ライフサイエンスコーパス: shutdown

1 ence of hypercoagulability and fibrinolytic "shutdown".

2 re significant again for those deployed post-shutdown.

3 romatin, resulting in global transcriptional shutdown.

4 ng the molecular mechanisms that mediate its shutdown.

5 tylation events correlate with induction and shutdown.

6 ient deprivation by reversible translational shutdown.

7 tive to PM extract acquired during the plant shutdown.

8 e II (RNAPII), and genome-wide transcription shutdown.

9 ving healthy workers stay at home during the shutdown.

10 ing ribosome run-off and orderly translation shutdown.

11 c apoptosis critical for neutrophil function-shutdown.

12 ption-dependent DNA damage and transcription shutdown.

13 al cell-cell communication failure and organ shutdown.

14 ted stress response and profound translation shutdown.

15 March 15 mandated COVID-19 pandemic societal shutdown.

16 protecting IFN expression from translational shutdown.

17 st and viral RNAs and inducing translational shutdown.

18 resistant to the stress-induced translation shutdown.

19 s MCL-1 and BCL-xL as sensors of translation shutdown.

20 ry molecular state following a proliferation shutdown.

21 al responses that result in host translation shutdown.

22 Severe TBI is associated with sustained shutdown.

23 on of the CME machinery does not account for shutdown.

24 near the outflow declined by 46% during the shutdown.

25 utical interventions, such as distancing and shutdowns.

26 drial dysfunction and the level of metabolic shutdown (analogous to a hibernation-type response), see

27 These data suggest that protein synthesis shutdown and apoptosis are separate responses of Ld652Y

28 ossible connection between protein synthesis shutdown and apoptosis, a series of recombinant AcMNPVs

29 without activating PKR-mediated translation shutdown and cell death.

30 sA and RNase I, acting on rRNA transcription shutdown and degradation, which abolished the formation

31 Both groups exhibited renal shutdown and died in 57 hours or less.

32 virus, is able to preclude protein synthesis shutdown and ensure production of AcMNPV progeny in Ld65

33 -infected cells do not undergo translational shutdown and fail to establish an antiviral state during

34 s-subunit reaction enabled complete activity shutdown and feed-forward inhibition of further T286 pho

35 35 was translated prior to protein synthesis shutdown and functioned to prevent apoptosis.

36 ing tumor vasculature, which causes vascular shutdown and leads to cancer cell death and necrosis.

37 e is registered via parallel transcriptional shutdown and Polycomb-dependent epigenetic silencing of

38 nction at lower levels of primary production shutdown and possess a lower collapse threshold than Cam

39 gene expression patterns caused by a general shutdown and reprogramming of protein synthesis.

40 The molecular mechanisms governing orderly shutdown and retraction of CD4(+) type 1 helper T (T(H)1

41 ng total procedure counts during the initial shutdown and subsequent COVID-19 surge with correspondin

42 ume during the 2020 initial COVID-19-related shutdown and subsequent fall and winter infection surge

43 n a specific order, allowing for coordinated shutdown and subsequent reinstatement of photosynthesis.

44 e replenishment induces CSR2 transcriptional shutdown and switches Csr2 to an inactive, deubiquitylat

45 reactive oxygen species that cause vascular shutdown and tumor cell death.

46 response to transient operating conditions (shutdowns and startups).

47 avirus disease (COVID-19) pandemic and that "shutdowns" and "social distancing" impeded access to soc

48 esponse is accompanied by increased vascular shutdown, and erlotinib increases the in vitro cytotoxic

49 support corrosion during vehicle startup and shutdown, and platinum dissolution during vehicle accele

50 th programs, proinflammatory signaling, host shutdown, and the innate immune response.

51 messenger RNA (mRNA) following transcription shutdown are linked by sharing the same sequence element

52 plan for the next possible COVID-19-induced shutdown as well as other large-scale pandemics and emer

53 n unusually wet February before the COVID-19 shutdown began in mid-March 2020.

54 This signal leads to global translational shutdown, but it also enables translation of the transcr

55 ithin 30 s, explaining the rapid translation shutdown, but mRNAs remained stable.

56 etermine the dynamics of FLC transcriptional shutdown, but the thermosensory mechanisms are still unr

57 ntly different for males deployed during the shutdown, but they were significant again for those depl

58 sts in an exaggerated CD4(+)Tem response and shutdown by apoptosis.

59 Consequently, the translational shutdown by NSP14 abolishes the type I interferon (IFN-I

60 24 to 26%) in Sweden and, as a result of the shutdown, by 4 additional percentage points (95% CI: 3 t

61 However, translation shutdowns caused by either proteolytic cleavage of eIF4G

62 an areas were substantially lower during the shutdown, characteristic of traffic in the mid-1950s.

63 P(-) cell populations were isolated from the shutdown clones, they quickly reverted to the original d

64 ing gene expression under global translation shutdown conditions.

65 Moreover, this shutdown could be closely coupled to fatty acid degradat

66 t February and before the mid-March COVID-19 shutdown, cumulative burned area was approaching record

67 control sites, 3 years before and after the shutdown date.

68 of pairs of pressure sensors for shutdown/no shutdown decisions, we apply a similar test to sensor pa

69 we conclude that endocytosis is temporarily shutdown during early mitosis.

70 After the initial shutdown, during the ensuing COVID-19 surge, surgical pr

71 HRF-1 prevented protein synthesis shutdown even when the cells were undergoing apoptosis,

72 n (BF) produced an initial transient network shutdown followed by diminished auditory responsiveness

73 id transcriptional activation and subsequent shutdown for the genes encoding transformation proteins.

74 nces recruit repressor machinery to actively shutdown gene expression.

75 ibition of Cdk9, cells with NELF efficiently shutdown gene transcription, while in NELF-depleted cell

76 This shutdown has adversely affected research infrastructure,

77 terruption of experimental productivity, the shutdown has proven for many PIs and trainees that doing

78 Furthermore, the shutdowns have solidified important emerging trends and

79 The PKR-induced translational shutdown helps host cells to establish an antiviral stat

80 In 2020, measurements collected during the shutdown in activity related to the COVID-19 pandemic in

81 ly reduced T helper 2 gene connectivity, and shutdown in co-expression activity between T helper 2 ef

82 that inactivation of TolC triggers metabolic shutdown in E. coli cells grown in minimal glucose mediu

83 It causes reversible vascular shutdown in established tumors in vivo, consistent with

84 functional hypertrophic adipocytes, a global shutdown in gene expression, along with elevated stress

85 We also observed a mitochondria shutdown in infected cells and mitochondrial swelling in

86 d block both apoptosis and protein synthesis shutdown in Ld652Y cells infected with p35 mutant AcMNPV

87 lymph nodes (LNs), coupled with a transient shutdown in lymphocyte exit, results in dramatic cellula

88 When soils were dry, however, the shutdown in plant N uptake, along with the activation of

89 Profiles for males deployed pre-shutdown in receiving water were significantly different

90 eviously unknown mechanism for translational shutdown in response to viral infection and identify mTO

91 The VTAs cause a rapid shutdown in the blood supply to the tumor that kills tum

92 some shed light on the mechanism of ribosome shutdown in the human pathogen S. aureus and might deliv

93 mg/kg i.p.) produced a preferential vascular shutdown in the tumor tissue at 2 and 6 h, leading to ma

94 of O(3) changes resulting from the economic shutdown in the United States on soybean crop yields for

95 othelial cells in vitro and induces vascular shutdown in tumor models in vivo.

96 eries, K(TdR) measurements showed a complete shutdown in tumor proliferation in patients in whom FDG

97 l tissue endothelia to induce acute vascular shutdown in tumors.

98 of type I IFN production followed by a rapid shutdown in vitro in equine endothelial cells (EECs).

99 mutant AcMNPVs but not the protein synthesis shutdown in wild-type AcMNPV-infected Ld652Y cells.

100 the innate immune system are known to cause shutdown, including interferon alpha/beta (IFN-alpha/bet

101 rrosion induced during fuel cell startup and shutdown is a far more potent failure mode than platinum

102 Fibrinolysis shutdown is common postinjury and predicts poor outcomes

103 eat shock of p68 homozygotes, and hsp70 gene shutdown is delayed.

104 In this study, we show that the mitotic shutdown is due to an unmet requirement for actin in CME

105 ctively, our findings imply that translation shutdown is indifferent to the specific initiating patho

106 till delayed in these mutants; however, CUP1 shutdown is normal.

107 The shutdown is not gradual: We describe a binary switch fro

108 This cellular shutdown is temporarily regulated, and during hypoxic ex

109 hese data indicate that CUP1 transcriptional shutdown, like induction, is an active process controlle

110 t is then a challenge to achieve an adequate shutdown margin throughout the core life while maintaini

111 This shutdown may increase an organism's susceptibility to se

112 Pre- and post-COVID-19 pandemic societal shutdown measures.

113 ranscriptionally by preventing translational shutdown mediated by the double-stranded RNA (dsRNA)-act

114 r domains and the light chains stabilize the shutdown molecule.

115 ing multiple periods (pre-, during, and post-shutdown) near the outflow for a wastewater treatment pl

116 to readings of pairs of pressure sensors for shutdown/no shutdown decisions, we apply a similar test

117 Rapid RNAP2 eviction, transcriptional shutdown, nucleosome invasion, and reduced transcription

118 olve the puzzle of the lack of translational shutdown observed in hantavirus-infected cells.

119 Transcriptional shutdown occurs concurrently with the induction of promo

120 began a bold experiment involving the total shutdown of a 500-bed state hospital.

121 facultative heterochromatin), and the stable shutdown of a developmentally regulated gene (developmen

122 sed metabolomic study was conducted during a shutdown of a pulp and paper mill (PPM) to assess the im

123 tor activity is also required for the proper shutdown of a subset of type I interferon-stimulated gen

124 rculosis (Mtb) is ensured by the coordinated shutdown of active metabolism through a broad transcript

125 nhances Ag presentation to T cells without a shutdown of Ag processing, allowing continued sampling o

126 mic control comparable to that of a complete shutdown of all airline travel.

127 We found that acute shutdown of all three D-cyclins in bone marrow of adult

128 Here we perturb the timing of the shutdown of Bicoid (Bcd)-dependent hunchback (hb) transc

129 Additionally, it causes a complete shutdown of both gonadotropins secretion.

130 d with the P/V-CPI(-) mutant show an overall shutdown of both host and viral translation at late time

131 Remarkably, prednisone induces a shutdown of bypass RTK signaling and inhibits key resist

132 Shutdown of CaCSE4 expression resulted in a sharp declin

133 M45 induces the degradation of NEMO and the shutdown of canonical NF-kappaB activation.

134 We observed rapid shutdown of carbon fixation in chloroplasts after SIPK/N

135 plicing followed by complete transcriptional shutdown of CD34.

136 g chemical genetic systems that enable acute shutdown of CDC7 in cultured cells and in live mice.

137 ession of PS as a component of the regulated shutdown of cellular function that permits hibernating g

138 rs appear to be a component of the regulated shutdown of cellular functions that permits hibernating

139 n undifferentiated cells, SV induced a rapid shutdown of cellular protein synthesis and pE2 was effic

140 In differentiated cells, the SV-induced shutdown of cellular protein synthesis was transient and

141 While DNA-damaging agents trigger the shutdown of co-transcriptional chromatin-associated 3'-e

142 OVID-19 pandemic initially led to the abrupt shutdown of collegiate athletics until guidelines were e

143 Further, the sudden shutdown of core facilities in response to the COVID-19

144 Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associat

145 we have traced this auxotrophy to a complete shutdown of cys-3+ gene expression.

146 line progression is most consistent with the shutdown of DC instead of MSCI, resulting in half gene d

147 litate host-mediated repair before the viral shutdown of DNA damage responses.

148 eas increased RIP1 level leads to a complete shutdown of DNA damage-induced p53 induction by enhancin

149 Aptazyme-mediated shutdown of E1A expression translates into inhibition of

150 ong-standing paradigm in cell biology is the shutdown of endocytosis during mitosis.

151 n receptor at the cell surface, and not to a shutdown of endocytosis.

152 a decline of the ATP level and followed by a shutdown of energy-consuming processes.

153 he FLC locus and accelerates transcriptional shutdown of FLC during cold exposure.

154 on of cyclin kinase inhibitor activity and a shutdown of G1 kinase activity.

155 suggest that insect diapause is not merely a shutdown of gene expression but is a unique, development

156 f mRNA transcription, thereby amplifying the shutdown of gene expression.

157 ars to be ideally positioned to enable rapid shutdown of genes associated with metabolism and growth

158 The progressive shutdown of HIV transcription following infection sugges

159 of D10 synthesis correlates better with the shutdown of host gene expression, and deletion of this g

160 f host mRNAs, can contribute to the profound shutdown of host protein synthesis and blunting of antiv

161 s has previously been shown to result in the shutdown of host protein synthesis, cell rounding, and c

162 plicative lefs also abrogated AcMNPV-induced shutdown of host protein synthesis, suggesting that viru

163 encodes two key proteins that antagonize the shutdown of host translation, US11 through preventing PK

164 ugh the CD4(+)CD8(+) stage involved a global shutdown of housekeeping genes that is rare among cells

165 Upon shutdown of Hoxb8 expression, near-unlimited numbers of

166 tential to differentiate into basophils upon shutdown of Hoxb8 expression.

167 lation of CD4(+) T cell apoptosis during the shutdown of immune responses is not fully understood.

168 preBotC neurons did not mimic the premature shutdown of inspiratory activity caused by water swallow

169 pan was shortened, results suggesting that a shutdown of insulin signaling prompts activation of the

170 In particular, shutdown of interleukin 2 (IL-2) in the highly Th1 cell-

171 eappearance of an organized cytoskeleton and shutdown of K-Ras activity.

172 gh adaptive programs that include reversible shutdown of key cellular processes, the formation of str

173 argeted inhibition of AEG1 might lead to the shutdown of key elemental characteristics of HCC and cou

174 e downregulation is not caused by the global shutdown of kinesin-1, as the ability of kinesin-1 to tr

175 o fundamental prerequisites is required: (i) shutdown of larval development by exposing larvae to low

176 ay lead to critical stroke outcomes due to a shutdown of leptomeningeal collaterals.

177 nano-scale respiratory virus and led to the shutdown of macro-scale economies.

178 Hypoxia (oxygen limitation) triggers the shutdown of major cellular processes, including gene exp

179 d by COVID-19, including school closures and shutdown of many childhood recreational activities.

180 ent on either MET or EGFR combined to create shutdown of many programs vital to hepatocytes.

181 hat Mdm30 interacts with Sub2, and temporary shutdown of Mdm30 enhances Sub2's abundance and impairs

182 We conclude that the shutdown of membrane ion currents by elevated pi(o) is n

183 ection of PI cells with wt SFV triggered the shutdown of minus-strand synthesis, which we believe is

184 in naturally aged cells, leading to a robust shutdown of mitophagy.

185 vation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arr

186 racellular retention or a global or specific shutdown of mRNA or protein synthesis.

187 a support the idea of a glacial weakening or shutdown of North Atlantic Deep Water production, wherea

188 This unsolved cellular stress resulted in a shutdown of overall host cell protein translation, mitoc

189 ations do not necessarily require a complete shutdown of overturning.

190 se is modulated by GPD2, which coordinates a shutdown of oxidative metabolism; this limits the availa

191 cted much of Italy on 28 September 2003: the shutdown of power stations directly led to the failure o

192 The coordinated shutdown of PPP and glycolysis leads to metabolic gridlo

193 During the shutdown of proliferation and onset of differentiation o

194 cient cells of each type have been produced, shutdown of proliferation and removal of excess cells.

195 le gene 153 (GADD153) that culminates in the shutdown of protein synthesis and apoptosis.

196 ism connecting mitochondrial stress with the shutdown of protein synthesis and broadens our understan

197 ond to viral infection and contribute to the shutdown of protein synthesis.

198 ts leads to increased persistence via global shutdown of protein synthesis.

199 arm of this pathway results in the transient shutdown of protein translation, through phosphorylation

200 that promotes virus production by preventing shutdown of protein translation.

201 s can accumulate by Muller's ratchet after a shutdown of recombination, as in an evolving Y chromosom

202 hritis into end-stage disease coincides with shutdown of renal DNaseI expression in (NZBxNZW)F1 mice.

203 ing bacterial sepsis and identify the global shutdown of renal protein translation mediated by the eu

204 ad.RFC may clear PCNA from DNA to facilitate shutdown of replication in the face of DNA damage.

205 ional role of Rv1738 is to contribute to the shutdown of ribosomal protein synthesis during the onset

206 t1, eviction of RNAPIII was reduced, and the shutdown of ribosome biogenesis genes was impaired upon

207 mutually exclusive relationship facilitates shutdown of sense FLC transcription in cis.

208 -level reconfiguration involving the partial shutdown of some but not all organs.

209 -modified lymphocytes persisted in vivo, the shutdown of TCR transgene expression was observed.

210 ls during the agonist-evoked response caused shutdown of the additional conductance; (iii) when appli

211 Snail2 knockdown, preventing transcriptional shutdown of the adhesion molecule Cad6b (Cadherin6b), th

212 ggests that, in order to ensure an effective shutdown of the apoptotic pathway, TNF induces multiple

213 the presence of Li dendrites and leading to shutdown of the battery before the dendrites become dang

214 e initiation was observed after the societal shutdown of the COVID-19 pandemic (risk ratio, 0.86; 95%

215 rease in apoE expression was due to cellular shutdown of the cytomegalovirus promoter.

216 tiation, which is essential for the complete shutdown of the ESC gene expression program and the tran

217 olytic lymphocytes in general, may involve a shutdown of the genes for these proteins.

218 ions are associated with the nearly complete shutdown of the hydrological cycle.

219 is caused by subsurface warming through the shutdown of the Labrador Sea open-ocean deep convection,

220 arent body, capturing the decay and eventual shutdown of the magnetic field as core solidification co

221 ascribed to the aftermath of almost complete shutdown of the ocean ecosystems for millions of years d

222 ll-like intermediate supported by incomplete shutdown of the pluripotency network.

223 nd in 2012-2015 coincided with the permanent shutdown of the reactors after the accident in 2011.

224 The shutdown of the Shenango coking plant, a significant fos

225 sponsive genes, thereby favoring a sustained shutdown of the synthesis of host cell proteins while th

226 cruitment could be responsible for a gradual shutdown of the undesirable Th2 arm of the immune respon

227 minks in Denmark and resulted in a complete shutdown of the world's largest mink production.

228 Ubiquitination was not required for the shutdown of these processes or for stress granule format

229 atory loops that fine-tune the timing of the shutdown of this highly conserved pathway.

230 Shutdown of this translation mechanism might selectively

231 tiple phosphorylation targets for the global shutdown of transcription at mitosis.

232 sults indicated that an essentially complete shutdown of transcription occurs upon temperature shift

233 RNAPII degradation results in a shutdown of transcriptional initiation, in the absence o

234 taining a 5'-GC-3' sequence causing a global shutdown of translation and the cell to enter a state of

235 and double-stranded RNA and thus prevent the shutdown of translation by a mechanism that differs from

236 ggesting that the growth defect stems from a shutdown of translation.

237 trinsic resistance of CTSL to stress-induced shutdown of translation.

238 Histology also confirmed shutdown of tumor vascular perfusion.

239 First, the long-term shutdown of tumour blood vessels by the anti-angiogenesi

240 through the FcR is not mediated by a global shutdown of tyrosine phosphorylation but is, rather, a s

241 atin condensation either by blocking mitotic shutdown of U1 and U2 snRNA transcription or by phenocop

242 actors from the promoter plays a role in the shutdown of U2 gene transcription in mitosis.

243 , causing inhibition of mRNA translation and shutdown of viral protein production.

244 nd strength as well as realistic buildup and shutdown of wind burst activity in the western Pacific.

245 Stay-at-home orders and shutdowns of non-essential businesses are powerful, but

246 altering interactions between genes through shutdown or activation of pathways.

247 not undergo further testing because of case shutdown or insufficient sample quantity.

248 During the initial shutdown, otolaryngology (ENT) procedures (IRR, 0.30; 95

249 adaptive anger/fight, fear/panic, depression/shutdown, pain, and predatory behaviors in response to c

250 otal number of procedures during the initial shutdown period and its corresponding period in 2019 (ie

251 to interventions can be overcome by a longer shutdown period and vice versa to arrive at similar epid

252 This study found that the initial shutdown period in March through April 2020, was associa

253 ns, CCHFV does not induce a host translation shutdown, posing the question of how its mRNAs are effic

254 also guides the user through the startup and shutdown procedures, provides a continuous update on the

255 ining the CBF1 gene under the influence of a shutdown promoter (tetO-ScHOP) arrested their growth aft

256 a route to decrease Co losses during device shutdown protocols.

257 surgical procedure volume during the initial shutdown (r = -0.00025; 95% CI, -0.0042 to -0.0009; P =

258 ivirus-infected cells showed a wide range of shutdown rates, with the majority showing a 50% silencin

259 ansgene and mRNA, suggesting a translational shutdown rather than a loss of transduced hepatocytes.

260 Stress induced-translational shutdown recruits the MSC to stress-granules, a depot fo

261 However, the mechanisms regulating this shutdown remain unclear.

262 Some shutdowns remain in place, yet the extent of the needs o

263 nversion to compete with normal operation or shutdown, respectively, of an existing NGCC power plant.

264 is involved in inducing a protein synthesis shutdown response in the absence of late viral gene expr

265 Although this shutdown response may be necessary for energy preservati

266 ss, with reversible cellular changes, and a 'shutdown-restart' physiological and transcriptomic progr

267 Consistent with general translation shutdown, ribosomal proteins contacting the mRNA showed

268 erfibrinolysis (HF; LY30 >/=3), fibrinolysis shutdown (SD; LY30 </=0.8), and normal (LY30 = 0.9-2.9)

269 f hyperfibrinolysis (LY30 >=3), fibrinolysis shutdown (SD; LY30 <=0.8), and physiologic (LY30 = 0.9-2

270 port a cryo-electron microscopy structure of shutdown smooth muscle myosin with a resolution of 6 ang

271 A delayed shutdown specifically increases Bcd-activated hb levels,

272 ow the regulatory light chains stabilize the shutdown state in different ways and how their phosphory

273 egulatory light chain promotes an inactive, 'shutdown' state with the filament-forming tail folded on

274 This shutdown structure is relevant to all isoforms of myosin

275 n, suggesting that it provides an "emergency shutdown" system to regulate metabolism in response to d

276 ities attempt to reopen following periods of shutdown, the detection of both SARS-CoV-2 and specific

277 slated into an extended period of lymph node shutdown, the induction of IFN-gamma-positive T cells, a

278 anti-angiogenesis agent, causing a vascular shutdown; the inner nanoparticle, which is trapped insid

279 on factor eIF2alpha and causes translational shutdown to create roadblocks for the synthesis of viral

280 prevents the PKR-induced host translational shutdown to ensure the continuous synthesis of viral pro

281 l infection, how cells balance translational shutdown to limit viral replication and the induction of

282 orghum activates a swift and robust stomatal shutdown to preserve leaf water content when water stres

283 e spikes reverse this process, buffering FLC shutdown to prevent premature flowering.

284 e thymocytes, increased apoptosis, or thymic shutdown to prevent tolerance to the pathogen from devel

285 Furthermore, we predict a fibrinolytic shutdown via endothelial upregulation of SERPINE1/PAI-1.

286 To circumvent stress-induced translational shutdown, viruses encode ISR antagonists.

287 The Wuhan shutdown was associated with the delayed arrival of COVI

288 st effective agents, dose-dependent vascular shutdown was demonstrated using dynamic bioluminescence

289 or example, 3-season operation with a winter shutdown was favored to avoid high greenhouse gas emissi

290 However, the long-term vascular shutdown was mediated by thrombus formation, as evidence

291 HF without associated shutdown was not related to poor outcome, but extreme HF

292 Area before and during the recent statewide shutdown, we evaluated whether a common songbird respons

293 ntrast, serine mutations in H2A prevent CUP1 shutdown when combined with spt10 deletions.

294 ad to unnecessary food recalls or production shutdowns, while low sensitivity resulting in false nega

295 enotype also exhibited an exaggerated immune shutdown with heightened sensitivity to activation-induc

296 many VOCs decreased significantly during the shutdown with variations in daily patterns reflective of

297 ied by site (from a 33% increase to complete shutdown), with sites that experienced the largest reduc

298 OTCH1 signaling in T-ALL induces a metabolic shutdown, with prominent inhibition of glutaminolysis an

299 ls, yet in practice one hopes that a partial shutdown would suffice.