ライフサイエンスコーパス: sialic acid

1 ar PL, terminating in mainly alpha2,3-linked sialic acid.

2 ormation of C5-azido analogue of 3-fluoro(a)-sialic acid.

3 olation and in complex with a 9-O-acetylated sialic acid.

4 conditions, such as the availability of free sialic acid.

5 rictly require the canonical EV-D68 receptor sialic acid.

6 ith its physiological substrates CMP and CMP-sialic acid.

7 reatment, which removes cell surface anionic sialic acid.

8 ot for unattached small-molecule cleavage of sialic acid.

9 el binding of T3SA(-), which does not engage sialic acid.

10 ved for both alpha-2,3- and alpha-2,6-linked sialic acid.

11 structures and PL structures with or without sialic acid.

12 ion enhances the capacity of CV-A24v to bind sialic acid.

13 ccus sanguinis, binds platelets via terminal sialic acid.

14 minidase (NA) with the cell surface receptor sialic acid.

15 ligosaccharide chain containing at least one sialic acid.

16 predominantly terminated in alpha2,3-linked sialic acid.

17 generally containing 0 or 1 alpha2-6-linked sialic acid.

18 strain T3SA(+), which is capable of engaging sialic acid.

19 ere adopted to resolve positional isomers of sialic acids.

20 sialic acids and human-like alpha 2,6-linked sialic acids.

21 is due to differences in erythrocyte surface sialic acids.

22 spectrum of glycans with alpha2,6/8/9-linked sialic acids.

23 antify the linkage (i.e., 2-3 versus 2-6) of sialic acids.

24 reincubation with synthetic alpha-2,3-linked sialic acids.

25 lack PL and are enriched in alpha2,6-linked sialic acids.

26 nthesis of such glycans, especially 3-fluoro-sialic acid (3F-Neu5Ac) containing sialosides, has been

27 ycan-based receptors carrying 9-O-acetylated sialic acid (9-O-Ac-Sia).

28 tors, whereas the others employ O-acetylated-sialic acid (a key feature of metallopeptidases) for ent

29 alpha2-3-linked sialic acid accounts for <20% of total sialic acid and i

30 Pasteurella multocida sialic acid aldolase (PmAldolase), but not its Escherich

31 ttachment protein binds to both alpha-linked sialic acid (alpha-SA) and JAM-A cell-surface receptors.

32 e-treated IgG lacking the Fc glycan terminal sialic acid also raised BP.

33 CMP-sialic acid analogs (CMP-nonulosonates [CMP-NulOs]) such

34 acid supplementation using a cell-permeable sialic acid analogue (Ac(5)Neu5Ac) boosted GD2 expressio

35 Our findings reveal that sialic acid analogues and HDAC inhibitors enhance GD2 ex

36 chemoenzymatically synthesized 3-fluoro(a/e)-sialic acid analogues were purified and chemically deriv

37 endence from well-characterized ephrinB2/B3, sialic acid and CD150-mediated entry pathways.

38 Injecting fluorophore-tagged sialic acid and fucose into the yolk of zebrafish embryo

39 etermine the role of known EV-D68 receptors, sialic acid and intracellular adhesion molecule 5 (ICAM-

40 inked sialic acid accounts for <20% of total sialic acid and is predominantly expressed on VWF O-glyc

41 acid binding is specific for alpha2-3-linked sialic acid and mediated by the exposed apical loops of

42 on, we assembled a five-member consortium of sialic acid and N-acetylglucosamine utilizers that imped

43 , which cleaved any terminal alpha2-3-linked sialic acid and underlying galactose yielding a terminal

44 sent in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosamin

45 erties to extant parvoviruses and also bound sialic acids and entered rodent cells.

46 Vs bound to both avian-like alpha 2,3-linked sialic acids and human-like alpha 2,6-linked sialic acid

47 ther nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth i

48 the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyz

49 assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were presen

50 ers in anammox granular sludge, focussing on sialic acids and sulfated glycosaminoglycans.

51 ors such as neuropilins, heparan sulfate and sialic acids and the putative alternative receptors, suc

52 ould catalyze the synthesis of 3-fluoro(a/e)-sialic acids and their C-9 analogues although PmAldolase

53 identify fucose, galactose, alpha2-6-linked sialic acid, and bisected N-acetylglucosamine, respectiv

54 N-glycan compositions with bisecting GlcNAc, sialic acid, and core fucosylation showed significant di

55 position (total protein, DNA, mucin content, sialic acid, and immunoregulatory proteins), as well as

56 he anti-phagocytic effect of alpha2,6-linked sialic acid, and inhibition of CD22 promotes the clearan

57 glycan structures containing alpha2-6-linked sialic acid are easily separated, detected, and quantifi

58 Sialic acids are a family of related sugars that play es

59 cells lining the human airway where terminal sialic acids are attached in the alpha2-6 configuration

60 where distributions of alpha2,3 and alpha2,6 sialic acids are critical for cell performance.

61 Sialic acids are found as the distal terminal sugar on g

62 od, by which alpha-2,6- and alpha-2,3-linked sialic acids are sequentially labeled with methylamide i

63 a1, which mediate cell surface expression of sialic acid, are required in murine microglial cells for

64 Like other polyomaviruses, MCPyV engages sialic acid as a (co)receptor.

65 pathogenic bacteria metabolize host-derived sialic acid as a nutrient source.

66 s enter epithelial cells of the airway using sialic acid as a receptor and cause only mild disease.

67 Although bacteria can use free sialic acids as a nutrient source(10-12), it is currentl

68 The family of NulOs includes the sialic acids as well as the prokaryote-specific NulOs.

69 e optimal collision energy for the m/z 290.1 sialic acid B-fragment differed consistently between sia

70 In addition to sialic acid, bacteria have the ability to biosynthesize

71 s much more effective than NanH3 in cleaving sialic acids bearing a 9-O-acetyl ester.

72 cally, nanodiscs carrying the viral receptor sialic acid bind to influenza virions and are co-endocyt

73 pared with the full-length HA with abolished sialic acid binding activity, with limiting Tfh cell eli

74 contacts, we observed a >1000-fold change in sialic acid binding affinity.

75 We confirmed a role for FapC in sialic acid binding by demonstrating that the parental s

76 residue previously shown to be essential for sialic acid binding did not decrease bacterial adhesion,

77 ararubulaviruses only recently diverged from sialic acid binding functionality.

78 A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal

79 While sialic acid binding is specific for alpha2-3-linked sial

80 ne response to the functionally important F1 sialic acid binding pocket improves the protective immun

81 CD22, a member of Siglec family of sialic acid binding proteins, has restricted expression

82 ne of the antibodies, L4A-14, bound into the sialic acid binding site and made contacts with haemaggl

83 ucture contains an artificial peptide in the sialic acid binding site.

84 nteractions, and that FapC may contribute to sialic acid binding.

85 However, the underlying mechanisms linking sialic acid-binding and function remain unknown.

86 e structure reveals a novel position for the sialic acid-binding attachment domain in the intact spik

87 Our studies revealed that the sialic acid-binding domain at the N terminus of the S1 s

88 CD22 and sialic acid-binding Ig-like lectin (Siglec)-G are member

89 N and type I IFN-stimulated genes, including sialic acid-binding Ig-like lectin 1 (Siglec-1), a recep

90 CRP), ILT-4, C-C motif ligand 18 (PARC), and sialic acid-binding Ig-like lectin 14 (SIG14) were signi

91 Siglec-15 is a conserved sialic acid-binding Ig-like lectin, which is expressed o

92 CD22, a sialic acid-binding Ig-type lectin (Siglec) family membe

93 Finally, using StcE, we discovered that sialic acid-binding Ig-type lectin-7 (Siglec-7), a glyco

94 Sialic acid-binding Ig-type lectins (Siglecs) are cell s

95 Sialic acid-binding immunoglobulin-like lectin (Siglec)

96 Sialic acid-binding immunoglobulin-like lectin (Siglec)-

97 Sialic acid-binding immunoglobulin-like lectins (Siglec)

98 endogenous binding partners of sialic acids, sialic acid-binding immunoglobulin-like lectins (Siglecs

99 I Fc receptors, C-type lectin receptors, and sialic acid-binding immunoglobulin-like lectins.

100 Sialic acid-binding immunoglobulin-type lectins (Siglecs

101 Sialic acid-binding immunoglubulinlike lectin 9 (Siglec-

102 site inaccessible to antibodies, that the F2 sialic acid-binding pocket contains a nonneutralizing ep

103 low potency, while antibodies targeting the sialic acid-binding pocket cover narrower breadth but us

104 of F1 is essential for binding, whereas the sialic acid-binding pocket in F2 appears dispensable.

105 s revealed that the functionally relevant F1 sialic acid-binding pocket is a privileged site inaccess

106 The sialic acid-binding pocket of F1 is essential for bindin

107 s reside in F1 on the opposite face from the sialic acid-binding pocket.

108 conserved sites in the stem region or to the sialic acid-binding pocket.

109 CD33 (Siglec-3) is a transmembrane sialic acid-binding receptor on the surface of microglia

110 d site-directed mutagenesis, and found a new sialic acid-binding region (site 2 containing R67) in ad

111 its interaction with the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which

112 alidases would provide distinct paradigms in sialic acid biochemistry.

113 Inhibition of the sialic acid biosynthesis may therefore hold considerable

114 ate (ManNAc-6-P), a critical intermediate in sialic acid biosynthesis.

115 fast macrocycle threading kinetics, and (c) sialic acid blocking groups that prevent macrocycle thre

116 es capping of lipooligosaccharide (LOS) with sialic acid by gonococcal sialyltransferase (Lst), utili

117 elial growth factor receptor 2 (VEGFR2) with sialic acid-capped N-glycans.

118 ous studies have shown that loss of terminal sialic acid causes enhanced von Willebrand factor (VWF)

119 ransferase (Lst), utilizing host-derived CMP-sialic acid (CMP-Neu5Ac in humans).

120 (Lst), using extracellular host-derived CMP-sialic acid (CMP-Neu5Ac in humans).

121 Previously, we showed that analogues of CMP-sialic acids (CMP-nonulosonates [CMP-NulOs]), such as CM

122 Addition of a single or multiple sialic acids conferred remarkable enhancement to the bio

123 These results demonstrate that simplified sialic acid conjugates represent a viable alternative to

124 the partner m/z shifts detail the number of sialic acids contained in the precursor species.

125 ostatic force between the negatively charged sialic acid-containing glycan residue of APOE and positi

126 Through recognition of sialic acid-containing glycans as ligands, they help the

127 GM2-synthase produces sialic acid-containing glycosphingolipids called ganglio

128 Gangliosides, sialic acid-containing glycosphingolipids, are especiall

129 ediated through viral attachment to alpha2,6-sialic acid-containing lactoseries tetrasaccharide c (LS

130 of human eosinophils and mast cells binds to sialic acid-containing ligands in the local milieu, resu

131 strate that BoNT/DC can use a broad range of sialic acid-containing moieties as co-receptors.

132 rotein, hemagglutinin (HA), which recognizes sialic-acid-containing glycans on host cells.

133 In addition, we identified the sialic acid content of the target cell membrane as an im

134 Our analysis reveals an increase in sialic acid content on total IgE from individuals with a

135 lary so that the presence of alpha2-6-linked sialic acids corresponded to a shift in the analyte migr

136 or of the recognition and internalization of sialic acid decorated apoptotic bodies and exosomes deri

137 Sialic acid deficiency is a hallmark of GNE myopathy, a

138 Recognition of GD2 by the 14G2a antibody is sialic acid-dependent and was blocked with the fluorinat

139 idered to function as an immunoreceptor in a sialic acid-dependent manner.

140 The compounds are Sialic acid derivatives and bind with low micromolar Kd

141 n addition, variation in the viral receptor, sialic acid, did not affect influenza virus evolution in

142 ptor-binding preference for alpha-2,3-linked sialic acids expressed on human AECs and infects them in

143 35a1 into the respective null cells restored sialic acid expression and T3SA(+) binding and infectivi

144 Slc35a1, which encode proteins required for sialic acid expression on the cell surface and mediate r

145 rrier family 35 member A1 (Slc35a1), promote sialic acid expression on the cell surface.

146 To effectively decrease the sialic acid expression, we synthesized C-5-modified 3-fl

147 Prototypic strains of EV-D68 depended on sialic acid for axonal infection and transport, while co

148 nutritive potential of 9-O-acetylated mucus sialic acids for foraging by bacteria that otherwise are

149 Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enz

150 periplasmic transporters (TRAPs) to scavenge sialic acid from host tissues.

151 Removal of sialic acid from IgE attenuates effector-cell degranulat

152 Furthermore, scavenging of sialic acid from the environment for energy has been cha

153 nH3 both displayed broad abilities to cleave sialic acids from alpha2-3- and alpha2-6-linked N- and O

154 d apoptosis, and cleavage of alpha2,6-linked sialic acids from gastric cancer organoid-derived monola

155 While removal of sialic acids from tissues prevented binding of all prote

156 nd contain varying levels of alpha2-6-linked sialic acid, galactose, and bisected N-acetylglucosamine

157 , we observed substantial decreases in total sialic acid, galactose, and GalNAc levels in glycans.

158 Sialic acid glycosphingolipids, molecules thought to med

159 ic glycans differing only in the linkages of sialic acid groups (e.g., alpha 2,3 versus alpha 2,6).

160 Influenza virus neuraminidase cleaves sialic acid groups from cell glycoproteins, enabling rel

161 ase also contributes to virus binding to the sialic acid groups of cell glycoproteins, which could co

162 O-Acetylated sialic acid has been found in the Neisseria meningitidis

163 e engineering (MOE) strategy using unnatural sialic acids has recently enabled the visualization of t

164 emonstrate that Cmah (cytidine monophosphate-sialic acid hydroxylase)-deficient mdx mice (Cmah-/-;mdx

165 (NanK) is the second enzyme of the bacterial sialic acid import and degradation pathway and adds phos

166 mplish this while avoiding immobilization by sialic acid in host mucus, viruses rely on a balance bet

167 imited capacity of SosV-RBP to interact with sialic acid in vitro and indicates that SosV-RBP undergo

168 However, the role of sperm-associated sialic acids in the leukocytic reaction remains unknown.

169 Removal of sialic acid increases the pro-inflammatory capacity of I

170 ere we investigated whether sperm-associated sialic acids inhibit activation of neutrophils, one of t

171 identified that carbamate-modified 3-fluoro sialic acid inhibitors are more efficiently metabolized

172 ical processes, while aberrant expression of sialic acid is associated with diseases such as cancer a

173 the Paramyxoviridae family that may not bind sialic acid is needed to anticipate their zoonotic poten

174 cid B-fragment differed consistently between sialic acid isomers, allowing differentiation between is

175 such subtle mass differences permit multiple sialic acids labeling without additional complexity of p

176 enables metabolic incorporation of exogenous sialic acids, leading to autoantibodies against N-glycol

177 ing more effective than ManNAc at increasing sialic acid levels in GNE-deficient cell lines.

178 haracterize the biosynthetic pathway for the sialic acid-like sugar pseudaminic acid and show its req

179 Sialylation and sialic acid linkage in N-glycans are markers of disease

180 structures that include 175 compositions, 64 sialic acid linkage isomers, 26 structural isomers, and

181 to reveal contributions to binding based on sialic acid linkage type, branched structures, and core

182 tly through alpha2-3 sialidase treatment and sialic acid linkage-specific alkylamidation (SALSA).

183 We used sialic acid linkage-specific derivatization methods to i

184 fied from urinary exosomes and determine the sialic acid linkages for many of those compositions.

185 alternative neuraminidase selective for 2-3 sialic acid linkages generated a KM value of 3 +/- 2 mM

186 in protein P1 mediates adherence to terminal sialic acids linked alpha-2,3, but P1-specific antibodie

187 Our results indicate that sperm sialic acids may interact with endometrial Siglecs and t

188 We investigated the LOS sialic acid-mediated resistance of NTHi to antibody-dire

189 pendent and was blocked with the fluorinated sialic acid mimetic Ac(5)3F(ax)Neu5Ac.

190 ons, including buffer selection, varying pH, sialic acid modification, and digestion temperature, in

191 p protocol involving protein immobilization, sialic acid modification, and N-glycan release.

192 sialic acid, unlike SSEA-3, which lacks this sialic acid modification.

193 bed here is the synthesis and utilization of sialic acids modified with a sydnone reporter for the me

194 se from Clostridium perfringens that cleaves sialic acid monomers with an alpha2-3,6,8,9 linkage, whi

195 human antibody constant regions with minimal sialic acid motifs in glycoengineered Escherichia coli.

196 Select bacteria biosynthesize the sialic acid N-acetylneuraminic acid (Neu5Ac), and the ab

197 which had high thermal stability, bound the sialic acid N-acetylneuraminic acid, and entered murine

198 exhibit a species-specific deficiency of the sialic acid N-glycolylneuraminic acid (Neu5Gc), due to p

199 ructures of nonmicrobial origin, such as the sialic acid N-glycolylneuraminic acid (Neu5Gc), might pl

200 Sialic acid (N-acetylneuraminic acid (Neu5Ac)) is common

201 tion of the LOS, which exploits host-derived sialic acid (Neu5Ac), can also block recognition of NTHi

202 The role of sialic acid O-acetylation in NmW CPS, however, is not cl

203 Moreover, we found that the terminal sialic acid of SSEA-4 plays a dominant role in dictating

204 nding and recruit IAVs to bind cells via the sialic acids of cell-tethered mucins.

205 issue and an ELISA-presented alpha2,3-linked sialic acid oligosaccharide ligand.

206 aran sulfate (HS), hyaluronic acid (HA), and sialic acid on human trophoblast cell lines and anchorin

207 nza A virus (IAV) enters cells by binding to sialic acid on the cell surface.

208 The switch is accompanied by a reduction of sialic acids on glycosylated surface components during p

209 with preferential binding to alpha2,6-linked sialic acids on long extended branches.

210 ffects of acidic residues (aspartic acid and sialic acid) on ion-pair formation and by nearest-neighb

211 at VEGFR2 Asn-247-linked glycans capped with sialic acid oppose ligand-mediated VEGFR2 activation, wh

212 nd the canonical influenza A virus receptor, sialic acid or any other glycan(1,3,4), despite its high

213 Overall, we revealed a unique sialic acid pathway in bacteria that has important impli

214 saccharide units, the presence or absence of sialic acid, peptide hydrophobicity, and the number of p

215 Sialic acids play many important roles in several physio

216 e formed by electro-polymerization with poly-sialic acid (PolySia) as a template molecule and p-amino

217 determined in HFD-fed mice administered the sialic acid precursor N-acetyl-D-mannosamine (ManNAc).

218 In HFD-fed mice, supplementation with the sialic acid precursor N-acetyl-D-mannosamine restored Ig

219 he parental virus recognized alpha2,3-linked sialic acids preferentially, the HA190 mutant bound to a

220 ential effects of GNE mutations, we compared sialic acid production in cell lines expressing wild typ

221 seudosymmetric relationship of the bacterial sialic acid, pseudaminic acid, and 3-deoxy-d-manno-oct-2

222 cid, which enhances overall virus binding to sialic acid receptor analogues.

223 microscopy techniques, we characterized the sialic acid receptor distribution and the cellular compo

224 but are not a natural host and have distinct sialic acid receptor profiles compared to humans.

225 in showed stronger binding to the human-type sialic acid receptor, with preferential binding to alpha

226 enza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employ

227 stringently conserved residues required for sialic acid recognition and hydrolysis.

228 nts a receptor-binding face incongruent with sialic acid recognition.

229 to TRX, a more rigorous description of this sialic acid-recognition motif given recent findings.

230 Domains mimicking sKlotho's sialic acid-recognizing activity inhibit TRPC6.

231 er, enzymatic cleavage of terminally exposed sialic acids reduces macrophage surface negativity and s

232 Loss of sialic acid residues is thought to feature in the aging

233 Sialic acid residues of the endothelial glycocalyx regul

234 enzyme processing steps the alpha2-6-linked sialic acid residues on an N-glycan correlated directly

235 acid (polySia), a polymer of alpha2,8-linked sialic acid residues that is largely absent during postn

236 nes heavily modified by fucose, sulfate, and sialic acid residues.

237 dues that are normally hidden below terminal sialic acid residues.

238 of human breast cancer cells that express a sialic-acid rich glycocalyx also induced protease releas

239 following NanA-dependent removal of terminal sialic acid, S. oralis bound exposed beta-1,4-linked gal

240 ther mutation modulated S protein binding to sialic acids, S protein activation by host cell protease

241 ition from avian-like to human-like terminal sialic acid (SA) receptor recognition via a single amino

242 and multiple bonds formed between synthetic sialic acid (SA) receptors and the two principal spike p

243 Both alpha2,6-linked and alpha2,3-linked sialic acid (SA) receptors, which preferentially bind th

244 the virus life cycle by binding to terminal sialic acid (SA) residues on host cells.

245 uraminidase (NA), with the cellular receptor sialic acid (SA).

246 Changes of alpha-2,3-/alpha-2,6-linked sialic acids (SAs) in sialylglycans have been found to b

247 -EM analysis, we reveal that, in contrast to sialic acid, sGAGs stimulate genome release from virions

248 ing that this footprint overlaps in part the sialic acid (SIA) footprint on AAV1.

249 The negatively charged sugar sialic acid (Sia) occupies the outermost position in the

250 ccharide (CPS) with terminal alpha2,3-linked sialic acid (Sia) residues that mimic a common epitope p

251 Glycans are frequently capped by sialic acid (Sia), and sialylation's crucial role for ki

252 Red meat-derived sialic acid (Sia), N-glycolylneuraminic acid (Neu5Gc), p

253 flora of different mucosal sites.IMPORTANCE Sialic acids (Sia) are involved in numerous different ce

254 Sialic acids (Sia) are the primary receptors for influen

255 The cognate endogenous binding partners of sialic acids, sialic acid-binding immunoglobulin-like le

256 ession, we synthesized C-5-modified 3-fluoro sialic acid sialyltransferase inhibitors.

257 t still dominant, binding to alpha2,3-linked sialic acids (SIAs) compared to a closely related avian

258 ) mice with human-like Cmah deficiency fed a sialic acids (Sias)-free high-fat diet (HFD) showed ~1.9

259 is not concordant with respect to binding by sialic acid-specific lectins.

260 upon addition of a recombinantly expressed, sialic acid-specific, carbohydrate binding module, while

261 Permethylation is a method of choice for sialic acid stabilization, but the harsh conditions duri

262 gens can grow by utilizing either glucose or sialic acids, such as N-acetylneuraminic acid (Neu5Ac),

263 Sialic acid sugars on mammalian cells regulate numerous

264 hese N-glycans were anionic, carrying either sialic acid, sulfate, or phosphate residues.

265 Interestingly, sialic acid supplementation using a cell-permeable siali

266 Furthermore, sialic acid supplementation with Ac(5)Neu5Ac combined wi

267 ic ablation of the Sia-activating enzyme CMP-sialic acid synthase (CMAS) resulted in embryonic lethal

268 to cause cell death were highly enriched for sialic acid synthesis and transport.

269 strains that differ in the capacity to bind sialic acid, T3SA(+) and T3SA(-), were used to evaluate

270 sylation profiles, with IgA1 possessing more sialic acid than IgA2.

271 first structure contains the natural ligand, sialic acid, the second structure contains an artificial

272 starts by specific oxidation of dihydroxy in sialic acid to aldehyde, which was then chemically label

273 ecise mechanism of FapC-mediated adhesion to sialic acid to be defined.

274 ta-1,4-linked galactose and alpha-2,6-linked sialic acid to N-glycans.

275 dase converted the remaining alpha2-6-linked sialic acid to terminal galactose.

276 numerous malignancies, adds alpha2-6-linked sialic acids to select membrane receptors, thereby modul

277 a linear homopolymer of alpha(2 -> 9)-linked sialic acid, to the size of the monomeric unit resulted

278 abolism across bacterial species and a novel sialic acid transport and catabolism pathway in E. coli.

279 structures of a mammalian NST, the mouse CMP-sialic acid transporter (mCST), in complex with its phys

280 encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in Salla disease, a ra

281 . coli depended on YjhC and on the predicted sialic acid transporter YjhB.

282 ive bacterial species and co-occurrence with sialic acid transporters.

283 d-state transition of VcSiaP, the SBP of the sialic acid TRAP transporter from V. cholerae.

284 The protein is the SBP of VcSiaPQM, a sialic acid TRAP transporter from Vibrio cholerae.

285 cally the capping of N-glycans at Asn-247 by sialic acid, tunes ligand-dependent activation and signa

286 ow that SSEA-4 is stabilized by its terminal sialic acid, unlike SSEA-3, which lacks this sialic acid

287 t the NA proteins of the N9 subtype can bind sialic acid via a separate binding site distinct from th

288 After enzymatic sialylation, the presence of sialic acid was confirmed using cyclic voltammetry by co

289 quence N-acetylgalactosamine, galactose, and sialic acid was consistently expressed on serine 94, thr

290 n of either gene, cell surface expression of sialic acid was diminished.

291 iotas, mutant F. nucleatum unable to consume sialic acids was impaired in vaginal colonization.

292 Linkage specific distribution of these sialic acids was quantitatively determined and unique fo

293 analogues site-specifically derivatized with sialic acid were prepared in an overall yield of 50-60%.

294 ing that a limited number of alpha2-6-linked sialic acids were present with biantennary, triantennary

295 steric hindrance, thus limiting NA access to sialic acids when adjacent to HA on whole virions.

296 ndrance, blocking access of neuraminidase to sialic acids when it abuts hemagglutinin on whole virion

297 larly as SARS-CoV-2 has the capacity to bind sialic acid which is a common, and highly variable, term

298 s N9 NA has an active Hb site which binds to sialic acid, which enhances overall virus binding to sia

299 ugates decorate the sperm surface, including sialic acids, which are abundant at the sperm surface wh

300 glycans, N-acetylgalactosamine (GalNAc) and sialic acid, with 10-20 nm precision in 2D and 3D.