ライフサイエンスコーパス: shut off

1 ssion of the inducible plasmid ccrM gene was shut off.

2 ranscription after active P-TEFb function is shut off.

3 is phosphorylated, and protein synthesis is shut off.

4 s activated raises the question of how it is shut off.

5 rylated and protein synthesis is prematurely shut off.

6 entual promoter eviction and transcriptional shut off.

7 but had no effect on the saturated response shut off.

8 ng infection, when host protein synthesis is shut off.

9 al mRNAs culminating in host transcriptional shut off.

10 in no longer is required and the gene can be shut off.

11 rgo ringdown decays when the cavity input is shut off.

12 ormally limits the rate of phototransduction shut-off.

13 or a strain where expression of Myo1p can be shut-off.

14 l a specific stimulus commands a coordinated shut-off.

15 thogen and a paradigm for virus-induced host shut-off.

16 prA interaction with ComE altered competence shut-off.

17 ontrol loop model that is proposed to aid in shutting off ABA signal transduction, to counteract leak

18 receptors bind ethylene, their signaling is shut off, activating responses.

19 to neuronal cell death, indicating that the shut-off aerobic glycolysis is essential for neuronal su

20 the first few days of differentiation and is shut off after 1 to 2 weeks.

21 First, when receptor synthesis is shut off, akr1 delta cells retain the ability to mate lo

22 nces in the rates at which PAR1 and PAR4 are shut off allow thrombin to trigger intracellular signali

23 uption to enhance NMJ stability, and is then shut off allowing NMJ disassembly during persistent cyto

24 -/-) cells in which the myogenic program was shut-off altogether, showed that p38 activity is critica

25 econd, signalling activities display a rapid shut off and a slower adaptation during which responsive

26 In turn, MYC is shut off and degraded, releasing TOP1 and TOP2A from MYC

27 fic mechanisms such as host cell translation shut off and different kinetics of replication organelle

28 ation and rapidly declining when the origins shut off and neighboring promoters turn on.

29 activated cells, host DNA synthesis is then shut off and replaced with virus DNA synthesis.

30 phorylation and arrestin binding, transducin shut-off and calcium feedback has revealed their respect

31 of chromosomal intertwines, transcriptional shut-off and complete segregation of chromosomes.

32 roarray analysis revealed host transcription shut-off and identified three temporal classes of phage

33 hosphate-responsive element-binding protein) shut-off and nuclear accumulation of class IIa histone d

34 Fah does not execute host transcription shut-off and relies on host RNA polymerase (RNAP) sigma(

35 sing knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two diff

36 ng the interaction between protein synthesis shut-off and virus control in chickens.

37 Finally, we show how shutting off and turning on the shallow carbonate factor

38 l differentiation, in which Tcf3 is normally shut off, and promote features of the follicle outer roo

39 ate decays, however, the enhanced back ET is shut off, and some of the re-excited electrons relocaliz

40 nic protein, and the subsequent inability to shut off angiogenesis.

41 Here, we describe a double-shut-off approach to deplete yeast cells of Toa1, the la

42 found to be maximal in exponential phase and shut off as the bacteria entered stationary phase, while

43 rains in which msbA synthesis is selectively shut off at 42 degreesC accumulate hexa-acylated lipid A

44 eraction and subvert the immune response are shut off at intermediate levels of CodY activity, while

45 there is a mechanism by which replication is shut off at late times after transfection, which may ref

46 n early event in viral infection and is then shut off at late times.

47 in early myeloid differentiation is abruptly shut off at the level of late progenitors/early differen

48 Vesicle motion is in turn impeded by shutting off axonal actin polymerization, mediated by ni

49 While normal B cells promptly shut off BCL6 when they exit the GC, many GC-derived B-c

50 n of replication, since it might normally be shut off before initiation, and never be limiting, even

51 ome replication, while mioC transcription is shut off before initiation.

52 l of GRK1 accelerated the dim flash response shut off but had no effect on the saturated response shu

53 The SRD has a GAGA tetraloop that is shut off by a Watson-Crick C2658 x G2663 pair.

54 e access to the encapsulated metal oxides is shut off by plugging the SWNT ends with size-matched ful

55 In the dark, the activity of PDE6 is shut off by the inhibitory gamma subunit (Pgamma).

56 n accumulation can be cleared after promoter shut-off by a combination of autophagy and vacuolar prot

57 ucer and activator of transcription 3, TSP-1 shut-off by HGF/SF is prevented solely by inhibiting mit

58 -1) protein ICP27, which contributes to host shut-off by inhibiting pre-mRNA splicing, interacts with

59 Tetracycline can effectively shut off c-Jun overexpression and prevent EC apoptosis.

60 In addition to its role in shutting off cap-dependent host mRNA translation, L(pro)

61 During mitosis, transcription is shut off, chromatin condenses, and most transcription fa

62 to active, phosphorylated GPCRs and thereby shut off 'classical' signalling to G proteins, trigger i

63 ntraction coupling, and ideally this release shuts off completely between heartbeats.

64 , suggesting that free opsin is less able to shut off cone current.

65 es, and previous data suggest that SOCS3 may shut off cytokine activation at the early stages of live

66 ter anomaly was carried to the Labrador Sea, shutting off deep convection.

67 ve demonstrated that cellular translation is shut off during apoptosis; however, details of the mecha

68 AKT to efficiently replicate, yet how AKT is shut off during HCMV infection has remained unclear.

69 shed the acceleration of saturated responses shut off during light adaptation.

70 LF delayed the time taken for these genes to shut off during recovery from heat shock.

71 s of a hormone-coupled molecular switch that shuts off earlier developmental programs to allow for la

72 vations suggest that the microcirculation is shut off early in severe sepsis, allowing the effects of

73 s coding for factors of host gene expression shut-off, enzymes of viral genome replication and expres

74 ha-P dephosphorylation, assessed by a kinase shut-off experiment, progressed normally in Sephin1-trea

75 of mature particles, as measured by promoter shut-off experiments, is normal in the absence of the Br

76 adults with COPD and all persistent strains shut off expression during persistence.

77 ranscription factor to a repressor form that shuts off expression of Shh target genes.

78 ne" diseases was the realization that merely shutting off expression of a disease-encoding transgene

79 apid loss of mating competence observed upon shutting off expression of a TLS mutant form of Kex2p (Y

80 Shutting off expression of the p38a mutant resulted in r

81 ENO was then shut off for 15 min before start of treatment with inhal

82 of G protein signaling' (RGS proteins) help shut off G-protein-mediated signaling by GTPase activati

83 penicillamine (SNAP), a NO donor essentially shut off glucose uptake, and in hearts from ecNOS (+/-)

84 We found that after 1 or 3 weeks of shutting-off hAPP expression, the glomerular circuit was

85 The effects of protein density on response shut-off have not been reported.

86 Failure to shut off histone expression disrupts centromeric chromat

87 d 3C(pro), to process their polyproteins and shut off host cell activities detrimental to virus repli

88 We also show that the viruses fail to shut off host cell polypeptide production.

89 had no effect on the ability of the virus to shut off host cell protein synthesis but did affect viru

90 amp is an ideal target for bacteriophages to shut off host DNA synthesis during host takeover.

91 han MP-12 did in Vero E6 cells and failed to shut off host protein synthesis in Vero cells.

92 Influenza A virus (IAV) infection shuts off host cell gene expression at transcriptional a

93 protein of encephalomyocarditis virus (EMCV) shuts off host cell nucleocytoplasmic trafficking (NCT)

94 n of type I IFNs and IFN-stimulated genes by shutting off host cell macromolecular synthesis, which i

95 its host cell pre-mRNA splicing, effectively shutting off host cell protein synthesis.

96 r surface can respond to immune complexes by shutting off IL-12 biosynthesis, to prevent the Th1-type

97 rods and the acceleration of their response shut off in background light.

98 ld-type virus, whereas protein synthesis was shut off in cells infected with R5103 virus.

99 ssion of a GAL1 promoter-driven KEX2 gene is shut off in MAT(alpha) cells, the TGN becomes depleted o

100 ve cytokines, although IL-17A production was shut off in the course of the infection.

101 though protein synthesis was not prematurely shut off in the human neuroblastoma cell line SK-N-SH, g

102 o-, aphtho-, and enterovirus groups causes a shut-off in cap-dependent translation of cellular mRNAs

103 emonstrate that RNase L drives translational shut-off in response to dsRNA by promoting widespread tu

104 ur study unveils how the rapid translational shut-off in response to stress coordinates with rRNA syn

105 l arrestin is indispensable for rapid signal shut-off in rod photoreceptors.

106 Polyadenylation shut-off in such cells results in a nearly normal ratio

107 This rapid shut-off indicates that the system is reset by an active

108 Interestingly, while IL-2 production was shut off, inhibitory anti-CTLA-4 mAbs permitted inductio

109 )-linked polyubiquitination of MAVS and thus shuts off innate antiviral immune response.

110 vent negative feedback loops that ultimately shut off insulin-dependent glucose uptake in vivo.

111 Our results imply that picornavirus-induced shut-off is not due to an intrinsic inability of p100 to

112 This shut-off is thought to be mediated in part by the proteo

113 mediated conformational switch of HK853 that shuts off its phosphatase activity under acidic conditio

114 The delayed shut-off kinetics of ISG43 mRNA corresponded to an incre

115 We focused on regulators of shut-off kinetics such as Recoverins, Arrestins, Opsin k

116 Thus PAR4 signaling is shut off less rapidly than PAR1, probably due to differe

117 f these GTP-binding proteins is an efficient shut-off mechanism that ensures the decay of the signal.

118 To prevent toxic accumulation, rapid shut-off mechanisms are required.

119 levels of OTUD1 inhibit cancer stemness and shut off metastasis.

120 h of gp55 is produced during T4 infection to shut off middle transcription by direct competition with

121 tion of poly(A)- mRNAs after polyadenylation shut-off might result from an increase in the ratio of r

122 The failure by the PI replicons to shut off minus-strand synthesis was not due to some defe

123 This defect shuts off miR-198 expression in favor of sustained FSTL1

124 of mitophagy altered in Parkinson's disease, shuts off mitochondrial dynamics and inhibits the non-ox

125 ith E. chaffeensis, respectively, which were shut off more rapidly than with LPS stimulation.

126 sis per activated receptor than PAR1 and was shut off more slowly than PAR1.

127 transport of Li ions, while the Li-based SEI shuts off Na-ion transport.

128 ld is predicted to decrease with time and to shut off naturally when the Moon recedes far enough from

129 ursts of transcriptional induction and rapid shut-off not detectable by RNAseq analysis.

130 EPEC barely elicits cytokine production and shuts off nuclear translocation of NF-kappaB p65.

131 recovery phase of phototransduction through shut off of GTP/Talpha-activated PDE.

132 luenza virus infection results in a dramatic shut-off of cellular protein synthesis that is concomita

133 The shut-off of flagellin synthesis in response to CF airway

134 pment (late schizogony), there was a general shut-off of gene expression, although a small set of gen

135 ation factor (eIF)-2 complex, resulting in a shut-off of general translation, induction of apoptosis,

136 deficient states, resulting in translational shut-off of global hepatic protein synthesis, including

137 of this cleavage correlates broadly with the shut-off of host cell protein synthesis in infected cell

138 e basal transcription factor THIIH to induce shut-off of host cell transcription.

139 Coliphage N4 infection leads to shut-off of host DNA replication without inhibition of h

140 due to their inability to prevent host-cell shut-off of protein synthesis caused by hyperphosphoryla

141 1alpha (PP1) and is required to prevent the shut-off of protein synthesis resulting from phosphoryla

142 and found that abd1-ts cells display a rapid shut-off of protein synthesis upon shift to the restrict

143 eIF-2alpha, that it has evolved to preclude shut-off of protein synthesis, and that GADD34 may have

144 pressed by serine withdrawal, which leads to shut-off of SRG1 synthesis.

145 ing that inhibition of NMD induces premature shut-off of TCR-beta rearrangement.

146 It is proposed that Ca(2+)-dependent shut-off of the On bipolar cell transduction current may

147 eting function, sigma(X) mediates the timely shut-off of the pneumococcal competence cycle, preservin

148 rther the role proteolysis of eIF4G plays in shut-off of translation, we altered the 2A cleavage site

149 eformed replicase, thereby resulting in slow shut-off of viral RNA synthesis.

150 d, little is known about how the systems are shut-off once the inducing stress has subsided, except t

151 t that is activated by this protocol rapidly shuts off, or desensitizes.

152 f Escherichia coli to uroepithelial cells is shut off outside the host at temperatures below 26 degre

153 tions, activated a general and dominant CREB shut-off pathway that blocked induction of BDNF expressi

154 at were treated with doxycycline for 3 weeks shut off Pdx1 expression, decreased insulin production,

155 Additionally, indomethacin, which shuts off PGE2 synthesis, and cAMP-blocking reagents fai

156 g Glc addition in the light, C. zofingiensis shuts off photosynthesis within days and accumulates lar

157 We show that TSP-1 shut-off plays an important, extrinsic role in HGF/SF-me

158 it can compensate for radiative cooling and shut off precipitation.

159 In our experimental validation, we report a shut-off pressure of 2 to 8 kPa and run-out flow rate of

160 Using a galactose shut-off procedure, we determined that the half-life of

161 n often includes activation of pathways that shut off protein synthesis and thereby inhibit viral rep

162 In the reticulocyte lysate system the W RNAs shut off protein synthesis through an ability to activat

163 cking general-base capability in this pocket shuts off rescue.

164 As rhodopsin kinase works with arrestin in shutting off rhodopsin after it has been activated by a

165 al), continue to activate phototransduction, shutting off rod circulating current.

166 AML1-ETO quickly shuts off scl expression, and restoration of scl express

167 scP mutant, or in an lcrG mutant effectively shut off secretion.

168 RNase L rapidly degrades all cellular mRNAs, shutting off several cellular processes.

169 nct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) s

170 tion; however, the mechanisms of PAR1 signal shut off still remain unclear.

171 Of 177 selected conditional shut-off strains tested, the virulence of 102 was blocke

172 We propose a so-called shut-off strategy that aims at inhibiting key inflammato

173 pathway deregulates mitochondrial dynamics, shuts off subcellular organelle movements, and prevents

174 As development proceeds deacetylation shuts off switch gene expression to end the critical per

175 The liver, skin, and tail fibroblasts shut off tadpole genes and activate frog genes in the sa

176 tory system, growth arrest can be induced by shutting off Tag expression in the presence of Tc.

177 possibly in combination with transcriptional shut-off that was confirmed for HSP101, ROF1 and GOLS1.

178 explain the ability of the alpha subunit to shut off the activity of the betagamma complex.

179 of the electrons in immediate contact pairs shut off the back electron transfer, whereas excitation

180 To enter into mitosis, cells must shut off the cell cycle inhibitor Wee1.

181 centrations of sodium dodecyl sulfate, which shut off the coalescence mechanism forcing ATPS formatio

182 3 are 87% identical, HSV-2 strains generally shut off the host more rapidly and completely than HSV-1

183 of this similarity, HSV-2 strains generally shut off the host more rapidly and completely than HSV-1

184 lizes kinetochore-microtubule attachments to shut off the spindle checkpoint, suggesting that cells r

185 hips that involved P binding to either G (to shut off the synthesis of P) or M (to stimulate its degr

186 The cold upper atmosphere shuts off the anticipated enhanced-Jeans, hydrodynamic-l

187 onstrated by the finding that angiopoietin-1 shuts off the expression of BMPR1A, a transmembrane prot

188 d a cell autonomous program that temporarily shuts off the insulin gene.

189 egative regulatory mechanism that ultimately shuts off the mating signal downstream of the receptor.

190 the AAA ATPases in the 19 S regulatory cap, shuts off the proteasome through the inhibition of ATPas

191 This system almost totally shuts off the reactions that form undesired CO and CO(2)

192 tical to control the differentiation program shutting off the c-Myc gene in large pre-B cells.

193 l rapidly "extinguished" but by periodically shutting off the current for short time intervals the av

194 accelerating turnover of Mre11 at DNA ends, shutting off the DNA damage checkpoint and allowing cell

195 nsistent with this possibility, we find that shutting off the ectopic expression of germline genes sp

196 Remarkably, shutting off the ectopic germline expression in spr-5; m

197 ding, NADP(+) bends and interacts with D317, shutting off the entrance to create a protected micro-en

198 (F) is sufficient to feminize XY germ cells, shutting off the expression of male-specific markers and

199 e and high quality printing while completely shutting off the nonilluminated counterparts.

200 intrinsic instability of Sda contributes to shutting off the pathway.

201 redistributed stress in southern California, shutting off the production of small earthquakes in some

202 Shutting off the promoter resulted in changes normally a

203 ctivated in the presence of immune complexes shut off their production of IL-12p70 and induced a Th2-

204 share an unexpected intrinsic mechanism for shutting off their action.

205 tly induced upon viral infection and rapidly shut off thereafter.

206 olved mechanisms to rapidly and specifically shut off these beneficial inflammatory activities before

207 or general anesthetics, their brains do not shut off - they just change how they operate.

208 lation of a strong cytotoxic drug completely shut off this unwanted immune response.

209 A key switch in the hypothalamus shuts off this arousal system during sleep.

210 locking the activity of its phosphatase that shuts off those signals.

211 iven transcriptional program must be rapidly shut off to allow two-cell exit and developmental progre

212 n the intestine, and environmental stressors shut off TRA-1 expression in the entire non-gonadal soma

213 ssible Top10 promoter system to specifically shut off transcription of the Fed-1 transgene.

214 impaired the cell's ability to appropriately shut off transcription of the induced ARG1 gene, indicat

215 richia coli, gidA and dnaA transcription are shut off transiently after initiation of chromosome repl

216 cellular compartments where it is unable to shut off translation and repress viral replication.

217 low the replicase copying from the 3' end to shut off translation of upstream ORFs and free the RNA o

218 e idea that a ribosomal protein binds to and shuts off translation of ceruloplasmin mRNA.

219 ing host cell antiviral pathways that act by shutting off translation.

220 trfAp is very strong and shuts off trbAp activity until trfAp is inhibited by Kor

221 al trafficking to the cortical cytoskeleton, shuts off tumor cell migration and invasion, and inhibit

222 or pharmacological targeting of this pathway shuts off tumor cell motility and invasion, kills Myc-ex

223 nts via interaction with RecA and competence shut-off via interaction with ComE, avoiding physiologic

224 ed these processes but subsequently acted to shut off viral gene expression and replication after the

225 age of a temperature-sensitive polymerase to shut off viral transcription, and we demonstrate that SI

226 ales, high sustained activity of SAG neurons shuts off vitellogenesis via continuous activation of th

227 expression had been induced and subsequently shut off were able to persist in vivo and reinitiate leu

228 ermits NO signalling, and this signalling is shut off when Hb alpha is reduced to the Fe(2+) state by

229 lity to nucleate microtubules is selectively shut off while maternal centrosomes remain competent to

230 irradiation with violet light, which can be shut off with green light.

231 cadBA expression was shut off within 4 min following a shift from acidic to n

232 osuppressed state with all Ty1-related genes shut off, without uncoordinated or mosaic expression in

233 cell division and the processes involved in shutting off YneA activity.

234 ctivation is a specific regulatory system to shut off zinc uptake activity in cells exposed to high e