ライフサイエンスコーパス: shut down

1 from chromatin rapidly once transcription is shut down.

2 omes stable at induced HSP70 genes that have shut down.

3 lied along with ParB, expression of lacZ was shut down.

4 Ag-L appears and HDV RNA synthesis begins to shut down.

5 e sperm, in which nuclear genome activity is shut down.

6 gen production and CCKAR expression were not shut down.

7 ignal in bright light when they are normally shut down.

8 ellular stress, cap-dependent translation is shut down.

9 the active ES, correlated with transcription shut-down.

10 r 31 was used, the electron-transfer pathway shuts down.

11 E1 RNA depletion shut down 18 rRNA formation, without overaccumulation of

12 , for the first time, that RTS-based control shuts down a dangerous short-circuit event 3 times earli

13 mediates a strong depolarizing plateau that shuts down action potential firing, which may or may not

14 are a class of serine/threonine kinases that shut down active signaling mediated by agonist-bound G p

15 they promptly inhibit neighbouring cells and shut down activity.

16 MPP+ shuts down aerobic oxidative phosphorylation and ETC-med

17 t of the food additive Zanthoxylum bungeanum shuts down AFB1 production in A. flavus.

18 d to be displayed, indicating that they were shut down after detection.

19 during embryonic development, but it usually shuts down after birth.

20 ch, thus preventing economies from having to shut down again.

21 crosstalk establishes a mechanism to rapidly shut down AHR-mediated transcription by decreasing its p

22 h as low nutrient levels, translation can be shut down almost entirely by inhibiting ribosomal functi

23 ripts from a gene before its activity can be shut down and its chromatin reset to an inactive state.

24 ed drug dose-dependent, long-term blood flow shut down and tumor growth delay in the MCaIV tumor, gro

25 th inhibition through induction of metabolic shut-down and redox imbalance in NOTCH1-mutated and less

26 ming of the cold-induced FLC transcriptional shut-down and upregulation of FLC antisense transcripts,

27 nation compromises products and necessitates shut-downs and extensive decontamination using nonspecif

28 even under the harsh conditions of start-up, shut-down, and/or hydrogen starvation.

29 gonists and antiandrogens, cannot completely shut down AR signaling.

30 However, the mechanisms leading to vascular shut-down are still unknown.

31 scribed during growth, and its transcription shut down as the cells approached stationary phase.

32 r ecosystem service of leguminous crops--was shut down at high nano-CeO(2) concentration.

33 Protein synthesis is globally shut down at late times postinfection in the baculovirus

34 lop in mice in which IFN-gamma expression is shut down at P16 do not.

35 p tumors, whereas if transgene expression is shut down at P16, the clinical symptoms and tumors progr

36 on from the mutagenized ptb promoter was not shut down at the end of exponential growth.

37 Ethylene production is shut down at the level of 1-aminocyclopropane-1-carboxyl

38 Further, the gating of the channel can shut down ATP flux completely while, simultaneously, all

39 lysis and oxidative phosphorylation, thereby shutting down ATP production.

40 e autoregulation (RPAR) loop is critical for shutting down ATP-consuming active potassium uptake to c

41 zation of azobenzene switching, while Cu(II) shuts down azobenzene isomerization.

42 US public buildings (including schools) were shut down because of the COVID-19 pandemic, and 42% of U

43 encing revealed that the T(reg) cell program shuts down before an intraepithelial program becomes ful

44 mosphere to the observed 3-cm GEL because it shuts down below about 10-100 m GEL(5,7).

45 ctivated during mitochondrial inhibition and shuts down biosynthetic processes to help conserve cellu

46 ular ischemia model in mice that selectively shuts down blood supply to the ipsilateral hippocampal f

47 Shutting down broad-specificity proteases, however, is p

48 on, decreasing ternary complex formation and shutting down bulk protein synthesis.

49 of 6, 17, and 27 kg N ha(-1) yr(-1) was not shut down but rather suppressed by 54, 69, and 74%, resp

50 stituent (R=tBu), this catalytic reaction is shut down, but the complex becomes active for aqueous el

51 lipid hydrolase, acid sphingomyelinase, was shut down by E11.

52 ent-ionization (RESI) channel, are virtually shut down by mid-IR fields.

53 ar antigen and DNA, but the activity was not shut down by Pol delta in accord with rapid association/

54 ated in a system where cross-presentation is shut down by pretreatment with CpG.

55 pathogen, but then, the NKT cell response is shut down by two mechanisms; apoptotic contraction and m

56 ectopic expression patterns and hence were "shut down" by the model.

57 ndfast sea ice produces enough resistance to shut down calving at the terminus.

58 romoting adipogenesis and lipogenesis and by shutting down catabolic processes such as lipolysis and

59 f the enzyme and induces a loop closure that shuts down catalysis at the active site.

60 ) even in the face of anergy protocol, which shut down CD40L expression in normal T cells.

61 broad EC protective functions by effectively shutting down cell death pathways initiated by inflammat

62 Ralpha functions as a dominant negative that shuts down cholesterol sensing.

63 rapy regimens, these xenograft breast tumors shut down classic estrogen signaling and activate altern

64 attenuates the TGFbeta signaling pathway to shut down clusterin expression, thereby stimulating angi

65 mediated cleavage of complement C3b, thereby shutting down complement activation.

66 ed significant inhibition, and nitrification shut down completely with TBP addition.

67 The RNA helicase YTHDC2 is required to shut down components of the mitotic program to facilitat

68 supplemented with corn trypsin inhibitor (to shut down contact activation) was studied in well-plates

69 Like immunophilins, Shut-down contains an FK506-binding protein domain and a

70 n common molecular mechanisms to efficiently shut down CRISPR immunity.

71 Instead of a single phage shutting down CRISPR-Cas immunity, a community of acr-ca

72 The likely contaminant responsible for shutting down cross-presentation is peptidoglycan (PGN).

73 both impaired CUP1 induction and failure to shut down CUP1 normally.

74 read into the interior region and eventually shut down deep convection in the Labrador Sea.

75 eceptor promotes M2-polarization in order to shut-down deleterious immune responses and limit bystand

76 isplatin activates ATR, CHK1 and WEE1, which shut down DNA replication and attenuate cisplatin induce

77 metabolism of alternative carbon sources is shut down, due to catabolite repression.

78 ecently, it was thought that trafficking was shut down during cell division.

79 Though many genes are shut down during diapause, others are specifically expre

80 CME is shut down during early mitosis, but the mechanism of thi

81 s continuously in non-dividing cells, but is shut down during mitosis, when clathrin concentrates at

82 tion of a long-chain phospholipid completely shuts down electron transfer.

83 shut-down encodes a novel Drosophila protein similar to

84 ne of reasoning suggests that bacteria might shut down endogenous fatty acid synthesis on the additio

85 nosa has evolved tight regulatory systems to shut down energy-expensive type III secretion apparatus

86 Thus, L. pneumophila can shut down ER-mitochondria communication through cleavage

87 -terminal kinase (JNK) phosphorylation while shutting down ERK1/2 and p38 phosphorylation.

88 OP1 provides a regulatory feedback loop that shuts down excessive inflammatory responses and thereby

89 is dependent upon its ability to completely shut down expression of its lytic genes during lysogenic

90 both on the non-recombining Y chromosome, to shut down expression of maladapted genes [3], and on the

91 ed with the same timing as those that either shut down expression prior to initiation or lacked expre

92 an erythrocyte, the developing erythroblast shuts down expression of most of its genes but preserves

93 aining NuRD complex plays a critical role in shutting down expression of specific synaptogenesis-rela

94 ic (D/DMga4) is completely inactive in vivo, shutting down expression of the Mga regulon.

95 of the mutant phenotypes can be recovered by shutting down FAF1 expression through the administration

96 S. Typhi of TviA, a regulatory protein that shuts down flagellin (FliC) expression when bacteria tra

97 t documents, but by 1967, it was effectively shut down following the refusal of journals to accept ar

98 ered to rotate substantially slower and even shut down from time to time, resulting in up to 80% of i

99 Clonal analysis indicates that shut-down functions autonomously in the germline.

100 s; and (ii) addition of succinate reduced or shut down further expression of plcH in osmoprotectant-i

101 methylation alone might not be sufficient to shut down gene expression.

102 ional cloning approach, we have isolated the shut-down gene.

103 This process shuts down general protein synthesis to conserve amino a

104 nslation factor eIF2alpha is phosphorylated, shutting down general translation but favoring the rapid

105 DNA damage shuts down genome-wide transcription to prevent transcri

106 s the damage, degrades RNA polymerase II and shuts down global transcription(1-4).

107 might correspond to regulatory mechanisms to shut down glycolysis in a reverse, step-wise fashion in

108 Our study also reveals a novel mechanism of shutting down gp96 post-translationally in regulating it

109 ties in HD-OB1 subdomains and find that DSS1 shuts down HD-OB1's DNA binding to enable ssDNA targetin

110 del suggests that the ability to suppress or shut down host cell mRNA translation may be a key factor

111 Human adenoviruses (HAdVs) shut down host cellular cap-dependent mRNA translation w

112 is study, we show that SARS-CoV-2 is able to shut down host protein synthesis and that SARS-CoV-2 non

113 . aeruginosa secreting ExoS, upon infection, shuts down host cell survival signal pathways by inhibit

114 ellular pathways that regulate apoptosis: it shuts down host cell survival signal pathways by inhibit

115 Together, we find that SARS-CoV-2 shuts down host innate immune responses via a translatio

116 somal subunit and blocks mRNA entry, thereby shutting down host protein synthesis.

117 sport networks of small safe conduits and/or shutting down hydraulic function by dropping leaves duri

118 proper timing even when transcription is not shut down; i.e., mioC does not serve as a negative regul

119 iation of a "switched" Th1 population, which shuts down IFN-gamma secretion and upregulates IL-10 and

120 ly, IL-10-producing neutrophils specifically shut down IL-17A production by Th17 CD4 cells, but not I

121 s in anergic cells and may enable T cells to shut down IL-2 production selectively during anergy.

122 These Treg shut down IL10, gain potential to express IL17, and swit

123 echanism by which activated transcription is shut down in human cells.

124 ns (0.01% oxygen) DNA replication is rapidly shut down in immortalized mouse embryo fibroblasts.

125 Oceanic convection shut down in response to this flow, concentrating the en

126 s be tightly controlled to keep the response shut down in the absence of pheromone.

127 Retrograde transport was effectively shut down in this membrane-bound state, allowing for eff

128 ain (CTD), we find that oocyte transcription shuts down independently of maturation.

129 The ligand's steric profile shuts down intermolecular reactivity with potential O at

130 at have opposite electronic polarizations to shut down intersystem crossing.

131 weak loss-of-function alleles confirms that shut-down is also required at later stages of oogenesis.

132 Here, we show that shut-down is essential for the normal function of the ge

133 bout 5 to 10 Myr ago, catastrophic slab loss shut down island-arc volcanic activity north of the Aleu

134 cts the TRP channel function so as to nearly shut down its activity.

135 subjected to degradation during apoptosis to shut down its signaling.

136 findings will help explain how L. heterotoma shuts down its hosts' immunity and shed light on the mol

137 tions become unfavorable in early autumn, it shuts down its reproductive axis, increases its body wei

138 orylation at S344 of MtCCaMK is adequate for shutting down its activity, and is epistatic over previo

139 minating the catalytic subunit or completely shutting down its enzymatic activity.

140 ings, national and international travel, and shut down large parts of the economy.

141 f an interaction with lysozyme still fail to shut down late transcription and, remarkably, have becom

142 ovides a basis for eukaryotes to effectively shut down mature mRNA transport and thereby tailor prote

143 Our results suggest that shut-down may regulate germ cell divisions in the germar

144 lcyclopropane and ethephon revealed that the shut-down mechanism in ethylene biosynthesis is developm

145 ling tubercle bacilli to restrict growth and shut down metabolism in a coordinated fashion.

146 Under these conditions, where motility is shut down, microarray experiments showed an increased RN

147 , was not influenced by the time required to shut down mioC transcription, since the eclipse was the

148 Galphas promotes maturation of endosomes and shuts down mitogenic MAPK-ERK1/2 signals from endosomes.

149 translation in response to diverse stresses shut down most protein translation to conserve energy an

150 ith clinical preparedness, universities have shut down most scientific research activities.

151 nding domains may be a general mechanism for shutting down motor protein activity and thereby regulat

152 tion, glucose starvation not only signals to shut down mTOR, but also results in the transient phosph

153 in dendritic cells serving to simultaneously shut down multiple pathways of inflammation.

154 on through depleting client oncoproteins and shutting down multiple oncogenic pathways.

155 It forced most institutions to shut down nearly every aspect of their research and educ

156 While RelA deamidation shuts down NF-kappaB activation and subsequent inflammat

157 alone in p53 negative tumors resulted in the shut down of angiogenesis and led to sustained tumor reg

158 of the tumor microenvironment including the shut down of angiogenesis and the induction of cellular

159 the p53-dependent induction of TSP-1 and the shut down of angiogenesis.

160 Stable shut down of miR-21, p47(phox) or STAT3 and overexpressi

161 tes that a fraction of tumour cells survives shut down of oncogenic signalling.

162 physiological changes occur that lead to the shut down of photosynthesis and a cessation of growth.

163 xicity syndrome includes the transcriptional shut down of PI3K expression.

164 he Drosophila model of aggression, the acute shut down of the entire serotonergic system yields flies

165 ly due to the across-the-board, non-specific shut down of transcription in a condition of growth arre

166 at later times postinfection, likely due to shut down of transgene expression, and indicating that t

167 Simulation models suggested a hypothetical shut-down of all training and competition activities.

168 In animal tumors, it can cause the shut-down of blood flow, leading to extensive tumor cell

169 ould form a positive feedback loop for rapid shut-down of ceramide channels.

170 ance of origin activity and, consequently, a shut-down of plasmid replication under conditions of hig

171 beneath the continent to shallow and led to shut-down of the arc.

172 ion (EHT) is a dynamic process involving the shutting down of endothelial gene expression and switchi

173 ation genes, but rather is important for the shutting down of the pluripotency network in differentia

174 s are driven toward the MS, and the field is shut down once the ions reach the vicinity of the MS inl

175 Finding the currently missing drugs to shut down oncogenic fusion proteins, to disrupt the cond

176 s X-linked genes in males [7], while mammals shut down one of the X chromosomes in females [8].

177 these organisms, equalization is achieved by shutting down one of the two X chromosomes in the somati

178 remain metabolically active, whereas others shut down or rely on anaerobic metabolism.

179 tems limit the spread of foreign invaders by shutting down or killing infected cells before the invad

180 tial highly efficient star formation rapidly shuts down, or quenches, giving rise to massive quiescen

181 re activated intracellularly (PrfA 'ON') but shut down outside the host (PrfA 'OFF').

182 Lytic cycle reporter promoters were shut down over time, and long-term survival of neurons h

183 of the IDH mutation on intrinsic apoptosis, shuts down oxidative phosphorylation and reduces ATP lev

184 oup from a methyl to t-butyl, which not only shut down pai-ligand exchange but also significantly red

185 overy tool to find molecular mechanisms that shut down pain.

186 and rapidly moved to restore Pak1 levels by shutting down Pak1 shRNA expression through a methylatio

187 Thus, upon abrupt glucose depletion, yeast shuts down pathways consuming large amounts of energy, i

188 aGCs involved a transcriptional switch that shuts down pathways promoting cell growth, such SoxC TFs

189 Once star formation has been shut down, perhaps during the quasar phase of rapid accr

190 the samples, and the modes of triggering and shutting down polymerization, we achieve exquisite contr

191 duced starvation response can be reverted by shutting down polyP synthesis genetically or pharmacolog

192 ctivated human blood basophils in vitro, and shut down preinitiated allergic reactions and anaphylaxi

193 Moreover, viomycin shuts down proofreading-based error correction.

194 d stress response pathways in bacteria, RelE shuts down protein synthesis by cleaving mRNA within the

195 elay, while pyrylium-like ether terminations shut down proton exchange.

196 es initiates immediately upon activation and shuts down quickly even in the continuous presence of th

197 Indeed, micrometastatic cells shut down Rab27-dependent production of EVs and, instead

198 ere, we demonstrate that RFS-1/RIP-1 acts by shutting down RAD-51 dissociation from ssDNA.

199 For example, it can be used to shut down radical pathways and to give access to aryl ca

200 Point mutations that disrupt the Y-Y dyad shut down radical transport.

201 Increasing steric bulk around the Mn shuts down rapid homolytic H(2) evolution rendering the

202 motes NRP internalization, which effectively shuts down receptor-mediated signaling by a second ligan

203 During stress, cells shut down ribosome biogenesis in part by halting rRNA sy

204 d that during mitosis, when transcription is shut down, Runx2 selectively occupies target gene promot

205 Knock-down of either pathway shuts down SA biosynthesis and abrogates pathogen resist

206 w the replication of the virus to be quickly shut down should adverse effects be detected.

207 NeuAc), added to the media of cultured cells shuts down sialylation by a mechanism involving its intr

208 rylation, VEGF, or VEGFR2 are ineffective in shutting down signaling to ERK1/2.

209 e homolog as a repair template is regulated, shutting down simultaneously for both CO and noncrossove

210 Wake-active wake-promoting neurons in turn shut down sleep-active neurons, thus forming a bipartite

211 inflammatory response has to be regulated or shut down so as to allow for the reestablishment of matr

212 that the Compound I (peroxidase) pathway is shut down, so that instead the reaction intermediate div

213 Surprisingly, Aire could be shut down soon thereafter and remain off for long period

214 hat the tropical terrestrial carbon sink may shut down sooner than current models suggest.

215 Many will shut down sooner.

216 flammatory cytokines and trophic factors, by shutting down STAT1/STAT5 signaling that mediate essenti

217 rations, favoring fast nutrient utilization, shutting down stress responses, and boosting growth.

218 ial immune responses to foreign antigens and shutting down such responses prematurely.

219 expressed on activated T cells and serves to shut down T-cell activation, culminating in T-cell death

220 s a minimal inhibitory potential required to shut down TF-initiated thrombin generation.

221 ressing the formation of H3+ and effectively shutting down that mode of cooling.

222 embly during DNA replication and the need to shut down the activating system under replication-stress

223 e acetylation marks at night, potentially to shut down the biosynthesis of floral volatile compounds

224 e V Acr proteins use enzymatic activities to shut down the Cas12a endonuclease, providing a multi-tur

225 K conditions, TORC is rapidly activated and shut down the CBL-CIPK low-K response pathway through re

226 While AG is known to shut down the expression of the stem cell maintenance ge

227 Here we show that SA can directly shut down the expression of the vir regulon.

228 This process may completely shut down the gated injection.

229 d with impurities and other methods that can shut down the hydrogenation reactions are highlighted in

230 The objective of HSCT is to immediately shut down the immune response and allow the transplanted

231 sor or valve during infection to temporarily shut down the lymph node to further antigenic challenge.

232 the N-RPS19 interaction is a novel target to shut down the N-mediated translation strategy and hence

233 en analyze indirect and direct approaches to shut down the oncogenic KRAS network.

234 ssion and glycolysis, and IFN-gamma addition shut down the oxidative metabolism in SYL-infected mphis

235 ker studies demonstrated the ability of 3 to shut down the PI3K/Akt pathway and induce apoptosis in c

236 of Gravin, paraxial mesodermal cells fail to shut down the protrusive activity mediated by the Rho/RO

237 low rapid transfer to activated Galpha(q) to shut down the signal.

238 ed task-related signals, but also completely shut down the spontaneous activity within the IO, which

239 ntegrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.

240 ectural elements to effectively condense and shut down the Xi.

241 mature (activated) form of SleC, whereby it shuts down the ability of spores to germinate in the pre

242 d isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of th

243 ids, a standard treatment of disease flares, shuts down the interferon signature, further supporting

244 The use of base shuts down the isomerization pathway and allows for the

245 m the environmental occurrence of P3N, which shuts down the Krebs cycle by inactivating succinate deh

246 ) encoding a type VI secretion system (T6SS) shuts down the native T6SS of Bacteroides fragilis.

247 R (PKR), a versatile antiviral host factor, shuts down the translation machinery upon activation in

248 Upon shutting down the CO(2) supply, the C=O hydrogenation ac

249 s might provide more specificity than simply shutting down the entire COX cascade for anti-inflammato

250 ng RNAs (siRNAs) and evaluated the effect of shutting down the expression of these proteins on rotavi

251 gnaling axes to the ENS by transcriptionally shutting down the intestinal neuropeptide secretion mach

252 It is generally believed that shutting down the kinase activity of BCR-ABL by imatinib

253 ibers, altering photophysical properties and shutting down the photocycloaddition reaction.

254 t contribute to decreasing DC activation and shutting down the production of pathogenic IL-23.

255 for achieving an effective HTP, is twofold: shutting down the radically induced chain-growth additio

256 These results suggest that shutting down the residual activity of the limbic-arousa

257 when the plant was operating to when it was shut down, the plant was found to contribute a large per

258 Activation of PLC can shut down their activity if it depletes the PIP(2) pool

259 pamine-containing neurons and can completely shut down their activity, with a following rebound excit

260 no acids to the bacteroids, enabling them to shut down their ammonium assimilation.

261 These 2C transcripts rapidly shut down their expression beyond the 2C stage of embryo

262 ly directed cell migration, but they fail to shut down their protrusive behavior and undergo the norm

263 rine bone marrow-derived M2 macrophages also shut down their TIMP-1 expression and produced proMMP-9

264 tiation of human dendritic cells effectively shuts down their immunogenic pathways and implicates tra

265 g infection, HSV-1 has evolved mechanisms to shut down these responses to evade the proinflammatory c

266 d that inhibition of the sensor domain would shut down this response system, and beta-lactam suscepti

267 ect of syndecan-mediated signaling either by shutting down this signaling pathway or by activating a

268 hotochemical azide activation pathway can be shut down through coordination of the terminal azide lig

269 onally thought as a consequence of the brain shutting down to external inputs, it is now acknowledged

270 caused by an indirect mechanism: these cells shut down transcription in response to DNA damage, effec

271 er growth-limiting conditions, budding yeast shut down transcription of genes of the translation appa

272 nse, and the ability of the immune system to shut down transgene expression without utilizing cytolyt

273 immune responses, the egress process can be shut down transiently.

274 by viral proteins.IMPORTANCEEukaryotic cells shut down translation by assembling stress granules (SGs

275 otes PRF, and reveal how 2A accumulation may shut down translation during virus infection.

276 These responses shut down translation, induce cytotoxicity, degrade host

277 Stressed cells shut down translation, release mRNA molecules from polys

278 in eukaryotic mRNA decay that simultaneously shuts down translation initiation and activates mRNA deg

279 d or absent ( murMN), the stringent response shuts down translation to avoid toxic generation of mist

280 tant Ndel1 lacking key phosphorylation sites shut down transport completely, as did a dominant-negati

281 phenotype than Lis1 RNAi alone, essentially shutting down transport.

282 of lysogeny by binding to Mu operator DNA to shut down transposition.

283 age Mu establishes and maintains lysogeny by shutting down transposition functions needed for phage D

284 age Mu establishes and maintains lysogeny by shutting down transposition functions needed for phage D

285 as trbA, encoding a repressor which helps to shut down trbBp.

286 l phenomenon whereby flagellum production is shut down under conditions which turn on T-pilus formati

287 How caspase activity is restrained and shut down under such nonapoptotic conditions remains unk

288 ntially cytotoxic proteins that specifically shut down various processes in the bacterial host, inclu

289 not dependent on protein synthesis, which is shut down very early during apoptosis before caspase-3 a

290 Until now, the silencer element, which shuts down vimentin synthesis in selected tissues during

291 ge detection triggers the toxSAS activity to shut down viral production.

292 aureus colonization by producing a signal to shut down virulence.

293 This exchange process is completely shut down when [Cp2TiCH2CH(CD3)(SiMe3)](+) is used, sugg

294 accharomyces cerevisiae, GPI biosynthesis is shut down when filamentation is activated and vice versa

295 ensive, therefore, it is unclear whether BNF shuts down when Nr availability is no longer a rarity.

296 D-19), some types of public spaces have been shut down while others remain open.

297 When IFN-gamma expression is shut down with doxycycline at postnatal day 12 (P12), th

298 e conditions until the decarbonation factory shut down with the collision of Greater India with Asia

299 hermal convection of either core composition shuts down within the duration of the high intensity mag