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1 postsynaptic D2 antagonist, and inhibitor of serotonin transporter.
2 ectual disabilities the functionality of the serotonin transporter.
3 rmalin-induced pain, as did mice lacking the serotonin transporter.
4 abolism), serotonin receptor 5-HT4, or mouse serotonin transporter.
5 ts reuptake at dopamine, norepinephrine, and serotonin transporters.
6 ine D2/D3 receptors ([(11)C]raclopride), and serotonin transporter (11)C-N,N-dimethyl-2-(-2-amino-4-c
9 SIDS).Mice with a targeted disruption of the serotonin transporter (5-HTT) develop in the presence of
10 gical signaling in mouse models of disrupted serotonin transporter (5-HTT) function, a risk factor fo
12 ic blockade of monoamine oxidase A (MAOA) or serotonin transporter (5-HTT) has antidepressant and anx
15 caine self-administration at a high level of serotonin transporter (5-HTT) occupancy with no detectab
17 unoreactive (IR) with antibodies against the serotonin transporter (5-HTT) protein were widely distri
18 th are involved in serotonin synthesis), and serotonin transporter (5-HTT) were measured in the ventr
19 imaging with a radiotracer specific for the serotonin transporter (5-HTT), (11)C-McN5652, we found t
20 is associated with reduced expression of the serotonin transporter (5-HTT), particularly in combinati
22 variations in the 5-hydroxytryptamine (5-HT; serotonin) transporter (5-HTT) gene are associated with
23 structural variants of the gene encoding the serotonin transporter [5-hydroxytryptamine transporter (
24 corresponding residues (R104E/E493R) in the serotonin transporter also rescues [(3)H](S)-citalopram
25 levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, i
26 med the causal relationship between amygdala serotonin transporter and an animal's sensitivity to thr
28 ed by platelet serotonin accumulated via the serotonin transporter and could be antagonized using ser
29 be single molecular interactions between the serotonin transporter and MFZ2-12 (a potent cocaine anal
30 functionally important Cl(-) binding site in serotonin transporter and other Cl(-)-dependent transpor
31 tion between microRNA 135 (miR135), and both serotonin transporter and serotonin receptor-1a transcri
33 involved in the pathogenesis of PAH such as serotonin transporter and tenascin-C was elevated in dis
34 18)F]MPPF, two PET radiotracers, marking the serotonin transporter and the 5-HT1AR, respectively.
36 ative affinity of the antidepressant for the serotonin transporter and to assess whether concomitant
37 capacitance induced by ligand binding to the serotonin transporter and to the glycine transporters (G
38 May, 2016, were studied with tracers for the serotonin transporter and vesicular monoamine transporte
39 hibits both the dopamine transporter and the serotonin transporter, and simple chemical modifications
40 and interactions with dopamine transporter, serotonin transporter, and vesicular monoamine transport
41 erotonin reuptake inhibitors targeting brain serotonin transporters are first-line treatments for bip
42 croscopy to study the diffusion of the human serotonin transporter at the ER and the plasma membrane.
44 sease subgroup had significantly lower raphe serotonin transporter availability but less severe stria
45 Parkinson's disease had significantly lower serotonin transporter availability in the brainstem raph
47 on's disease patients and that reduced raphe serotonin transporter availability is associated with th
48 s and release, are downregulated in SAD, and serotonin transporter availability might be increased; h
51 d [11C]DASB binding potential as an index of serotonin transporter availability were acquired during
52 hy, markers of dopamine storage capacity and serotonin transporter availability, to investigate wheth
56 Future studies should investigate midbrain serotonin transporter binding as a predictor of suicidal
57 nt with postmortem work showing low midbrain serotonin transporter binding capacity in depressed suic
61 ding, VMAT2 binding, (18)F-FDOPA uptake, and serotonin transporter binding in multiple brain regions
63 ehavior and completed suicide, including low serotonin transporter binding in postmortem studies of c
65 rkinson's disease had significantly elevated serotonin transporter binding in the hypothalamus (compa
66 manifest Parkinson's disease show increased serotonin transporter binding in the striatum, brainstem
68 sion who attempt suicide have lower midbrain serotonin transporter binding potential compared with th
69 region (F1,10 = 0.83; P = .38), and midbrain serotonin transporter binding potential did not predict
71 el-based analysis localized further relative serotonin transporter binding reductions in the cingulat
72 atients with fatigue had significantly lower serotonin transporter binding than patients without fati
73 onin transporter promoter gene (5-HTTLPR) on serotonin transporter binding using in vivo imaging tech
77 s with bipolar disorder had 16% to 26% lower serotonin transporter BP(1) in the midbrain, amygdala, h
79 e inhibition, excellent selectivity over the serotonin transporter, but no selectivity over the dopam
81 ng PET, we assessed whether dopaminergic and serotonin transporter changes are similar in LRRK2 mutat
82 factor (BDNF), reduced Glut4, with unchanged serotonin transporter concentrations were noted in (F) (
83 y; on the other candidate genes, such as the serotonin transporter, continue to dominate in genetic s
84 s provide evidence that molecular imaging of serotonin transporters could be used to visualise premot
86 er was significantly higher than that of the serotonin transporter, despite similar in vitro potencie
87 upport the hypothesis that inhibition of the serotonin transporter during neonatal life by an SSRI is
88 necessary to confirm that inhibition of the serotonin transporter during the neonatal period is suff
89 findings provide evidence that high amygdala serotonin transporter expression contributes to the high
92 havior in any of the targeted brain regions, serotonin transporter expression, specifically within th
93 extent of down-regulation is potentiated by serotonin transporter function (IC50 of 2.3 +/- 1.0 muM,
95 associations between genetic variability in serotonin transporter function and stress-related psycho
96 patients seem to have upregulation of brain serotonin transporter function at the early phase of the
98 reuptake inhibitor, fluvoxamine, to inhibit serotonin transporter function in ovariectomized rats.
99 ch locus, supporting the notion of increased serotonin transporter functioning being pathogenetically
100 lymorphisms (5-HTTLPR and STin2 VNTR) of the serotonin transporter gene (5-HTT), we find strong evide
102 Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) and exposure to ea
104 a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) offering equivocal
105 a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR), we found that ind
106 ed the hypothesis that a polymorphism in the serotonin transporter gene (locus, SLC6A4; variant, sero
107 etic variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked
109 udies have reported associations between the serotonin transporter gene (SLC6A4) and alcohol, heroin,
110 hism (5HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A4) and exposure to chil
112 ects in two candidate genes of interest--the serotonin transporter gene (SLC6A4) and the integrin bet
113 rphisms in the repeat upstream region of the serotonin transporter gene (SLC6A4) are associated with
114 R polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) has been found to mo
116 nalyses of common functional variants of the serotonin transporter gene (SLC6A4), a long-standing OCD
117 rphism located in the promoter region of the serotonin transporter gene (SLC6A4), is implicated in sp
119 iry: variation in the promoter region of the serotonin transporter gene (SLC6A4; also known as 5-HTT)
120 e-environment interactions (GxE) between the serotonin transporter gene and stress on risk of depress
121 entifying two common genetic variants of the serotonin transporter gene and their association with in
123 plicated in emotion regulation revealed that serotonin transporter gene expression in the ventrolater
127 igates whether a genetic polymorphism of the serotonin transporter gene moderates susceptibility to a
128 e is associated with brain morphology is the serotonin transporter gene polymorphism within the promo
129 rs1042173-TT (SLC6A4-LL/TT) genotypes in the serotonin transporter gene predicted a significant reduc
130 d that increased promoter methylation of the serotonin transporter gene predicted increased threat-re
131 re we show that a common polymorphism in the serotonin transporter gene relates to an accurate and ro
132 R, a functional promoter polymorphism of the serotonin transporter gene SLC6A4, influences cerebral c
133 The HTTLPR, a functional polymorphism of the serotonin transporter gene solute carrier family 6 (neur
134 s, carrying at least one short allele of the serotonin transporter gene was associated with a 26% hig
135 Individuals with 1 or 2 short alleles of the serotonin transporter gene were at higher risk for an in
137 methylation of the proximal promoter of the serotonin transporter gene, which predicts greater incre
141 renaline transporter (NAT) gene, and not the serotonin transporter genes, in dopaminergic cells, whic
142 s meta-analysis yielded no evidence that the serotonin transporter genotype alone or in interaction w
143 structural characterization of dopamine and serotonin transporters have opened the way for structure
147 spite the well-established role of the human serotonin transporter (hSERT) in the treatment of depres
150 e photoaffinity ligands (PALs) for the human serotonin transporter (hSERT) were synthesized based on
152 SLC6 family of proteins, including the human serotonin transporter (hSERT), utilize Na(+), Cl(-), and
157 t in the relative importance of dopamine and serotonin transporters in the abuse-related-effects of c
159 ucing doses of SSRIs reduces their effect on serotonin transporter inhibition in a linear manner.
161 E2, the density of fibers immunoreactive for serotonin transporter innervating the auditory midbrain
163 s in humans mirror the phenotypic effects of serotonin transporter knockout in mice, highlighting the
164 he amygdala and cingulate cortex between the serotonin transporter knockout mouse, a genetic animal m
165 Parkinson's disease; and (ii) whether raphe serotonin transporter levels correlate with severity of
166 rs increased SLC6A4 transcription, increased serotonin transporter levels in brain and other tissues
168 e investigated with SPECT using the dopamine/serotonin transporter ligand (123)I-N-omega-fluoropropyl
169 ied the influence of genetic variance in the serotonin transporter linked polymorphic region (5-HTTLP
170 pothesis: 1) observational studies about the serotonin transporter linked polymorphic region (5-HTTLP
171 ing the report of an interaction between the serotonin transporter linked polymorphic region (5-HTTLP
175 er region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLP
176 less than 150 nucleotides centromeric of the serotonin transporter-linked polymorphic region indel kn
177 ta suggest that differential function of the serotonin transporter may mediate differential response
178 ed decreases in tryptophan hydroxylase 2 and serotonin transporter mRNA in the dorsal raphe dorsalis
183 cupancy was extrapolated (85%); however, low serotonin transporter occupancy prevented similar seroto
186 and from mice with PH induced by hypoxia or serotonin-transporter overexpression (SM22-5HTT(+) mice)
187 nomethyl-phenylsulfaryl)-benzonitrile (DASB) serotonin transporter PET imaging was performed in a sub
188 onin signaling in the form of a common human serotonin transporter polyadenylation polymorphism (STPP
192 association of the STin2 and/or the 5-HTTLPR serotonin transporter polymorphisms in adult males with
193 elationship of a functional variation of the serotonin transporter promoter gene (5-HTTLPR) on seroto
195 hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with
196 was no association between genotypes of the serotonin transporter promoter region polymorphism and s
197 of serotonin and serotonergic receptors are serotonin transporter protein (SERT or soluble carrier p
198 of a genetic polymorphism (5-HTTLPR) in the serotonin transporter protein gene on the likelihood tha
199 ions in TnaT-D268S, in wild type TnaT and in serotonin transporter provide direct evidence for the in
201 ing the dopamine transporter (DAT(-/-)), the serotonin transporter (SERT(-/-)), or both (DAT(-/-)SERT
202 of the alternate conformation in a mammalian serotonin transporter (SERT) (a member of the same trans
204 Expression of 14 5-HT receptor subtypes, the serotonin transporter (SERT) and 5-HT-producing enzymes
206 ion tomography for two serotonergic markers: serotonin transporter (SERT) and serotonin 1A (5-HT1A) r
207 ial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pu
209 y measure the interaction forces between the serotonin transporter (SERT) and the S- and R-enantiomer
210 f juvenile grasshopper mice labeled with the serotonin transporter (SERT) antibody, revealing a strik
212 We have developed a homology model for the serotonin transporter (SERT) based on the crystal struct
213 ptoms was associated with change in cerebral serotonin transporter (SERT) binding following intervent
217 ty of using (11)C-DASB for quantification of serotonin transporter (SERT) density and affinity in viv
218 lthio)benzylamine ((11)C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy control
220 of intracellular solute-binding to the human serotonin transporter (SERT) expressed in HEK-293 cells.
222 panes 1-4 were synthesized as ligands of the serotonin transporter (SERT) for use as positron emissio
224 ould be via HPA axis-dependent impairment of serotonin transporter (SERT) function, the high-affinity
226 k and reports on the optimization of DAT and serotonin transporter (SERT) functional assays, as well
227 identified genetic interactions between the serotonin transporter (SERT) gene and ITGB3, which encod
229 Antagonist dissociation experiments on the serotonin transporter (SERT) have also unveiled the exis
230 t years, a number of PET studies imaging the serotonin transporter (SERT) have been used and provided
231 opane (betaFEpZIENT, 1) was synthesized as a serotonin transporter (SERT) imaging agent for both posi
233 oimaging, and genetic findings implicate the serotonin transporter (SERT) in autism spectrum disorder
248 rotonin (5-HT) into neurons and other cells, serotonin transporter (SERT) modulates the action of 5-H
249 rported anti-addiction properties, inhibited serotonin transporter (SERT) noncompetitively by decreas
250 opiate withdrawal, has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contra
251 to assess D(2)/D(3), 5-HT(1A), 5-HT(2A) and serotonin transporter (SERT) occupancies of brexpiprazol
253 This 5-HT signal was not potentiated by the serotonin transporter (SERT) or the noradrenaline transp
264 ability in IBS-D including a decrease in the serotonin transporter (SERT) which is also seen followin
265 zing enzyme tryptophan hydroxylase (TPH) and serotonin transporter (SERT) with semiquantitative immun
266 lore structure-activity relationships at the serotonin transporter (SERT), a series of (+/-)-4- and 5
267 isms regulating disulfide bond formation for serotonin transporter (SERT), an oligomeric glycoprotein
268 f its DAT affinity were only observed at the serotonin transporter (SERT), dopamine D2-like, and sigm
270 n, (123)I-FP-CIT has modest affinity for the serotonin transporter (SERT), predominantly represented
271 nity for DAT and robust selectivity over the serotonin transporter (SERT), whereas affinity improved
272 rter (LeuT), dopamine transporter (DAT), and serotonin transporter (SERT)-by the use of porcine pepsi
282 subsequently causes the translocation of the serotonin transporter (SERT, SLC6A4) to the synaptic ter
289 Channel properties are also attributed to serotonin transporters (SERTs); however, SERT regulation
290 ciation of region-specific expression of the serotonin transporter (SLC6A4) and serotonin receptor (H
292 ential interactions between these factors on serotonin transporter (slc6a4) mRNA expression, we inves
293 ters of the SLC6 family, including the human serotonin transporter (SLC6A4), is critical for efficien
295 norepinephrine transporter (SLC6A2, NET) and serotonin transporter (SLC6A4, SERT) genes and remission
296 f the maternal polymorphism, 5HTTLPR, in the serotonin transporter, SLC6A4, coupled with prenatal str
298 activation of p38alpha MAPK translocated the serotonin transporter to the plasma membrane and increas
299 ubstituents on the 7-position with the human serotonin transporter Tyr175 versus dopamine transporter
300 and intermediate, but not low, affinity for serotonin transporter were associated with upper gastroi