ライフサイエンスコーパス: serine racemase

1 te the conversion of l-serine to d-serine by serine racemase.

2 porin 4, actin, and glutamine synthetase and serine racemase.

3 nd is created by conversion from L-serine by serine racemase.

4 zation of L- to D-serine by a membrane-bound serine racemase.

5 Serine racemase activity was also detected in membrane p

6 lacking the predicted transmembrane domain, serine racemase activity was detected in the cytoplasm.

7 n was overexpressed in Escherichia coli, and serine racemase activity was detected in the membrane bu

8 The serine racemase activity was partially (64%) inhibited b

9 the astrocytic d-serine-synthesizing enzyme serine racemase after CCI injury improved synaptic plast

10 reversibly converting l-serine to d-serine, serine racemase also deaminates serine via beta-eliminat

11 We now report cloning and expression of serine racemase, an enzyme catalyzing the formation of D

12 -8)), whereas a variant in SRR (that encodes serine racemase and is associated with schizophrenia) co

13 d-serine is synthesized from its l-isomer by serine racemase and is metabolized by the D-amino acid o

14 oxyaspartate follow this trend, with both WT serine racemase and the S84N mutant being competitively

15 HPASMCs also express high levels of serine racemase and vesicular glutamate transporter 1, s

16 urial components of rat spinal nerve contain serine racemase, and western blot analysis detected the

17 tions of D-serine and it biosynthetic enzyme serine racemase approximate the distribution of NMDA rec

18 5.1.1.13, and 41% identical to the mammalian serine racemase, EC 5.1.1.18.

19 and fibroblasts, and both cell types showed serine racemase expression by immunofluorescence and Wes

20 d modulate neuronal activity in the CNS, but serine racemase expression in the PNS has not been repor

21 knockouts showed a compensatory increase in serine racemase expression.

22 Purified serine racemase has a molecular mass of 37 kDa and requi

23 two genetically modified mouse strains: the serine racemase homozygous knockout (SR-/-) and glycine

24 The first dual-function assay for human serine racemase (hSR), the only bona fide racemase in hu

25 fication of slow binding inhibitors of human serine racemase (hSR).

26 Occurrence of serine racemase in the brain demonstrates the conservati

27 tected d-serine and its synthesizing enzyme, serine racemase, in the retinas of several vertebrate sp

28 ded periods, the broad expression pattern of serine racemase indicates it to be a host enzyme whose a

29 Serine racemase is a protein representing an additional

30 enzymatically depleting D-serine or by using serine racemase knock-out (SR-KO) mice, confirming its s

31 increase the NMDAR potentials in slices from serine racemase knock-out mice, which are devoid of D-se

32 We utilized two genetic mouse models, the serine racemase knockout (SR-/-) and the glycine transpo

33 Serine racemase knockout (SR-/-) mice, which lack D-seri

34 blished model of chronic NMDAR hypofunction, serine racemase knockout (SRKO) mice, and their wild-typ

35 In this study, we utilize a serine racemase knockout (SRKO) mouse to explore the con

36 O-Lys(114) hydrogen-bonding network in human serine racemase lowers the pKa of the Ser(84)re-face bas

37 These expression patterns of serine racemase may indicate roles for D-serine in perip

38 olymerase chain reaction, further confirming serine racemase mRNA in Schwann cells and fibroblasts.

39 ptor (NMDAR) hypofunction, and thus used the serine racemase-null mutant mouse (SR(-/-)), which has l

40 e enzyme responsible for D-serine synthesis (serine racemase) or blocking NMDA receptor glycine coago

41 ynapses) is racemized by the neuronal enzyme serine racemase (SR) from L-serine.

42 Serine racemase (SR) generates D-serine, a coagonist wit

43 Moreover, deletion of serine racemase (SR) in glutamatergic neurons abrogated

44 Serine racemase (SR) is the enzyme that converts L-serin

45 D-Serine, formed from L-serine by serine racemase (SR), is a physiologic coagonist at NMDA

46 ow that the biosynthetic enzyme of d-serine, serine racemase (SR), is expressed almost entirely by ne

47 Serine racemase (SR), localized to astrocytic glia that

48 DISC1 binds to and stabilizes serine racemase (SR), the enzyme that generates D-serine

49 ale genome-wide association study identified serine racemase (SR), the enzyme that produces the NMDAR

50 We show that serine racemase (SR), which generates D-serine from L-se

51 We identify serine racemase (SR), which generates the N-methyl-d-asp

52 thesized in the brain by the neuronal enzyme serine racemase (SR).

53 in synapses and is synthesized by the enzyme serine racemase (SR).

54 duced by glycine, a competitive inhibitor of serine racemase (SR).

55 hesized from L-serine by the neuronal enzyme serine racemase (SR).

56 ession quantitative trait locus of the human serine racemase (SRR) gene, was associated with fear-rel

57 NMDARs generated from l-serine by the enzyme serine racemase (Srr).

58 Serine racemase, the D-serine-synthesizing enzyme, is ex

59 There is currently great interest in human serine racemase, the enzyme responsible for producing th

60 Whereas l-serine is not transported, serine racemase, the synthesizing enzyme for d-serine, i

61 pe mice as well mice deficient in microglial serine racemase (TMEM119creErt2:SRRfl/fl) or neuronal Gl

62 D-Serine is formed by serine racemase, which directly converts L-serine to D-s

63 Our findings reveal that human serine racemase, which is broadly expressed in multiple