ライフサイエンスコーパス: serologic

1 We collected clinical, serologic, (1)H-MRS PDFF, and liver biopsy data from 94

2 SHIVAD8 that developed broadly neutralizing serologic activity targeting the V3-glycan region of HIV

3 cted with SHIVs develop broadly neutralizing serologic activity, but less is known about the nature o

4 Serologic analyses showed that the 93 isolates cross-rea

5 lar diagnostic assays and highly multiplexed serologic analyses, as well as the development of animal

6 Following immunization of mice, serologic analysis demonstrated that the covalently coup

7 Usually, immunoglobulin M (IgM) serologic analysis is not sufficiently specific to confi

8 We compared findings from serologic analysis with findings from biopsy analyses, f

9 but who test negative by reference 2-tiered serologic analysis.

10 ure, polymerase chain reaction analysis, and serologic analysis.

11 cantly improving the quality and quantity of serologic and B-cell memory responses to clinically rele

12 ficiency virus, which were ruled out through serologic and clinical examinations.

13 Both serologic and genetic data show an association between P

14 cteristics, treatments, clinical course, and serologic and genetic markers.

15 A diagnosis of celiac disease based on serologic and histologic evidence requires patients to b

16 ated with tumor viral status, as assessed by serologic and immunohistochemical testing.

17 Serologic and immunologic deficits were most frequent in

18 The data also suggest that serologic and molecular testing using blood and cerebros

19 laboratory testing was performed, including serologic and nucleic acid amplification testing for B.

20 We identified serologic and radiographic indicators of pMR that could

21 in mCRC demonstrated that it safely induced serologic and T-cell responses.

22 We conducted a cross-sectional serologic and vaccination coverage survey in Nayapara Re

23 rant or 14% had Possible, 8% Convincing, 24% Serologic, and 16% Confirmed allergy.

24 disease is made based on clinical, genetic, serologic, and duodenal morphology features.

25 Symptomatic, serologic, and histological outcomes evaluated gluten to

26 going integration of advances in histologic, serologic, and molecular diagnostic techniques to produc

27 The clinical, serologic, and virologic features were compared between

28 ns can have practical implications, altering serologic approaches to allergen testing and bringing a

29 Serologic approaches to diagnosis remain inaccurate, and

30 To close these gaps, we sought to develop a serologic assay capable of distinguishing among infectio

31 Using the same serologic assay, we compared the estimated anti-HEV immu

32 erning given that the commercially available serologic assays are highly variable, differing in their

33 Well-characterized multiplexed serologic assays are needed to aid in rapid detection an

34 piratory syndrome coronavirus 2 (SARS-CoV-2) serologic assays are needed to inform diagnostic, therap

35 We evaluated three commercial serologic assays as stand-alone tests and as components

36 There are currently five serologic assays available for detection of anti-Zika vi

37 Serologic assays can potentially produce precise exposur

38 h it rapid development of both molecular and serologic assays for identification of COVID-19 infectio

39 f historical perspective on the evolution of serologic assays for Lyme disease and provides a summary

40 rest continues to grow regarding the role of serologic assays for the detection of prior infection wi

41 Available commercial serologic assays for typhoid fever have limited sensitiv

42 validated serologic test exists, and current serologic assays have low sensitivity in early HTBRF.

43 piratory syndrome coronavirus 2 (SARS-CoV-2) serologic assays is needed to guide clinical decision-ma

44 ef summary of the performance of a number of serologic assays reported in the literature, comment on

45 We used H pylori multiplex serologic assays to analyze serum samples from 4063 inci

46 explosion in the number and availability of serologic assays to test for antibodies against SARS-CoV

47 and implementing a variety of molecular and serologic assays to test for SARS-CoV-2 infection.

48 We evaluated performance of these three serologic assays using 72 specimens characterized by pla

49 We have developed multiple serologic assays using newly designed SARS-CoV-2 reagent

50 ailed verification strategies for SARS-CoV-2 serologic assays with FDA EUA are provided, as are insig

51 tly a voluntary process for manufacturers of serologic assays.

52 logy-a rate comparable to the error rate for serologic assays.

53 uthorization (EUA) status to many SARS-CoV-2 serologic assays.

54 y, antibody maturation was evaluated using 3 serologic assays: the BED capture enzyme immunoassay (CE

55 ve homologous helminth proteins in IgE-based serologic assessment of allergic disorders in a helminth

56 ombined use of rOVOC3261 with OV-16 improved serologic assessment of O. volvulus infection, a current

57 rtant implications for our interpretation of serologic binding patterns of anti-HLA antibodies in sen

58 A combination of baseline basophil and serologic biomarkers defined a subset of patients in whi

59 FM from other disorders and for establishing serologic biomarkers of FM-associated pain.

60 To identify novel serologic biomarkers of malaria exposure, we evaluated r

61 ologic changes, in patients who did not have serologic confirmation at the time of diagnosis, and in

62 ction in human fetal brain tissue along with serologic confirmation proves the vertical transmission

63 Many studies assume that the serologic correlate of protection from measles disease i

64 on, critical knowledge gaps remain regarding serologic correlates of protection from infection or dis

65 Subjects were included if they met serologic criteria for syphilis (ie, a positive nontrepo

66 We estimated the levels of serologic cross-reactivity among humans primed with seas

67 Based on serologic cross-reactivity of H3N8 EIV from different li

68 Serologic cross-reactivity, a hallmark of orthopoxvirus

69 f occurrence in the same geographic regions, serologic cross-reactivity, and similar but often less s

70 st-quarter plasma TFV and end-of-study HSV-2 serologic data available.

71 We analyzed serologic data collected from health care workers and fi

72 n hemagglutinin (HA) affecting variations in serologic data for human and swine H1N1 IAVs.

73 e MTL-SGL method are not only able to handle serologic data generated from multiple reagents, supplie

74 ning (GG-MTSL) model that uses multi-sourced serologic data to learn antigenicity-associated mutation

75 rs associated with narcolepsy, together with serologic data, collectively point to an autoimmune orig

76 osis of Lyme disease in the United States is serologic detection of antibodies against Borrelia burgd

77 Serologic determination of human leukocyte antigen antib

78 females; mean age: 42.7 years) with previous serologic diagnosis of HIV, from the acquired immunodefi

79 -on-a-chip point of care (POC) assay for the serologic diagnosis of human Lyme disease.

80 Definitive serologic diagnosis of the infection during gestation is

81 ights the ongoing challenges associated with serologic diagnosis of ZIKV infection.

82 (ELISA) has been proposed as an alternative serologic diagnostic test to the indirect immunofluoresc

83 ck-borne infection in the United States, and serologic evaluation for antibodies to Borrelia burgdorf

84 , to April 1, 2016, in blinded comprehensive serologic evaluation for autoantibody profiles to aid th

85 Serologic evaluation for Zika virus (ZIKV) infection cur

86 Reproductive histories and serologic evaluations were used to determine menopausal

87 The 13 participants who lacked PCR and serologic evidence for exposure to B. burgdorferi could

88 tions across northeast Australia, as well as serologic evidence for HPG in multiple pteropid bat spec

89 Blood samples were tested for serologic evidence of CD.

90 1 asymptomatic recipient in each cluster had serologic evidence of exposure that decreased over time.

91 However, serologic evidence of exposure to an orthopoxvirus was d

92 hases of disease, KD patients do not exhibit serologic evidence of exposure to known viruses that dif

93 nfected children, but not HEU children, lack serologic evidence of immunity to MMR, despite documente

94 ome consistent with Balamuthia infection and serologic evidence of infection.

95 autoinflammatory signs and symptoms without serologic evidence of inflammation as part of an atypica

96 ients born in or after 1957 was reviewed for serologic evidence of measles immunity.

97 No serologic evidence of MERS-CoV transmission was found am

98 Serologic evidence of previous infection in asymptomatic

99 Records of 302 patients with serologic evidence of recent T gondii infection (a posit

100 atory from June 2004 through August 2010 for serologic evidence of recent Toxoplasma gondii infection

101 hese, 35 patients (88%) had molecular and/or serologic evidence of recent ZIKV infection in the serum

102 and T. pallidum from none; one woman showed serologic evidence of syphilis.

103 examinations on 290 of 454 individuals with serologic evidence of T gondii infection during the epid

104 associates with poor allograft outcomes and serologic evidence of viral infections and alloimmunity.

105 These findings do not support routine serologic examination for Borrelia in uveitis patients.

106 FD affects symptoms, histology, immunity, or serologic features of patients with celiac disease.

107 nd study their association with clinical and serologic features.

108 en-detected celiac disease based on positive serologic findings found initiation of a gluten-free die

109 Based on clinical and serologic findings, the genetic defect was detected by m

110 s inability to cross-tabulate histologic and serologic findings.

111 ore was a useful tool in predicting positive serologic findings.

112 tivity was associated strongly with positive serologic findings.

113 e 3 to 15 months, increased in Confirmed and Serologic groups but decreased in Convincing and Possibl

114 t age 2 and 4(+) years only in Confirmed and Serologic groups.

115 Serologic HBV markers, including hepatitis B surface ant

116 LA-DR/DQ single molecule eplet mismatch with serologic, histologic, and clinical outcomes.

117 istent children were more likely to elicit a serologic immune response, and both infection groups had

118 men and control women mount similarly robust serologic immune responses to IIV, with no significant d

119 ut and are useful tools in the evaluation of serologic immunity conferred by vaccination or prior SAR

120 der two opposing models to explain long-term serologic immunity.

121 However, point-of-care technologies and serologic immunoassays are rapidly emerging.

122 In addition, serologic incidence predictions from cross-sectional sam

123 the risk of anti-Saccharomyces antibodies, a serologic marker of IBD, in patients with CeD vs control

124 rapy and medical treatment on the level of a serologic marker of inflammation (high-sensitivity C-rea

125 2 (Ara h 2)-specific IgE is to date the best serologic marker to diagnose peanut allergy.

126 , numbers of intraepithelial lymphocytes, or serologic markers of celiac disease.

127 We assessed associations of serologic markers of monocyte activation, soluble CD163

128 sought to identify potential radiologic and serologic markers of pancreatic tumor response to therap

129 The development of serologic markers specific to CD has revolutionized the

130 specificity and kinetics of these potential serologic markers.

131 Serologic measures of increased intestinal permeability

132 e of glomerular dysfunction and conventional serologic measures, even in patients with other manifest

133 Serologic methods are an important part of a clinical la

134 t of care and add to the currently available serologic methods of nontreponemal and treponemal tests.

135 Time-consuming, costly and middle-throughput serologic methods using virus isolates are routinely use

136 , there is a need for high-throughput, rapid serologic methods.

137 been the development and validation of host serologic microbial biomarkers, which have achieved a di

138 The human serologic observations supported the translational relev

139 ting can therefore improve the accuracy of a serologic panel for the diagnosis of acute toxoplasmosis

140 me-linked immunosorbent assay (ELISA) to the serologic panel of tests done for the diagnosis of acute

141 g only smokers found no correlations between serologic parameters and demographic or clinical paramet

142 of faecal calprotectin (fcal), clinical and serologic parameters in the inflammatory activity evalua

143 , histopathologic (Banff classification) and serologic parameters were compared between both groups b

144 d/convincing diagnosis or last classified as serologic PNA (<2 years, >=5 kUA/L, otherwise >=14 kUA/L

145 IP.4mut suggest utility as an immunogen or a serologic probe; moreover, the specific four alterations

146 An interpretation of the syphilis serologic profile using the traditional algorithm showed

147 dentified specific aortic autoantigens using serologic proteomic studies.

148 We find that serologic reactivity to dengue 1 virus (DENV1) EDIII bef

149 to test for antigens for which there are no serologic reagents is a major medical advance to identif

150 However, after long-term clinical and serologic remission, approximately 11 years after initia

151 identify their target antigens and assessed serologic response among KD patients and controls to spe

152 Maternal serologic response during pregnancy after adequate syphi

153 In addition, we report the serologic response in SOT recipients, documenting a posi

154 The clinical features, disease course, and serologic response of COVID-19 among immunosuppressed pa

155 Factors that negatively influenced serologic response rates were high doses of immunosuppre

156 Serologic response to Cryptosporidium infection was asso

157 ectively, these data suggest that a positive serologic response to HPV16 oncoproteins may be the best

158 ectively, these data suggest that a positive serologic response to HPV16 oncoproteins may be the best

159 We assessed factors that influenced the serologic response to vaccination.

160 Several different patterns of serologic response to VIT were seen; some subjects had a

161 PsA-TT generated robust tetanus serologic responses in 1- to 29-year-olds, similar to th

162 t of a polyclonal immune system and produced serologic responses targeting the CD4bs on Env.

163 alpha blocker use was associated with better serologic responses than other immunosuppressive drugs.

164 ns produce a variety of signs, symptoms, and serologic responses that cause morbidity in patients and

165 Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, wi

166 s representing diverse populations, we found serologic responses to H pylori VacA to associate with i

167 compromised patients showed moderate to good serologic responses to hepatitis A vaccination, but may

168 n long-term memory by measuring cellular and serologic responses to measles.

169 ca assessed whether PsA-TT generated tetanus serologic responses when tested in African populations (

170 hed pathways, and genes that correlated with serologic responses.

171 grans lesion or a positive standard 2-tiered serologic result in a patient with symptoms compatible w

172 dular ocular and systemic manifestations and serologic results in men compared to women.

173 he prior season was indicated by both VE and serologic results.

174 Objective: To assess the evidence on serologic screening and preventive interventions for gen

175 coccidioidal screening; 925/1951 (47.4%) had serologic screening either before beginning TNFi therapy

176 1, 2004 to October 31, 2014, in whom routine serologic screening for Borrelia burgdorferi (IgG as det

177 Conclusions and Relevance: Serologic screening for genital herpes is associated wit

178 Serologic screening for genital herpes was associated wi

179 ation: The USPSTF recommends against routine serologic screening for genital HSV infection in asympto

180 uded that the harms outweigh the benefits of serologic screening for genital HSV infection in asympto

181 ence on the accuracy, benefits, and harms of serologic screening for HSV-2 infection in asymptomatic

182 es; studies evaluating accuracy and harms of serologic screening tests for HSV-2; RCTs assessing prev

183 nd the available evidence on the accuracy of serologic screening tests, the USPSTF concluded that the

184 ients with severe COVID-19 produced a unique serologic signature, including an increased likelihood o

185 Most recent serologic specimen was used to determine measles seropro

186 ation, and clinical data were abstracted and serologic specimens collected.

187 alyzed the impact of donor and recipient EBV serologic status on overall survival, relapse-free survi

188 the B. pertussis receptors was obtained from serologic studies demonstrating pertussis patient serum

189 Even though serologic studies have shown that children are exposed t

190 Previous serologic studies suggest that some Ebola virus survivor

191 ody detection tests and their application to serologic studies, reviews currently available assays, h

192 Our results show that serologic surveillance platforms represent an important

193 l transmission of diverse enteropathogens in serologic surveillance.

194 nch Guiana through individual interviews and serologic survey during June-October 2017.

195 d repeated clinical surveys for active yaws, serologic surveys for latent yaws, and molecular analyse

196 Serologic surveys were conducted from May 2013 to Decemb

197 No validated serologic test exists, and current serologic assays have

198 A serologic test for antibodies to chlamydia may be a usef

199 iduals with a negative result from the first serologic test for tTGA had a positive result from the s

200 Although the availability of a commercial serologic test for ZIKV has greatly expanded the nationa

201 ies to tissue transglutaminase (tTG) are the serologic test of choice for diagnosing celiac disease (

202 osis remains challenging in the absence of a serologic test.

203 Combining the BAT with routine serologic testing allows classification of patients with

204 We review aspects of both molecular and serologic testing and discuss the logistical challenges

205 ia should be used to determine when to order serologic testing and when the results of such testing s

206 for Lyme disease with standardized 2-tiered serologic testing between 2005 and 2010 at a single hosp

207 Although serologic testing does not provide information on the in

208 Serologic testing for antibodies to H. pylori remains th

209 Serologic testing for B. miyamotoi was performed using a

210 t, C-reactive protein or fecal calprotectin, serologic testing for celiac disease, and age-appropriat

211 ithout optic nerve enhancement should prompt serologic testing for CRMP5 IgG to expedite vision-spari

212 % took antiretroviral prophylaxis, 23.8% had serologic testing for hepatitis B and 43.1% for hepatiti

213 PSTF previously found adequate evidence that serologic testing for hepatitis B surface antigen accura

214 ether or not they had undergone coccidioidal serologic testing for screening or diagnostic purposes.

215 The role of serologic testing for severe acute respiratory syndrome

216 we present our initial experiences with ZIKV serologic testing from a national reference laboratory p

217 In addition to suggestive symptoms, serologic testing has high diagnostic reliability and bi

218 Manual treponemal and nontreponemal serologic testing has historically been used for the dia

219 piratory syndrome coronavirus 2 (SARS-CoV-2) serologic testing has rapidly increased.

220 light and reinforce the known limitations of serologic testing in early LD, with only 29% of individu

221 Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical

222 Next, we reviewed the outcome of serologic testing in patients with select clinical syndr

223 l identified three potential indications for serologic testing including: 1) evaluation of patients w

224 CD4 percentage between last vaccine dose and serologic testing independently improved the cumulative

225 In early Lyme disease (LD), serologic testing is insensitive and seroreactivity may

226 As the landscape of SARS-CoV-2 serologic testing is rapidly changing, this document pro

227 Serologic testing of 1863 asymptomatic contacts revealed

228 Serologic testing of all 356 patients found 129 (36.2%)

229 We report here findings from the serologic testing of blood for EBOV-specific antibodies,

230 lar testing for EBOV in blood and semen, and serologic testing of peripheral blood mononuclear cells

231 To improve vaccine strain selection, human serologic testing on vaccination-induced cross-reactivit

232 ied by metagenomic NGS, 11 were diagnosed by serologic testing only, 7 were diagnosed from tissue sam

233 The conventional 2-tiered serologic testing protocol for Lyme disease (LD), an enz

234 Serologic testing revealed a high prevalence (29 of 81;

235 Serologic testing ruled out toxoplasmosis, rubella, cyto

236 Serologic testing shows that antibodies to this region c

237 Current diagnostic methods rely on serologic testing that are complicated by cross reactivi

238 uld be collected and analyzed at the time of serologic testing to determine exposure to gluten and ac

239 The utility of serologic testing to evaluate vaccine efficacy of season

240 termined on the basis of testing history and serologic testing to have been recently infected.

241 Results of serologic testing were not predictive of relapse.

242 Ophthalmic and systemic evaluations and serologic testing were performed on all infants.

243 Changes in reimbursement for serologic testing will likely drive future provider orde

244 and provide a number of scenarios for which serologic testing will play a role during our global res

245 correlated with results from viral culture, serologic testing, and immune markers.

246 s were systematically collected for culture, serologic testing, antigen detection, and molecular diag

247 Serologic testing, contact-tracing, and next-generation

248 ldhood were followed for up to 38 years with serologic testing, imaging, and noninvasive fibrosis mar

249 ratory diagnosis of Lyme disease relies upon serologic testing.

250 disseminated Lyme disease underwent 2-tiered serologic testing.

251 best practice guidance related to SARS-CoV-2 serologic testing.

252 The children underwent serologic tests and clinical analyses every 6 months and

253 BEST PRACTICE ADVICE 2: Serologic tests are essential for an accurate diagnosis

254 Mainstay serologic tests are insensitive during the acute phase o

255 inical performance and utility of SARS-CoV-2 serologic tests are rapidly emerging.

256 We propose that serologic tests based on VMPs are of additional value in

257 These serologic tests cannot distinguish active infection, pas

258 For surveillance, the need for serologic tests emerged.

259 Newer diagnostic tools, including serologic tests for antibodies against tissue transgluta

260 ected enteropathy, but negative results from serologic tests for celiac disease (seronegative enterop

261 Only 2 studies of serologic tests for celiac disease involving 62 and 158

262 tein, fecal lactoferrin, fecal calprotectin, serologic tests for celiac disease, tests for bile acid

263 c disease; studies on diagnostic accuracy of serologic tests for celiac disease.

264 Here, we evaluated four high-throughput serologic tests for detection of anti-SARS-CoV-2 IgG ant

265 precedented influx of commercially available serologic tests for detection of antibodies against SARS

266 There was insufficient evidence to recommend serologic tests for irritable bowel syndrome at this tim

267 se is characterized by positive results from serologic tests for tissue transglutaminase antibodies (

268 utcomes of adults with positive results from serologic tests for tissue transglutaminase antibodies (

269 Serologic tests have a greater sensitivity, but their re

270 Pairing two different serologic tests in a two-test algorithm improves the PPV

271 ons related to the optimal use of SARS-CoV-2 serologic tests in a variety of settings.

272 The absence of FDA oversight of serologic tests is concerning given that the commerciall

273 Based on serologic tests of a community population for celiac dis

274 chistosomiasis (based on positive results of serologic tests or detection of ova) and 17 healthy cont

275 with results of laboratory testing, such as serologic tests or polymerase chain reaction.

276 infected with T. gondii based on a panel of serologic tests performed at the Palo Alto Medical Found

277 Retrospective serologic tests suggested that HHV-8 was likely transmit

278 Accurate serologic tests to detect host antibodies to severe acut

279 er tick bite, were evaluated by the relevant serologic tests to determine if they had been infected w

280 Molecular and serologic tests were performed to diagnose CRT infection

281 disease (identified by positive results from serologic tests) had lower mean levels of vitamin B-12 a

282 those screened, 861/925 (93.1%) had negative serologic tests, of which 11/861 (1.3%) subsequently dev

283 A large number of serologic tests, platforms, and methodologies are being

284 of US Food and Drug Administration-approved serologic tests, such as an enzyme immunoassay (EIA), fo

285 ted celiac disease but negative results from serologic tests, total IgA level should be measured; pat

286 -of-care tests and discuss the basis for new serologic tests.

287 0,425 adults with positive results from both serologic tests.

288 f 1.44 to increase in 1.86), or results from serologic tests.

289 mab interference with transfusion laboratory serologic tests.

290 ponses to a questionnaire and the results of serologic tests.

291 l questions related to the use of SARS-CoV-2 serologic tests.

292 related to gluten, but negative results from serologic tests.

293 ed celiac disease, but negative results from serologic tests.

294 by the stage of syphilis, for nontreponemal serologic tests?

295 tures of LAM (i.e., clinical, radiologic, or serologic), the guideline panel made conditional recomme

296 rom patient isolates correlated with initial serologic titers and with mortality in murine pneumonia.

297 exposure, and also inform the development of serologic tools to monitor gametocyte exposure in popula

298 Serologic (total and A fumigatus-specific IgE), pulmonar

299 ived both injections, and 2.2% had evidence (serologic, virologic, or both) of SARS-CoV-2 infection a

300 Serologic work-up for inflammatory disease was negative.