ライフサイエンスコーパス: severely

1 lar signatures of reaction severity (ie, how severely a peanut-allergic child reacts when exposed to

2 We found that GJA1M213L/M213L mice had severely abnormal electrocardiograms despite preserved c

3 periods, a total of 5,321 patients presented severely abnormal vital signs.

4 ed that 24-nucleotide smRNA accumulation was severely abrogated in irAGO4 plants.

5 of etrasimod in patients with moderately to severely active ulcerative colitis (UC).

6 common motor symptoms of such disorders, can severely affect patients' independence and quality of li

7 ocated within the central core of the domain severely affect secretion efficiency.

8 accumulation of invert sugar and byproducts severely affect sucrose manufacturing.

9 n be linked to the presence of GFAP in blood severely affect the human central nervous system.

10 lobal COVID-19 pandemic has the potential to severely affect those with rheumatic diseases or who are

11 asciculus, connecting both of them, was most severely affected anteriorly, as would correspond to a l

12 s region of Belgium, a country that has been severely affected by coronavirus disease 2019 (COVID-19)

13 ndicate that long-range connections are more severely affected by multiple sclerosis-specific damage

14 nct regions in the cellular chromosomes were severely affected by rereplication stress, the integrity

15 diology unit in a hospital in Spain that was severely affected by the COVID-19 pandemic.

16 lity of these interventions in settings most severely affected by tuberculosis are needed.

17 In response, severely affected countries have had to impose a range o

18 1 prevention strategies in Nigeria and other severely affected countries.

19 isual acuity (VA) per eye (i.e., in the more severely affected eye), VA per patient (i.e., VA when bo

20 d province and a neighbor province with less severely affected famine in China through multi-stage cl

21 on, and cardiac remodeling and function were severely affected from the onset of MI.

22 ation and late viral protein expression were severely affected in feather follicles wherein MDV is sh

23 d in fibroblast cell lines derived from more severely affected individuals, indicating the identified

24 and toxicity, with the liver being the most severely affected organ.

25 Coronavirus disease 2019 (COVID-19) in severely affected patients includes atypical pneumonia c

26 lopmental myelination, and more recently, in severely affected patients with early disease onset due

27 e disease and current treatment practices in severely affected patients.

28 ts were selected into the present study from severely affected province and a neighbor province with

29 protein, the D252H homozygous mice were more severely affected than null homozygotes on the same gene

30 wer wall of single furnace main channel were severely affected wear regions, which is caused by silic

31 hyporeactive neutrophil phenotype, patients severely affected with COVID-19 are characterized by exc

32 We report the initial results of nine severely affected X-linked CGD (X-CGD) patients who rece

33 ansfer process in the AbCntA-E205A mutant is severely affected, which likely accounts for the signifi

34 more widespread methylation changes are more severely affected.

35 missense mutation in the other are the most severely affected.

36 tory tract and kidneys are most commonly and severely affected.

37 ed sterility because of ovulation failure by severely affecting the contractile actin networks in the

38 Stroke often severely affects function and network dynamics.

39 is, demonstrating that mylpf impairment most severely affects limb movement.

40 lectron-nuclear hyperfine interaction, which severely affects nuclear coherence.

41 lysosomal cholesterol storage disorder, that severely affects the brain, and is caused by mutations i

42 cooling power is extremely limited, and this severely affects the prospects of practical quantum comp

43 , decreased ability to form tumorspheres and severely affects tumor growth.

44 FcgammaRIIA expression by bone marrow cells severely aggravated lupus nephritis and accelerated deat

45 In contrast, mutations in arginine display a severely altered conformation, static binding to RNA, an

46 d individuals showed normal ciliogenesis but severely altered Hh-signal transduction as a result of e

47 Decision-making was also severely altered, with correct foraging choice nearly 40

48 dyspnea, sleep, and financial problems were severely and persistently affected.

49 an ancestry (AA) experience the disease more severely and with an increased co-morbidity burden compa

50 Here, we analyze the locomotor behavior of severely ataxic reeler mutants and compare and contrast

51 ythrocytic cycle of Pbyop1Delta parasites is severely attenuated and the incidence of experimental ce

52 d that all the mutations studied resulted in severely attenuated Ca(2+) release when expressed as hom

53 pe strain, the infectivity of the mutant was severely attenuated in a murine infection model.

54 T) strain, the infectivity of the mutant was severely attenuated in a murine infection model.

55 Targeting SOX2 severely attenuated ZIKV infection, in contrast to AXL.

56 Disruption of DBT severely attenuates ERK/MAPK signaling, p53 activation,

57 Here, we describe a severely autistic male patient carrying a single amino a

58 the strand transfer structure, target DNA is severely bent and the TTAA target is unpaired.

59 s as single cells in downstream analyses can severely bias a study's conclusions, and therefore compu

60 ransposon-mediated domain insertion that was severely biased and sparse for some genes, SPINE generat

61 e magnitude of initial calcium signaling and severely blunted persistent calcium influx.

62 Severely burned and non-burned trauma patients are at ri

63 However, this is hindered severely by the high negative potential required to acti

64 atherectomy (CA) can be utilized in treating severely calcified coronary lesions; however, the tempor

65 ssess the safety and effectiveness of IVL in severely calcified de novo coronary lesions.

66 ffectively facilitated stent implantation in severely calcified lesions.

67 Conditional VDR deletion severely changed metabolites specifically produced from

68 Patients who called out were moderately or severely cognitively impaired, often had delirium, were

69 This is because many of these patients are severely cognitively impaired, often immobile and depend

70 bioturbation in restoring the structure of a severely compacted soil.

71 skewing of 80:20 or more, 57% were affected severely compared with 8% for those with XCI of less tha

72 Shedding of gp120, known to severely complicate structural studies, can be prevented

73 DNA lesions can severely compromise transcription and block RNA synthesi

74 or truncating the C-terminal domain of TPS1 severely compromised growth.

75 mitochondrial one-carbon metabolism that is severely compromised in CI mutant cells.

76 ngs in myo2-S1 cell ghosts were unstable and severely compromised in contraction on ATP addition.

77 well by albumin expression and secretion, is severely compromised in telomerase mutant cells with sho

78 Severely compromised LPL activity causes familial chylom

79 s toward memory phenotype, which resulted in severely compromised memory CD8 T cell development.

80 Particularly alarming is the severely compromised survival of female patients (4-year

81 Further, Shank3 knockout severely compromised the in vivo ability of visual corti

82 in the RPE from miR-211(-/-) mice that show severely compromised vision.

83 methyltransferases whose widespread presence severely compromises all aminoglycosides in current clin

84 e show here that the ablation of eosinophils severely compromises antitumor immunity in syngeneic and

85 facing unprecedented levels of degradation, severely compromising habitat suitability for wildlife.

86 Spatiotemporal bias in genome sampling can severely confound discrete trait phylogeographic inferen

87 Uncorrected, these allele frequency clines severely confounded inferences of selection.

88 Thus, despite severely curtailed CD25 expression and function, Treg ce

89 loss of IL-10 signaling by B cells led to a severely curtailed peanut-specific IgE response, decreas

90 lly found that blocking with skim milk could severely damage the performance of the capture nanobody

91 corn fields producing Cry3Bb alone that were severely damaged by this pest in 25 crop-reporting distr

92 porcine models of hindlimb ischemia rescues severely damaged tissues by the ingrowth of neighboring

93 n be assembled by DEP within the crevices of severely damaged wires to create stretchable interconnec

94 evin; Homoptera: Tropiduchidae) attacks that severely damages the tree's growth and reduces fruit pro

95 is of CNS complications that potentially are severely debilitating and may even be lethal.

96 The visual field was severely decreased and electroretinogram was undetectabl

97 ) generate few isotype-switched B cells with severely decreased frequencies of somatic hypermutations

98 The formation of dislocations, which severely degrade electronic/photonic device performances

99 m participating in ionic transport, and thus severely degrade the total conductivity.

100 ls and common lymphoid progenitors causing a severely depleted acquired immune system.

101 Patients with severely deviating vital signs and suspected infection w

102 For the first time, we show severely diminished availability of glycolytic and citri

103 ave the capacity to respond to bacteria, are severely diminished in circulation and liver tissue.

104 Despite severely diminished MAIT cell numbers and impaired pheno

105 se is greater and assuming independent noise severely diminishes decoding performance.

106 the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4-6), compared with

107 ve prognostication could leave patients in a severely disabled state, with the possibility that inacc

108 from any stroke was 82%, while freedom from severely disabling stroke was 89%.

109 After the resection of the 3 severely diseased segments, the remaining 2 discontinuou

110 Our findings show that these mutations severely disrupt PM association of fibroblast growth fac

111 mpetence in VPAC2 cells by deletion of Bmal1 severely disrupted circadian behavioral rhythms and comp

112 Mutating region V severely disrupted function without affecting subcellula

113 ferentiation (Wnt7a, Hoxa10, and Msx2), were severely disrupted on PND5 in GEN-exposed mice.

114 The COVID-19 pandemic has severely disrupted worldwide supplies of viral transport

115 in polymerization in PFN1 knockout cells was severely disrupted, particularly at the leading edge, wh

116 Here we show chronic CL13 infection severely disrupts the expansion, proliferation, activati

117 A total of 4522 (26.2%) patients came from severely distressed communities (top quartile).

118 ha in oligodendroglial myelination, which is severely disturbed in preterm infants affected with diff

119 lecularly, the specific HR protein Rad51 was severely downregulated by the combination via two mechan

120 expression in Arabidopsis plants resulted in severely dwarfed plants that could be rescued by the exo

121 Prepregnancy diabetes, especially when severely dysregulated, is associated with an increased r

122 though life-threatening condition related to severely elevated ferritin is hemophagocytic lymphohisti

123 y is performed in patients presenting with 3 severely fibrotic and deformed bowel loops separated by

124 mall bowel Crohn's disease presenting with 3 severely fibrotic and deformed bowel loops separated by

125 the 593 patients classified as moderately to severely frail (2.5%).

126 For severely frail patients aged 55-64 years, the NNT was 24

127 or prefrail, mildly frail, and moderately to severely frail patients, respectively, beyond the CMS-HC

128 acid copolymers used for this purpose suffer severely from buffer incompatibilities.

129 nd limited availability of serum-derived RIG severely hamper its wide use in resource-limited countri

130 )-binding site and observed that this change severely hampered antibody stability and its ability to

131 , Al and Ca) in oxygen reduction reaction is severely hampered by the tight-bonding of active centers

132 Interestingly, phospholipid synthesis was severely hampered in cells in which PlsX was detached fr

133 rity and ability to form hydrogen bonds, has severely hampered the development of the field.

134 ated most immune responses, this shortcoming severely hampers the development of effective immunother

135 These policies severely harm American science by stripping it of talent

136 ot using beta-adrenoceptor antagonists would severely harm patients with recommended indications, suc

137 Aromatic hydrocarbon pool species severely hinder the diffusion and their spatial distribu

138 aves, their use in practical applications is severely hindered by intrinsically narrow band performan

139 tion/discrimination of intermixed stimuli is severely hindered by the difficulty of efficient integra

140 models capable of mimicking human physiology severely hinders the development and clinical translatio

141 T2D rats were obese and severely hyperlipidemic, with impaired glucose and insul

142 ciated with MCM3AP variants, by describing a severely hypotonic child and a sibling pair with a progr

143 hin the vascular cylinder; the extent of the severely hypoxic core increased as external O(2) was red

144 ature of aggressive HNSCC is the presence of severely hypoxic regions in tumors and activation of hyp

145 respiration to ethanolic fermentation as the severely hypoxic/anoxic core became a progressively grea

146 t, earlier presentation, patients being less severely ill and receiving treatment sooner.

147 ydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive

148 vestigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovat

149 Mortality of severely ill patients with liver disease in district gen

150 drome Coronavirus 2 (SARS-CoV-2) or becoming severely ill.

151 escribing a chronic case of influenza B in a severely immunocompromised child we infer an N(e) of 2.5

152 articularly skin infections and arthritis in severely immunocompromised patients.

153 iled to induce significant infection even in severely immunocompromised- SCID or inducible NO synthas

154 Among severely immunosuppressed adults with HIV infection who

155 ebilitating and painful side-effect that can severely impact an individual's quality of life.

156 ynapse, more so in already damaged ears, and severely impact auditory sensitivity in cancer survivors

157 neralization and immobilization, which could severely impact grassland structure and functioning.

158 CIED infections severely impact mortality, quality of life, healthcare u

159 Loss of glycine decarboxylase (GLDC) can severely impact neurological development as seen in non-

160 deficits in locomotor speed encoding likely severely impact path integration systems in dementia.

161 break unfolds, COVID-19 has the potential to severely impact solid organ transplant recipients.

162 For patients with severely impacted aortic valves that require replacement

163 e hippocampal neurons, a region of the brain severely impacted by AD.

164 e number of deaths reported in the next most severely impacted country.

165 lement eliminate NC binding to this site and severely impair RNA packaging into virus-like particles.

166 d of the tether but maintain overall binding severely impair this enhancement.

167 tective against venous thrombosis results in severely impaired binding to both activated alpha(IIb)be

168 ferating HepaRG bioenergetic parameters were severely impaired by day 8, with 1 and 12 muM ddC, where

169 ral and pulmonary venous pressures, and more severely impaired cardiac output and stroke volume respo

170 d neutrophils and white blood cells showed a severely impaired chemotactic response.

171 ace expression of mutant murine GABA(A)Rs is severely impaired compared with WT, due to retention in

172 rin signaling leading to dysplastic MKs with severely impaired demarcation system formation and throm

173 mmunological synapse (IS) formation and have severely impaired exocytosis of lytic granules.

174 elicited robust interferon responses and was severely impaired for replication in PK1 cells.

175 ein precursor variant, present in ticks, has severely impaired function in human cells.

176 susceptible to infections, likely because of severely impaired immune function.

177 Further, 17dmiR-H1/H6 was severely impaired in epinephrine-induced reactivation in

178 Microcirculation is severely impaired in patients with refractory cardiogeni

179 differentiated, and leukemia progression was severely impaired in the absence of AMD1 in vivo.

180 tive phosphorylation dependent, mitophagy is severely impaired in the PRKN mutant patient neurons.

181 abetes is an autoimmune disease resulting in severely impaired insulin secretion.

182 letion of Kir6.1 or SUR2 subunits results in severely impaired lymphatic contractile responses to pin

183 1 gain-of-function (GoF) subunit resulted in severely impaired lymphatic contractions and hyperpolari

184 In vitro assays demonstrated severely impaired mineralised matrix formation and incre

185 e significant limitations, with users having severely impaired pitch perception.

186 The patients' B cells had severely impaired proliferation and in vitro immunoglobu

187 ceptors, we expressed mutant arrestin-1 with severely impaired self-association in mouse rods and ana

188 capacity, and spermatogenesis that were more severely impaired than those of maternal lineage males.

189 Type I IFN-mediated JAK-STAT signaling is severely impaired, and activation of MAPKs and PI3K sign

190 y clearance in the respiratory epithelium is severely impaired, the disorder is referred to as primar

191 n-deficit/hyperactivity disorder (ADHD) is a severely impairing neurodevelopmental disorder with a pr

192 f 14-3-3 proteins with their client proteins severely impairs high temperature-induced stomatal openi

193 These findings demonstrate that Shank3 loss severely impairs the ability of central circuits to harn

194 We conclude that the tubulin mutation severely impairs the central hearing pathway most probab

195 molecular defects behind beta-thalassemia is severely impeded by paucity of material from patients an

196 with CUB overly similar to that of the host severely impeded host translation.

197 st shoot biomass and shoot : root ratio more severely in high water than low water, irrespective of N

198 mate and rainfall across the world, and most severely in nations surrounding the Indian Ocean(1-4).

199 reas other primates have flat feet that bend severely in the midfoot(7,10,11).

200 Interestingly, blood-glucose-levels drop severely in treated animals, presumably due to glucose c

201 Dp-ucMGP was severely increased in COVID-19 patients, indicating extr

202 The examination showed unilaterally severely increased intraocular pressure, bilateral dense

203 impacts the climate, reduces visibility and severely influences human health.

204 Low fluoride concentrations severely inhibit biocontainment strain growth, which is

205 ally, restraining iron availability in vitro severely inhibited CD4 T cell proliferation and cell cyc

206 isruption of the Nesprin-2/BicD2 interaction severely inhibited nuclear movement, centrosome advance

207 HAO efficiently removes hydroxylamine, which severely inhibits calcium-dependent, and as we show here

208 Patients were severely injured (median injury severity score 33); 33%

209 Fibrosis was more persistent in more severely injured Grp78 knockout (KO) mice.

210 abolites that are increased in the plasma of severely injured patients that developed ARDS versus sev

211 injured patients that developed ARDS versus severely injured patients that did not, and assay if the

212 All severely injured patients who were transferred to the hy

213 ular metabolites accumulate in the plasma of severely injured patients.

214 st trauma systems have improved outcomes for severely injured patients.

215 s that range from mild (e.g. pharyngitis) to severely invasive (e.g. necrotizing fasciitis).

216 Even eyes that were severely ischemic at baseline had no significant changes

217 about one third of the world population and severely jeopardizes economic development.

218 val of a similar, previously encoded item is severely lacking.

219 (2002-2011), for which conventional analyses severely limit the quality of inference.

220 and impaired systolic function, which could severely limit the therapeutic potential of targeting Gr

221 rfaces for vortex beam generation are either severely limited by bulky optical setups or by restricte

222 ge of solid tumors, but its effectiveness is severely limited by gastrointestinal (GI) tract toxicity

223 We conclude that growth rate was severely limited by low pCO(2) at the LGM, that current

224 c studies are based on (1)H 1D spectroscopy, severely limited by peak overlap.

225 s of PTMs 3D structural signatures have been severely limited by the deficiency of the data.

226 However, those advanced technologies are severely limited by the efficiency, selectivity, and dur

227 The size of the pixels, however, are severely limited by the fundamental constraints of light

228 ever, the performance and utility of IFC are severely limited by the fundamental trade-off between th

229 sponses were sparse and broadly tuned, which severely limited decoding performance from small DSGC po

230 zheimer's disease-related processes may have severely limited efficacy in these co-morbid populations

231 bed DNA probe suggest that DNA permeation is severely limited for higher EFs.

232 gh sequence identity across transcripts, has severely limited our collective understanding of tRNA ge

233 t preclinical models of brain metastasis has severely limited such investigations, underscoring the i

234 due to the volatile organic components have severely limited their potential applications.

235 halide perovskites in their solid state have severely limited their practical applications.

236 ally mark tubulin PTMs in living cells, thus severely limiting our understanding of their dynamics an

237 es, for example, are highly autofluorescent, severely limiting the utility of light microscopy.

238 BM's location behind the blood-brain barrier severely limits chemotherapeutic options.

239 invasive and costly nature of this procedure severely limits its application outside intensive care u

240 e-forming enzymes in biosynthesis, this also severely limits our ability to predict natural product s

241 This severely limits our capacity to devise mitigation measur

242 in the ceramics was virtually unknown, which severely limits our understanding about the process of l

243 , but lack of long-term climate observations severely limits our understanding of the global processe

244 but a lack of robust palaeotemperature data severely limits reconstruction of the processes that dro

245 The missense mutation severely limits the glycosylation of NCSTN to its mature

246 urface roughness in the composite transducer severely limits the phonon relaxation time in sputter-de

247 xygen supply to cells within the tissue bulk severely limits the tissue culturing potential of many b

248 tures with specific diameters or chiralities severely limits their potential applications.

249 ass index of >=25 kg/m(2) were moderately or severely malnourished, depending on the nutritional inde

250 eurotrophic factor (BDNF) mutants, which are severely obese and have diminished glucose balance contr

251 In this study, we genetically screened 225 severely obese children from consanguineous Pakistani fa

252 Severely obese donors more likely had diabetes mellitus

253 of obesity have been identified in <=10% of severely obese European patients.

254 We performed a prospective study of 180 severely obese patients with biopsy-proven NASH, defined

255 In severely obese patients with previous MI, metabolic surg

256 io of 4.71 (95% CI, 2.81-7.89) was found for severely obese subjects (BMI >=35 kg/m(2)), as compared

257 d with a reduced risk of breast cancer among severely obese women.

258 tal defects of the nervous system leading to severely paralyzed animals.

259 ts in addition to standard care for patients severely poisoned with either chloroquine or quinine (st

260 al oxygen is required to promote survival of severely premature infants, hyperoxia is simultaneously

261 of soluble, processed globulin subunits was severely reduced and a major part of the cruciferin mole

262 s piezoelectricity and magnetostriction, are severely reduced by the substrate clamping effect.

263 The hk5 hk6 mutant also exhibited a severely reduced cytokinin response, consistent with the

264 Bsg(-/-) mice have severely reduced electroretinograms (ERGs) and progressi

265 mitotic spindle localization, which becomes severely reduced in tail-deleted motors.

266 HG patients have severely reduced levels of antibody-producing B cells an

267 assays, show impaired enzymatic activity and severely reduced NAD levels.

268 uSCs, we found that myog(-/-) myofibres have severely reduced nuclear number, but increased myonuclea

269 , MAR did not confer a benefit in those with severely reduced renal function.

270 Severely reduced skeletal muscle Ca(2+) transients in GB

271 Best-corrected visual acuity was severely reduced to residual light perception and hand m

272 S modules bearing non-cognate TE domains was severely reduced.

273 While L268F severely reduces expression of heteromeric channels in h

274 Salinity severely reduces plant growth and limits agricultural pr

275 tion of ACO2 reduced total lipid content and severely repressed in vivo prostate cancer progression.

276 fabrication process and their flexibility is severely restricted by the relatively large cross-sectio

277 bination between the Sb and SB haplotypes is severely restricted in all species, a low level of gene

278 networks and support recovery of function is severely restricted, contributing to chronic neurologica

279 ad of coronavirus disease 2019 (COVID-19) by severely restricting travel and in-person commercial act

280 stralian catchments-29% of which are already severely salt-affected-from the Australian Water Availab

281 is, and aplastic anemia, is characterized by severely short telomeres, often resulting in hematopoiet

282 ar-neurectomy was performed in goldfish that severely shortened OKAN, but pOKR was acquired comparabl

283 ively affecting hole/electron conduction and severely shortening device lifetime.

284 Patients were severely sick (Survival After Venoarterial ECMO score me

285 Importantly, under severely stressed conditions, chronic administration of

286 h-for-age z-score [LAZ] <= -2) who were also severely stunted (LAZ <= -3) at the time of sampling exh

287 t experiences negligible water stress but is severely stunted by low-nutrient and acidic soil, to inv

288 postnatal EC-specific loss of Kif11 leads to severely stunted growth of the retinal vasculature, mild

289 ucture, but plants grown in this medium were severely stunted in growth due to removal of essential s

290 ce lacking endometrial epithelial Arid1a are severely sub-fertile due to defects in implantation, dec

291 H(8) ) over a Pt/TiO(2) -WO(3) catalyst that severely suffers from oxygen poisoning at high O(2) /C(3

292 ity, protein matrix and starch granules more severely than 600 MPa; however, tightly-packed complexes

293 ones, teeth, and brain and is known to limit severely the performances of biomedical optical imaging.

294 ny of these organisms are rare, cryptic, and severely threatened, making population-level sampling un

295 overing hearing for more than half a million severely-to-profoundly hearing-impaired people.

296 Expression of most of the severely toxic genes confers altered cellular morphologi

297 Potential outliers may severely undermine the correct classification of patient

298 Such waste has been severely underutilized, resulting in both resource wasta

299 In severely water-limited sites, models only agree on the i

300 ration of spintronics, ferromagnetism decays severely when the thickness is scaled to the nanometer r