ライフサイエンスコーパス: sex determination

1 d could mediate the impact of temperature on sex determination.

2 separate but linked genes as responsible for sex determination.

3 Chinese tongue sole is a marine fish with ZW sex determination.

4 g a central role of epigenetic regulation in sex determination.

5 ication of Notch activation, at the onset of sex determination.

6 rily responsible for the hormonal control of sex determination.

7 at short lifespan might have co-evolved with sex determination.

8 ge, especially in species with environmental sex determination.

9 ians, which are assumed to only have genetic sex determination.

10 testis development long after the period of sex determination.

11 te meristems, fasciation, and alterations in sex determination.

12 hromosome Y is important in processes beyond sex determination.

13 ametogenesis, developmental transitions, and sex determination.

14 nd yet, paradoxically, is essential for male sex determination.

15 lecular pathways underlying the evolution of sex determination.

16 ome 4 and chromosomal regions that influence sex determination.

17 lopment, including stem cell maintenance and sex determination.

18 ve effects on gene expression during primary sex determination.

19 genesis, gonad differentiation, and possibly sex determination.

20 wing ancestral exposure during fetal gonadal sex determination.

21 iation for growth rate, vertebral number and sex determination.

22 wing ancestral exposure during fetal gonadal sex determination.

23 imal steroids, which are decisive factors of sex determination.

24 ge differs between female and male PGCs post-sex determination.

25 on factor regulating both chondrogenesis and sex determination.

26 liability of the ion chromatogram method for sex determination.

27 nesis are well conserved, while they vary in sex determination.

28 transformer gene (Bdtra) required for female sex determination.

29 odel system to study evolution of dioecy and sex determination.

30 ng model for studying this enigmatic mode of sex determination.

31 iggered a revolution in our understanding of sex determination.

32 As, which are hypothesized to participate in sex determination.

33 , particularly in species with plasticity in sex determination.

34 Anopheles gambiae appears to be involved in sex determination although very little is known about bo

35 These data suggest that during primary sex determination, an oocyte-derived signal acts on the

36 es, origin of new species, and mechanisms of sex determination and development.

37 he question of how the genes responsible for sex determination and differentiation are regulated.

38 ntial follow-up studies of genes involved in sex determination and differentiation in catfish.

39 Sex determination and differentiation is a complex proce

40 elopment, Rspo1 is a key factor required for sex determination and differentiation of the follicular

41 nvestigations of the molecular mechanisms of sex determination and evolution in cichlid fishes.

42 al male functions in many species, including sex determination and fertility.

43 ic control of meiotic maturation to germline sex determination and gamete maintenance.

44 f the complex genetic network that underlies sex determination and identifies regions that potentiall

45 anscriptional repressor), which acts both in sex determination and in physiological demand control of

46 Despite its function in sex determination and its role in driving genome evoluti

47 ecific Y chromosome plays a critical role in sex determination and male fertility.

48 ells was blocked when Wt1 was deleted before sex determination and most genital ridge somatic cells d

49 conditions, including temperature-dependent sex determination and obligate use of beaches subject to

50 boxyglutamate protein, key mediators of male sex determination and osteogenesis, respectively.

51 activating genes normally involved in female sex determination and ovarian development and show that

52 nvestigate the impact of fatty acids (FA) on sex determination and reproductive development, we exami

53 which FA, an environmental factor, regulates sex determination and reproductive development.

54 ms to identify multiple loci responsible for sex determination and reproductively adaptive color phen

55 tes conditions for cytonuclear conflict over sex determination and sex ratio, as well as conditions f

56 Medaka is an ideal model for sex determination and sex reversal, such as XY phenotypi

57 Although the basic tenants are shared, sex determination and sexual reproduction occur in myria

58 the diagnostic reliability of NIPD for fetal sex determination and single gene disorders.

59 sual plasticity in the bipotential system of sex determination and some of the diverse mechanisms tha

60 rovide evidence that JA is required for male sex determination and suppression of female reproductive

61 ure during embryonic days 8 to 14 of gonadal sex determination and the incidence of adult onset disea

62 -linked markers, to understand mechanisms of sex determination and to investigate differences between

63 as the developmental switch gene for somatic sex determination and X-chromosome dosage compensation.

64 inbred populations exhibiting environmental sex determination and/or differentiation.

65 ation gene doublesex (DMRT proteins) control sex determination and/or sexual differentiation in diver

66 ce, readily available technology of prenatal sex determination, and fertility decline.

67 n formation, venom production, haplo-diploid sex determination, and host-symbiont interactions.

68 es of this complex in neuronal functions and sex determination, and implicate the nuclear YT521-B pro

69 m2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its

70 transcriptional repression during C. elegans sex determination, and provide evidence that this import

71 gamma and Map3k4 genetically interact during sex determination, and transgenic overexpression of Map3

72 n embryos, genes involved in the cell death, sex-determination, and RNAi pathways, and transposable e

73 Three principal types of chromosomal sex determination are found in nature: male heterogamety

74 ermatogenesis, testicular determination, and sex determination are poorly understood.

75 could either have evolved soon after genetic sex determination arose or considerably later.

76 t between germ cells at the onset of gonadal sex determination at embryonic day 13 (E13) and after co

77 ir-35 family is required for not only proper sex determination but also viability, showing that a sin

78 Sex determination cascade in insects terminates with the

79 he importance of alternative splicing in the sex determination cascade of the honeybee Apis mellifera

80 a molecular switch at the base of the insect sex determination cascade, and triggers male or female s

81 ey transcription factor gene involved in the sex determination cascade.

82 tis elegans hermaphrodite, the developmental sex-determination cascade specifies gamete sex in the di

83 ound that deletion of Wt1 in the ovary after sex determination caused ectopic development of steroido

84 With lists of candidate genes for sex determination containing fewer than 200 in each spec

85 inates sexual development by reinforcing the sex-determination decision and directing downstream sexu

86 ases, including campomelic dysplasia (SOX9), sex determination disorders (SOX8 and SOX9) and Waardenb

87 ey have been the subject of much research on sex determination due to problems caused by early matura

88 of the testis that play an essential role in sex determination during embryogenesis and in spermatoge

89 Sry is believed to function primarily in sex determination during fetal life.

90 that will investigate the interplay between sex determination, ecology and behavior in additional di

91 Environmental sex determination (ESD) - a change in sexual function du

92 SD) is the predominant form of environmental sex determination (ESD) in reptiles, but the adaptive si

93 alichthys lethostigma) exhibit environmental sex determination (ESD), where environmental factors can

94 vey our current understanding of how and why sex determination evolves in animals and plants and iden

95 sults provide crucial evidence for genotypic sex determination facilitating land-water transitions in

96 mo promotes expression of the canonical male sex determination factor DoublesexM (Dsx(M)) within CySC

97 nnections with neurons expressing the neural sex determination factor fruitless (fru), which have bee

98 nt regulation of alternative splicing of the sex determination factor Sex lethal (Sxl).

99 invasive prenatal diagnosis (NIPD) of fetal sex determination, fetal rhesus D status and some single

100 Crosses with sex-reversed strains uncoupled sex determination from sex chromosome identity and revea

101 As with gld-1, no sex determination function for fbf or puf-2 orthologs is

102 nt maize, BRs have been coopted to perform a sex determination function not found in plants with bise

103 both the regulatory system and SXL protein's sex-determination function have remained largely unknown

104 netic analysis suggests that the SXL's novel sex-determination function in Drosophila is more likely

105 Knockdown of the sex determination gene intersex produced a partial femal

106 We analyzed a custom-built sex determination gene set consisting of 32 genes using

107 With the exception of DMRT1, genes in the sex determination gene set have not previously been iden

108 The sex determination gene set ranked highly compared with c

109 fter removal of DMRT1 from the gene set, the sex determination gene set remains associated with TGCT

110 We show that the sex determination gene transformer (tra) acts in the dev

111 We demonstrate that the female sex determination gene, Sex-lethal (Sxl), functions in c

112 Here, we identify a novel sex determination gene, spenito (nito) that encodes a SP

113 we identified the mat1-Mc gene, a mammalian sex-determination gene (SRY) homolog, as the primary gen

114 Transcription factors related to the insect sex-determination gene doublesex (DMRT proteins) control

115 Here, we focus on the conserved sex-determination gene doublesex (dsx) and the mechanism

116 ential role played by neurons expressing the sex-determination gene doublesex (dsx) in regulating the

117 Here we show that the sex-determination gene doublesex (dsx) underlies importa

118 onses via sensory neurons that coexpress the sex-determination gene fruitless (fru) and the proprioce

119 The sex-determination gene set (false discovery rate, FDRM <

120 and processes, in addition to a custom-built sex-determination gene set, were subject to enrichment a

121 temperature-sensitive point mutation in the sex-determination gene, transformer-2 (tra-2), using CRI

122 report an excellent candidate for the master sex-determination gene: a translocated copy of Amh (Amhy

123 to the nervous system via the actions of the sex determination genes doublesex (dsx) and fruitless (f

124 male-specific P1 neurons that coexpress the sex determination genes fru (M) and dsx, but does not af

125 Here the authors identify the sex determination genes fruitless and doublesex, and a s

126 Genetic screens on the sex determination genes in genetic females for size poly

127 omosomes can function through linkage of two sex determination genes.

128 ive neuronal marker pickpocket (ppk) and the sex-determination genes doublesex (dsx) and fruitless (f

129 ence that the neural circuits expressing the sex-determination genes fruitless and doublesex drive qu

130 model to determine how degree of inbreeding, sex determination, genomic location, pattern of gene exp

131 those of a virtual population with genotypic sex determination (GSD) and fixed sex ratios.

132 tudy of sex chromosome evolution, as genetic sex determination has evolved repeatedly and is often ab

133 In flies, the sex-determination hierarchy terminates in the doublesex

134 nt of convergence of the two branches of the sex-determination hierarchy.

135 n the male gonadal development pathway, post sex determination, implies a vital role in testis gonada

136 well established, the importance of genetic sex determination in adult lineages remains largely unex

137 Sex determination in animals and fungi is regulated by s

138 Molecular understanding of sex determination in B. tabaci, an emerging invasive ins

139 of reproduction and development such as male sex determination in branchiopod crustaceans.

140 Since sex determination in C. elegans requires zygotic gene ex

141 has pointed to an unusual 3-locus system of sex determination in dioecious populations.

142 The genes governing sex determination in dioecious species remain unknown, b

143 cate that PUF family genes were co-opted for sex determination in each hermaphrodite via their long-s

144 indicate that miR-1-3p is required for male sex determination in early embryogenesis in B. dorsalis

145 hAG2, was identified as a candidate gene for sex determination in F. hispida.

146 m subdaily temperature fluctuations and that sex determination in fathead minnows can be influenced b

147 resource for understanding the evolution of sex determination in insects.

148 We show that BRs control sex determination in maize revealed through characteriza

149 Sex determination in mammals is governed by antagonistic

150 Sex determination in mammals requires interaction betwee

151 vation, both of which are essential for male sex determination in mice.

152 Sex determination in papaya is controlled by a recently

153 l stress responses, but their involvement in sex determination in plants has been only speculative.

154 special value for studying the mechanism of sex determination in plants.

155 We studied sex determination in Psocodea-a species-rich order of in

156 Clearly, sex determination in reptiles is far more complex than i

157 aps surprisingly given its multiple origins, sex determination in the GIFT strain breeding nucleus wa

158 ild grapevine, providing a coherent model of sex determination in the latter and for transition from

159 Sex determination in the mosquito Aedes aegypti is gover

160 Irx3 and Irx5 expression begins after sex determination in the ovary but remains absent in the

161 may underlie emergence of non-Sry-dependent sex determination in the radiation of Muroidea.

162 ndings therefore suggest that the outcome of sex determination in these reptiles is heavily influence

163 es the understanding of the genetic basis of sex determination in Vitis and provides the information

164 d to a better understanding of the origin of sex-determination in Drosophila and also raise some new

165 ethal (Sxl) functions as the switch gene for sex-determination in Drosophila melanogaster by engaging

166 ight of a model for the mechanism underlying sex-determination in seed plants, in which AP3/PI orthol

167 all crocodilians, has temperature-dependent sex determination, in which the sex of an embryo is dete

168 Here, we investigate sex determination, inbreeding depression and inbreeding

169 Here we assess whether the type of genetic sex determination influences the ASR using data from 344

170 Mammalian sex determination initiates in the fetal gonad with spec

171 delian inheritance which can be used to bias sex determination, install exogenous information, or rem

172 n gynodioecious Beta vulgaris ssp. maritima, sex determination involves cytoplasmic male sterility (C

173 In zebrafish, sex-determination involves establishment of a bipotentia

174 Sex determination is a fundamental developmental pathway

175 Mammalian sex determination is controlled by antagonistic pathways

176 species, future research can address whether sex determination is controlled via similar physiologica

177 These regions were compared to understand if sex determination is controlled via the same physiologic

178 In many insect lineages, sex determination is either completely unknown or poorly

179 The mechanisms of sex determination is known for only a handful of such sp

180 We verified that sex determination is linked to the sex determining locus

181 it lacks heteromorphic chromosomes (instead, sex determination is polygenic) and has reduced opportun

182 patterns include haploid- and diploid-phase sex determination, isogamous mating systems, and dimorph

183 Our results show that PGCs prior to sex determination lack a G1 cell cycle checkpoint.

184 ence of suppressed recombination surrounding sex determination loci.

185 Mammalian sex determination (male versus female) is largely contro

186 An understanding of the genetic basis of sex determination may lead to new methods of managing th

187 odel species have led to the impression that sex determination mechanisms are old and conserved.

188 However, a range of sex determination mechanisms exists in nature, not alway

189 ctor (M-factor) is one of a diverse array of sex determination mechanisms found in insects.

190 ions, but few systems with rapid turnover of sex determination mechanisms have been rigorously studie

191 Sex determination mechanisms often differ even between r

192 ikely related to differences in haplodiploid sex determination mechanisms, which in eusocial species

193 genes are conserved during the evolution of sex determination mechanisms.

194 nce, functional diploid males or alternative sex determination mechanisms.

195 Although transitions of sex-determination mechanisms are frequent in species wit

196 n algae, their mating-type-determination and sex-determination mechanisms have been investigated in o

197 n (TSD), commonly found among reptiles, is a sex determination mode in which the incubation temperatu

198 pecific differentiated cell types long after sex determination occurs during development.

199 The application of this method will make sex determination of adults and, for the first time, juv

200 Here we present a method for sex determination of human remains by means of a minimal

201 Consequently, sex determination of juvenile remains is rarely undertak

202 aman spectroscopy enables contactless in ovo sex determination of the domestic chicken (Gallus gallus

203 Sex determination of the gonads begins with fate specifi

204 el and non-model organisms that suggest that sex determination operates as an antagonistic network wi

205 mosome, such as its minor feminizing role in sex determination or its targeting by a chromosome-speci

206 show that this microRNA family regulates the sex determination pathway at multiple levels, acting bot

207 used elegant genetic studies to unravel the sex determination pathway in Caenorhabditis elegans He i

208 al (Sxl) encodes the master regulator of the sex determination pathway in Drosophila and acts by cont

209 The sex determination pathway is a well-established molecula

210 Localized repression of dac by the sex determination pathway is necessary for male-specific

211 r link between environmental temperature and sex determination pathway is yet to be elucidated.

212 egulatory subnetwork within the well-studied sex determination pathway of Caenorhabditis elegans Repr

213 t chinmo acts in parallel with the canonical sex determination pathway to maintain the male identity

214 the activity of at least four pathways: the sex determination pathway, the appendage patterning path

215 lternative splicing events in the Drosophila sex determination pathway.

216 to the female sex, suggesting input from the sex determination pathway.

217 at times development works together with the sex-determination pathway to control the timing of sexua

218 f MPK-1/MAPK and key factors in the germline sex-determination pathway.

219 /NR1F1 functions downstream of the canonical sex-determination pathway.

220 ion under the cell-autonomous control of the sex-determination pathway.

221 for TRA-1 feedback regulation of the global sex-determination pathway: TRA-1 binds its own locus and

222 Sexual dimorphisms are established by sex determination pathways and are maintained during reg

223 They also reveal that, even though the sex determination pathways in Drosophila and mammals are

224 ty between the mating-type specification and sex determination pathways of volvocine algae, and revea

225 We show that in contrast to the sex determination phase, which relies on the GATA4-FOG2

226 n feature of human traits; however, the role sex determination plays in human genetic variation remai

227 ion in animals and humans, and environmental sex determination potentially plays a role in the proces

228 Temperature-dependent sex determination, present in most turtle species, is a

229 egion of high divergence corresponded to the sex determination region and included a candidate male s

230 Finally, the expression of sex determination region of Y chromosome (SRY)-related h

231 antagonistic alleles in close linkage to the sex determination region.

232 he palindrome are homologous to genes in the sex determination regions of the closely related genus P

233 the Hox protein Abdominal-B (Abd-B) and the sex-determination regulator Doublesex (Dsx).

234 nsufficient feminization (TIF) branch of the sex-determination regulatory pathway.

235 However, no sex determination-related genes have been functionally i

236 nd Cbr-puf-1.2, do have a redundant germline sex determination role.

237 meiotic function of RA during the embryonic sex determination (SD) period and in mature gonads.

238 In species with genetic sex determination, sex chromosome-specific processes, su

239 evolution of the genetic pathways underlying sex determination, sex chromosomes and sexual reproducti

240 male and female neurons were studied without sex determination.)SIGNIFICANCE STATEMENT Neurotransmiss

241 ism appears to be single-locus complementary sex determination (sl-CSD), in which individuals that ar

242 n mechanism resembles that of the Drosophila sex-determination Slx gene.

243 vast influence on invertebrate reproduction, sex determination, speciation, and behavior worldwide.

244 maleness, as it encodes a gene driving male sex determination, Sry, as well as a battery of other ge

245 the first time, from specification until the sex determination stage in fetal gonads using Prdm14 H2B

246 th proteins in testis development beyond the sex determination stage; their roles in the postnatal ov

247 The 20th-century theory of mammalian sex determination states that the embryo is sexually ind

248 omosome dose by repressing the masculinizing sex determination switch gene xol-1 (XO lethal) in a dos

249 ative pre-mRNA splicing of xol-1, the master sex-determination switch gene that triggers male develop

250 Primary sex-determination "switches" evolve rapidly, but Doubles

251 brown alga Ectocarpus sp. that has a haploid sex determination system (UV system) recovering the sex

252 Rainbow trout has a male heterogametic (XY) sex determination system controlled by a major sex-deter

253 The XX/XO sex determination system found in many nematodes [1] fac

254 f male-specific scaffolds and supports an XY sex determination system in arapaima.

255 onment interactions that support a polygenic sex determination system in domesticated (laboratory) ze

256 ADS-box genes, demonstrating that the Ginkgo sex determination system is of the XY type.

257 es such as Caenorhabditis elegans have an XO sex determination system while others, such as the filar

258 the Z chromosome in an organism with the ZW sex determination system, Bombyx mori.

259 Catfish has a male-heterogametic (XY) sex determination system, but genes involved in gonadoge

260 Both have an XO sex determination system.

261 raction with either X-chromosome dose or the sex determination system.

262 rol of any pest or vector species with an XY sex-determination system by targeting sequences exclusiv

263 The genetic sex-determination system explains 24% of interspecific v

264 em to ascertain the extent to which the same sex-determination system has been conserved following ge

265 of the mechanism, the effects of the genetic sex-determination system on the adult sex ratio are like

266 sarcomere morphology, but the hermaphrodite sex-determination system promotes more growth.

267 been conducted in species with conventional sex determination systems (XY and ZW) and exceptions to

268 a model to study evolutionary transitions in sex determination systems and pave the way to molecularl

269 Sex determination systems are highly variable in many ta

270 eny revealed between 3 and 13 transitions of sex determination systems during the evolution of these

271 male and female offspring in similar ratios) sex determination systems evolved into one with a domina

272 werful agents of evolutionary transitions in sex determination systems in animals.

273 dosymbionts triggered recurrent turnovers of sex determination systems in terrestrial isopods.

274 Although plant sex determination systems probably often evolved more re

275 mologous autosomes which differentiated into sex determination systems, such as XY or ZW system, as a

276 ther distorted sex ratios, understanding the sex-determination systems in X. tropicalis is critical f

277 A common feature of most genetic sex-determination systems studied so far is that sex is

278 ion promotes establishment of new vertebrate sex-determination systems.

279 genome elimination (PGE), an unusual mode of sex determination that involves genomic imprinting.

280 estating female rat during embryonic gonadal sex determination, the F1 and F3 generation progeny adul

281 Despite its variable roles in sex determination, the function of gld-1 in female meiot

282 In organisms with temperature-dependent sex determination, the incubation environment plays a ke

283 ested the effect of gibberellic acid (GA) on sex determination through exogenous applications of GA a

284 extend from a focus on temperature-dependent sex determination to a focus on temperature-linked hatch

285 ening vertebrates with temperature-dependent sex determination (TSD) by disrupting sex ratios and oth

286 r mechanism underlying temperature-dependent sex determination (TSD) has been a long-standing mystery

287 The study of temperature-dependent sex determination (TSD) in vertebrates has attracted maj

288 Temperature-dependent sex determination (TSD) is the predominant form of envir

289 Temperature-dependent sex determination (TSD), commonly found among reptiles,

290 Australian lizard with temperature-dependent sex determination under three thermal regimes; some eggs

291 which coincides with testis development post sex determination, using the Amh-Cre mouse model.

292 s important to characterize diverse modes of sex determination utilized by metazoans.

293 To identify regulatory sites during sex determination, we subjected Sertoli cells from mouse

294 he molecular basis of gender differences and sex determination, we used RNA-sequencing (RNA-Seq) to i

295 No other genomic regions linked to sex determination were apparent.

296 species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolu

297 this article, I propose a general theory of sex determination, which recognizes multiple parallel pr

298 Further, sex determination, which revealed ZZ/ZW sex microchromos

299 Snakes exhibit genetic sex determination, with female heterogametic sex chromos

300 re are no reliable morphological methods for sex determination without resorting to DNA analysis, whi