ライフサイエンスコーパス: serine-threonine kinase

1 its deactivating phosphorylation by Mst1, a serine/threonine kinase.

2 menon depends on the RTKs activating the AKT serine/threonine kinase.

3 ivation segment conformation of tyrosine and serine/threonine kinases.

4 Fs) and the protein kinase D (PKD) family of serine/threonine kinases.

5 phosphorylation at Ser133 by various protein serine/threonine kinases.

6 t plant phytochromes are autophosphorylating serine/threonine kinases.

7 sensus amino acid sequences of human protein-serine/threonine kinases.

8 T and reduced levels of receptor-interacting serine-threonine kinase 1 and CRC cell necroptosis.

9 ed with lower levels of receptor-interacting serine-threonine kinase 1 and shorter survival times of

10 target Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) expression, and miR-155-5p in

11 T reduced levels of the receptor-interacting serine-threonine kinase 1, a mediator of necroptosis, in

12 Cyclins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M phase

13 Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of

14 allosteric inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK-1).

15 opJ required caspase-8, receptor-interacting serine/threonine kinase 1 (RIPK1), and Fas-associated de

16 mitogen-activated protein kinase interacting serine/threonine kinase 1 activation significantly suppr

17 ate-activated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as

18 d protein kinase) and MNK1 (MAPK-interacting serine/threonine kinase 1) signaling.

19 stream TBK1 (TANK-Binding Kinase 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory f

20 ryonic fibroblasts from receptor interacting serine/threonine kinase 1-knockout mice or their WT litt

21 ymphocyte-oriented kinase (LOK), also called serine threonine kinase 10 (STK10), is synthesized mainl

22 nase B1 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Mullerian duct

23 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is one of the mo

24 The tumor suppressor serine/threonine kinase 11 (STK11 or LKB1) is mutated in

25 Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11) is the major energy s

26 Serine/threonine kinase 11 (STK11, also known as LKB1) f

27 Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor

28 domain containing (Nod)/receptor-interacting serine-threonine kinase 2 (Ripk2) signals in DCs.

29 the dysregulation of microtubule-associated serine/threonine kinase 2 and protein-o-mannose kinase S

30 act is mediated through receptor-interacting serine/threonine kinase 2, and the transcriptional regul

31 t critically depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kina

32 em to mice deficient in receptor-interacting serine-threonine kinase 3 (RIPK3).

33 involved in TGF-beta signaling, such as AKT Serine/Threonine Kinase 3 (AKT3) and Sulfatase 1 (SULF1)

34 vitro and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of p

35 1, -11, -12, and -8 and receptor interacting serine/threonine kinase 3 (RIPK3).

36 We also validated that serine/threonine kinase 35 is a target of miR-377 using

37 lakophilin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiat

38 We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin

39 e D2 (PKD2) is a member of the PKD family of serine/threonine kinases, a subfamily of the CAMK super-

40 monstrated that IkappaB kinase beta is a key serine/threonine kinase activated by autophagy stimuli a

41 teracting protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 p

42 ual-specificity kinase and both tyrosine and serine/threonine kinase activities are required for its

43 of GO terms protein kinase activity/protein serine threonine kinase activity, response to heat and r

44 Pak2 serine/threonine kinase activity is required for stromal

45 The p.E80K mutation abolished serine/threonine kinase activity, resulting in altered I

46 athways, including the regulation of protein serine/threonine kinase activity.

47 (3)K (phosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint

48 identified a signaling pathway-involving the serine-threonine kinase AKT and the transcription factor

49 The serine-threonine kinase Akt is a key regulator of cell p

50 Activation of the serine-threonine kinase Akt promotes the survival and pr

51 The serine-threonine kinase AKT regulates proliferation and

52 lic checkpoint kinase complex mTORC2 and the serine-threonine kinase Akt, and loss of this activity r

53 gering depends on the activation of PI3K and serine-threonine kinase Akt, and protein synthesis relie

54 al and activation-induced phosphorylation of serine-threonine kinases Akt and mechanistic target of r

55 aluate mice lacking specific isoforms of the serine/threonine kinase AKT and bone marrow chimeras, we

56 Pharmacologic inhibition of the serine/threonine kinase Akt has recently been shown to p

57 Although the role of the key serine/threonine kinase Akt in promoting CNS myelination

58 Here we examined the role of the serine/threonine kinase Akt in the generation of protect

59 The serine/threonine kinase AKT is a key mediator of cancer

60 In response to growth factors, the serine/threonine kinase AKT phosphorylates Thr(24) and S

61 The serine/threonine kinase Akt plays a central role in cell

62 The serine/threonine kinase Akt, which regulates HTT functio

63 risphosphate (PIP3), and the activity of the serine/threonine kinase AKT.

64 oral inhibitor of all three isoforms of the serine/threonine kinase AKT.

65 This results in AKT serine/threonine kinase (Akt) activation, membrane focal

66 tivated phosphoinositide 3-kinase (PI3K)/Akt serine/threonine kinase (Akt) and mitogen-activated prot

67 Akt is a family of three serine-threonine kinases, Akt1, Akt2, and Akt3.

68 disease has led to the identification of the serine/threonine kinase ALK2 as a potential target for t

69 LKB1 is a serine/threonine kinase and a commonly mutated gene in l

70 ke kinase (NLK) is an evolutionary conserved serine/threonine kinase and a negative regulator of the

71 Here we show that SPA1 acts as a serine/threonine kinase and directly phosphorylates PIF1

72 expression of general control nonrepressed 2 serine/threonine kinase and increased expression of mamm

73 Expression of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamyci

74 w will focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by sca

75 induce downstream signaling through the ERK serine/threonine kinase and the Fos transcription factor

76 The liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppressor that couple

77 RATIONALE: LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regu

78 The serine/threonine kinases and sole phosphatase of Mtb tun

79 (384) by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is req

80 induce expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcrip

81 We show that the apically localized serine/threonine kinase aPKC directly phosphorylates an

82 e identify CDK5, a predominantly cytoplasmic serine/threonine kinase, as an important regulator of DL

83 homologous to penicillin-binding protein and serine/threonine kinase associated (PASTA) domains, and

84 extracellular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which

85 of bacterial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of

86 monovalent cations and contains a functional serine/threonine kinase at its carboxyl terminus.

87 , FBXO31 is phosphorylated by the DNA damage serine/threonine kinase ATM, resulting in increased leve

88 ession led to reduced phosphorylation of the serine/threonine kinases ATM and Chk2 and of histone H2A

89 ic aberrations in FA-complex genes or in ATM serine/threonine kinase (ATM) exhibited significantly lo

90 recruitment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where

91 expression of Gene 33 triggers DDR in an ATM serine/threonine kinase (ATM)-dependent fashion and thro

92 Classically defined as a serine/threonine kinase, BIK1 is shown here to possess t

93 Mutations in the serine/threonine kinase BRAF are found in more than 60%

94 tral element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in develop

95 The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequent

96 The protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver an

97 lator phenotype (CIMP), B-Raf proto-oncogene serine/threonine kinase (BRAF) mutation, and Kirsten rat

98 te instability, and the B-Raf protooncogene, serine/threonine kinase (BRAF), mutation) in the Nurses'

99 es such as PLK1 (Polo-like kinase 1), C-MYC, serine-threonine kinase BUB1B and regulates their expres

100 eurin and protein phosphatase-1, as well the serine/threonine kinases CaMKII and PKA.

101 rpC activity is controlled by the Pkn8/Pkn14 serine/threonine kinase cascade, which phosphorylates Mr

102 Here we report that the conserved serine/threonine kinase, casein kinase II (CK2), promote

103 es containing both an ion channel pore and a serine/threonine kinase (chanzyme).

104 that the 7-amino acid truncation in NUAK2, a serine/threonine kinase, completely abrogated its cataly

105 Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subuni

106 inspection of their primary sequences, many serine-threonine kinases display a significant preferenc

107 A key serine/threonine kinase distantly related to the MAPK fa

108 n the late 1970s, is composed of at least 10 serine/threonine kinases, divided into three groups base

109 he pro-apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with bet

110 p21-activated kinases (PAK) are a family of serine/threonine kinases downstream of multiple critical

111 p21-activated kinases (PAKs) are serine/threonine kinase effectors of the small GTPases R

112 like kinase 1 (DCLK1), a microtubule binding serine threonine kinase, emerged as a promising target d

113 ere, we show that the kinase activity of the serine/threonine kinase encoded by TAOK2 is required for

114 The Escherichia coli eukaryote-like serine/threonine kinase, encoded by yeaG, is expressed i

115 studies, we find that phosphorylation of the serine/threonine kinase ERK (pERK) preferentially occurs

116 is now well appreciated that eukaryotic-like serine/threonine kinases (eSTKs) control essential proce

117 on affecting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient with congen

118 CD transactivation of microtubule associated serine/threonine kinase family member 4 (MAST4).

119 The Fas-activated serine/threonine kinase (FASTK) family of proteins has r

120 Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and imp

121 alian target of rapamycin complex 1 (mTORC1) serine/threonine kinase from the lysosomal membrane.

122 Somatic inactivation of the serine/threonine kinase gene STK11/LKB1/PAR-4 occurs in

123 tic and in vitro functional studies, a novel serine/threonine kinase gene, unc-51-like kinase 4 (ULK4

124 Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer

125 We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3

126 ubstrate specificity of the host pleiotropic serine/threonine kinase GSK3.

127 ycogen synthase kinase-3 beta (GSK-3beta), a serine/threonine kinase, has been identified as a potent

128 lates p53Ser46(P) by binding and stabilizing serine-threonine kinase HIPK2.

129 The serine/threonine kinase HIPK2 functions as a regulator o

130 The serine/threonine kinase IL-1R-associated kinase (IRAK)4

131 nase 3 (GSK-3, isoforms alpha and beta) is a serine-threonine kinase implicated in cellular processes

132 hat Minibrain (Mnb; also known as Dyrk1A), a serine/threonine kinase implicated in autism spectrum di

133 kinase kinase kinase kinase 4 (MAP4K4) is a serine/threonine kinase implicated in the regulation of

134 Protein kinase C (PKC) is a family of serine/threonine kinases implicated in a variety of phys

135 The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis

136 ase D (PKD) is a family of stress-responsive serine/threonine kinases implicated in the regulation of

137 one of the highly overexpressed genes of the serine/threonine kinase in CTCL.

138 ULK1/Atg1 is the only serine/threonine kinase in the core autophagy pathway an

139 kinome, we identified PIM1, a non-essential serine-threonine kinase, in a synthetic lethal interacti

140 ene, which encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples.

141 is also a target of casein kinase 2 (CK2), a serine/threonine kinase, in proliferating myoblasts.

142 f rapamycin (TOR), an evolutionary conserved serine/threonine kinase, in the plant defense response.

143 stressful stimulus or treatment with the AKT Serine/Threonine kinase inhibitor SH-6 restored splicing

144 s, P. falciparum exports a family of 18 FIKK serine/threonine kinases into the host cell, suggesting

145 e kinase-3 (GSK3) are ubiquitously expressed serine-threonine kinases involved in a plethora of funct

146 mTOR is a serine/threonine kinase involved in a variety of cellula

147 phosphorylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentia

148 mprise an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis

149 e previously determined that a transmembrane serine/threonine kinase (IreK) and its cognate phosphata

150 LAK cell-originated protein kinase (TOPK), a serine-threonine kinase is activated by SUV irradiation

151 The Aurora family of serine/threonine kinases is essential for mitosis.

152 The specificity of serine/threonine kinases is partly determined by interac

153 ound that casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survi

154 que member of the polo-like kinase family of serine-threonine kinases, is a master regulator of centr

155 1alpha (CK1alpha), a ubiquitously expressed serine/threonine kinase, is a key negative regulator of

156 mTOR, a serine/threonine kinase, is a master regulator of cellul

157 Liver kinase B1 (LKB1), a serine/threonine kinase, is a tumor suppressor and metab

158 ke kinase (NLK), an evolutionarily conserved serine/threonine kinase, is highly expressed in the brai

159 Protein kinase C (PKC) theta, a serine/threonine kinase, is involved in TH2 cell activat

160 Akt, a serine/threonine kinase, is known to increase cell survi

161 urs via the phosphorylation by WNKs of other serine-threonine kinases known as SPAK-OSR1.

162 n of apoptosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflamm

163 atwall kinase (called microtubule-associated serine/threonine kinase like [Mastl] in mammals) is esse

164 We found that the serine/threonine kinase LKB1 and one of its substrates,

165 We identify the serine/threonine kinase LKB1 as a key driver of synapse

166 The serine/threonine kinase LKB1 has been identified as a po

167 We demonstrate that the serine/threonine kinase LKB1 regulates MCU expression, m

168 The serine/threonine kinase mammalian/mechanistic target of

169 mitogen-activated protein kinase-interacting serine-threonine kinases MAP kinase-interacting kinase 1

170 In recent years, the serine/threonine kinase mechanistic target of rapamycin

171 -kinetochore attachments is monitored by the serine/threonine kinase monopolar spindle 1 (MPS1).

172 The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapa

173 The serine/threonine kinase mTOR participates in growth fact

174 endogenous PTEN-induced kinase 1 (PINK1), a serine/threonine kinase mutated in a recessive forms of

175 we identify protein kinase C (PKC) gamma, a serine/threonine kinase mutated in the neurodegenerative

176 In this study, we show that the serine/threonine kinase Ndr2 controls integrin-dependent

177 PRL activates the serine/threonine kinase NEK3, which was reported to enha

178 the screen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen

179 of noncanonical NF-kappaB signaling via the serine/threonine kinase NIK (NF-kappaB-inducing kinase)

180 s abrogated by the liver kinase B1 (LKB1), a serine-threonine kinase of the calcium calmodulin family

181 t was located within STK32C, which encodes a serine/threonine kinase, of unknown function.

182 ociated protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase

183 ociated protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase

184 Some of these binding partners include the serine/threonine kinases, p21-activated kinase 1 (PAK1),

185 ere, we determined that d-flow activated the serine/threonine kinase p90RSK, which subsequently phosp

186 Ovaries in flies mutant for the serine/threonine kinase Pak exhibit a novel phenotype, i

187 Serine/threonine kinase PAK1 is activated by estrogen an

188 The p21-activated serine-threonine kinase (PAK1) regulates cell motility a

189 The protein kinase D family of serine/threonine kinases, particularly PKD1, has been im

190 The hypoxia-inducible, pro-oncogenic, serine-threonine kinase PIM1 (Proviral Integration site

191 The serine-threonine kinase PINK1 is responsible for recruit

192 PKD is a family of three serine/threonine kinases (PKD-1, -2, and -3) involved in

193 We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and pho

194 In eukaryotes, serine/threonine kinases play a central role in antivira

195 Dysregulated oncogenic serine/threonine kinases play a pathological role in div

196 IRAK4, a serine/threonine kinase, plays a key role in both inflam

197 The Akt protein, a serine/threonine kinase, plays important roles in cell s

198 The polo family serine threonine kinase Plk4 has been proposed as a ther

199 We have identified the serine/threonine kinase Polo-like kinase 1 (PLK1) as a h

200 In this context, the serine/threonine kinase, polo-like kinase (PLK1) regulat

201 d to interphase of the cell cycle by NEK7, a serine-threonine kinase previously linked to mitosis.

202 rotein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate poly

203 le for RIPK1 and RIPK3, a pair of homologous serine/threonine kinases previously implicated in the re

204 y the mechanistic target of rapamycin (mTOR) serine/threonine kinase promotes myelination, but factor

205 urn gradually suppressed RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK signaling through the

206 UHMK1 is a nuclear serine/threonine kinase recently implicated in carcinoge

207 Here, we have identified the serine threonine kinase receptor-associated protein (STR

208 eptor-like kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic

209 Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wi

210 teracting protein kinase (Hipk), a conserved serine-threonine kinase, regulates numerous factors duri

211 , Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mit

212 genetic approach identified PKCtheta as the serine/threonine kinase responsible for alphaPIX serine

213 cal and siRNA-mediated inhibition of various serine/threonine kinases revealed ERK1/2 as a positive r

214 randed RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mi

215 The serine/threonine kinase RIPK1 is recruited to TNFR1 to m

216 pressing cell-death-inducing activity of the serine/threonine kinase RIPK1.

217 Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Pr

218 tically, OGT-mediated O-GlcNAcylation of the serine-threonine kinase RIPK3 on threonine 467 (T467) pr

219 membrane translocation and activation of the serine/threonine kinase ROCK1, a downstream target of th

220 how mTORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and Polycomb proteins at ge

221 ion of fibrosis-relevant tyrosine kinase and serine/threonine kinase signaling pathways.

222 iched in protein folding, protein synthesis, serine/threonine kinase signalling, glycolysis and gluco

223 striction-like (drl-1) gene, which encodes a serine/threonine kinase similar to the mammalian MEKK3 k

224 followed by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding p

225 followed by mass spectrometry identified the serine-threonine kinase SPEG as the only novel binding p

226 s phosphorylated at Thr-50 within the LDS by serine/threonine kinase (STK) 3 and STK4.

227 Silencing the serine/threonine kinase STK11 (also known as LKB1) in HT

228 re, we identify a previously uncharacterized serine/threonine kinase STK19 as a novel NRAS activator.

229 two markers, one (rs10937625) located in the serine/threonine kinase STK32B and one (rs17590046) in t

230 YAP1 is under the control of a serine-threonine kinase, STK4.

231 nce also interferes with the activity of the serine/threonine kinase StkP, the central regulator of p

232 In plants and algae, the serine/threonine kinase STN7/STT7, orthologous protein k

233 Trans-membrane signaling involving a serine/threonine kinase (Stt7 in Chlamydomonas reinhardt

234 s for identifying degrader hits based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) and

235 olved in Lm vacuolar rupture, among them the serine/threonine kinase Taok2.

236 We generated Taok3(-/-) mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic

237 The serine/threonine kinase TBK1 (TANK-binding kinase 1) and

238 ed a novel gene fusion of MAP3K8, encoding a serine-threonine kinase that activates MEK(3,4).

239 -coil-containing protein kinase 2 (ROCK2), a serine-threonine kinase that can be therapeutically targ

240 Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that coordinates nutrient and gr

241 how that cyclin-dependent kinase 5 (Cdk5), a serine-threonine kinase that is highly active in postmit

242 CMLSCs is PIM2, which encodes a prosurvival serine-threonine kinase that phosphorylates and inhibits

243 Cdc7 is a serine-threonine kinase that phosphorylates components o

244 Unc-51-like kinase 1 (ULK1) is a conserved serine-threonine kinase that plays a central role in the

245 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiati

246 Serine-threonine kinases that activate NKCC2 have been i

247 The Rho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream ef

248 mTOR is a serine/threonine kinase that acts in two distinct comple

249 LKB1 is a multi-functional serine/threonine kinase that associates with actin at th

250 et of rapamycin (MTOR) is a highly conserved serine/threonine kinase that critically regulates cell g

251 or-interacting protein kinase 1 (RIPK1) is a serine/threonine kinase that dictates whether cells surv

252 ic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular fu

253 an target of rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes, mTORC1

254 acting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development an

255 Aurora B is a serine/threonine kinase that has been implicated in regu

256 GSK-3 is a serine/threonine kinase that has numerous substrates.

257 The HipA toxin functions as a serine/threonine kinase that inhibits cell growth, while

258 n kinase (AMPK) is an evolutionary conserved serine/threonine kinase that integrates cellular energy

259 Receptor-interacting protein (RIP1) is a serine/threonine kinase that integrates inflammatory and

260 AMPK is a serine/threonine kinase that is activated by upstream ki

261 y revealed that Polo-like kinase 1 (PLK1), a serine/threonine kinase that is essential for cell cycle

262 Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that is overexpressed in gastroi

263 e screens was GSG2 (also known as Haspin), a serine/threonine kinase that phosphorylates histone H3 a

264 CK2 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival a

265 Here we identify Stk2, a staphylococcal serine/threonine kinase that provides efficient immunity

266 Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a diverse array o

267 n kinase A (PKA) is a ubiquitously expressed serine/threonine kinase that regulates a variety of cell

268 activated kinases (PAKs) are a family of six serine/threonine kinases that act as key effectors of RH

269 ases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associat

270 inases are a family of constitutively active serine/threonine kinases that are partially redundant an

271 LegK1-4 proteins are eukaryotic-like serine/threonine kinases that are translocated by the Do

272 e (smMLCK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal assoc

273 NEK family kinases are serine/threonine kinases that have been functionally imp

274 re 2 homologous and functionally overlapping serine/threonine kinases that phosphorylate multiple pro

275 L-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in ini

276 d family of abundant, ubiquitously expressed serine/threonine kinases that regulate multiple cellular

277 tudy, we examine the STE20 family of protein serine-threonine kinases to investigate basic mechanisms

278 ippo signaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes

279 The translocation of Akt, a serine/threonine kinase, to the plasma membrane is a cri

280 The serine-threonine kinase TOR, the Target of Rapamycin, is

281 The serine/threonine kinase tumor progression locus 2 (Tpl2,

282 brosis through binding and activation of the serine/threonine kinase type II TGF-beta receptor (Tbeta

283 levels of the essential autophagy initiator serine-threonine kinase ULK1, and increased in the activ

284 protein of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncog

285 Aurora kinases are a family of serine/threonine kinases vital for cell division.

286 ptor type II (TbetaRII) and type I (TbetaRI) serine/threonine kinases, whereby Smad2 and Smad3 are ph

287 endent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the ne

288 AKT and mTOR are serine/threonine kinases which play important roles in c

289 TSPYL2 interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked

290 PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for sev

291 nt Kinase II (CaMKII) is a calcium-regulated serine threonine kinase whose functions include regulati

292 ROCK2 is a serine-threonine kinase whose role in lymphomagenesis is

293 AMPK is a conserved serine/threonine kinase whose activity maintains cellula

294 tivated protein kinase (AMPK) is a conserved serine/threonine kinase with a critical function in the

295 rotein-coupled receptor kinase 2 (GRK2) is a serine/threonine kinase with an important function in th

296 or-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necro

297 Casein kinase 1 alpha (CK1alpha) is a serine/threonine kinase with numerous functions, includi

298 of the polo-like kinases (PLK), a family of serine/threonine kinases with well-known roles in cell c

299 Two of these genes encode the serine-threonine kinases WNK1 and WNK4.

300 One such protein, the serine/threonine kinase YopO (YpkA in Yersinia pestis),