 demonstrated that the type II transmembrane serine proteinase (TTSP) matriptase acts as a novel init

283 family member, interacting with the same six serine proteinases under the same conditions.

284 ester analog interacting with a panel of six serine proteinases, we have determined that the P1 NH-->

285 Serine proteinases were detected by casein substrate zym

286 zymography, one metalloproteinase and three serine proteinases were detected in the conditioned medi

287 A panel of mammalian serine proteinases were screened and Bm-SPN-2 protein wa

288 are directed against proteinase-3 (PR-3), a serine proteinase which is located in azurophilic granul

289 of stable mechanism-based inhibitors of the serine proteinases which can be readily synthesized usin

290 expression of matrix metalloproteinases and serine proteinases, while others induce apoptosis throug

291 Neutrophil elastase (NE) is a potent serine proteinase whose expression is limited to a narro

292 This proteinase was a serine proteinase, whose identity is not known.

293 A serine proteinase with a broad band around 180 kDa was f

294 ten-containing medium from which an alkaline serine proteinase with a molecular mass of 28.7 kDa was

295 rophil elastase (NE) is a neutrophil-derived serine proteinase with broad substrate specificity.

296 Granzyme B, a serine proteinase with substrate specificity similar to

297 f these variants with six well characterized serine proteinases with hydrophobic S1, cavities.

298 Seven of the variants inhibited mammalian serine proteinases, with association rate constants comp

299 y inducing non-proteolytic activation of the serine proteinase zymogen, plasminogen (Pg), in the SK.P

300 tic activation mechanism of trypsinogen-like serine proteinase zymogens, insertion of the first 2 res