ライフサイエンスコーパス: severe impairment

1 t 1.447 [CI, 1.235 to 1.695] for moderate to severe impairment).

2 nt, 33% had moderate impairment, and 29% had severe impairment.

3 ction: intact, mild-moderate impairment, and severe impairment.

4 ny renal impairment, and 29% had moderate to severe impairment.

5 ce was 9.8% for mild impairment and 2.6% for severe impairment.

6 for future episodes than did those with less severe impairment.

7 ribed progressive loss, and 93% had moderate-severe impairment.

8 variant carriers who are not yet exhibiting severe impairment.

9 k ratios (RRs) and corresponding 95% CIs for severe impairment.

10 e with scores of less than 16 as having less severe impairment.

11 tantial likelihood of developing moderate to severe impairment.

12 t, and 210 (78.7%) patients with moderate to severe impairment.

13 had mild impairment, and 267 had moderate to severe impairment.

14 time, especially in those with moderate and severe impairments.

15 y were up to 2.5 months old without signs of severe impairments.

16 normal (24-27), mild impairment (18-23), or severe impairment (0-17); cognitive decline was defined

17 (5-year ACGL, 53.0% vs 24.2%; P = 0.04); aHR severe impairment, 2.92 (95% CI, 1.13-7.50; P = 0.03).

18 nterval [CI] 1.30 to 1.77, p < 0.001; OR for severe impairment 3.73, 95% CI 2.55 to 5.45, p < 0.001;

19 2.06, 95% CI 1.59 to 2.66, p < 0.001; OR for severe impairment 3.81, 95% CI 2.57 to 5.65, p < 0.001).

20 ild impairment (60 <= 3MS < 80) and 3.3% for severe impairment (3MS < 60).

21 had higher ACGL risk than recipients without severe impairment (5-year ACGL, 53.0% vs 24.2%; P = 0.04

22 ce interval [CI], 1.78-16.34; P < 0.01); aHR severe impairment, 5.57 (95% CI, 1.29-24.00; P = 0.02).

23 group 3; 22%) exhibited consistent levels of severe impairment across domains and did not experience

24 entage of children and adolescents with less severe impairment and no impairment.

25 Patients with less severe impairment and shorter asthma duration at initiat

26 s with scores of 16 or higher as having more severe impairment and those with scores of less than 16

27 cipants, 201 (51%) were women, 125 (28%) had severe impairment, and 318 (80%) died or survived with s

28 and 5, be simply termed moderate impairment, severe impairment, and kidney failure, respectively.

29 nin I in enhancing force production, and the severe impairment associated with su195sd highlights imp

30 axons from the noninfarcted cortex predicted severe impairment at 2 years.

31 mes at 3 months, especially in patients with severe impairment at baseline.

32 0 to 260, with higher scores indicating more severe impairment) at 36 weeks.

33 orward, P=0.003 for observed cases), and the Severe Impairment Battery (P<0.001 with the last observa

34 o undertake normal daily activities were the severe impairment battery (SIB) and the seven-item minim

35 e secondary efficacy end points included the Severe Impairment Battery and other measures of cognitio

36 Standardised Mini Mental State Examination, Severe Impairment Battery.

37 significant absolute decrease in moderate to severe impairment between each week of gestation (6.5% [

38 able to open their hand at will, those with severe impairment cannot.

39 This suggests that the severe impairment caused by inferotemporal ablations on

40 aired (CBI score=3-4), and 3 showed signs of severe impairment (CBI score > 4).

41 ymptom number and severity, role disability, severe impairment, comorbidity, and treatment compared w

42 9-5.24), and 1 (2.9%) child with moderate to severe impairment compared to 3 (4.6%) in the non iGBS g

43 d with a 1.5- to threefold increased risk of severe impairment compared with no CRT (eg, intelligence

44 des at 1 year after surgery, indicating less severe impairment, compared with patients who had late s

45 , or cystatin-C >1.03 mg/dl) and moderate to severe impairment (creatinine > or =1.5, CrCl or eGFR <5

46 to severe problems were associated with more severe impairment, depression, anxiety, arthritis, highe

47 tion lesions of the amygdala that produced a severe impairment did so because they interrupted connec

48 ny renal impairment and 51% with moderate to severe impairment died versus 24% without impairment.

49 nd near vision impairment (DNVI), and 37 had severe impairment (distance or near worse than 20/200 [>

50 paired in emotional comprehension, with more severe impairment for emotions with negative valence, in

51 In patients with moderately severe impairment from Alzheimer's disease, treatment wi

52 to 4.19 million) than among those with more severe impairment (from 1.56 million to 2.28 million).

53 ental health services among youths with more severe impairment (from 26.2% to 43.9%) was larger than

54 airment, and 318 (80%) died or survived with severe impairment (functional, cognitive, or both) withi

55 d-moderate impairment group and 31.0% in the severe impairment group.

56 d-moderate impairment group and 56.3% in the severe impairment group.

57 group, and OR 1.99, 95% CI 1.12-3.55 for the severe impairment group.

58 group and OR 0.57, 95% CI 0.32-1.00 for the severe impairment group.

59 s were statistically significant only in the severe impairment groups.

60 risk in the co-twin, while index twins with severe impairment had a substantially higher risk for fu

61 Similarly, DDKT recipients with severe impairment had higher ACGL risk than recipients w

62 te increase in service use, youths with more severe impairment had the greatest relative increase in

63 For women with severe impairment, however, those living alone had a gre

64 CI] 1.53 to 1.60, p < 0.001) and moderate to severe impairment (HR = 2.31; 95% CI 2.18 to 2.44, p < 0

65 The prevalence of severe impairment (ie, at least two standard deviations

66 E3 variants, whereas dominant alleles showed severe impairment in all areas and dominant-negative cha

67 e impairment in most areas of functioning or severe impairment in at least 1 area).

68 ng-term follow-up neurocognitive testing had severe impairment in at least 1 neurocognitive domain at

69 h or mutant TDP-43 in motor neurons caused a severe impairment in axon outgrowth, which was dependent

70 KE family, in which half of the members have severe impairment in both speech and language.

71 ified oligonucleotides, which contributed to severe impairment in cell proliferation.

72 ncies during double-strand break repair, and severe impairment in DNA end resection.

73 0, Glu208, Glu241, Gly63, or Gly214 caused a severe impairment in eIF5A(Dhp) binding, with a complete

74 that loss of VDAC2 in the myocardium causes severe impairment in excitation-contraction coupling by

75 ust play an important part in generating the severe impairment in higher-order social, emotional and

76 Conditional removal of this myosin caused severe impairment in host cell invasion and parasite spr

77 attenuation in IFN-defective Vero cells but severe impairment in IFN-competent cells.

78 were not protected by immunization and had a severe impairment in IgG2c Ab production in response to

79 uman myoblasts, IR-Mut myotubes demonstrated severe impairment in insulin signaling and insulin-stimu

80 As a consequence, mutant mice displayed a severe impairment in lymphocyte homing and a compromised

81 for immune regulation is highlighted by the severe impairment in lymphoid cell function in IL-2Rbeta

82 ive analyses indicated a trend toward a less severe impairment in medicated than in unmedicated patie

83 However, Calhm1(-/-) mice showed a severe impairment in memory flexibility, assessed in the

84 Exposure to LB caused more severe impairment in microglial ramification and synapti

85 argeted disruption of FRS2 alpha gene causes severe impairment in mouse development resulting in embr

86 However, among adults with more severe impairment in neuromuscular and movement-related

87 erefore, use of rituximab is associated with severe impairment in neutralization against Omicron desc

88 This knock-in mutation causes severe impairment in NMDAR synaptic incorporation and NM

89 A lesion in the OT caused a severe impairment in orientation discrimination specific

90 /s), which provides further evidence for the severe impairment in P-selectin-mediated rolling.

91 link (AB), which refers to the transient but severe impairment in perceiving the second of two tempor

92 ions into the hippocampus and PR resulted in severe impairment in performance.

93 In the chop -/- animals, in spite of the severe impairment in renal function, evidence of cellula

94 Male mice treated with ACEi show severe impairment in reproductive capacity when mated wi

95 progressive infections are associated with a severe impairment in SIV-specific antibody production.

96 (Foxk1-/-) display growth retardation and a severe impairment in skeletal muscle regeneration follow

97 defects; rather, these KO animals exhibited severe impairment in spatial learning, contextual learni

98 This severe impairment in synaptic development was associated

99 ted with an increased likelihood of death or severe impairment in the 2.5 years after LTCH hospitaliz

100 The primary outcome was death or severe impairment in the 2.5 years after LTCH hospitaliz

101 These abnormalities are associated with a severe impairment in the acquisition of classical eyebli

102 feline astrocytes that is associated with a severe impairment in the astrocytes' ability to uptake g

103 gfr2 (K5-R1/R2 mice) in the epidermis have a severe impairment in the epidermal barrier, which leads

104 of beta-arrestin2 preferentially leads to a severe impairment in the establishment and propagation o

105 KO mice showed a severe impairment in the functional and structural sharp

106 Base-line assessments documented severe impairment in the patients' health-related qualit

107 had disrupted glutamate co-transmission and severe impairment in the refinement of this inhibitory p

108 Severe impairment in the short term did not portend poor

109 es of genes in the ventral telencephalon and severe impairment in the tangential migration of cortica

110 an neonatal cord blood monocytes demonstrate severe impairment in TNF-alpha production in response to

111 ostatic cytoplasmic Ca(2+) concentration and severe impairment in tonic IFN-I signaling.

112 slightly elevated adenosine K(m) values, the severe impairment in transport resulted from drastically

113 We found that mice deficient in Raldh3 bear severe impairment in vestibular functions.

114 uman hepatoma cell line identified many with severe impairment in virion secretion, which can be resc

115 amygdala were found previously to produce a severe impairment in visual discrimination learning for

116 rtex underlying these structures, leads to a severe impairment in visual recognition.

117 n on chromosome 7q11.23, is characterized by severe impairment in visuospatial construction.

118 velop spontaneous ulcerated lesions due to a severe impairment in wound healing; their keratinocytes

119 ve been several successful investigations of severe impairments in a number of isolated families with

120 Arf4(+/-) mice at 4-5 months of age display severe impairments in a pattern separation task, as well

121 orders of consciousness are characterized by severe impairments in arousal and awareness.

122 g, greater ventricular interaction, and more severe impairments in cardiac output, O2 delivery, and p

123 However, EF-hand mutants did show severe impairments in cellular resistance to detachment

124 t delta-cat(-/-) animals are viable and have severe impairments in cognitive function.

125 en with T1D (but not control children), more severe impairments in deactivation of the DMN were assoc

126 (P = 0.002), which was based on presence of severe impairments in gross motor, fine motor, communica

127 Patients with type 2 diabetes exhibit severe impairments in insulin signalling in the brain an

128 tion of liver glucose release in the face of severe impairments in MGU.

129 In conclusion, MCAO induced severe impairments in microcirculatory perfusion within

130 abnormal vision through closed lids produces severe impairments in neuronal selectivity, rendering th

131 re we report that Ophn1 deficiency generates severe impairments in performance at spatial working mem

132 Btk mutations lead to severe impairments in proinflammatory cytokine productio

133 In contrast, Myd88 null mice showed severe impairments in signal transducer and activator of

134 haracterized by a chronic illness course and severe impairments in social relationships and independe

135 pression of the ASD gene FOXP1, which causes severe impairments in speech and language learning, affe

136 AS patients have severe impairments in speech, learning and memory, and m

137 bilateral ST cortex lesions also resulted in severe impairments in the ability to relearn the auditor

138 vements over time, many reported moderate to severe impairments in well-being 3 months later.

139 efrontal cortex and, as shown here, produces severe impairments in working memory.

140 llow-up, abnormal VA (considered moderate to severe impairment) in the more severely affected eye was

141 months of age) Cln1(-/-) mice exhibited more severe impairments, including decreased locomotor activi

142 Among women without severe impairment, Instrumental ADL deterioration was si

143 The prevalence of severe impairment is greater than expected in the genera

144 that excluding people in source studies with severe impairments may produce imprecise estimates of th

145 We investigated whether their severe impairment might, in part, be caused by activity-

146 Two mutants that lead to severe impairment (mut0) are Gly-630 --> Glu and Gly-703

147 hydroxytryptamine for 3 h resulted in a more severe impairment of 15 mm glucose-induced secretion.

148 nts was markedly reduced in association with severe impairment of activation of metalloproteinase-9 a

149 hin the catalytic loop of the enzyme, caused severe impairment of agrin-dependent MuSK phosphorylatio

150 says to reveal that loss of TgTic20 leads to severe impairment of apicoplast protein import followed

151 Lack of B and T cells resulted in a severe impairment of bacterial clearance in blood, splee

152 n content dropped 10- to 20-fold, suggesting severe impairment of beta-cell function.

153 63fsdelC IPF-1 mutation is associated with a severe impairment of beta-cell sensitivity to glucose an

154 In vivo physiological analyses show a severe impairment of both contractility and relaxation i

155 n using a working heart preparation revealed severe impairment of both contractility and relaxation i

156 KRAS(12V) mice show a severe impairment of both short- and long-term memory in

157 is thought to be indicative of an early and severe impairment of both the rod and cone photoreceptor

158 ast apoptosis was detected before indices of severe impairment of cardiac function became apparent.

159 of symptomatic transgenic mice documented a severe impairment of cardiac function evidenced by biven

160 , and fibrosis levels in MI mice, leading to severe impairment of cardiac function.

161 The most severe impairment of catalysis occurred with the modific

162 directed knockdown of caspase-8 results in a severe impairment of CDIP-dependent cell death.

163 Embryonic lethality results from a severe impairment of cell proliferation that is not acco

164 -depleted primary and cultured cells reveals severe impairment of cell spreading and adhesion on fibr

165 Anaphylactic shock is associated with severe impairment of cerebral blood flow despite correct

166 for which substitution with uridine leads to severe impairment of cleavage but folding characteristic

167 placement by any other nucleotide results in severe impairment of cleavage, yet folding of the substr

168 In addition, ATXN2+ patients have a more severe impairment of cognitive functions.

169 Ate1 knockout cells have severe impairment of cytoskeletal organization throughou

170 n age, 4.1 year vs 2 months) and showed less severe impairment of degranulation and cytotoxic functio

171 Severe impairment of distance vision (77.9%) and blindne

172 re introduced in the kinase domain triggered severe impairment of downstream signaling.

173 splay incomplete budding of ER membranes and severe impairment of ER-phagy flux.

174 y, and its genetic deletion in mice leads to severe impairment of eye, skeletal and kidney developmen

175 distress syndrome (ARDS) is characterized by severe impairment of gas exchange.

176 es that skeletal muscle IR in T2D involves a severe impairment of glucose transport and additional im

177 We show that mutation of Y145 leads to severe impairment of glycoprotein VI (GPVI)-mediated res

178 these same nutrient concentrations elicit a severe impairment of growth of nsd cells.

179 virus (HCV) infection is characterized by a severe impairment of HCV-specific CD4+ T cell help that

180 ulated intracellular fumarate and manifested severe impairment of HIF prolyl but not asparaginyl hydr

181 anced drug sensitivity was associated with a severe impairment of homologous recombination-directed D

182 This study provides evidence for a severe impairment of hypoxic pulmonary vasoconstriction

183 K-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling.

184 /+) mice, newborn NF90(-/-) mice demonstrate severe impairment of IL-2 expression.

185 GlcN infusion induced severe impairment of insulin action on Rd (39.4 +/- 3.2

186 icial effects, hyperinsulinemia also induces severe impairment of insulin-stimulated GS activity and

187 the LCx and LAD groups, along with early and severe impairment of LA function.

188 Both analyses showed moderate to severe impairment of left ventricular function and reduc

189 d by massive destruction of hepatocytes with severe impairment of liver function.

190 n in the dentate gyrus was normal, there was severe impairment of long-term potentiation (LTP) as a r

191 2 Delta-infected, male, aged hamsters show a severe impairment of lung function at rest.

192 Moderate to severe impairment of lung function is an independent pre

193 Moderate to severe impairment of lung function related to complexity

194 Moderate to severe impairment of lung function was an independent pr

195 In contrast, there was a severe impairment of memory for autobiographical events

196 Severe impairment of methylation invariably led to a dra

197 density by dexamethasone is associated with severe impairment of mineralized extracellular matrix fo

198 gly polarized Th2 host immune response and a severe impairment of mitogen-driven proliferation and ty

199 d (90 mg/kg) over a 5-day period resulted in severe impairment of movement and loss of neurons in the

200 f CP47 (CP47 RR384385EE), exhibited the most severe impairment of MSP binding, whereas the Arg384Arg3

201 ular dystrophy in boys progresses rapidly to severe impairment of muscle function and death in the se

202 These defects stemmed from severe impairment of neurogenesis associated with uncont

203 riking decline in rod visual sensitivity and severe impairment of nocturnal vision.

204 These effects correlated with the severe impairment of normal, developmental sharpening, a

205 m3 function in nociceptive neurons result in severe impairment of noxious heat-evoked behaviors.

206 accumulation in HEK293 cells and caused more severe impairment of osteoblastic differentiation of MC3

207 We observe a surprisingly severe impairment of plus-end motion due to these altera

208 KCtheta, Bcl10, and Malt1 knockout mice show severe impairment of proliferation in response to TCR st

209 rain damage are frequently associated with a severe impairment of reading, called hemianopic dyslexia

210 from the full-length polypeptide resulted in severe impairment of Rep-Rep interaction.

211 e binding by substitutions was offset by the severe impairment of signal generation of cAMP and/or in

212 hat motor presymptomatic R6/1 HD mice show a severe impairment of somatosensory-discrimination learni

213 e non-restraint ApoE-deficient mice showed a severe impairment of spatial memory similar to that of t

214 d prevent unrecoverable information loss and severe impairment of speech-in-noise intelligibility.

215 Np73, results in male infertility because of severe impairment of spermatogenesis.

216 Downregulation of SON leads to severe impairment of spindle pole separation, microtubul

217 ncy of Foxo1, Foxo3, and Foxo4 resulted in a severe impairment of SSC self-renewal and a complete blo

218 enital lipoid adrenal hyperplasia results in severe impairment of steroid biosynthesis in the adrenal

219 a mutation in troponin I or tropomyosin show severe impairment of systolic function.

220 inhba/junb double KO (DKO) tadpoles exhibit severe impairment of tail regeneration compared with eit

221 migration of cortical projection neurons and severe impairment of tangential migration by the ventral

222 A severe impairment of TFIIH and RNA polymerase II recruit

223 parietal or frontal cortices often induces a severe impairment of the ability to redirect gaze to vis

224 te that overexpression of cPLA(2) results in severe impairment of the calcium and secretory responses

225 Furthermore, a severe impairment of the coupled activities occurred whe

226 ich progressed to loss of endothelial cells, severe impairment of the endothelial barrier function, a

227 isingly, these effects are evident despite a severe impairment of the immunoreceptor tyrosine-based a

228 Depletion of uDCs resulted in a severe impairment of the implantation process, leading t

229 placode organization, with both resulting in severe impairment of the invagination.

230 Severe impairment of the kyphotic nursing posture in lac

231 interaction of complex 1 with DNA and to the severe impairment of the mitochondrial function.

232 residues of the beta7-beta8 loop results in severe impairment of the polymerase function of the hete

233 suggests the requirement for Rpn4p reflects severe impairment of the proteasome by UPR-M/C stress.

234 sing the downregulation of NKG2D and in turn severe impairment of the responsiveness of tumour-antige

235 of neighboring genes and, more importantly, severe impairment of their mRNA translation, leading to

236 We hypothesized that the severe impairment of these patients in real-life decisio

237 In MNGIE, severe impairment of TP enzyme activity leads to increas

238 with a surrogate misfolded protein revealed severe impairment of UPS function in CR-Csn8KO hearts.

239 This severe impairment of vasomotor tone after CTO reopening

240 DNA is depleted from the cells, we observed severe impairment of viral replication.

241 nfectious molecular clone, HXB2, resulted in severe impairment of virus infectivity.

242 In 3-mo-old kittens, we show that a severe impairment of visual acuity is also fully reverse

243 r parietal region also results in an equally severe impairment of visually mediated redirection of ga

244 life (Qol), higher depressiveness, and more severe impairment of visuospatial constructability.

245 All five patients showed severe impairments of episodic memory (memory for events

246 cently reported on three young patients with severe impairments of episodic memory resulting from bra

247 Behavioral studies revealed severe impairments of fear-related associative learning

248 Deletion carriers present with severe impairments of phonology and of inhibition skills

249 As expected, the DPs showed severe impairment on the face recognition task, relative

250 radiofrequency lesions of the amygdala yield severe impairments on object reversal learning, a task t

251 airment ratings (mild/moderate impairment or severe impairment) on the three consent abilities.

252 r disruption of metabolism and can result in severe impairment or death.

253 All boxers with severe impairment possessed at least 1 APOE epsilon4 all

254 erall rates of survival and survival without severe impairment ranged from 5.1% (IQR, 0 to 10.6) and

255 l variation in survival and survival without severe impairment, respectively, among children born at

256 unction (78.9% versus 46.2% with moderate or severe impairment, respectively; P<0.001).

257 tencies were found in patients with the most severe impairment (rs = -0.57; P < 0.01, two-tailed).

258 ddition to panic phenomena contribute to the severe impairment seen in patients with panic disorder.

259 ern the arm and hand in stoke survivors with severe impairment, so hand opening, which is required to

260 litudes were found in patients with the most severe impairment (Spearman rank correlation coefficient

261 Conversely, in patients with severe impairment, successful recovery critically depend

262 both models, the Dhps-KO mice displayed more severe impairment than their Eif5a-KO counterparts.

263 Shank3(e4-9) male mice display more severe impairments than females in motor coordination.

264 ical injury to the carotid artery revealed a severe impairment to occlusion as a consequence of the P

265 Results show severe impairment to processes upstream of photosynthesi

266 The risk of severe impairment to the ocular surface and ocular tissu

267 her odds of low physical performance scores (severe impairment vs normal hearing: OR for composite ph

268 0 to 52, with higher scores indicating more severe impairment); we classified youths with scores of

269 , and the odds of death among residents with severe impairment were 1.64 (95% CI, 1.30-2.08) times hi

270 impairment, slight impairment, and moderate/severe impairment were defined, based on scores from the

271 gs (no impairment, mild/moderate impairment, severe impairment) were also identified for individual p

272 Social function scores showed severe impairment with only modest albeit statistically

273 ensitivity of 86% and specificity of 55% for severe impairment, with a negative predictive value of 9

274 -aged and older adults died or survived with severe impairment within 2.5 years of LTCH hospitalizati