ライフサイエンスコーパス: serum iron

1 ficiency virus (HIV) infection, and elevated serum iron.

2 transferrin saturation, serum ferritin, and serum iron.

3 ice also have elevated Zn protoporphyrin and serum iron.

4 acts and hyperferritinemia without increased serum iron.

5 hanges in striatal dopamine, anaemia and low serum iron.

6 Additionally, bdh2 null mice exhibit reduced serum iron.

7 as higher (0.47, 95% CI 0.30, 0.64) than for serum iron (0.30, 95% CI 0.09, 0.51) and transferrin sat

8 mbined risk ratio, 1.0; 95% CI, 0.7 to 1.5), serum iron (0.8; 95% CI, 0.7 to 1.0), and total dietary

9 at baseline (follow-up) were 0.08 (0.09) for serum iron, 0.08 (0.07) for transferrin saturation, and

10 rol (1.09 [1.01-1.18]; p=0.025), circulating serum iron (1.17 [1.00-1.36]; p=0.049), and serum vitami

11 med the profound early postnatal decrease in serum iron (22.7 +/- 7.0 umol/L at birth to 7.3 +/- 4.6

12 al chow, carbonyl iron-fed rats had elevated serum iron (42 vs. 21 muM; P=0.007) and TGs (190 vs. 115

13 Homozygous b/b rats had greater serum iron (68 vs. 28 muM; P=0.0004) and TG levels (180

14 Serum iron, a potential pro-oxidant, also decreased by 4

15 assing unresolving inflammation, anemia, low serum iron, altered iron-homeostasis gene expression and

16 or health (including chronic conditions, low serum iron and albumin levels) and exclusion of 44 death

17 vation in acute-phase reactants, and fall in serum iron and albumin.

18 There was no association between serum iron and colorectal cancer risk in women.

19 This regulatory pathway is modulated by serum iron and contributes to hepcidin suppression and i

20 patocyte TfR1 impacts hepcidin regulation by serum iron and erythropoietic signals, and its contribut

21 iron-chelation therapy for FRDA, we measured serum iron and ferritin concentrations in 10 FRDA patien

22 Serum iron and ferritin levels declined rapidly on MG2 a

23 Serum iron and ferritin levels were markedly elevated (P

24 In contrast, serum iron and ferritin were not significant.

25 ortin synthesis is a critical determinant of serum iron and finetunes hepcidin-dependent functional o

26 n, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant incre

27 Adults aged 30 or more years at baseline had serum iron and high density lipoprotein cholesterol (HDL

28 lation in iron metabolism, including reduced serum iron and increased hepatic and splenic iron storag

29 logical evidence on the relationship between serum iron and liver diseases is limited.

30 erved differences in the association between serum iron and nonskin cancer risk is unclear.

31 was associated with ferritin (positive) and serum iron and retinol (negative, P < 0.05).

32 Serum iron and TIBC fell significantly over time [P < 0.

33 GSTT1-0 (n = 37), was associated with higher serum iron and total and LDL-cholesterol concentrations

34 On the contrary, serum iron and transferrin levels were decreased in ICU

35 12 hours, coinciding with a 50% reduction in serum iron and transferrin saturation over the 24-hour p

36 with reduced intestinal (59)Fe uptake, lower serum iron and transferrin saturation, but no change in

37 ted alcohol use disorder was associated with serum iron and transferrin saturation.

38 We compared serum iron and triglycerides (TGs) in Belgrade rats, a g

39 from depleted iron stores (decreased liver, serum iron, and ferritin), reduced erythropoiesis, and s

40 required to correct the low-hemoglobin, low-serum iron, and high-hepcidin status in MT2 (-/-) mice.

41 g tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mic

42 s BMP6 improved hepcidin deficiency, reduced serum iron, and redistributed tissue iron to appropriate

43 dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance o

44 ssessed prognostic associations of ferritin, serum iron, and TSAT among 2050 participants with heart

45 Both tissue iron overloading and elevated serum iron are also found in hea and fsn neonates.

46 These findings identify serum iron as a critical protective factor in renal allo

47 den of protein aggregates, mildly increasing serum iron availability in aging mice.

48 posure to microgravity sustainably increases serum iron availability in males, and consequently the r

49 cularly transferrin saturation, that reflect serum iron availability, are strong outcome predictors i

50 over time but cannot be taken as a proxy for serum iron biomarkers and they may reflect physiological

51 displayed a greater induction of hepcidin by serum iron compared with Tfrcfl/fl;Alb-Cre- controls.

52 Infants who received HIP had higher serum iron concentration (by 48.4%; 95% CI: 15.4%, 91.0%

53 Transferrin saturation (serum iron concentration divided by total iron binding c

54 igher hepcidin levels and consequently lower serum iron concentration on days 14 and 21, and manifest

55 morphism most strongly associated with lower serum iron concentration was rs4820268 (P = 5.12 x 10(-9

56 Serum iron concentration, iron saturation, and unsaturat

57 Independently from AG, we found that both serum iron concentrations (+31.3%, P = 0.027) and transf

58 macrophage iron retention, resulting in low serum iron concentrations (hyposideremia).

59 Seventy-two hours later, serum iron concentrations and hepatic levels of STAT3 ph

60 Serum iron concentrations and serum ferritin concentrati

61 usly decreasing hepcidin levels and reducing serum iron concentrations and transferrin saturation (al

62 or menopausal status (breast cancer), higher serum iron concentrations and transferrin saturation wer

63 The mean serum iron concentrations and transferrin-saturation val

64 hepcidin messenger RNA levels and decreased serum iron concentrations in Alk2- but not Alk3-deficien

65 hepatic hepcidin gene expression and reduce serum iron concentrations is dependent on the BMP type I

66 Most AN patients had normal serum iron concentrations on admission.

67 Conversely, in men, higher serum iron concentrations were associated with decreased

68 Higher transferrin saturation or serum iron concentrations were associated with increased

69 plenic macrophage iron content and increased serum iron content.

70 values correlated with ferritin levels, and serum iron correlated strongly with transferrin saturati

71 receptor (sTfR) increased (P < 0.0001), and serum iron decreased from 2M to 5M (P < 0.01).

72 vated day 3), hepcidin (elevated days 2, 3), serum iron (depressed days 2-4), transferrin saturation

73 e evolved effective mechanisms to circumvent serum iron deprivation.

74 as up-regulated with concomitant lowering of serum iron during acute murine Influenza A/PR/8/34 virus

75 ligoribonucleotide, prevents the decrease in serum iron during experimental human endotoxemia.

76 ne increased hepcidin expression and reduced serum iron, effects that were inhibited by LDN-193189 or

77 luble transferrin receptor (sTfR), hepcidin, serum iron, erythropoietin, serum folate, vitamin B-12,

78 ce and viral load, whereas neutralization of serum iron facilitated dengue virus infection in A. aegy

79 A total of 366 patients with available serum iron, ferritin and total iron binding capacity (TI

80 ene [TMPRSS6]) that associate with increased serum iron, ferritin, and transferrin saturation and dec

81 Serum iron, ferritin, transferrin, interleukin (IL)-6, a

82 Moreover, the increase in serum iron following induction of erythropoiesis was ent

83 lasts, a cell type that consumes most of the serum iron for use in hemoglobin synthesis.

84 e (indicated by increased haemoglobin level, serum iron, FPN expression and decreased ferritin level)

85 At T = 9 hours, serum iron had increased by 15.9 +/- 9.8 micromol/L from

86 ottom quartile, those in higher quartiles of serum iron had no significant ORs for AHF in males, but

87 ratio 0.92; 95% CI, 0.89-0.95; P < .001) and serum iron (hazard ratio 0.98; 95% CI, 0.97-0.99; P = .0

88 injection of hepcidin caused a rapid fall of serum iron in a dose-dependent manner, with a 50-microg

89 Lowering serum iron in Belgrade rats reduced TG levels (274 to 67

90 use model of AI and demonstrated to modulate serum iron in cynomolgus monkeys.

91 Likewise, LPS modestly decreased serum iron in hepcidin-deficient Hjv(-/-) mice, model of

92 cantly lower, with a concomitant increase in serum iron in Hri-/- mice upon LPS treatment.

93 Here we report that serum iron in human blood influences dengue virus acquis

94 P6 increases hepcidin expression and reduces serum iron in mice.

95 t the decreased hepcidin expression and high serum iron in Neo1fl/fl;Alb-Cre+ mice.

96 Here, we investigated the role of serum iron in the sterile inflammation that follows kidn

97 f the proteins that help hepcidin to monitor serum iron, including HFE and, in rarer instances, trans

98 more, since patients with elevated available serum iron, including those with diabetic ketoacidosis (

99 is condition and pre-dispose to increases in serum iron indices, are over-represented in diabetic pop

100 This study aims to investigate whether serum iron is associated with nonalcoholic fatty liver d

101 Serum iron is bound to transferrin and enters erythroid

102 , when blood transfusion can further elevate serum iron, is worth consideration.

103 shown to be due to an increase in available serum iron leading to enhanced red cell hemoglobinizatio

104 In conclusion, higher serum iron level was associated with lower risk of NAFLD

105 gue-Dawley rats resulted in no change in the serum iron level, a marked increase in the urinary excre

106 rpuscular volume, mean corpuscular Hb level, serum iron level, and Tfsat, and increased red blood cel

107 independently associated with elevations in serum iron level, serum transferrin-iron saturation, ser

108 els of serum cholesterols and persistent low serum iron level.

109 Deferoxamine infusion decreased serum iron levels (P<0.001).

110 tion [SD] increase in genetically determined serum iron levels 0.72, 95% confidence interval [CI] 0.6

111 ions and inflammation, causing a decrease in serum iron levels and contributing to the development of

112 ive iron overload in the liver and increased serum iron levels and iron deposition in several organs

113 le T cells resulted in a significant rise in serum iron levels and liver iron content.

114 itionally, the Btbd9 mutant mice had altered serum iron levels and monoamine neurotransmitter systems

115 and 1200 ng/ml (reference 100 to 199 ng/ml), serum iron levels between 60 and 120 microg/ml (referenc

116 hich is secreted by the liver, and decreases serum iron levels by causing the down-regulation of the

117 decreased hepcidin expression and increased serum iron levels by mobilizing iron from splenic stores

118 Hepcidin reduces serum iron levels by promoting degradation of the iron e

119 eral or oral administration to mice, lowered serum iron levels comparably to those after parenteral n

120 The results suggest that elevated serum iron levels coupled with either high VLDL-C or low

121 ide association study summary statistics for serum iron levels from two cohorts and two previous meta

122 nistic support for interventions that reduce serum iron levels in individuals at risk for hypertrigly

123 els of bioactive hepcidin and its effects on serum iron levels in mice infected with Borrelia burgdor

124 dietary iron caused significant elevation of serum iron levels in p53(-/-) mice.

125 Increasing serum iron levels in patients may thus improve prognosis

126 serum phosphate concentrations and increased serum iron levels in the Col4alpha3 knockout mice.

127 mobilizes splenic iron stores, and increases serum iron levels in vivo.

128 increases hepcidin expression and decreases serum iron levels in vivo.

129 Serum iron levels were decreased with DFO treatment afte

130 However, serum iron levels were reduced to a significantly greate

131 LFKO(-/-) mice on either diet, although the serum iron levels were slightly elevated in LFKO-/- mice

132 Iron loading was confirmed by increases in serum iron levels, percentages of transferrin saturation

133 lso associated with significant increases in serum iron levels, total iron-binding capacity, and tran

134 was associated with significant increases in serum iron levels, total iron-binding capacity, and tran

135 ped an anemia associated with abnormally low serum iron levels, yet accumulated hepatic and renal iro

136 evels induced by BMP2/9, resulting in normal serum iron levels.

137 tissue ferroportin expression and determines serum iron levels.

138 erroportin downregulation and a reduction of serum iron levels.

139 e induces hepcidin and diminishes tissue and serum iron levels.

140 lted in reduced liver hepcidin and increased serum iron levels.

141 hepcidin production and increased tissue and serum iron levels.

142 2 in Hfe-null mice had no effect on liver or serum iron levels.

143 ducibly antagonize the effect of hepcidin on serum iron, likely because of its rapid conversion to in

144 s that were inappropriately high relative to serum iron, liver iron, and erythroferrone levels.

145 ection fraction), 46% had TSAT <20%, 48% had serum iron <=13 mumol/L, 57% had serum ferritin <100 ng/

146 TSAT <20% and serum iron <=13 mumol/L, but not guideline criteria, wer

147 mary viremic phases of HCV or HBV infection; serum iron marginally increased during acute HBV infecti

148 We analyzed the associations of serum iron measures and antioxidant concentrations with

149 Serum iron measures were also collected.

150 ary hemochromatosis in persons with elevated serum iron measures, but even this use is limited by unc

151 We measured serum iron metabolism biomarkers at baseline, 12 weeks,

152 d individuals with anemia, microcytosis, low serum iron, or low blood hemoglobin.

153 er risk of hospitalization with COVID-19 for serum iron; OR 1.29 (CI 0.97-1.72, P = 0.08), whereas se

154 ted a similar degree of hepcidin deficiency, serum iron overload, and tissue iron overload compared w

155 sfusion was followed by increases in AUC for serum iron (P < 0.01), transferrin saturation (P < 0.001

156 Serum iron parameters at admission were correlated with

157 usion: Our findings demonstrate that several serum iron parameters significantly associate with 3-wee

158 cate that the presence of elevated available serum iron predisposes the host to mucormycosis.

159 rate that the presence of elevated available serum iron predisposes the host to mucormycosis.

160 on:transferrin ratio in lactating mice whose serum iron ranged from 8 to 66 microM.

161 Serum iron, rather than haem-bound iron, was utilized by

162 L-6)-induced hypoferremia, NOX-H94 inhibited serum iron reduction completely.

163 Serum iron remained suppressed for more than 48 hours af

164 Iron parameters (serum iron, serum ferritin, total iron-binding capacity

165 dmixture-mapping and association studies for serum iron, serum ferritin, transferrin saturation (SAT)

166 Serum iron, serum hepcidin, and hepatic iron concentrati

167 rd ratio, 0.84 [95% CI, 0.76-0.93]; P=0.001; serum iron: standardized hazard ratio, 0.87 [95% CI, 0.7

168 th hemochromatosis diagnosed on the basis of serum iron studies and liver biopsy findings, 60 (91%) w

169 Serum iron studies, quantitative hepatic iron concentrat

170 mochromatosis is traditionally done by using serum iron studies.

171 using HFE gene testing were less costly than serum iron studies.

172 tical model of the relation between milk and serum iron suggests that the affinity of apotransferrin

173 dren with T1D and CD had significantly lower serum iron than children with T1D alone (8.5 mugm/L Vs 1

174 d the first genome-wide association study of serum iron, total iron binding capacity (TIBC), transfer

175 decreased ESA resistance index and increased serum iron, total iron binding capacity, transferrin sat

176 rous indices of iron mobilization (ferritin, serum iron, total-iron-binding-capacity, transferrin sat

177 romatosis (Hfe(-/-)) significantly decreased serum iron, transferrin saturation and liver iron accumu

178 We measured serum iron, transferrin saturation, and ferritin in all

179 Plasma TAS, serum ferritin, serum iron, transferrin saturation, and hemoglobin were

180 llected clinical data, including hemoglobin, serum iron, transferrin saturation, and serum ferritin c

181 clinical diagnosis of COVID-19 and measured serum iron, transferrin saturation, ferritin, hepcidin a

182 f anemia of inflammation, FeM-1269 increases serum iron, transferrin saturation, hemoglobin and hemat

183 ron, ferritin, soluble transferrin receptor, serum iron, transferrin saturation, hemoglobin, hematocr

184 of HDT bed rest did not significantly change serum iron, transferrin saturation, or hepcidin levels.

185 Hepcidin, serum iron, transferrin, transferrin saturation, haptogl

186 Milk iron was linearly related to the serum iron:transferrin ratio in lactating mice whose ser

187 alter the relation between milk iron and the serum iron:transferrin ratio.

188 The serum iron transport protein human transferrin (hTf) is

189 ric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE

190 nsects have evolved distinctive forms of the serum iron transport protein, transferrin, and the stora

191 In the absence of serum, iron treatment was associated with a reduction of

192 aneurysm pathophysiology and investigated if serum iron values are associated with ruptured intracran

193 Many patients with HH have abnormal serum iron values before the development of any signific

194 from observational studies that have linked serum iron variables and cancer outcomes has been incons

195 Serum iron was also significantly higher in the Fe than

196 deviation increase in genetically-predicted serum iron was associated with odds ratio (OR) of 1.14 (

197 riable adjustment for potential confounders, serum iron was significantly and inversely associated wi

198 rin receptor, transferrin receptor index, or serum iron-was related to APP concentrations, but poor p

199 Reductions in serum iron were associated with high hepcidin and IL-6 l

200 sociated with outcomes, whereas low TSAT and serum iron were associated with the risk of all-cause de

201 rvals (CIs) of NAFLD and AHF associated with serum iron were estimated using multivariable logistic r

202 in, haemoglobin with erythrocyte indices and serum iron were recorded for all patients.

203 There are also decreases in serum iron when wild-type mice are administered a mu-opi

204 6 inhibits hepcidin expression and increases serum iron, whereas DRAGON.Fc has no effect.

205 d CRP remained significantly associated with serum iron, with no evidence that such a relationship wa