ライフサイエンスコーパス: sex hormone

1 Testosterone (T) is the principal male sex hormone.

2 vertebrate body change under the control of sex hormones.

3 echanism dependent on IL-6 and expression of sex hormones.

4 differs in men and women and is sensitive to sex hormones.

5 C2 development is greatly influenced by male sex hormones.

6 xes from AKI, independent of the presence of sex hormones.

7 nd also was related to the effects of female sex hormones.

8 e gender disparities suggest an influence of sex hormones.

9 females and are likely driven by changes in sex hormones.

10 ty, and can decrease serum concentrations of sex hormones.

11 ting factors, apolipoprotein E genotype, and sex hormones.

12 sal women, which may be attributed to female sex hormones.

13 account for within-woman variation in these sex hormones.

14 that are directly or indirectly regulated by sex hormones.

15 which was dependent on the presence of adult sex hormones.

16 able evidence supports an important role for sex hormones.

17 ociated with epilepsy may alter responses to sex hormones.

18 nce in males, an effect that is dependent on sex hormones.

19 females after puberty, suggesting a role for sex hormones.

20 are intimately tied to day-by-day changes in sex hormones.

21 patic mTORC2 is not reversed by depletion of sex hormones.

22 NK in lung cancer and may explain why female sex hormones accelerate lung cancer development.

23 pes are pituitary-dependent, suggesting that sex hormones act via the gonadal-hypophyseal axis.

24 nt investigation in vivo of the mechanism of sex hormone action on the development of colonic adenoma

25 disease are typically mediated through acute sex hormone actions, sex-specific differences in brain t

26 ical and disease processes sensitive to male sex hormone actions, thereby not only affecting the path

27 How sex hormones affect non-reproductive organs is poorly un

28 dermal adipose tissue, innate immune system, sex hormones, aging, circadian rhythm and seasonal rhyth

29 CC than females, an effect largely driven by sex hormones, albeit through still poorly understood mec

30 in metabolism, adipokines, inflammation, and sex hormones all contribute to the adverse effects of ob

31 ductive age and thus cannot be attributed to sex hormones alone.

32 Sex hormones also regulated VAT inflammation, which shap

33 tionally, the type I interferon response and sex hormones alter both CVB3 intestinal replication and

34 ms of T cells, we focus in this study on how sex hormones alter T cell development and function throu

35 omen in adulthood, suggesting that shifts in sex hormones alter the course of the disease.

36 Last, serum sex hormone and adipocyte estrogen/testosterone receptor

37 , and mineralocorticoid receptor, as well as sex hormone and corticosteroid binding globulins.

38 Testosterone is the main male sex hormone and is essential for the maintenance of male

39 Serum level of sex hormone and QOL questionnaires were also evaluated a

40 chanisms underlying the associations between sex hormones and AF in older men merit continued investi

41 Sex hormones and blood lipids were deviated in all subje

42 are prone to vitamin D deficiency, deviated sex hormones and blood lipids.

43 Biological sex is determined by sex hormones and chromosomes, but effects of sex chromos

44 ition of the gut microbiota is influenced by sex hormones and colorectal cancer (CRC).

45 n was used for the multivariable analysis of sex hormones and current asthma, which was conducted sep

46 a variety of factors including age, gender, sex hormones and diabetes status.

47 experimental evidence indicates that female sex hormones and hormonal contraceptives regulate suscep

48 cell counts measured and blood analysed for sex hormones and inflammatory markers.

49 orononanoic acid (PFNA), may alter levels of sex hormones and insulin-like growth factor-1 (IGF-1) in

50 des the well-known associations of risk with sex hormones and insulin-regulated physiological axes, o

51 study was to assess the relationship between sex hormones and natriuretic peptide levels in community

52 influencing levels of circulating endogenous sex hormones and outcome in these various malignancies.

53 has been shown to mediate the metabolism of sex hormones and prostaglandin D(2) (PGD(2)), a lipid me

54 al studies to establish a connection between sex hormones and renal disease development or progressio

55 have implications for the therapeutic use of sex hormones and sex hormone modulators, which are now b

56 This study suggests that sex hormones and systemic inflammation may be mediating

57 f anaphylaxis and explore the role of female sex hormones and the mechanisms responsible.

58 Moreover, sex hormones and their metabolites can directly act on n

59 Possible synergism between female sex hormones and vitamin D on periodontitis pathology ha

60 rain states, revealing relationships between sex hormones and within-network integration in Ventral A

61 In addition, in-vitro treatment with sex hormones and/or their agonists significantly (*p < 0

62 ollected in 2005-2006 and analyzed for PFAS, sex hormones, and IGF-1.

63 Perfluoroalkyl substances, sex hormones, and insulin-like growth factor-1 at 6-9 ye

64 Inherited risks, developmental factors, sex hormones, and psychosocial adversity interact to inc

65 fluences of biological sex, gender identity, sex hormones, and sexual orientation on white matter mic

66 or equal to 28 days and not taking exogenous sex hormones answered a postal questionnaire regarding t

67 Sex hormones are linked to inflammation and bone turnove

68 We hypothesized that sex hormones are related to atrial fibrillation (AF) in

69 Female gonadal sex hormones are responsible for this sexual dimorphism,

70 ertension (PAH), but it is not known whether sex hormones are risk factors for PAH in men.

71 e is evidence implicating the role of female sex hormones as a major factor in determining migraine r

72 uch attention has been directed toward adult sex hormones as drivers of sex differences, that female

73 e include immunological pathways affected by sex hormones, as well as consequences of differential ex

74 nsure binding to the second laminin/neurexin/sex hormone binding (LNS2) domain of Nrxn1alpha, but thi

75 sport proteins human serum albumin (HSA) and sex hormone binding globulin (SHBG) as models.

76 hether prediagnostic circulating hormone and sex hormone binding globulin (SHBG) levels were associat

77 hether prediagnostic circulating hormone and sex hormone binding globulin (SHBG) levels were associat

78 rized by higher luteinizing hormone (LH) and sex hormone binding globulin (SHBG) levels with relative

79 ne, dehydroepiandrosterone sulfate (DHEAS)], sex hormone binding globulin (SHBG), and EOC risk by tum

80 in resistance (P=6 x 10(-4)) and lower serum sex hormone binding globulin concentrations (P=5 x 10(-4

81 strone, progesterone, free testosterone, and sex hormone binding globulin measurements.

82 ; positive associations for progesterone and sex hormone binding globulin merit additional study.

83 unassociated with cognitive composites, but sex hormone binding globulin was positively associated w

84 irculating levels of 25-hydroxyvitamin D and sex hormone binding globulin with ovarian cancer or its

85 of PCOS (obesity, elevated testosterone, low sex hormone binding globulin) may explain the associatio

86 ing serum levels of testosterone, estradiol, sex hormone binding globulin, and androstenediol glucuro

87 te (GFR), testosterone, androstenedione, and sex hormone binding globulin.

88 rations of high-density lipoprotein (9%) and sex-hormone binding globulin (SHBG) (21%), and lower con

89 ation of known and unknown recombinant human sex hormone-binding globulin (rhSHBG)-binding designer s

90 one, free testosterone, androstenedione, and sex hormone-binding globulin (SHBG) concentrations (seco

91 lored associations of total testosterone and sex hormone-binding globulin (SHBG) concentrations at ag

92 Sex hormone-binding globulin (SHBG) determines the equil

93 , androstanediol glucuronide, estradiol, and sex hormone-binding globulin (SHBG) for 3,043 cases and

94 hydroepiandrosterone sulfate, prolactin, and sex hormone-binding globulin (SHBG) improved risk predic

95 Sex hormone-binding globulin (SHBG) is a circulating gly

96 Sex hormone-binding globulin (SHBG) is the high-affinity

97 Low plasma sex hormone-binding globulin (SHBG) levels are associate

98 ine increased and significantly decreased as sex hormone-binding globulin (SHBG) levels at follow-up

99 (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) levels were measured

100 udy were analyzed to examine whether ESH and sex hormone-binding globulin (SHBG) were associated with

101 serum concentrations of total testosterone, sex hormone-binding globulin (SHBG), dehydroepiandroster

102 t-specific 6 chimeras, with either the whole sex hormone-binding globulin (SHBG)-like domain (Val243-

103 l and free testosterone (TT and FT) and high sex hormone-binding globulin (SHBG).

104 mproved and levels of C-reactive protein and sex hormone-binding globulin but not interleukin-6 incre

105 (decreased blood concentration and increased sex hormone-binding globulin concentration).

106 serum testosterone in male subjects and the sex hormone-binding globulin in both groups.

107 rve (SUV(AUC,WB)); and SUV(BW) corrected for sex hormone-binding globulin levels (SUV(SHBG)).

108 A dramatic 45-fold increase in sex hormone-binding globulin levels during hibernation d

109 free testosterone (FT) levels decreased and sex hormone-binding globulin levels increased in tandem

110 l pathways of cardiovascular disease, and of sex hormone-binding globulin on type 2 diabetes.

111 peptide (NT-proBNP), total testosterone, and sex hormone-binding globulin plasma levels in 4,056 men

112 ween the fifth LNS (laminin-alpha, neurexin, sex hormone-binding globulin) domain and the third EGF-l

113 by gamma-glutamyltransferase, fetuin-A, and sex hormone-binding globulin), markers of dyslipidemia (

114 There were no differences in testosterone, sex hormone-binding globulin, and blood lipids between t

115 ostenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-pept

116 Other antiepileptic drugs increase sex hormone-binding globulin, which reduces the bioactiv

117 the single LNS-domain (for laminin/neurexin/sex hormone-binding globulin-domain) of neurexin-1beta o

118 d by hormonal contraceptives and mediated by sex hormone-binding globulin.

119 minase (beta = 0.002; P = 3 x 10(-5)), lower sex-hormone-binding globulin (beta = -0.010; P = 9 x 10(

120 rexophilin-1 and the second laminin/neurexin/sex-hormone-binding globulin domain (LNS2) of neurexin-1

121 d residues on the pentraxin/laminin-neurexin-sex-hormone-binding-globulin-like (PLL) domain of GPR56

122 main that we term Pentraxin/Laminin/neurexin/sex-hormone-binding-globulin-Like (PLL).

123 f some haematopoietic cells are regulated by sex hormones, but haematopoietic stem-cell function is t

124 ound that the type I interferon response and sex hormones can alter both viral replication and lethal

125 Although sex hormones can directly alter gene transcriptional pro

126 Steroid sex hormones can induce prostate carcinogenesis, and are

127 ale and female mice, and we show that female sex hormones can promote lung cancer progression via the

128 Sex hormones cause differences in cardiac electrophysiol

129 studies have documented distinct patterns of sex hormone changes, as well as adverse alterations in b

130 Sensory cues and sex hormones control the entire repertoire of sexually d

131 Sex hormones, cortisol, and insulin levels were measured

132 Circulating levels of sex hormones, cortisol, and insulin were also determined

133 mere diseases, we administered the synthetic sex hormone danazol orally at a dose of 800 mg per day f

134 bserved skeletal phenotype is secondary to a sex hormone deficiency.

135 The adrenal sex hormone dehydroepiandrosterone (DHEA), which is pres

136 The growth of uterine fibroids is sex hormone-dependent and commonly associated with highl

137 presents a valid target for the treatment of sex hormone-dependent cancers and diseases (polycystic o

138 d tubules (GCTs), which is regulated through sex hormone-dependent cascades.

139 In addition to identifying a sex hormone-dependent role for hepatic mTORC2 in female

140 EFNB3 regulates blood pressure in a sex- and sex hormone-dependent way.

141 VAT are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inf

142 er by existing cancer treatments, especially sex hormone deprivation.

143 explore NK3R antagonists as therapeutics for sex-hormone disorders that can potentially benefit from

144 intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial

145 Sex hormone dysregulation and altered end-organ hormone

146 span (e.g. puberty and menopause), exogenous sex hormones (e.g. hormonal contraception or hormone the

147 urface trafficking and its modulation by the sex hormone E2 is a cellular mechanism critical for a ma

148 studied predominantly within the context of sex hormone effects.

149 It remains unclear whether endogenous sex hormones (ESH) are associated with risk of type 2 di

150 k suggests that sex chromosomal genes and/or sex hormones, especially testosterone, may modulate the

151 indings were significant while adjusting for sex hormones (estradiol-to-progesterone ratio in women a

152 sought to delineate the contribution of the sex hormone estrogen to the EoE phenotype and esophageal

153 Together, these results indicate that female sex hormones, estrogens, and X chromosome complement ind

154 eproductive factors reflective of endogenous sex hormone exposure might have an effect on cardiac rem

155 inal progenitors within lobuloalveoli during sex hormone exposure or pregnancy.

156 = 3 x 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.

157 ata reveal an unrecognized role of transient sex hormone exposures during neonatal development as lon

158 Here, we modeled a biphasic ovarian sex hormone fluctuation using a gonadotropin-releasing h

159 Sex-hormone fluctuations make the female brain particula

160 ) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative e

161 Female sex hormones have been hypothesized to play a role in th

162 Sex hormones have been implicated in experimental and cl

163 Both systemic inflammation and sex hormones have been proposed as potential mediators o

164 Endogenous sex hormones have been related to cardiovascular outcome

165 Sex hormones have easy access to the brain and their rec

166 topoietic cell types are known to respond to sex hormones, hematopoietic stem cells (HSCs) are genera

167 glucocorticoid overtreatment and control of sex hormone imbalances.

168 pellets validates an important role of male sex hormone in castration-induced nigrostriatal patholog

169 pecific ILP was identified as the androgenic sex hormone in Crustacea.

170 Gender bias and the role of sex hormones in autoimmune diseases are well established

171 Aside from the protective actions of sex hormones in females, emerging evidence suggests that

172 We further investigated the role of sex hormones in kras(V12) transgenic fish.

173 stress-related neurohormonal modulators and sex hormones in male and female participants who were ex

174 umulating evidence suggests a major role for sex hormones in mediating these differences.

175 hypersensitivity is dependent on circulating sex hormones in mice, where estrogen caused an extension

176 lorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal wome

177 Prospective cohort studies examining sex hormones in relation to cancer risk have generally c

178 TFV-DP in dried blood spots and sex hormones in serum were measured at weekly intervals.

179 remains uncertainty about the role of female sex hormones in the development of asthma.

180 This has suggested an etiologic role of sex hormones in the development of these conditions.

181 ized mice, we highlighted the role of female sex hormones in the phenotype.

182 These results highlight a possible role of sex hormones in the regulation of ABCG2 urate transporte

183 itro and to interfere with the production of sex hormones in vivo.

184 re associated with lower levels of IGF-1 and sex hormones in young children.

185 Sex hormones, in particular progesterone, drive the deve

186 Graph theory metrics probed sex hormones' influence on topological brain states, rev

187 time exposure to increased concentrations of sex hormones is associated with the risk of some cancers

188 activation could be augmented by circulating sex hormones, leading to an increased effect of Npas2 mu

189 To examine sex hormone levels and asthma in adults.

190 study is to explore the association between sex hormone levels and periodontitis in men using data f

191 Plasma sex hormone levels in men with idiopathic, heritable, or

192 he first nanomolar hLH-R antagonist reducing sex hormone levels in vivo.

193 tal, half the TCSs had at least one of three sex hormone levels outside the reference range at SII.

194 ence of an association of periodontitis with sex hormone levels, especially testosterone, in men.

195 sociations were not driven by differences in sex hormone levels, sexually transmitted infections, or

196 circulating glycoprotein and a regulator of sex hormone levels, which has been shown to influence va

197 response to acute and pronounced changes in sex-hormone levels during, for example, the perimenopaus

198 nd irregular periods, among other markers of sex-hormone levels, have been associated with a higher r

199 d low prevalence in childhood reinforce that sex hormones, like estrogen, play an important, complex

200 Removing circulating sex hormones makes these signals slower and less discrim

201 Sex hormone manipulation with GnRHa significantly trigge

202 Sex hormones may contribute to the symptomatology of fem

203 ory, and fluctuating physiological levels of sex hormones may contribute to this effect.SIGNIFICANCE

204 Although sex hormones may explain sex differences in asthma, thei

205 Sex hormones may play a role in predisposing to gastric

206 in rapid, reversible suppression of ovarian sex hormones, may reduce fibroid-associated bleeding.

207 Despite extensive studies of sex hormones, mechanisms underlying these sex difference

208 ; adequate consideration of sex differences, sex hormones/menopausal status, age, and other reproduct

209 ing mechanisms, with particular focus on how sex hormones modulate the immune responses necessary for

210 Sex hormones modulating serotonergic transmission are pr

211 for the therapeutic use of sex hormones and sex hormone modulators, which are now being prescribed t

212 suggest that obesity modifies the effects of sex hormones on asthma in adults.

213 Given an interaction between obesity and sex hormones on current asthma, we stratified the analys

214 ssess mechanisms behind the impact of female sex hormones on host immune responses to P. aeruginosa W

215 sers suggests a possible influence of female sex hormones on host response to HPV infection.

216 or histocompatibility antigens, influence of sex hormones on immune activation, sex- and age-related

217 The influence of sex hormones on melanoma risk has been suggested, but th

218 Because actions of female sex hormones on normal renal tissue might protect agains

219 te a predominantly negative effect of female sex hormones on oral immunity with role in the aetiopath

220 model and present evidence for the action of sex hormones on pancreatic beta-cell function and the va

221 fluence of sensory cues, social context, and sex hormones on progesterone receptor (PR)-expressing ne

222 the protective effects of testicular-derived sex hormones on the development of joint and lung diseas

223 The impact of sex hormones on the T-helper 1/T-helper 2 cytokine balan

224 olorectal cancer was not associated with any sex hormone or reproductive factor, serum calcium, or ci

225 fied by circulating concentrations of IGF-1, sex hormones, or their major binding proteins.

226 tudy was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemi

227 he naturally occurring changes in endogenous sex hormones over the lifespan (e.g. puberty and menopau

228 ng reproductive years have implicated female sex hormones, particularly 17-beta estradiol (E2), in th

229 idence suggests that in premenopausal women, sex hormones, particularly estrogen exerts a profound ca

230 The effects of sex hormone pathways on the expression of TERT with both

231 Our findings suggest that sex hormones play a role in known sex differences in ast

232 ovide little support for the hypothesis that sex hormones play a role in lymphomagenesis.

233 nted for over two millennia, suggesting that sex hormones play a role in regulating epidermal melanoc

234 ronment and show that, depending on prenatal sex hormone priming, testosterone administration in wome

235 Sex-based differences in sex hormone processing and signaling may contribute to u

236 genes, notably those involved in retinol and sex hormone processing as well as in detoxification.

237 The human ovary orchestrates sex hormone production and undergoes monthly structural

238 cm(2)), weekly) for 10 weeks, and endogenous sex hormone production was abrogated by ovariectomy.

239 nd essentially involved in the regulation of sex hormone production.

240 The sex hormone progesterone has been shown to improve outco

241 throughout the body, mediated by the female sex hormones progesterone and estrogen.

242 alpha /PPT or ERbeta: DPN); or non-selective sex hormone receptor antagonists (ER/ICI 182,780, or pro

243 imorphism of hepatocellular carcinoma (HCC), sex hormone receptor signaling has been implicated in nu

244 on-coding RNA that coactivates several human sex hormone receptors and is strongly associated with br

245 It has been long appreciated that sex hormone receptors are expressed in various non-gonad

246 SMC markers, expression of VEGF-D and female sex hormone receptors, reduced autophagy, and metabolic

247 While sex hormones regulate airway inflammation, it remained u

248 In tissue culture and animal models, sex hormones regulate expression of the telomerase gene.

249 review recent advances in understanding how sex hormones regulate T cell responses to alter suscepti

250 However, it remains unclear how sex hormones regulate the morphogenesis of these non-gon

251 We find that adult sex hormones regulate these expression patterns in a sex

252 Thus, sex hormone regulation of a neurotrophic factor signal d

253 nature was independent of biological age and sex-hormone regulation and was regulated by the transcri

254 While such stress and sex hormone-related alterations occur in regions mediati

255 cal ingredient used to treat a wide range of sex hormone-related disorders, including advanced prosta

256 eptor (PR) as an approach to avoid potential sex-hormone-related adverse effects and improving biopha

257 tudies are needed to investigate the role of sex hormone replacement in mitigating the burden from ad

258 oid gonad tumours in later life, appropriate sex-hormone replacement at puberty and beyond, and an em

259 he elucidation of complex interactions among sex hormones, sex chromosomes, and immune response genes

260 ual dimorphisms may be due to differences in sex hormones, sex chromosomes, or both.

261 ross-talk between glucocorticoid and steroid sex hormone signaling represents an important and unders

262 lating NT-proBNP levels were associated with sex/hormone status (overall p < 0.0001).

263 markedly attenuated the association between sex/hormone status and NT-proBNP concentrations.

264 Across sex/hormone status groups, free testosterone (FT) levels

265 Sex/hormone status was grouped as: 1) men; 2) post-menop

266 onadotropin receptors and several enzymes of sex hormone steroidogenesis were greater than in control

267 Sex hormones such as estrogen and testosterone are essen

268 While sex hormones such as estrogens decrease CAD risk, hormon

269 nhibition of the transcriptional activity of sex hormones, such as estrogens and androgens, and the a

270 red with men, has been reported, but whether sex hormones, such as estrogens, are involved in this se

271 based disparity are unknown and the specific sex hormone target for therapeutic manipulation has not

272 linear relationship with the level of a male sex hormone, testosterone, using the Pearson correlation

273 The estrogens are female sex hormones that are involved in a variety of physiolog

274 ether progesterone (P4), one of the dominant sex hormones that regulates multiple biological function

275 Various factors, including sex hormones, the presence or absence of a second X chro

276 In addition to sex hormones, the X and Y sex chromosomes, and their uni

277 pose of this study is to investigate whether sex hormones/their receptors can attenuate altered Nucle

278 s in transgender populations receiving cross-sex hormone therapy (CSHT) limits appropriate primary an

279 TGM and TGW on at least 6 months of stable sex hormone therapy containing testosterone or estradiol

280 Sex hormone therapy has strict recommendations in the tr

281 in women and has potential implications for sex hormone therapy.

282 ng women suggests important contributions of sex hormones to differential responses of MSNA to fallin

283 , epidemiological studies have linked female sex hormones to lung cancer in women; however, the under

284 rentiation receptor RANK(4,5) couples female sex hormones to the rewiring of the thymus during pregna

285 erminants of testosterone levels and related sex hormone traits in 425,097 UK Biobank study participa

286 these studies establish that female gonadal sex hormones underlie the sexual dimorphic differences i

287 all ages, suggesting that factors other than sex hormones underlie this discrepancy.

288 Whether exposure to endogenous sex hormones underlies this relationship should be inves

289 tive contribution of X chromosome dosage and sex hormones using a humanized mouse model in which male

290 Levels of sex hormones were categorized according to quartiles and

291 and severity of periodontitis and levels of sex hormones were determined and expressed as odds ratio

292 Sex hormones were evaluated as categorized and continuou

293 gonadal secretions (commonly referred to as sex hormones), which substantially influence many aspect

294 ALE: Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and o

295 with increased circulating concentrations of sex hormones, which in turn may increase hormone-depende

296 ulating concentrations of growth factors and sex hormones, which may be important in prostate cancer

297 IL2Cs, uterine ILC2s are regulated by female sex hormones, which may specialize them for specific phy

298 Progesterone, a key female sex hormone with pleiotropic functions in maintenance of

299 igraine and estrogen, the predominant female sex hormone, with a focus on studies published in the la

300 endered the TERT transcription responsive to sex hormones, with enhancement by androgen receptor (AR)