ライフサイエンスコーパス: shigellosis

1 ly tRNAs in Shigella, the causative agent of shigellosis.

2 g in the discovery of new treatments against shigellosis.

3 associated with increased susceptibility to shigellosis.

4 ic, therapeutic, and diagnostic tool against shigellosis.

5 for fucosylated glycans in susceptibility to shigellosis.

6 lity to produce desired results in childhood shigellosis.

7 e international epidemiological landscape of shigellosis.

8 its crucial homeostatic contributions during shigellosis.

9 oughly 164 000 annual deaths attributable to shigellosis.

10 recapitulate the clinical features of human shigellosis.

11 ded means of treating and perhaps preventing shigellosis.

12 activity is sufficient to protect mice from shigellosis.

13 re form of bacillary dysentery also known as shigellosis.

14 is both immunogenic and efficacious against shigellosis.

15 of live, oral vaccines for the prevention of shigellosis.

16 ers from a restaurant-associated outbreak of shigellosis.

17 help explain the susceptibility of humans to shigellosis.

18 tibodies in serum confers protection against shigellosis.

19 y play a crucial role in the pathogenesis of shigellosis.

20 uinolones remain the recommended therapy for shigellosis(1-7).

21 Of the 500 cases of shigellosis, 249 were associated with overseas travel an

22 l was excreted in the urine in children with shigellosis: 8% excreted >0.10 micromol/d (15% of the da

23 Shigellosis, a diarrheal disease, is endemic worldwide a

24 Shigellosis, a leading cause of diarrhoeal mortality and

25 pithelial cells as the first step in causing shigellosis, a life-threatening form of dysentery.

26 ate in intestinal epithelial cells and cause shigellosis, a severe diarrheal disease that resolves sp

27 Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease driven by

28 Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease that is a

29 Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is s

30 (s) of infection as precipitating factors in shigellosis-affected MSM.

31 Shigella spp. cause shigellosis, also called bacillary dysentery, and invade

32 Repeated outbreaks of locally acquired shigellosis among men who have sex with men highlight th

33 commended antimicrobial for the treatment of shigellosis, among Shigella isolates.

34 Endemic and epidemic shigellosis, an acute invasive disease of the lower inte

35 Shigellosis, an enteric disease, is on the World Health

36 re are approximately 163 million episodes of shigellosis and 1.1 million deaths annually.

37 November 2013 and 31 March 2014, concurrent shigellosis and cryptosporidiosis outbreaks occurred amo

38 feasibility of a multivalent vaccine against shigellosis and ETEC diarrhea consisting of multiple Shi

39 We observed a substantial increase in severe shigellosis and shift from sexually transmitted S. sonne

40 Ty21a-AR-Ss in protecting against S. sonnei shigellosis and typhoid fever, as compared with the curr

41 nt oral vaccine to protect against S. sonnei shigellosis and typhoid fever.

42 me biology and protective mechanisms against shigellosis, and (iv) the controlled human infection mod

43 a diarrhea episodes, antibiotic use to treat shigellosis, and bystander exposures due to shigellosis

44 With no vaccine available, shigellosis annually kills over 600,000 children in deve

45 Symptoms of shigellosis are produced by severe inflammation caused b

46 Shigella spp., the bacteria responsible for shigellosis, are one of the leading causes of diarrheal

47 utinely collected data for notified cases of shigellosis between 2008 and 2012 in Victoria, Australia

48 s of the reporting rate, suggesting that the shigellosis burden in the United States may be more than

49 o the severe tissue damage characteristic of shigellosis but also ultimately participate in clearance

50 mice from IDO1 inhibition-driven aggravated shigellosis by restoring the cytokine balance and subseq

51 he loss of IDO1 function in vivo exacerbates shigellosis by skewing the inflammatory cytokine respons

52 ia which cause a diarrheal disease, known as shigellosis, by invading and destroying the colonic muco

53 Shigellosis can present variably as watery diarrhea alon

54 is, fever was observed more frequently among shigellosis cases [adjusted OR 2.21; (95% CI 1.58, 3.09)

55 Thirty suspected shigellosis cases aged 24-59 months were randomized acro

56 s-sectional genomic epidemiological study of shigellosis cases collected from 29 countries between De

57 Shigellosis causes considerable public health burden, le

58 eaks still occur in military operations, and shigellosis causes hundreds of thousands of deaths per y

59 al costs incurred by households were more in shigellosis children than Campylobacter-induced enteriti

60 n tended to incur less cost in case of their shigellosis children.

61 ss vaccine immunogenicity against influenza, shigellosis, cholera, enterotoxigenic Escherichia coli,

62 Severe shigellosis definition included hospitalization, bactere

63 Household contacts of patients with shigellosis diagnosed only by PCR had significantly high

64 Sexual health care for MSM should include shigellosis diagnosis and prevention.

65 eriae type 1 infection than in children with shigellosis due to less virulent strains of Shigella.

66 tional sampling to determine factors driving shigellosis emergence in MSM linked to an outbreak in th

67 llosis is either in returning travelers from shigellosis-endemic regions or in men who have sex with

68 om transmission is an important component of shigellosis epidemiology in high-income nations.

69 ctively used to further our understanding of shigellosis epidemiology, antimicrobial resistance, and

70 There were 273.8 diarrhea episodes, 30.6 shigellosis episodes, and 457.6 antibiotic courses per 1

71 m-negative bacteria, including those causing Shigellosis, evidence of safety and pharmacokinetics dat

72 Since the 1970s, shigellosis has also been reported as a sexually transmi

73 e lack of a tractable physiological model of shigellosis has impeded our understanding of this import

74 overy of 90 children with dysentery (66 with shigellosis) hospitalized in Bangladesh.

75 Azithromycin is frequently used to treat shigellosis; however, clinical outcomes are uncertain.

76 Of the 4,950 confirmed cases of shigellosis identified during this period, the highest p

77 the morbidity and mortality associated with shigellosis, improve child health, and decrease the need

78 tionality associated with protection against shigellosis in a high-burden endemic setting.

79 e selection studies showed that SC602 causes shigellosis in a majority of volunteers when 3 x 10(8) o

80 otection against the most severe symptoms of shigellosis in a stringent human challenge model of dise

81 ate vaccine that provides protection against shigellosis in a stringent, human challenge model.

82 Cefixime showed some promise in treating shigellosis in an open labeled trial.

83 arable to azithromycin in treating childhood shigellosis in Bangladesh.

84 standard for the detection and diagnosis of shigellosis in children in low-income countries.

85 Shigella sonnei is the most common agent of shigellosis in high-income countries, and causes a signi

86 nd microbiologic characteristics of systemic shigellosis in South Africa, where rates of HIV infectio

87 be a pragmatic clinical endpoint for severe shigellosis in vaccine trials.

88 Symptoms of shigellosis include bloody diarrhea, associated to colon

89 , we inferred individual-level parameters of shigellosis infection, including seasonal transmissibili

90 Shigellosis is a clinical syndrome caused by invasion of

91 Shigellosis is a gastrointestinal infection caused by sp

92 Shigellosis is a global public health challenge that mos

93 Shigellosis is a leading cause of diarrhoea in children

94 Shigellosis is a leading cause of diarrhoeal deaths, wit

95 Shigellosis is an acute, severe bacterial colitis that,

96 Shigellosis is an important disease in the developing wo

97 Systemic shigellosis is associated with HIV-infected patients, pr

98 Our development of vaccines to prevent shigellosis is based on the hypothesis that a critical (

99 In urban Australia, the burden of shigellosis is either in returning travelers from shigel

100 Shigellosis is hyperendemic in Utah.

101 Drug-resistant shigellosis is increasing, particularly among men who ha

102 hat the acute inflammation characteristic of shigellosis is initially triggered by apoptotic macropha

103 Globally, shigellosis is the most common cause of invasive bloody

104 Shigella flexneri, the causative agent of shigellosis, is a gram-negative bacterial pathogen that

105 te to the low infective dose associated with shigellosis, is dependent upon the expression of the sta

106 Shigellosis most often targets young children in underde

107 During shigellosis, neutrophils are abundantly recruited to the

108 However, patients with shigellosis often do not seek medical care.

109 addition to describing a new mouse model of shigellosis, our results suggest that the lack of an inf

110 This distinct clone caused six waterborne shigellosis outbreaks in China from 2015 to 2020.

111 We included all shigellosis patients notified during the study period, w

112 f millions of cases of the diarrheal disease shigellosis per year worldwide.

113 Shigellosis (previously bacillary dysentery) was the pri

114 clude that piglets are highly susceptible to shigellosis, providing a useful tool with which to compa

115 netic analysis of isolates from all cases of shigellosis referred to Public Health England between 20

116 nimal model that mimics key aspects of human shigellosis remains a major obstacle to addressing quest

117 Onset of shigellosis requires bacterial invasion of colonic epith

118 However, how shigellosis resolves remains poorly understood due to th

119 y population characteristics associated with shigellosis shifted from MSM (45; 98%) to PEH (86; 77%).

120 nly by PCR had significantly higher rates of shigellosis than household contacts of patients who did

121 , mumps, rabies, rubella, salmonellosis, and shigellosis than in either of 2 nonborder comparison reg

122 eport, we confirmed in a guinea pig model of shigellosis that both S. flexneri 5a and S. sonnei induc

123 testinal cells to cause bacillary dysentery (shigellosis) that is responsible for over one million de

124 of live attenuated vaccines directed against shigellosis, the guinea pig keratoconjunctivitis model w

125 with an intraperitoneal (IP) murine model of shigellosis to test the efficacy of ciprofloxacin and am

126 The consensus endpoint enabled "shigellosis" to present as severe diarrhea or moderate d

127 contributes to a better understanding of FQR shigellosis transmission and highlights the added value

128 The dynamics of shigellosis transmission show strong annual and multiyea

129 shigellosis, and bystander exposures due to shigellosis treatment.

130 ughout regions traditionally at low risk for shigellosis via sexual transmission in MSM.

131 subjects among case patients with S. sonnei shigellosis was also significantly lower than in the con

132 This study showed that shigellosis was associated with a significant, transient

133 Severe shigellosis was significantly higher in the recent versu

134 To estimate the burden of shigellosis, we extended time-series susceptible-infecte

135 Using in vitro and in vivo models of shigellosis, we found that S. flexneri induces the expre

136 veloped Nlrc4(-/-)Casp11(-/-) mouse model of shigellosis, we unexpectedly find no major role for neut

137 Most cases of systemic shigellosis were diagnosed on blood culture (408 of 429

138 From 2003 to 2009, 429 cases of invasive shigellosis were identified through national laboratory-

139 ntibodies were associated with resistance to shigellosis, whereas total OSP-specific IgA was not, sug

140 ella, (iii) a pioneering oral mouse model of shigellosis, which has helped to discover new inflammaso

141 Shigella spp. are the causative agents of shigellosis, which remains a leading cause of death in c

142 Treatment of shigellosis with appropriate antimicrobial agents shorte

143 Six of the control volunteers developed shigellosis with fever and severe diarrhea or dysentery,

144 um retinol in children with culture-positive shigellosis with severity of illness, anthropometric ind

145 Prompt diagnosis of shigellosis with the GI panel may provide the opportunit