ライフサイエンスコーパス: serum protein

1 column (which depletes the 64 most-abundant serum proteins).

2 a model biomolecule against a background of serum protein.

3 otein at the level of 4.0 fmol of ospA/mg of serum protein.

4 d aspartate aminotransferase, AST) and total serum protein.

5 ted in the corresponding lysine of the human serum protein.

6 proteolysis when tethered to the long-lived serum protein.

7 alpha-trypsin inhibitor (IaI) is an abundant serum protein.

8 were significantly altered as CBLG bound to serum proteins.

9 le resilience to the non-specific binding of serum proteins.

10 bs) not previously tested for cross-reacting serum proteins.

11 adsorption surface coverage of crude bovine serum proteins.

12 rs-of-magnitude lower than the most abundant serum proteins.

13 sensor surface with considerable amounts of serum proteins.

14 ell attachment and binding and inhibition of serum proteins.

15 ed by correlating the skin transcriptome and serum proteins.

16 that these are ligands stabilizing the major serum proteins.

17 ce the production of abnormally glycosylated serum proteins.

18 the presence of high salt concentrations and serum proteins.

19 ell as in casein micelles separated from the serum proteins.

20 onto live cell membranes in the presence of serum proteins.

21 to IFN-gamma in the presence of overabundant serum proteins.

22 ia, remains a mystery due to the plethora of serum proteins.

23 in factor H (FH) and additional unidentified serum proteins.

24 that some bacteria mask their surfaces with serum proteins.

25 nsive global profiling and quantification of serum proteins.

26 E to prevent it from binding drug-haptenated serum proteins.

27 SERS-hotspot blockages and fouling by blood-serum proteins.

28 ones responsible for MODS and do not bind to serum proteins.

29 d endolysosomal degradation of extracellular serum proteins.

30 tors assessed in splenic gene expression and serum proteins.

31 ies of more than two dozen membrane-bound or serum proteins.

32 l course of AD using clinical parameters and serum proteins.

33 ficant interference from other cytokines and serum proteins.

34 ve been identified, including GDF-associated serum protein-1 (GASP-1) and GASP-2, which are capable o

35 growth and differentiation factor-associated serum protein-1) as a novel downstream target of PPARbet

36 The presence of milk serum proteins accelerated the aggregation of lactoferri

37 Tubular epithelial cells exposed to serum proteins adopted phenotypic and functional charact

38 protein adsorbers effectively competed with serum protein adsorbers for the hydroxyapatite surface.

39 icles to exhibit not only high resistance to serum protein adsorption but also pH-dependent adsorptio

40 Variations in serum protein adsorption correlate with differences in t

41 e of size and surface chemistry in mediating serum protein adsorption to gold nanoparticles and their

42 Nonspecific serum protein adsorption was minimized with effective su

43 These gold NPs resist serum protein adsorption, escape liver uptake, target ca

44 ve biological environment due to nonspecific serum protein adsorption.

45 ves supported cell adhesion independently of serum protein adsorption.

46 induced aggregation of lactoferrin with milk serum proteins affected both its digestion and its bacte

47 e respiratory distress syndrome in which the serum protein albumin adsorbs to an air-liquid interface

48 iers by leveraging the long-lived endogenous serum protein albumin as an siRNA carrier.

49 transcriptional changes were induced by the serum protein albumin via TGFbeta signaling in primary a

50 f phospholipid-bound vesicles containing the serum proteins albumin, fetuin-A, and apolipoprotein A1;

51 A number of prominent serum proteins (albumin and IgG) were detected in the vi

52 d with passive immunity measures (serum IgG, serum protein, albumin, globulin and total protein conce

53 concentrations of the two main metal-binding serum proteins, albumin and transferrin.

54 mpared directly, 34 differentially expressed serum proteins allowed the separation of these two patie

55 sibly occurs as a result of competition with serum proteins, although our data seem to rule out a dir

56 nsform into malignant disease in our series, serum protein analysis should be considered in patients

57 ement procedure development of low abundance serum protein analytes.

58 fluorescent gold nanoprobe that can bind to serum protein and be transported to the liver, we non-in

59 irectly correlated with the intensity of the serum protein and indirectly with the tryptic peptides m

60 rognostic and predictive strategies based on serum protein and messenger RNA biomarkers can identify

61 e surface chemistry, reduces its affinity to serum protein and significantly alters its blood retenti

62 tions and examined correlations between this serum protein and the antibiotic treatment outcomes of p

63 thyretin (TTR) is an abundant homotetrameric serum protein and was selected here for engineering high

64 able to measure liposomes in the presence of serum proteins and can yield information on the shape an

65 E-exposed rats had significant changes in 66 serum proteins and caused decreased NOS activity and inc

66 -specific binding to cells, interaction with serum proteins and cell adhesion molecules and can lead

67 ate analysis of these markers, together with serum proteins and cytokines, revealed a general signatu

68 ion, several co-linear relationships between serum proteins and DTI measures reported in healthy cont

69 Serum proteins and extracellular matrix (ECM) markers we

70 esis and storage of nutrients, production of serum proteins and hormones, and breakdown of toxins and

71 ading to edema, excitotoxicity, and entry of serum proteins and inflammatory cells.

72 ble EVs; however, the separation of EVs from serum proteins and non-EV lipid particles represents a c

73 rkable binding resistance to a wide range of serum proteins and nucleic acids.

74 order to minimize nonspecific adsorption of serum proteins and other biomolecules, and (ii) a signal

75 A/(ng/ml), with negligible interference from serum proteins and other cytokines.

76 unique interactions of FhbA with individual serum proteins and provide support for the hypothesis th

77 akdown associated with brain accumulation of serum proteins and several vasculotoxic and/or neurotoxi

78 We examined 171 serum proteins and small molecules measured in 1,676 par

79 presses an unexpected dependence of Nodal on serum proteins and that it is critically required for no

80 s are the major barrier to the filtration of serum proteins, and altered podocyte function and/or red

81 drug can enhance its half-life by binding to serum proteins, and be targeted to bacterial membranes.

82 ictors of smoking, alcohol, body mass index, serum proteins, and cell proportions.

83 some of its natural inhibitors, nonspecific serum proteins, and diluted plasma.

84 ulation frequencies, cytokine responses, and serum proteins, and found that 77% of these are dominate

85 aphy, blocked blood-brain barrier leakage of serum proteins, and increased the number of endothelial

86 and mucin type O-glycosylation was found on serum proteins, and reduced metabolic labeling of sialic

87 ss the strength of association between these serum proteins, and to determine group sizes needed for

88 The interaction of 1 with the serum proteins apotransferrin (apoTf) and human serum al

89 ealed significant binding of (177)Lu-cm09 to serum proteins ( approximately 91%) in plasma, compared

90 spectrometry, we find that over 70 different serum proteins are heterogeneously adsorbed to the surfa

91 Although serum proteins are implicated in the activity of Ti(IV)

92 Blood-based factors like serum proteins are in contact with every organ in the bo

93 Serum proteins are known to assist in this complex proce

94 ular the effect on this of the adsorption of serum proteins, are directly examined by measuring the f

95 Second, the extravasation of serum proteins as a result of brain microvascular diseas

96 on the use of the nonspecific adsorption of serum proteins as an additional layer of surface passiva

97 ptors or indirectly by exploiting matrix and serum proteins as molecular bridges.

98 tient subgroups were performed to assess the serum proteins associated with anti-Jo-1 antibody-positi

99 ith collagen IV, fibronectin, laminin-332 or serum proteins before seeding with 125 mouse islets.

100 ogous to the target antigen of antiCl on the serum protein beta-2 glycoprotein-I (beta2GPI) and thus

101 s are induced via molecular mimicry with the serum protein beta2-glycoprotein 1 (beta2GP1), the targe

102 Taken together, these data suggest that the serum protein beta2-GPI initiates the IR-induced intesti

103 lipid alterations that are recognized by the serum protein, beta2-glycoprotein I (beta2-GPI).

104 We investigated the role of the serum protein, beta2-glycoprotein I as an initiating Ag

105 evious studies indicated that binding of the serum protein, beta2-glycoprotein I, to the endothelium

106 roperties upon disassembly, we observed that serum proteins bind to and interact with the polymeric a

107 ide engineering strategy that incorporates a serum protein binding motif onto a covalent side-chain s

108 compromised targeting owing to non-specific serum protein binding, and hindered tumor penetration.

109 By taking advantage of the inherent serum-protein-binding property of lipid motifs and their

110 n of clinical, radiographic, functional, and serum protein biomarker assessments, this study was aime

111 strated that combinations of these and other serum protein biomarkers can distinguish these disease s

112 It is expected that serum protein biomarkers in Duchenne muscular dystrophy

113 aim of this study was to establish panels of serum protein biomarkers representative of active TB pat

114 We sought to develop multivariate models of serum protein biomarkers that explained observed variati

115 Serum protein biomarkers were identified by stability se

116 Serum protein biomarkers, discovered in two animal model

117 We also find that the serum protein-bound form of NY is photoacoustically well

118 to normalize the basal metabolic rate and/or serum protein-bound iodine level, but thyrotoxic adverse

119 ling of peptides has been measured for a few serum proteins, but this approach awaits full validation

120 e proteins can be separated from the bulk of serum proteins by high-speed centrifugation causing subs

121 We explored cord blood serum proteins by profiling a UCB pool of 12 neonates wi

122 vidence further supported the replacement of serum proteins by salivary proteins.

123 It is demonstrated how serum protein can be efficiently, cost-effectively, and

124 The accumulation of serum proteins can block targeting functionalities and a

125 sis of changes in the heat capacity of blood serum proteins can provide an insight into patient respo

126 These data indicate that host and pathogen serum proteins can serve as reliable biomarkers for trac

127 ransduction occurs via an unidentified mouse serum protein capable of bridging HAdV-5 to CAR.IMPORTAN

128 The serum protein changes identified with the aptamer-based

129 plexed proteomics approach to identify novel serum protein changes that might help distinguish betwee

130 Human breast cancer cells (MCF-7) grown on serum protein-coated gold sensors were placed in dynamic

131 rated that ERFE messenger RNA expression and serum protein concentration increase in mice subjected t

132 into the underlying genetic architecture of serum protein concentrations and their association with

133 repair of DNA strand breaks improves, as do serum protein concentrations that are associated with th

134 expression of olfactomedin-4 messenger RNA, serum protein concentrations, and percentage of neutroph

135 Many disorders are associated with altered serum protein concentrations, including malnutrition, ca

136 Apolipoprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanoso

137 ter alpha inhibitor (IalphaI) is an abundant serum protein consisting of three polypeptides: two heav

138 nsideration to modulate the formation of the serum protein corona (PC) and the resultant immune respo

139 We find that the presence of a serum protein corona on the tip strongly modifies the in

140 tration in particular, of T cells as well as serum proteins correlate with lupus disease activity.

141 scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient response to the

142 Albumin, the most abundant serum protein, did not interfere in the detection of the

143 Fortified human blood serum, protein digest and fractions collected after prot

144 distributed, obstructed amines) rapidly bind serum proteins, diverse cells types in vitro, and endoth

145 If chemotherapy is effective, serum proteins DSC curve of non-small cellular lung canc

146 Serum protein electrophoresis (SPEP) demonstrated a 3.5

147 Appropriate evaluation including serum protein electrophoresis and hematology consultatio

148 (90%, 95% confidence interval, 74%-97%); by serum protein electrophoresis and/or immunofixation elec

149 erapeutic antibodies with immunofixation and serum protein electrophoresis assays may lead to underes

150 s of sFLC, SRM data was more consistent with serum protein electrophoresis than nephelometric data an

151 Serum protein electrophoresis with immunofixation and se

152 ve metabolic panel, vitamin B12 measurement, serum protein electrophoresis with immunofixation, fasti

153 of differential scanning calorimetry (DSC), serum protein electrophoresis, and free light chain assa

154 Serum protein electrophoresis, immunofixation electropho

155 Blood samples were collected for serum protein electrophoresis.

156 Its interaction with serum proteins, elemental distribution, and coordination

157 conclusion, although significant numbers of serum proteins emanate from the gingival sulcus, their a

158 FLD and NASH and demonstrates key changes in serum protein expression levels between control subjects

159 res 1,305 proteins to search for large-scale serum protein expression pattern changes in sepsis.

160 The serum proteins factor H (FH), consisting of 20 complemen

161 vent extraosseous calcification in vivo, the serum protein fetuin-A stabilizes calcium and phosphate

162 Prospectively characterize changes in serum proteins following sport-related concussion and de

163 and renders them resistant to disassembly by serum proteins for >24 h.

164 emoglobin could be completely substituted by serum proteins for the provision of amino-acids in vitel

165 glomerular filtration barrier prevents large serum proteins from being lost into the urine.

166 A rank comparison of undepleted serum proteins from common bottlenose dolphins (Tursiops

167 ns-junction protein, resulting in leakage of serum proteins from the damaged barrier.

168 f hemoglobin in comparison with glycation of serum proteins (fructosamine), the glycation gap.

169 were the first to report that a bifunctional serum protein, Gas6, bridges envelope phosphatidylserine

170 We reported levels of serum protein glycation, oxidation and nitration and rel

171 Analysis of serum protein glycovariants has the potential to identif

172 Binding of phenolic acids with serum proteins greatly influences their pharmacological

173 riteria (a ratio of pleural fluid protein to serum protein >0.5, a ratio of pleural fluid LDH to seru

174 comprehensive human plasma proteome, 5 of 11 serum proteins had a differential rank greater than 200.

175 The results demonstrated that serum proteins had significant interactions with Mg-base

176 far prevented comprehensive measurements of serum protein half-lives.

177 This serum protein, HIV-1 enhancing serum protein (HESP), might promote viral transcription

178 This serum protein, HIV-1 enhancing serum protein (HESP), mig

179 ood colourant tartrazine with two homologous serum proteins, HSA and BSA, were investigated, employin

180 ce-response patterns were obtained from five serum proteins (human serum albumin, immunoglobulin G, t

181 A number of serum proteins identified by this immunoproteomic study

182 ated with glucose and lipid metabolism, e.g. serum protein Igfbp1 and lipoprotein lipase.

183 Additionally, the serum protein, IgG, was observed to leak from capillarie

184 actors, such as glucose, ascorbic acid human serum protein, immunoglobulin G, and immunoglobulin M),

185 lts suggest the potential benefit of using a serum protein in a non-covalent manner in conjunction wi

186 es, which also did not adsorb any detectable serum protein in undiluted FBS.

187 levels of 190 multiplex immunoassay profiled serum proteins in 149 schizophrenia patients and 198 mat

188 nstrated a robust overexpression of multiple serum proteins in SSc patients, particularly those with

189 ies have emphasized the likely role of human serum proteins in the transportation and accumulation of

190 The presence of serum proteins in the vitreous was detected by Coomassie

191 These serum proteins include vitellogenins, which are egg yolk

192 evaluating the stabilizing effect of several serum proteins including albumin and immunoglobulin G.

193 g fever in North America, binds host-derived serum proteins including factor H (FH), plasminogen, and

194 nosis interactions were identified for eight serum proteins including Factor-VII[rs555212], Alpha-1-A

195 Serum proteins, including CD14 and LPS-binding protein,

196 is subfamily of proteins degrade a number of serum proteins, including circulating complement, provid

197 ells become exposed to ultrafiltrate-derived serum proteins, including complement factors.

198 nt IE sequestration often depends on soluble serum proteins, including IgM.

199 g to the quantification of a large number of serum proteins, including those with an abundance of 10(

200 The environmental pH, binding to serum proteins, interaction with biomembranes, differenc

201 of brain microvascular disease is leakage of serum proteins into the brain extracellular space, in a

202 e leakage of a fluorescent tracer as well as serum proteins into the developing brain and reduced the

203 utrophilic inflammation, vascular leakage of serum proteins into the lung tissue, and exudation of pr

204 nal molecule with affinity for albumin and a serum protein involved in cholesterol metabolism, PCSK9,

205 Turnover of blood serum proteins is a vital function in mammals, but techn

206 and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.

207 the interactions of nanoparticles (NPs) with serum proteins is necessary for the rational development

208 ximately 10(7) lower in abundance than major serum proteins, is feasible.

209 mmunoaffinity depletion of the most abundant serum proteins, isobaric tags for relative and absolute

210 minidase that removes sialic acid from human serum proteins; it is required for T.denticola to grow i

211 ins is greatly enhanced by two lipid-binding serum proteins known as lipopolysaccharide-binding prote

212 t diaphragm are the final barrier to prevent serum proteins leak into urine, and podocyte foot proces

213 polymorphism and pSS and found an increased serum protein level of IL-12p70 in patients with pSS car

214 th mutant AAT mRNA in the liver and defected serum protein level were inhibited by 95%, whereas liver

215 0.03 g/dl (95% CI 0.008-0.05; p < 0.009) in serum protein level.

216 or gene expression by RNA sequencing and for serum protein levels by Luminex and enzyme-linked immuno

217 Serum protein levels for these candidates were measured

218 Serum protein levels improved significantly over time.

219 affect growth, we performed GWAS of measured serum protein levels of IGF-I, IGF binding protein-3 (IG

220 ycoprotein (AGP) hepatic mRNA expression and serum protein levels.

221 ing was not correlated with the standard HCC serum protein marker alpha fetoprotein (P = 0.57).

222 ranslational application, S-glutathionylated serum proteins may be useful as biomarkers in individual

223 The adsorption of even a single serum protein molecule on a gold nanosphere used in biom

224 f cell-penetrating lipophilic metallocorrole/serum-protein nanoparticles (NPs).

225 Unlike networks in solid tissues, serum protein networks comprise members synthesized acro

226 ofiling, measuring the concentrations of 182 serum proteins obtained from acute HAV- (18), HBV- (18),

227 icants is often affected by their binding to serum proteins, of which the most abundant in humans is

228 The adsorption of serum protein on the unmodified sensing membrane led to

229 After heating, the effect of milk serum proteins on aggregation of lactoferrin was charact

230 establish the effect of the presence of milk serum proteins on heat-induced changes to lactoferrin, l

231 potency between compounds and the effects of serum proteins on the metabolic stability of compounds d

232 phagocytosis assay, we studied the effect of serum proteins on this phagocytic process.

233 c resistance to inactivating agents, such as serum proteins or meconium.

234 tial biomarker candidates, we determined the serum proteins overlapping with the retinal proteins kno

235 oresis/mass spectrometry identified specific serum proteins oxidized under cardiotoxic conditions.

236 L-13 as potential upstream regulators of the serum protein patterns in the sera of patients with diff

237 Quantitative serum protein profiling showed that myelofibrotic transf

238 nce of DMD boys was effectively modeled with serum proteins, proximal strength associated with growth

239 Proteomic analysis identified three serum proteins reduced in susceptible animals; lipidomic

240 Transthyretin (TTR) is a largely beta-sheet serum protein responsible for transporting thyroxine and

241 INTERPRETATION: We have identified serum proteins secreted from metaplastic epithelium that

242 Cell viability and serum protein secretion functions were assessed.

243 The PERSEVERE biomarkers are serum proteins selected from among the proteins directly

244 Candidate serum protein septic acute kidney injury biomarkers were

245 Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive pro

246 lly, cytokine expression was examined in the serum (protein), spleen, and hypothalamus (mRNA).

247 ives is evaluation of their interaction with serum proteins such as albumin.

248 Interestingly, some of the serum proteins such as Serum amyloid A, Apolipoprotein A

249 they also degrade via removal of the iron by serum proteins, such as transferrin, over a period of se

250 ER-B with proteomic techniques allowed human serum proteins susceptible to oxidative damage to be det

251 An established multivariate serum protein test can be used to classify patients acco

252 nce of a significant interaction between the serum protein test classification and treatment.

253 ing history, centre, and masked pretreatment serum protein test classification, and randomly assigned

254 Our findings indicate that serum protein test status is predictive of differential

255 ighly induced protein was DPP4, a measurable serum protein that has well-described roles in cancer pr

256 th the sera of mice deficient in fetuin-A, a serum protein that inhibits calcification, and the sera

257 Mannose-binding lectin (MBL) is a serum protein that plays an important role in host defen

258 etween RBP4 and transthyretin (TTR), another serum protein that protects RBP4 from renal clearance.

259 Retinol binding protein 4 (RBP4) is a serum protein that serves as the major transport protein

260 e studied the identity and quantity of human serum proteins that bind to spherical nucleic acid (SNA)

261 urfaces close to the gingival sulcus contact serum proteins that emanate via this sulcus, which may i

262 kidney mineral nanoparticles contain several serum proteins that inhibit ectopic calcification in bod

263 The second group consisted of 17 serum proteins that were associated with DMD and these t

264 The first group consisted of 80 serum proteins that were not associated with DMD and eit

265 -based proteomics analyses, we identified 24 serum proteins that were significantly variant between t

266 Our goal was to identify a combination of serum proteins that would provide a biological measure f

267 For antibodies, like many other serum proteins, the folding and assembly steps involve t

268 n hapten-like drug metabolites conjugated to serum proteins, through their interactions with specific

269 tion of the capacity for a large, endogenous serum protein to gain unobstructed access to the transie

270 t sufficiently distinguish between these two serum proteins to allow it to hijack the regulator alone

271 n caused many of the differentially abundant serum proteins to be restored towards wild-type levels.

272 dhesion of human endothelial cells and human serum proteins to bioceramics of different compositions,

273 (SDS) denaturation and chemical reduction of serum proteins to dissociate ADA-drug bindings, followed

274 imple approach based on selective binding of serum proteins to the surface of nanodiamonds.

275 Heating lactoferrin and milk serum proteins together accelerated the loss of bacterio

276 nanocrystal-based formulation stabilized by serum protein transferrin in a non-covalent manner.

277 The serum protein transferrin was selected for use after eva

278 and Bruch's membrane and, together with the serum proteins transferrin and albumin, elevated in BM/C

279 weight loss along with serum levels of total serum protein (TSP), albumin, C-reactive protein, and le

280 The secreted serum protein TXNDC16 is bound in circulating immune com

281 This serum protein undergoes intensive posttranslational modi

282 yses were conducted for adiponectin mRNA and serum protein using a maximum likelihood-based variance

283 ticle (AuNP) probe from interaction with the serum proteins, virtually eliminating protein corona for

284 s of infected, apoptotic cellular debris and serum protein was consistently observed.

285 selectivity for venomous PLA2 over abundant serum proteins, was not cytotoxic, and showed substantia

286 rom several glycoprotein standards and human serum proteins, we demonstrated that the Y1 ion triggere

287 affinities of linear PFOS and PFOA to total serum protein were confirmed when both calf serum and hu

288 and a second membrane strip containing human serum proteins were coincubated with a ssDNA library con

289 ity, stability up to 260 min, and binding to serum proteins were determined.

290 The total serum proteins were digested with trypsin at 50 degrees

291 Interferences from serum proteins were first significantly reduced by prote

292 Using this method, a series of serum proteins were identified to have weak, but specifi

293 To study competition, saliva and serum proteins were labeled with CyDyes, mixed in variou

294 xpression levels of 7 IRGs and IFN-inducible serum proteins were monitored as potential biomarkers fo

295 tive and integrin-selective binding of human serum proteins, whereas the binding and adhesion of huma

296 erefore, the aim of this study was to detect serum proteins whose abundance is distinctively associat

297 of the patients, we identified a monoclonal serum protein with the same heavy- and light-chain isoty

298 etry-based approach we identified over 1,700 serum proteins with a peptide identification (ID) confid

299 ment of either human serum or isolated human serum proteins with various oxidizing agents, damaged, b

300 FEPR = [serum creatinine x urine protein] / [serum protein x urine creatinine], %) and PCR ([urinary