ライフサイエンスコーパス: sex steroid

1 excitatory/inhibitory network influenced by sex steroids.

2 ence in ECs are more likely to be targets of sex steroids.

3 e a potential marker of exposure to prenatal sex steroids.

4 ), insulin-like growth factor-1 (IGF-1), and sex steroids.

5 oduction of fishes through the disruption of sex steroids.

6 in older men, they were not associated with sex steroids.

7 eness of neurons to GABA can be modulated by sex steroids.

8 hat are regulated by physiological levels of sex steroids.

9 em is resistant to the modulatory effects of sex steroids.

10 limits through negative feedback actions of sex steroids.

11 is not sex linked, we evaluated the role of sex steroids.

12 neurons and are differentially regulated by sex steroids.

13 ness in songbirds and its fast modulation by sex steroids.

14 ation of small, lipophilic molecules such as sex steroids.

15 validated by secretion of gonadotropins and sex steroids.

16 ified the unusual concentrations of measured sex steroids.

17 designed to modulate the bioavailability of sex steroids.

18 in human synthesis of androgen and estrogen sex steroids.

19 Consistent with this, sex steroid ablation (SSA) led to increased expression o

20 keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic thymus restoration

21 s, with analysis of elderly males undergoing sex steroid ablation therapy for prostatic carcinoma, de

22 In this study, we demonstrate that sex steroid ablation using leuprolide acetate, a luteini

23 thymic rejuvenation efforts associated with: sex steroid ablation, cytokines, growth factors, and hor

24 LHRHa allows for reversible (and temporary) sex steroid ablation, has a strong safety profile, and h

25 dies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the gr

26 complex interaction between inflammation and sex steroids across development.

27 e HDACs, shown here for the antihypertrophic sex steroid acting at ERbeta.

28 r novel insights into the molecular basis of sex steroids actions, brain dimorphisms, reproductive an

29 These results suggest that a sequential sex steroid activation of NPY and MOR circuits regulates

30 n study of a molecular test for detection of sex steroids administration in calves, based on quantifi

31 The mechanisms by which sex and sex steroids affect the immune system and autoimmunity a

32 y, it has been increasingly appreciated that sex steroids also play an important role in the propensi

33 Administration of the female sex steroid and potent neuroprotective agent, 17beta-est

34 to a more tightly regulated producer of both sex steroids and glucocorticoids in mammals.

35 Because sex steroids and gonadotropins are both part of the HPG

36 in leuprolide acetate, which suppresses both sex steroids and gonadotropins.

37 Understanding how sex steroids and leptin regulate hypothalamic developmen

38 ure to undergo puberty in the setting of low sex steroids and low gonadotropins.

39 analyze the associations between endogenous sex steroids and mammographic density, the authors condu

40 ble to examine regulatory pathways involving sex steroids and the periodontium.

41 teractive effects of growth hormone (GH) and sex steroids and their influence on strength and enduran

42 Sex steroids and their metabolites may also provide trea

43 Although sex steroids and their receptors are well characterized

44 n and the insulin-like growth factor-I axis, sex steroids, and adipokines-but there are shortfalls to

45 ally differentiated as a result of postnatal sex steroids, and also specific neuronal populations in

46 sing MEDLINE with the keywords of menopause, sex steroids, and hormone replacement therapy.

47 ihydrotestosterone (DHT), a cocktail of four sex steroids, and inhibitors of sex steroid synthesis (a

48 are thought to be mediated by sensitivity to sex steroids, and the chromosomal rearrangement underlyi

49 least partially attributed to the effects of sex steroids, and their removal promotes enhanced thymop

50 axis; (3) parathyroid hormone signaling; (4) sex steroids; and (5) the OPG/RANKL/RANK cytokine system

51 enopausal women, higher levels of endogenous sex steroids are associated with an increased risk of br

52 he purpose of this study was to determine if sex steroids are associated with periodontitis and tooth

53 Sex steroids are critical for peak bone mass acquisition

54 a compromised positive feedback response to sex steroids, as shown by significantly lower Kiss1 mRNA

55 ions, free testosterone was unaffected while sex steroid bioactivity on male and female reproductive

56 The synthesis of DHEA and sex steroids, but not mouse glucocorticoids and mineralo

57 ypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tis

58 nto an endocytic mechanism for the uptake of sex steroids by mammalian cells.

59 rine, paracrine, and endocrine regulation of sex steroids by primary cultures of human skin epidermal

60 A number of sex steroids can be synthesized de novo in the brain, in

61 Sex steroids can both modulate and be modulated by behav

62 These results suggest that sex steroids can modulate the inflammatory response and

63 H) receptor antagonism bypassed the surge in sex steroids caused by LHRH agonists, the gold standard

64 rate), carnitine, prostaglandins, conjugated sex steroids, cGMP, odorants, and enterobiome metabolite

65 pothesis in vivo, we examined total and free sex steroid concentrations and bioactivity on target org

66 Serum sex steroid concentrations and the weights of the reprod

67 11-deoxycortisol implants reduced sex steroid concentrations and up-regulated gill Na+, K+

68 or the determination of free or bioavailable sex steroid concentrations in medicine, and clarify impo

69 Despite markedly raised total sex steroid concentrations, free testosterone was unaffe

70 es has been proposed as a mechanism by which sex steroid deficiency causes bone loss.

71 In germ-free (GF) mice, sex steroid deficiency failed to increase osteoclastogen

72 In murine models, sex steroid deficiency increased gut permeability, expan

73 ying mechanism of some of these effects, and sex steroid deficiency or glucocorticoid excess contribu

74 a modulates inflammatory responses caused by sex steroid deficiency, leading to trabecular bone loss.

75 rating that the gut microbiota is central in sex steroid deficiency-induced trabecular bone loss.

76 ove the depressed cardiovascular function in sex steroid-deficient female rats (i.e., ovariectomized

77 n of progesterone after trauma-hemorrhage in sex steroid-deficient females improved cardiovascular re

78 robiotics reversed hypogonadal osteopenia in sex steroid-deficient mice by preventing the disruption

79 demonstrated that twice-weekly treatment of sex steroid-deficient mice with the probiotics Lactobaci

80 that are critical for inducing bone loss in sex steroid-deficient mice.

81 uring the menopause and during treatment for sex-steroid dependent cancers.

82 cidating the receptor-mediated mechanisms of sex steroid-dependent growth and the clinical success of

83 This indicates a sex steroid-dependent plasticity of spinal KOR functiona

84 ategy may have arisen to mediate reversal of sex steroid-dependent repression of a limited cohort of

85 s associated with differential expression of sex steroid-dependent reproductive and aggressive behavi

86 The effect of sex steroids depends on the genetic background.

87 logical and psychological effects of 2 human sex-steroid derived compounds, 4.16-androstadien-3-one (

88 e (TH) in the male AVPV than the female, and sex steroids determine this sex difference, yet the role

89 whether different conditions of circulating sex steroids directly alter Kiss1 neuronal activity.

90 Alterations in sex steroids during pregnancy are associated with the de

91 ity to manipulation of circulating levels of sex steroids during the neonatal period.

92 pharmacologic approaches, we establish that sex steroid effects on human pigment synthesis are media

93 Limited prior data suggest that endogenous sex steroids either are not associated (total estradiol

94 classes (i.e. glucocorticoids, progestogens, sex steroids), emphasizing the modularity and interconne

95 A prenatal sex steroid environment of high prenatal testosterone an

96 rauterine interactions often are mediated by sex steroids (estrogens and androgens) produced by the d

97 Sex steroids exert anti-apoptotic effects on osteoblasts

98 Sex steroids exert profound effects on multiple immunolo

99 Ligated receptors for all sex steroids exist at the plasma membrane and rapidly si

100 trinsic differences driven by chromosomes or sex steroid exposure and gender differences accumulated

101 right and left 2D:4D (biomarker of prenatal sex steroids exposure) and primary lung cancer in women

102 ors tested the hypothesis that low levels of sex steroids facilitate the expression of pro-social beh

103 The negative sex steroid feedback was found to act specifically on ar

104 eurons controls fertility and is sculpted by sex-steroid feedback.

105 erving sex-typical behavior are dependent on sex steroids for both their organization early in life a

106 rophy, coincident with increased circulating sex steroids from puberty.

107 les important in disease processes including sex steroids, glucocorticoids, eicosanoids, and neurotra

108 Serum gonadotropins, sex steroids, glucose, insulin, ghrelin, and leptin conc

109 ts in the form of thyroxine, hydrocortisone, sex steroids, growth hormone, and desmopressin.

110 Sex steroids have a significant effect on skeletal biolo

111 Both aging and loss of sex steroids have adverse effects on skeletal homeostasi

112 From these results we conclude that sex steroids have non-genomic actions in isolated intact

113 st cases, sex differences are induced by the sex steroid hormonal milieu during early perinatal devel

114 e data reveal mechanisms not only for female sex steroid hormone action but also in the regulation of

115 It is also a major site of sex steroid hormone action.

116 t correlations between urinary BPA and serum sex steroid hormone concentrations in adults.

117 These results suggest that both absolute sex steroid hormone levels and the rates at which the le

118 Sex steroid hormone levels were measured in 24-h urine s

119 Genetic variation in genes in the sex steroid hormone pathway is associated with differenc

120 rtium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to

121 P<5 x 10(-8)), implicating genes involved in sex steroid hormone pathways (FN1, CCDC170, ESR1, SYNE1

122 The sex steroid hormone progesterone (Pg) is critically invo

123 Sex steroid hormone receptors are expressed in the colon

124 in and support the important role of nuclear sex steroid hormone receptors in modulating social behav

125 near specific genes with important roles in sex steroid hormone signalling and function, and offer u

126 ed endogenous concentrations of estradiol, a sex steroid hormone that is known to influence UL risk.

127 Here, we used the cross-sex steroid hormone treatment of transsexuals seeking se

128 Together, sex steroid hormone-induced activation of WOX1 and WOX2

129 The sex-steroid hormone estradiol (E2) enhances the psychoac

130 ing and estradiol in the mechanisms by which sex-steroid hormone fluctuations provoke depressive symp

131 sical function, frailty, renal function, and sex-steroid hormone levels and seemed to be partially me

132 leotide polymorphisms (SNP) in genes for the sex-steroid hormone receptors are not strongly associate

133 hemicals (EDCs) due to their ability to bind sex-steroid hormone receptors.

134 The female sex steroid hormones 17beta-estradiol and progesterone m

135 In order to better understand where sex steroid hormones act to regulate social behavior in

136 suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (S

137 Seven sex steroid hormones and SHBG were quantitated using gas

138 Seven sex steroid hormones and SHBG were quantitated using gas

139 sequent nuclear translocation in response to sex steroid hormones and stress stimuli.

140 ted with an increase in urinary excretion of sex steroid hormones and their metabolites in humans.

141 These results underscore the role of sex steroid hormones and their receptors in diseases tha

142 tions in endogenous postmenopausal levels of sex steroid hormones are not substantially related to th

143 sheep but not in monkeys or humans, although sex steroid hormones are still secreted.

144 in male 3xTg-AD mice depleted of endogenous sex steroid hormones by gonadectomy (GDX).

145 Sex steroid hormones contribute significantly to sex-bas

146 act symptoms (LUTS), and it is not clear how sex steroid hormones contribute to the rates of change i

147 ally relevant circuit.SIGNIFICANCE STATEMENT Sex steroid hormones drive changes in brain circuits in

148 may be mediated by organizational actions of sex steroid hormones during development.

149 ns and songbirds is linked to the actions of sex steroid hormones during ontogeny but also in adultho

150 evaluated how the organizational effects of sex steroid hormones during postnatal development may af

151 Sex steroid hormones exert a profound influence on the s

152 rain neurons are differentially regulated by sex steroid hormones in a dose-dependent manner.

153 sities of neurons that express receptors for sex steroid hormones in a pattern that is remarkably sim

154 Ovariectomy-induced depletion of sex steroid hormones in adult female 3xTg-AD mice signif

155 and clinical observations suggest a role of sex steroid hormones in the occurrence of meningioma.

156 and their relation to circulating levels of sex steroid hormones in women and to risk of endometrial

157 Sex steroid hormones influence the development of sex di

158 al. show that resistance (insensitivity) to sex steroid hormones is encountered in animals lacking m

159 different between men and women, and female sex steroid hormones likely have a role in this regulati

160 lum has been characterized, the influence of sex steroid hormones on intrinsic cerebellar network dyn

161 Despite the well-known influence of sex steroid hormones on the incidence of cardiovascular

162 stem provides a model for the important role sex steroid hormones play in mediating adult neural plas

163 Although age, genetics, and sex steroid hormones play prominent roles in the cause o

164 Sex steroid hormones regulate various neural functions t

165 Sex steroid hormones released from the gonads play an im

166 Sex steroid hormones such as 17beta-estradiol (estradiol

167 Sex steroid hormones such as estrogen and testosterone h

168 general neuromodulators of memory processes, sex steroid hormones such as the potent oestrogen 17beta

169 tional analyses of caregiving and endogenous sex steroid hormones were also conducted.

170 ine epinephrine output (but not cortisol and sex steroid hormones) correlated inversely with proinfla

171 use, it is becoming increasingly clear that sex steroid hormones, and in particular the principle fe

172 Vocal plasticity is linked to the actions of sex steroid hormones, but the precise mechanisms are unc

173 The female sex steroid hormones, estrogens and progesterone, are pr

174 Altered concentrations of sex steroid hormones, impaired reproductive performance,

175 rtility, with low levels of gonadotropic and sex steroid hormones, small testes or ovaries, impaired

176 07, to examine associations between baseline sex steroid hormones, the rate of change in these hormon

177 ke outcomes seen during life stages with low sex steroid hormones.

178 ence that likely results from the effects of sex steroid hormones.

179 onse to changing photoperiod and circulating sex steroid hormones.

180 ted with differences in circulating SHBG and sex steroid hormones.

181 as puberty approaches, and is independent of sex steroid hormones.

182 Several endocrine factors, including sex-steroid hormones are known to influence adiponectin

183 lar and biochemical mechanisms through which sex-steroid hormones modulate memory, and a specific hyp

184 recent decades has demonstrated that ovarian sex-steroid hormones, particularly 17beta-estradiol (E2)

185 asonal fluctuations in circulating levels of sex-steroid hormones, which are known to be potent neuro

186 he rate-limiting step in the biosynthesis of sex-steroid hormones.

187 The phenotype depends on sex-steroid hormones: dihydrotestosterone treatment of g

188 lished data on circulating concentrations of sex steroids, IGFs, or IGFBPs and prostate cancer risk u

189 nt a useful tool to study suspected cases of sex steroid illicit administration in veal calves, compl

190 fore have evolved from a general producer of sex steroids in lower vertebrates to a more tightly regu

191 The role of sex steroids in mammalian maturation is well established

192 tudies of interactions between adiposity and sex steroids in serum and tissues, including adipose.

193 underlying mechanisms, including the role of sex steroids in the etiology of ASD.

194 e more widespread neuroprotective actions of sex steroids in the mammalian nervous system, in the AVP

195 memory retrieval task, strongly implicating sex steroids in the regulation of this circuitry.

196 regulates the actions of glucocorticoids and sex steroids in these species.

197 To assess the role of sex steroids in this process, we studied mice deficient

198 Sex steroids, including testosterone, regulate the devel

199 stasis in a sexually dimorphic and partially sex steroid-independent manner; therefore, alterations i

200 We show that one mechanism by which sex steroids influence thymopoiesis is through direct in

201 nd IL-22), and hormonal modulation including sex steroid inhibition and growth hormone administration

202 including growth hormone administration and sex steroid inhibition.

203 ystem to investigate the complex pathways of sex steroid intracrinology in human skin.

204 s underlying the developmental activities of sex steroids involve interactions between nuclear hormon

205 Exposure to circulating sex steroids is felt to be a chief contributor to this p

206 ndrosterone (DHEA), a 19-carbon precursor of sex steroids, is abundantly produced in the human but no

207 Moreover, there was no relationship between sex steroid levels and periodontitis progression or inci

208 FSH and sex steroid levels were not altered.

209 Endogenous sex steroid levels were unassociated with cognitive comp

210 evidence, the epidemiologic data correlating sex steroid levels with disease risk is inconsistent.

211 ts readily respond to and metabolize various sex steroid-like substrates, we find that they also gene

212 ch hormone.) These results suggest that some sex steroids may increase the risk of breast cancer by s

213 RATIONALE: Sex steroids may play a role in plaque composition and i

214 and neurogenesis in songbirds indicate that sex steroids may provide crucial cues to newly divided c

215 ghting the potential for local regulation of sex steroid-mediated traits.

216 ological studies indicate that the exogenous sex steroid medroxyprogesterone acetate (MPA) can impair

217 psilon4 and genetic polymorphisms related to sex steroid metabolism and AD risk need to be further in

218 eted, including multiple genes with roles in sex steroid metabolism, olfaction and drug response.

219 he SDR domain is predicted to be involved in sex-steroid metabolism and the WW domains are likely inv

220 We tested the hypothesis that circulating sex steroids modulate single-unit responses in the avian

221 Sex steroids modulate vertebrate sensory processing, but

222 Sex steroid modulation of MOR in the MPN acts through NP

223 Our results suggest that female sex steroids, most likely estrogen, have important effec

224 injections of 100 mg) (n = 35); GH + placebo sex steroid (n = 30); sex steroid + placebo GH (n = 35);

225 placebo GH (n = 35); or placebo GH + placebo sex steroid (n = 31) in a 2 x 2 factorial design.

226 The available information indicates that sex steroids not only modulate the immune/cardiovascular

227 The common involvement in these of sex steroids, nutritionally-related signals, and emotion

228 ones, and in particular the principle female sex steroid oestrogen, exerts potent effects upon the im

229 in sexual differentiation has contended that sex steroids of gonadal origin organize the neural circu

230 hip probesets, and showed similar effects of sex steroids on GABA receptor subunit gene expression in

231 rons mediate the negative feedback effect of sex steroids on gonadotropin secretion in mammals.

232 Furthermore, the differential action of sex steroids on the density of afferents from the BSTp i

233 To examine the acute effects of sex steroids on VZ cell proliferation, male and female a

234 ts significantly extend our understanding of sex steroid pathways in the cichlid brain and support th

235 (n = 35); GH + placebo sex steroid (n = 30); sex steroid + placebo GH (n = 35); or placebo GH + place

236 Sex steroids play a significant role in organizing male

237 Nonetheless, it is unclear what role sex steroids play in the maintenance of immune function

238 the human fetus proceeds through the adrenal sex steroid precursor dehydroepiandrosterone, which is c

239 The adrenal gland is a source of sex steroid precursors, and its activity is particularly

240 dectomy, INH(-/-)-LH-CTP mice develop large, sex steroid-producing adrenal tumors that arise from the

241 ns in glucocorticoid, mineralocorticoid, and sex steroid production that require hormone replacement

242 ytes, although all other enzymes involved in sex steroid production were expressed almost entirely in

243 mal recessive Mendelian disorder of aberrant sex steroid production.

244 ogen and the expression of genes involved in sex steroid production/signaling (cyp19a1b, cyp17, hsd11

245 cing occurs through the action of the female sex-steroid progesterone.

246 Concentration levels of Delta4 sex steroids (progesterone, 17alpha-hydroxy-progesterone

247 Together, these data suggest that sex steroids promote the survival of an initial populati

248 of diabetes in females suggests that female sex steroids protect from beta-cell injury.

249 use of the H295R steroidogenesis assay, and sex steroid receptor binding activity using the yeast es

250 onferring more efficient functioning of this sex steroid receptor is associated with "masculinization

251 anation for the profound skeletal effects of sex steroid receptor ligands, including synthetic ones t

252 ovel targets to selectively inhibit membrane sex steroid receptor localization and function.

253 ollectively, these data provide insight into sex steroid receptor-mediated regulation of androgen-ina

254 Classical sex steroid receptors (SRs) localize at the plasma membr

255 nucleus (PMV) expresses dense collections of sex steroid receptors and receptors for metabolic cues,

256 ing that the classical genotropic actions of sex steroid receptors are dispensable for their bone-pro

257 dition to the well-characterized role of the sex steroid receptors in fertility and reproduction, org

258 rminal L/HX7LL motif, selectively present in sex steroid receptors, that causes recruitment of TAB2 a

259 7 and -21 proteins as conserved PATs for the sex steroid receptors.

260 rane translocation and function of classical sex steroid receptors.

261 refrontal cortex, are densely populated with sex steroid receptors.

262 Additionally, sex steroids regulate inflammatory cytokines that cause

263 Because sex steroids regulate the life span of bone cells by mod

264 e of placental mammals and could account for sex steroid regulation of LGALS1 expression, thus provid

265 ether GnIH serves as a signaling pathway for sex steroid regulation of the reproductive axis, we used

266 othalamic arcuate nucleus participate in the sex-steroid regulation of reproduction.

267 is a common molecular feature in subsets of sex-steroid-related tumors including endometrium and bre

268 ifferential gene regulation, particularly in sex steroid-responsive genes, may contribute to a sexual

269 lation in males and females, particularly in sex steroid-responsive genes.

270 h part of the HPG feedback loop, any loss in sex steroids results in a proportionate increase in gona

271 ial for metabolic and endocrine processes in sex steroid-sensitive uterine cells.

272 he posterodorsal medial amygdala (MePD) is a sex-steroid-sensitive area that modulates reproductive b

273 ymphatic circulation, infiltration/invasion, sex steroid sensitivity, and local and remote tissue des

274 nts, and suggest that in humans too, sex and sex steroids shape brain development in a spatiotemporal

275 ommon mechanism likely independent of direct sex steroid signaling.

276 ness in songbirds and its fast modulation by sex steroids.SIGNIFICANCE STATEMENT Neuroestrogens can a

277 Sex steroids such as androgens and estrogens have trophi

278 t is distinguished by its ability to secrete sex steroids such as estrogen.

279 tail of four sex steroids, and inhibitors of sex steroid synthesis (aminoglutethimide, ketoconazole,

280 P450c17-knockout mice would have disordered sex steroid synthesis and disordered brain DHEA producti

281 a HIF-1-induced leptin expression, modulates sex steroid synthesis by acting directly on steroidogeni

282 Peripheral intracrine sex steroid synthesis from adrenal precursors dehydroepi

283 one (LH), a pituitary hormone that regulates sex steroid synthesis in the testes.

284 pment, all of the genes required for de novo sex steroid synthesis would be expressed in regions that

285 ed the role of CYP17, a key enzyme mediating sex steroid synthesis, in Xenopus ovarian androgen produ

286 followed by 17,20 lyase activity needed for sex steroid synthesis.

287 is and the 17,20 lyase activity required for sex steroid synthesis.

288 These cells secrete sex steroids that control the ovulatory cycle and influe

289 tudies that demonstrate an interplay between sex steroids, the intestinal immune response, and the in

290 , the gold standard for clinical ablation of sex steroids, thereby facilitating increased Dll4 expres

291 ncluding nutrient and fat status, stress and sex steroids, thus providing a link between these factor

292 eedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differenti

293 Sex steroid treatment led to numerous alterations in gen

294 health risks faced by individuals receiving sex steroid treatment.

295 of reproductive function involves actions of sex steroids upon their nuclear receptors in the hypotha

296 he exposure and responsiveness of tissues to sex steroids varies among individuals and between the se

297 the bone anabolic, nongenotropic effects of sex steroids while having no effect on the uterus or sem

298 deficiencies in growth hormone (GHD) and/or sex steroids with low BMD and frailty.

299 that reproduces the nongenotropic effects of sex steroids, without affecting classical transcription,

300 20 micro g/kg, subcutaneously 3 times/wk) + sex steroids (women: transdermal estradiol, 100 micro g/