ライフサイエンスコーパス: sex-specific

1 pe is sexually shared, and the other two are sex specific.

2 , up to 61% of the illness-related genes are sex specific.

3 nine (CpG) sites and such an association was sex-specific.

4 nd carcinogens and their health risks may be sex-specific.

5 s effect on AKI was also tissue-specific and sex-specific.

6 Race- and sex-specific 10-year risk equations for HF were derived

7 tivity cardiac troponin (hs-cTn) assays with sex-specific 99th percentiles may improve management of

8 mplementation of hs-cTnI assay together with sex-specific 99th percentiles was associated with an inc

9 plementation of hs-cTnI assay (Abbott) using sex-specific 99th percentiles.

10 Our data suggest that sex-specific activation of the ISR leads to maternal inf

11 r than new mutations, is the driver of rapid sex-specific adaptation.

12 sexes in the new environment but also rapid sex-specific adaptation.

13 antidepressant actions of ketamine and show sex-specific adaptive mechanisms to GluN2B modulation.

14 e of postnatal nutrition in facilitating the sex-specific adipogenic programming in the IUGR offsprin

15 ights into the possible mechanism underlying sex-specific adipogenic programming in the IUGR offsprin

16 mRNA and functional profiling, we determined sex-specific adipogenic programming of WAT progenitors i

17 on mutations, show genomic distributions and sex-specific age dependencies indicative of double-stran

18 ific chromatin differences may contribute to sex-specific ageing in flies.

19 incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers

20 A dominant role of fru in specifying sex-specific aggressive behavior may underscore a geneti

21 r, the neurogenetic mechanism that generates sex-specific aggressive behavior remains largely unknown

22 nd support further need to evaluate dose and sex-specific alcohol effects in multiple sclerosis (MS)

23 In particular, we found sex-specific alterations of mitochondrial dynamics follo

24 Sex-specific analyses indicated seven additional loci.

25 confidence intervals (CIs) are presented in sex-specific analyses.

26 g (WGS) studies, family-based designs enable sex-specific analysis approaches that can be applied to

27 examined in European and Asian cohorts, both sex specific and sex combined.

28 associated with mental disorders, including sex-specific and age-specific mortality rate ratios (MRR

29 Finally, PLP and HKr demonstrated highly sex-specific and corroborating associations with age.

30 If sex-specific and lineage effects are common, then grandp

31 en used fixed-effects models to estimate the sex-specific and overall associations across strata and

32 Overall, sex-specific and race/ethnicity-specific PAFs and 95% CI

33 ios (SMRs) were estimated with age-specific, sex-specific, and calendar year-specific US rates.

34 f ATS class frequency are gene-, stage-, and sex-specific, and cATS frequency strongly correlates wit

35 ergy metabolism and demonstrate the need for sex-specific approaches in obesity research and potentia

36 alliative care intervention, suggesting that sex-specific approaches to palliative care may be needed

37 associations of hsCRP, ICS, IL-1beta and the sex-specific association of IL-12 with DeltaCES-D(total)

38 l loci (GRID1, RIOK3, MCPH1, ZBTB7C) showing sex-specific association with AD risk.

39 als from the general population and only few sex-specific associations became apparent.

40 Sex-specific associations between genotypes and phenotyp

41 We evaluated sex-specific associations of adiposity characteristics a

42 Our population-based cohort study suggests sex-specific associations of altered pubertal developmen

43 The purpose of this study was to evaluate sex-specific associations of CV risk factors and biomark

44 Logistic regression was used to examine sex-specific associations of DNAm changes with asthma ac

45 diposity in mid to late adulthood, with some sex-specific associations.

46 These CpGs are potential biomarkers of sex-specific asthma acquisition in adolescence.

47 en shown to be involved in the expression of sex-specific behavior and is thought to be a critical me

48 Finally, we found that sex-specific behavior effects were not mediated by AKT e

49 ur findings demonstrate that EIA can produce sex-specific behavioral effects and immune responses in

50 e, flexibly linking auditory perception with sex-specific behavioral responses.

51 First, we identified sex-specific behavioral strategies, showing that females

52 -held belief that the yellow gene determines sex-specific behaviors in fruit flies by acting in the b

53 in regions associated with the generation of sex-specific behaviors.

54 l provide insights into neural mechanisms of sex-specific behaviors.

55 cts of one mode of the male's song and drive sex-specific behaviors.

56 The current evidence on possible sex-specific biological risk factors for AD is intriguin

57 Using sex-specific blood and gastrointestinal parasite prevale

58 and central obesity were defined as age- and sex-specific BMI z-score > International Obesity Task Fo

59 observed genetic interactions, we discovered sex-specific brain volumetric alterations in double hete

60 consumption were used to estimate total and sex-specific cardiometabolic disease-free life expectanc

61 It programmes sex-specific cardiovascular dysfunction in rat offspring

62 ticle uses a case scenario to examine female sex-specific cardiovascular risk factors across the life

63 ion changes in the diseased brain, including sex-specific changes and marked differences in male and

64 oderated-mediation analysis found that these sex-specific changes are likely to alter contextual free

65 ry and visual brain regions and if there are sex-specific changes in DSD in these regions that occur

66 anges revealed that although VS induced many sex-specific changes in gene expression, it increased se

67 o a novel temperature regime, we demonstrate sex-specific changes in gene expression, metabolic and b

68 es revealed that EIA also produced prominent sex-specific changes in inflammation-related gene expres

69 n males and females might also contribute to sex-specific changes in performance across lifespan.

70 females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and

71 Sexual selection results in sex-specific characters like the conspicuously pigmented

72 This suggests that sex-specific chromatin differences may contribute to sex

73 ale and female mice, both before and after a sex-specific chronic variable stress protocol, to probe

74 Sex-specific circadian changes were found in P-gp ileum

75 Sex-specific cohort-wide quartiles of waist indices corr

76 diseases and 12 mortality risk factors into sex-specific composite PRS (cPRS).

77 Sex-specific correlations were found between metabolic o

78 We also analysed sex-specific correlations.

79 ronmental conditions in interaction with the sex-specific costs of sexual selection.

80 ll social decisions is how animals integrate sex-specific cues from conspecifics.

81 Using these sex-specific cutpoints, paradoxical LF was independently

82 In this primer, we highlight sex-specific CVD risk factors in women, stress the impor

83 In conclusion, the sex-specific D1R and D2R signaling on SVZ cell prolifera

84 Since then, the body of sex-specific data has grown, in addition to updated hype

85 These sex-specific deficits are linked to reductions in intrin

86 how no behavioural abnormalities but do have sex-specific deficits in body mass and motor function.

87 Conversely, sex ratio (SR) and sex-specific density explained 52.8% (males) and 91.0% (

88 emale isoforms, which are both essential for sex-specific development.

89 gh-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial infarc

90 eas in children < 15 years we did not find a sex-specific difference in the prevalence.

91 Understanding sex-specific differences and dissociation between baseli

92 .IMPORTANCE Previous studies have identified sex-specific differences during chronic HIV-1 infection,

93 ndomized trials powered to address potential sex-specific differences in CS are still necessary.

94 We investigated sex-specific differences in general and according to the

95 t mediated by environmental interactions and sex-specific differences in genetic architecture for the

96 im of this post hoc analysis was to evaluate sex-specific differences in MACE and limb events in the

97 Conclusions The present study highlights sex-specific differences in older adults undergoing tran

98 Sex-specific differences in response to ED peptide appli

99 also provide a possible explanation for the sex-specific differences in survival, a unique character

100 Overall, we find that sex-specific differences in T(reg) cells from VAT are de

101 Here, we test for sex-specific differences in the demography of northern (

102 idepressant actions of ketamine and revealed sex-specific differences that are associated with excita

103 n males during the incubation period, but no sex-specific differences were observed for mercury and P

104 ellar endocannabinoid system exhibits robust sex-specific differences, malleable through early-life s

105 s per 100 000 population without substantial sex-specific differences.

106 -related disease outcomes should account for sex-specific differences.

107 enuated in female DPP3(-/-) mice, indicating sex-specific differences.

108 bjectives of this study were to identify (1) sex-specific differentially expressed genes (DEGs), (2)

109 shment of a bipotential ovary that undergoes sex-specific differentiation and maintenance to form the

110 ipher the genetic hierarchy of regulators of sex-specific differentiation.

111 This study reveals extreme, sex-specific dynamism of the neuronal epigenome, and est

112 Our study reveals that sex-specific ecological differences can lead to divergen

113 however, this appears to be a female infant sex-specific effect.

114 This suggests that there may be fetal sex specific effects of the use of progesterone in early

115 dary exploratory objectives were to test for sex-specific effects and whether elevated inflammation p

116 However, the application of FBATs to assess sex-specific effects can require additional filtering st

117 Our results demonstrated sex-specific effects of E(z) mutation on gene expression

118 tion) and further reveal links to well-known sex-specific effects of liver disease progression.

119 Sex-specific effects of prenatal BPA exposure on the sus

120 e we have aimed to identify the differential sex-specific effects of prenatal challenges on lung func

121 Our studies revealed AKT isoform- and sex-specific effects on anxiety, spatial and contextual

122 ated on IFRD1 linked to asthma, shows strong sex-specific effects on asthma transition (P-values <.01

123 There were also strong sex-specific effects on brain gene expression: exposing

124 In addition, we noted sex-specific effects on exploratory behavior and long-te

125 ales, we examined whether H2A.Z cKO also has sex-specific effects on fear sensitization in the stress

126 Sex-specific effects on lesion morphology were observed.

127 agonist treatment after puberty onset exerts sex-specific effects on social- and affective behavior,

128 We tested for sex-specific effects using interactions terms and perfor

129 Sex-specific effects were only a few, e.g. the female-sp

130 Regional and sex-specific effects were present at baseline and follow

131 Little is known about temporally distal and sex-specific effects, especially in cerebellum, which is

132 ion of the two indicators, with attention to sex-specific effects.

133 Sex-specific epigenetic regulation of Cdk5 may reflect d

134 These data suggest that H2A.Z may be a sex-specific epigenetic risk factor for PTSD susceptibil

135 Sex-specific estrogen action is an integral component fo

136 We constructed sex-specific expression quantitative trait locus regulat

137 ce of specific sex chromosomes which control sex-specific expression, and sex chromosomes evolve thro

138 turbance, with comorbid ethanol intake, in a sex-specific fashion that approximates clinical comorbid

139 maternal age alters placental phenotype in a sex-specific fashion.

140 However, not all sex-specific features are static: for example, C. elegan

141 nsity of sexual competition as well as other sex-specific features of life history when investigating

142 To address these deficits, we use sex-specific fitness data from 202 fully sequenced hemic

143 emotional states and highlight an important sex-specific function of this pathway.

144 val exposure to fungi, potentially revealing sex-specific fungal-bacterial-host dynamics in A. aegypt

145 It is currently unclear to what extent sex-specific gametocyte diagnostics obviate the need for

146 odel, calibrated to capture age-specific and sex-specific gaps in the scale-up of ART, to estimate th

147 Recently, relaxed selection due to sex-specific gene expression has also been put forward t

148 The presence of sex-specific genes and pathways demonstrates that sex-co

149 fter adolescence when the expression of many sex-specific genes change, and suggests the need for sex

150 hat dehydration tolerance may be impacted by sex-specific genes.

151 Using multivariate models, we then estimated sex-specific genetic (co)variance matrices (G(m) and G(f

152 testosterone and highlight the importance of sex-specific genetic analyses.

153 l traits related to risk-taking may lack the sex-specific genetic architecture for further dimorphism

154 We looked for sex-specific genetic associations with Alzheimer's disea

155 Our analyses revealed sex-specific genetic associations, and this finding was

156 , CREST exploits the profound differences in sex-specific genetic maps to classify pairs as maternall

157 Sex-specific group-based modeling assessed the variation

158 by differences in LV size and hence predict sex-specific guidelines for CRT.

159 ines for CVD prevention in women (the latest sex-specific guidelines to date) did not include informa

160 Bonferroni correction, our meta-analysis of sex-specific GWAS identified 1 variant at chromosome 6q1

161 We performed sex-specific GWAS of BE/EA in 3 separate studies and the

162 tate life table models were used to estimate sex-specific health expectancy at the ages of 50, 60 and

163 protein transcription between sexes suggests sex-specific hierarchical mechanisms of selenoprotein ex

164 We hypothesize that, ancestrally, sex-specific immune modulation evolved to facilitate sur

165 fort should be made to better understand the sex-specific impact of ELS within the human brain, speci

166 e, we demonstrate using gonadectomy that the sex-specific impact of reduced hepatic mTORC2 is not rev

167 There are also sex-specific in vivo HDAC expression differences in brai

168 is unknown whether microglial microRNAs have sex-specific influences on disease.

169 (6 females)-that circadian misalignment has sex-specific influences on energy homeostasis independen

170 te that developmental period exerts critical sex-specific influences on striatal cellular estrogenic

171 These data demonstrate sex-specific innate immune selection of HIV associated w

172 asolateral amygdala (BLA) to PFC to identify sex-specific innervation trajectories through juvenility

173 ample of the role of spatial organization in sex-specific interorgan communication.

174 Sex-specific rescue is achieved by inserting sex-specific introns into the coding sequences of antibi

175 sexually dimorphic traits are controlled by sex-specific isoforms of the doublesex (dsx) transcripti

176 These findings suggest that the sex-specific K212Hcy modification in albumin might have

177 ces based on new theory about the effects of sex-specific life history and given pedigree-based estim

178 age and repair in the germline interact with sex-specific life history traits to shape mutation patte

179 ls were affected by fairly recent changes in sex-specific life history.

180 notypes of future generations in response to sex-specific life-history strategies.

181 lactation alone can programme adiposity in a sex specific manner.

182 pressive-like behavior can be developed in a sex-specific manner and demonstrate that ovarian hormone

183 ing and taking during abstinence in a partly sex-specific manner and prevented acute oxycodone-induce

184 ronic adolescent stress alters behavior in a sex-specific manner at the end of adolescence and in adu

185 DNA methylation changes in F2 offspring in a sex-specific manner following perinatal exposure to nico

186 susceptibility to metabolic alterations in a sex-specific manner when challenged with environmental s

187 al microRNAs influence tau pathogenesis in a sex-specific manner.

188 pression of Sult1e1 in a tissue-specific and sex-specific manner.

189 utritional constraint impacting fitness in a sex-specific manner.

190 rm metabolic defects in an age-, organ-, and sex-specific manner.

191 ion increases in a both an IFN-inducible and sex-specific manner.

192 nse responses in the nasal mucosa occur in a sex-specific manner.

193 value of assessing genetic associations in a sex-specific manner.

194 se risk for liver tumorigenesis in mice in a sex-specific manner.

195 regulates depression-related behaviors in a sex-specific manner.

196 vity and global transcriptomics changes in a sex-specific manner.

197 behavioral adaptation to chronic stress in a sex-specific manner.

198 turtles but not females and can be used as a sex-specific marker.

199 nt on energy metabolism, indicating possible sex-specific mechanisms and countermeasures for obesity

200 ut not females; suggesting that there may be sex-specific mechanisms driving the emergence of leaders

201 Overall, sex-specific mechanisms in the initiation and maintenanc

202 e propose that increasing awareness of these sex-specific mechanisms is important for optimizing heal

203 ess and injury, with important insights into sex-specific mechanisms provided by work in rodents.

204 flammation may be more relevant in assessing sex-specific mechanisms since the findings correlate wit

205 These results provide important insight into sex-specific mechanisms that drive excessive alcohol dri

206 e missed opportunities to uncover underlying sex-specific mechanisms.

207 y distinct with unique regulators modulating sex-specific metabolic outcomes.

208 = 197) and normal tissues (n = 39) revealed sex-specific metabolic subphenotypes dependent on anatom

209 Here we show sex-specific microbiome signatures contributing to obesi

210 causal associations in both sex-combined and sex-specific models.

211 Functional annotation analysis revealed sex-specific modulation of the oxytocin signaling pathwa

212 efrontal PV(+) cells could represent a novel sex-specific modulator of anxiety-related behaviors, pot

213 We identified sex-specific modules of genetically correlated metabolit

214 tible and resistant cohorts, and identifying sex-specific molecular determinants of disease susceptib

215 is represents a lost opportunity to identify sex-specific molecular etiologies that may underpin the

216 o hosts, making parasitism a likely cause of sex-specific mortalities.

217 Sex-specific mortality is frequent in animals although t

218 Sex-specific mortality rates and rate differences were d

219 al methods will encourage further studies of sex-specific neural, physiological, and behavioral adapt

220 ing this is a very precise and local form of sex-specific neuropeptide signaling.

221 udies suggest testosterone may contribute to sex-specific NP differences.

222 Here, we evaluate the potential for sex-specific parental effects in a freshwater population

223 es that show sex-interaction effects and (3) sex-specific pathways and networks enriched in asthma ri

224 Failing to account for these sex-specific patterns (e.g. by pooling sons and daughter

225 essed humans and display complex region- and sex-specific patterns of regulation.

226 articular neuron only in one sex, leading to sex-specific patterns of synaptic connections.

227 printed placental genes, overall or in fetal sex-specific patterns, across two independent epidemiolo

228 ult mouse PFC neurons, we mirrored the human sex-specific phenotype by inducing stress resilience sol

229 This sex-specific phenotype was accompanied by changes in syn

230 s, few studies have considered how tactical, sex-specific plasticity over an individual's lifespan va

231 he need for additional studies to understand sex-specific pollutant-induced effects.

232 This study provides age- and sex-specific population reference charts for sleep durat

233 There is a need to obtain more sex-specific population-based and standardized internati

234 ct trait phenotypes and generated trait- and sex-specific prediction models that provide novel insigh

235 However, we identified infant sex-specific preeclampsia-associated differentially meth

236 Age-specific and sex-specific prevalence of peripheral artery disease was

237 We estimated age-specific and sex-specific prevalences of increased carotid intima-med

238 We assessed the country-specific and sex-specific proportions of participants who had undergo

239 f posttranslational regulation that involves sex-specific protein stabilization through ubiquitin bin

240 djustments to assess the association between sex-specific Qs of the SDI and risk of obesity and overw

241 models to estimate the associations between sex-specific quintiles (Qs) of the SDI and weight change

242 Associations between sex-specific quintiles of DF intake and the risk of chro

243 tion was divided into 6 groups: no VPA and 5 sex-specific quintiles of VPA rate (Q1 to Q5).

244 stratified according to median BMI, PAL, and sex-specific ratio of fat mass (FM) to fat-free mass (FF

245 Through analysis of sex-specific read coverage, we identify and validate gen

246 There was a weaker, non-sex-specific, reduction in the prevalence of myopia at a

247 Greater cortical thickness was observed in sex specific regions; further, cortical thickness differ

248 This contributes to sex-specific regulation of excitability, [Ca(2+)](i), an

249 ces using Poisson regression, also examining sex-specific relations.

250 cterisation of putative parents, we assessed sex-specific relationships between such dendrophenotypic

251 dings support a role for fat distribution in sex-specific relationships with the composition of the m

252 fference in sleep characteristics as well as sex-specific relationships.

253 important insight into the immunological and sex-specific relevance of asthma-associated risk variant

254 Together, these data are consistent with a sex-specific requirement for microRNA-210 in kidney deve

255 Sex-specific rescue is achieved by inserting sex-specifi

256 We found sex-specific response patterns despite similar behaviora

257 nd examines evidence for tissue-specific and sex-specific responses to fructose.

258 To identify potential sex-specific responses to PCB-exposure we established ge

259 covaried differently with sex, likely due to sex-specific responses to potential mate availability.

260 Conditional gene knockout resulted in sex-specific responses wherein PDYN knockout decreased a

261 , under the counterfactual that the age- and sex-specific risk factor profile in Russia was as in Nor

262 nitiate appropriate preventive measures when sex-specific risk factors are present.

263 AAA, no studies have prospectively examined sex-specific risk factors, such as premature menopause a

264 However, we observed a critical sex-specific role for RFRP neurons in mediating acute an

265 hat GHRH/Kiss1 dual-phenotype neurons play a sex-specific role in the crosstalk between the somatotro

266 However, the sex-specific role of dopamine D1 and D2 receptors (D1R,

267 The sex-specific role of murine Dusp8 in governing hypothala

268 inance coefficients, to sex-linked loci with sex-specific selection coefficients, and to inbreeding p

269 ace between intergenerational plasticity and sex-specific selective pressures, sexual conflict and se

270 ex-separated mice and robustly responsive to sex-specific semiochemicals.

271 conducted on wild populations have compared sex-specific senescence trajectories outside of polygyno

272 he chances of false positive-findings due to sex-specific sequencing errors.

273 ince the described system exploits conserved sex-specific splicing mechanisms and reagents, it has th

274 hich sexual differentiation is controlled by sex-specific splicing.

275 hese models were performed within study- and sex-specific strata in the New Hampshire Birth Cohort St

276 uppressing nigral Sry synthesis represents a sex-specific strategy to slow or prevent DA cell loss in

277 Sex-specific synaptic connectivity is beginning to emerg

278 ation, and can be used to quantify race- and sex-specific T2D risk, providing a new, powerful predict

279 eptibility, with implications for developing sex-specific therapeutic interventions.

280 Furthermore, the use of sex-specific thresholds (<40 ml/m(2) for men and <32 ml/

281 derived from these curves were compared with sex-specific thresholds for sarcopenia by using chi(2) t

282 Sex-specific thresholds for sarcopenia demonstrated that

283 Use of sex-specific thresholds identified 5 times more addition

284 gh-sensitivity cardiac troponin I assay with sex-specific thresholds increased myocardial injury in w

285 nin I assay to a high-sensitivity assay with sex-specific thresholds, in patients with suspected acut

286 ases during development in a region- but not sex-specific time-course, resulting in extranuclear expr

287 increases by adulthood in a region- but not sex-specific time-course.

288 re adulthood and disappears in a region- and sex-specific time-course.

289 released in nerve injury triggers multisite, sex-specific transcriptome changes, leading to neuropath

290 ablishes a foundation for the development of sex-specific treatments for disorders such as anxiety an

291 ific genes change, and suggests the need for sex-specific treatments.

292 We compared sex-specific trends in life expectancy since 1970 and ag

293 Sex-specific variability has eco-evolutionary ramificati

294 The identified novel sex-specific variants associated with BE/EA could improv

295 d degradation in the integument, rather than sex-specific variation in physiological functions such a

296 12 weeks to investigate interindividual- and sex-specific variations in the development of NAFLD.

297 ay help to unravel the mechanisms underlying sex-specific vulnerability in ALS-FTD.

298 Preclinical models demonstrating sex-specific vulnerability may help to understand female

299 t grandparental effects are transmitted in a sex-specific way down the male lineage, from paternal gr

300 The downregulation was sex specific, with males expressing reduced DBH mRNA lev