ライフサイエンスコーパス: sialidase

1 cause of the lack of endogenous F. nucleatum sialidase.

2 hed endothelial cell (EC) expression of NEU1 sialidase.

3 ar calcium, activating P38MAPK and then Neu3 sialidase.

4 o and in vivo), despite the presence of Neu3 sialidase.

5 es and might contribute to research on viral sialidase.

6 treatment with an alpha2,3-linkage-specific sialidase.

7 ains and several other proteins, including a sialidase.

8 HI and NanH, with the latter being the major sialidase.

9 fringens strains produce NanI as their major sialidase.

10 a, and Escherichia coli) that do not produce sialidases.

11 lent adducts with virus, bacteria, and human sialidases.

12 lyl moiety modifies tyrosine residues of the sialidases.

13 ed target-specific irreversible inhibitor of sialidases.

14 by storage in the presence of inhibitors of sialidases.

15 ght express one or more catalytically active sialidases.

16 y sialylated upon addition of parasite trans-sialidases.

17 N-propionylneuraminic acid are sensitive to sialidases.

18 reased inhibitory activity against bacterial sialidases.

19 e constellation, not previously described in sialidases.

20 tion of glycoconjugates, and upregulation of sialidases.

21 equential actions of bacterial esterases and sialidases.

22 of MMP-8 (94 ng/muL), elastase (33 ng/muL), sialidase (23 ng/muL), and levels of P. gingivalis (0.23

23 dase activity is presumed to derive from the sialidase A gene, named here nanH1 In this study, BLAST

24 NEU3 sialidase, a key enzyme in ganglioside metabolism, is ac

25 eas overexpression of Neu1 or treatment with sialidase abrogated LPS-induced tolerance, as defined by

26 Neu3 sialidase activation in DRGs is initiated by an influx o

27 ractions in subsite 2 of the influenza virus sialidase active site.

28 ia a separate binding site distinct from the sialidase active site.

29 n the ranked hemagglutination and endogenous sialidase activities of these strains (Spearman's r = 0.

30 F. alocis showed nongingipain protease and sialidase activities.

31 tion in a pattern correlated with endogenous sialidase activity (r = 0.91, P < 0.001), although not c

32 Variation in sialidase activity and cytadherence among isolates was t

33 was then determined that culture supernatant sialidase activity and expression of exosialidase genes,

34 to the classic sialidase fold, but it has no sialidase activity and fulfills a purely non-enzymatic f

35 e the dynamic relationship between commensal sialidase activity and liberation of mucosal sialic acid

36 high glucose levels repressed F4969 culture sialidase activity and nanI expression even in the prese

37 trations repressed F4969 culture supernatant sialidase activity and nanI transcription levels.

38 NanH deficiency resulted in a total loss of sialidase activity associated with the outer-membrane an

39 NA displays sialidase activity by cleaving off the terminal N-acetyl

40 ed, FP and Db strains had little supernatant sialidase activity compared to other type A or C human i

41 knockdown of NEU1 and NEU3 each decreased EC sialidase activity for 4-MU-NANA by >65 and >17%, respec

42 crovascular EC lysates contained heat-labile sialidase activity for a fluorogenic substrate, 2'-(4-me

43 The EC lysates also contained sialidase activity for a ganglioside mixture.

44 t NanH2 and NanH3 are the primary sources of sialidase activity in G. vaginalis and that these two en

45 s used for in situ imaging of the changes of sialidase activity in live cells.

46 tochemical imaging assay for influenza virus sialidase activity in living cells by using a new fluore

47 Sialidase activity in P. gingivalis FLL401 was reduced b

48 no significant differences in the levels of sialidase activity in the outer membrane or secreted fra

49 Sialidase activity in vaginal fluids is diagnostic of BV

50 Inhibiting sialidase activity interferes with sperm binding to the

51 Sialidase activity is a diagnostic feature of BV and is

52 Sialidase activity is activated by caspase-dependent mec

53 Sialidase activity is most predictive of BV status and c

54 etic basis has not been formally identified, sialidase activity is presumed to derive from the sialid

55 , risk assessment of BV patients in terms of sialidase activity levels, and monitoring antibiotic the

56 these results suggest that the P. gingivalis sialidase activity may be involved in regulating gingipa

57 The role of sialidase activity of mKL acting inside is supported by

58 or mouse polyomavirus and that inhibition of sialidase activity promotes virion binding in the absenc

59 orted by findings that mutations of putative sialidase activity sites in sKL and mKL abrogated the re

60 luid-generated NanI fragments possessed more sialidase activity than did full-length rNanI, further s

61 LPS-activated microglia exhibited a sialidase activity that desialylated PC12 cells and coul

62 ly 27.6% of those with BV had high levels of sialidase activity with a signal to cutoff ratio of 10 o

63 "give back" to the community by reinforcing sialidase activity, a biochemical feature of human dysbi

64 We demonstrate that sialidase activity, a diagnostic feature of BV, promoted

65 GBS wild-type and DeltanonA strains lack sialidase activity, but forced expression of pneumococca

66 concentrations increased culture supernatant sialidase activity, largely by stimulating nanI transcri

67 hat DAS181 (Fludase), an antiviral drug with sialidase activity, potently inhibited replication of wi

68 -derived glycoproteins or from surface-borne sialidase activity, respectively.

69 ence its function and is dictated in part by sialidase activity, we asked whether airway epithelia ex

70 ted hBMEC invasion depends only partially on sialidase activity, whereas the N-terminal lectinlike do

71 lted in only a slight reduction in the total sialidase activity, with no significant differences in t

72 sma membrane, where it greatly increases the sialidase activity.

73 ellular receptor while retaining substantial sialidase activity.

74 Both effects involve putative Klotho sialidase activity.

75 in levels, and NEU1 accounted for >70% of EC sialidase activity.

76 ed from capacitated sperm and measured sperm sialidase activity.

77 ved in apoptosis-related increase of surface sialidase activity.

78 the plasma membrane by inhibiting host cell sialidase activity.

79 acid (Neu5Ac), which are the end products of sialidase activity.

80 ne region, a stalk, and a globular head with sialidase activity.

81 on the latter is actually independent of its sialidase activity.

82 lence factor, NanA, which has neuraminidase (sialidase) activity and promotes blood-brain barrier pen

83 e latter of which possesses enzymatic NA (or sialidase) activity.

84 nd epididymal epithelial cells by endogenous sialidases after a premature acrosome reaction during ac

85 We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conver

86 TrkC is activated by T. cruzi surface trans-sialidase, also known as parasite-derived neurotrophic f

87 n some neurons is reversed by treatment with sialidase, an enzyme that hydrolyzes sialic acids and el

88 ented by glycosidase assisted analysis using sialidase and endoglycosidase F2/F3, respectively, to im

89 the feedback loop, cause a downregulation of sialidase and TGF-beta1 accumulation.

90 Inhibition studies against several bacterial sialidases and a recombinant human cytosolic sialidase h

91 sialic acids help resist the action of many sialidases and are present at high levels in the mammali

92 osite to that observed for influenza A virus sialidases and hNEU2, compounds with axial fluorine at C

93 s differed most notably by its complement of sialidases and other genes of the N-acetylneuraminate sc

94 lications associated with BV, the role(s) of sialidases and the participation of individual bacterial

95 tic digestion procedures (i.e., glycosidase, sialidase, and protease) was systematically employed to

96 fibrosis is associated with up-regulation of sialidases, and injections of sialidase inhibitors atten

97 ong with the T. cruzi Tc24 antigen and trans-sialidase antigen 1 (TSA1), induced significant numbers

98 rrhea of CPE-associated AAD and SD, but this sialidase appears to be dispensable for the acute pathog

99 Bacterial sialidase appears to play an important role in bacterial

100 Sialidases are important bacterial virulence factors.

101 d Neu5Gc showed that mammalian and bacterial sialidases are much less able to hydrolyze alpha2-8-link

102 Sialidases are therefore orchestrators of cellular biolo

103 date sialoglycans as therapeutic targets and sialidase as a candidate therapy for spinal cord injury.

104 s in P. gingivalis showed the characteristic sialidase Asp signature motif (SXDXGXTW) and other uniqu

105 Here, we report a biochemiluminescent sialidase assay that uses a substrate derivatized with f

106 The parent compound inhibits influenza virus sialidase at a sub-muM level; the introduction of small

107 ary small airway and A549 ECs expressed NEU1 sialidase at the mRNA and protein levels, and NEU1 accou

108 SAP) inhibits fibrocyte differentiation, and sialidases attenuate SAP function.

109 Consistent with NanI sialidase being the major C. perfringens sialidase when

110 ion in CNS axons and in PNS axons after Neu3 sialidase blockade.

111 investigated the roles of the SiaHI and NanH sialidases by generating and characterizing specific del

112 Bacterial sialidases can play roles in pathogenesis by cleaving si

113 Neuraminidases (sialidases) catalyse the removal of terminal sialic acid

114 showed that the sialosides are stable under sialidase catalysis and the rituximab glycoform with a s

115 Neuraminidases (sialidases) catalyze the removal of sialic acid residues

116 lation transition states for Vibrio cholerae sialidase-catalyzed hydrolysis reactions.

117 nhibitors (up to 100-fold) against bacterial sialidases compared to their 3F-equatorial counterparts.

118 The antibody-sialidase conjugate desialylated tumor cells in a HER2-d

119 Here, we report the development of antibody-sialidase conjugates that enhance tumor cell susceptibil

120 Sialidase conjugation to trastuzumab enhanced ADCC again

121 Externally applied sialidase converted GD1a ganglioside to GM1 and rescued

122 tment complete, a third zone of alpha2-3,6,8 sialidase converted the remaining alpha2-6-linked sialic

123 ease of Neu5Gc from red meat using bacterial sialidases could reduce the risk of inflammatory disease

124 Analysis of sialidase-deficient bacterial mutants confirms the key c

125 Colonization of gnotobiotic mice with a sialidase-deficient mutant of Bacteroides thetaiotaomicr

126 In vitro foraging studies demonstrated that sialidase-dependent E. coli growth on mucin is enabled b

127 s and was eliminated by the polySia-specific sialidase, Endo-NF.

128 hes with disrupted microbiomes had increased sialidase enzyme and cytadherence activity, traits assoc

129 Neuraminidase (NA) is a sialidase expressed on the surface of influenza A viruse

130 We show that a recently discovered sialidase family, whose first member EnvSia156 was isola

131 ler structure with similarity to the classic sialidase fold, but it has no sialidase activity and ful

132 through enzyme zones that contained alpha2-3 sialidase, followed by beta1-3,4 galactosidase, which cl

133 ype D animal disease strain CN3718 uses NanI sialidase for adhering to enterocyte-like Caco-2 cells.

134 omes by competitively displacing this labile sialidase from PPCA.

135 ion selectively against pathogenic bacterial sialidases from Clostridium perfringens (CpNanI) and Vib

136 yses indicate the GBS NanA ortholog has lost sialidase function - and for this distinction we designa

137 NanA in GBS, potential costs of maintaining sialidase function.

138 Ganglioside conversion by Neu3 sialidase further activates the ERK pathway.

139 DAS181 (Fludase) is a sialidase fusion protein in clinical development as a br

140 TLV) and subdominant TSKB74 (VNYDFTLV) trans-sialidase gene (TS)-encoded epitopes with up to 40% of a

141 y drives sequence diversity in the passenger sialidase gene of M. synoviae.

142 T cells recognizing the immunodominant trans-sialidase gene-encoded peptide TSKB20 (ANYKFTLV) account

143 nscript levels of the known vaginolysin, and sialidase genes.

144 NEU3 sialidase has been shown to be a key player in many phys

145 KdoH1 (related to sialidases) has a single predicted N-terminal transmembr

146 popolysaccharide, toxin coregulated pilus A, sialidase, hemolysin A, flagellins (FlaB, FlaC, and FlaD

147 sialidases and a recombinant human cytosolic sialidase hNEU2 indicated that sialidase inhibition was

148 ast two decades, human neuraminidases (human sialidases, hNEUs) have been found to be involved in num

149 model in which 1) G. vaginalis extracellular sialidase hydrolyzes mucosal sialoglycans, 2) liberated

150 NanA has been shown to be a promiscuous sialidase, hydrolyzing the removal of Neu5Ac from a vari

151 ct and measure the relative concentration of sialidase in a vaginal sample as a means of BV diagnosis

152 s and intranasal instillation of recombinant sialidase in murine airways enhanced transduction effici

153 hesis of a physiological role played by NEU3 sialidase in protecting cells from hypoxic stress and ma

154 NanC is an unusual sialidase in that its primary reaction product is 2-deox

155 In the presence of sialidase in the reaction, the substrate is cleaved to r

156 is-associated cytokine TGF-beta1 upregulates sialidases in human airway epithelium cells, lung fibrob

157 Evidence of IT-sialidases in human metagenomes indicates that this enzy

158 ously described substrate breadth cleaved by sialidases in human vaginal specimens of women with BV.

159 U1 and NEU3 identified a lack of one or both sialidases in sperm of some male idiopathic infertility

160 rix metalloproteinase [MMP]-8, elastase, and sialidase) in GCF and subgingival plaque levels of Porph

161 erfringens can produce up to three different sialidases, including NanI, its major exosialidase.

162 platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and

163 Intravenous administration of recombinant sialidase increased tissue levels of terminally galactos

164 In PNS axons, axotomy activates Neu3 sialidase, increasing the ratio of GM1/GD1a and GM1/GT1b

165 lence and supports the clinical potential of sialidase inhibition for dampening inflammation caused b

166 man cytosolic sialidase hNEU2 indicated that sialidase inhibition was affected by the C-3 fluorine st

167 id from SIgA, but not in the presence of the sialidase inhibitor dehydro-deoxy-sialic acid.

168 s that for mice on an HFD, injections of the sialidase inhibitor N-acetyl-2,3-dehydro-2-deoxyneuramin

169 Conversely, sialidase inhibitor Neu5Gc2en prevented TLR4 ligand-indu

170 topoietic cells or systematic treatment with sialidase inhibitor Neu5Gc2en protected mice against end

171 Exposure of AMs in the presence of a sialidase inhibitor or anti-IAV antibody resulted in vir

172 but that the extracellular application of a sialidase inhibitor prevented the regulation of TRPV5 by

173 ose-dependently inhibited by the competitive sialidase inhibitor, 2,3-dehydro-2-deoxy-N-acetylneurami

174 permatozoa was effectively counteracted by a sialidase inhibitor.

175 lso known as DANA), a nonspecific hydrolytic sialidase inhibitor.

176 ld be inhibited by Tamiflu, a neuraminidase (sialidase) inhibitor.

177 Importantly, sialidase inhibitors ameliorate anti-GPIbalpha-mediated

178 -regulation of sialidases, and injections of sialidase inhibitors attenuate bleomycin-induced pulmona

179 dases potentiates fibrosis, and suggest that sialidase inhibitors could be useful for the treatment o

180 Injections of the sialidase inhibitors DANA and oseltamivir (Tamiflu) star

181 Sialidase inhibitors protect mice against sepsis by a me

182 ing a role for NanI in host cell attachment, sialidase inhibitors reduced F4969 adhesion to Caco-2 ce

183 compounds were less-efficient antibacterial sialidase inhibitors, 9-N(3)-modified 2,3-difluoro-Neu5A

184 human RVs and the majority of animal RVs are sialidase insensitive.

185 ns with terminal sialic acid (Sia), whereas 'sialidase-insensitive' human rotavirus strains bind to g

186 We delivered recombinant sialidase intrathecally to rats following a spinal cord

187 . perfringens to enterocyte-like cells, NanI sialidase is now emerging as a potential auxiliary virul

188 ance of alpha2-8-linked Neu5Gc to vertebrate sialidases is the detrimental effect requiring the relat

189 DAS181, an inhaled sialidase, is undergoing clinical development for the tr

190 9149 strain produces an intramolecular trans-sialidase (IT-sialidase) that cleaves off terminal alpha

191 Sialidase levels are altered in obese rodents and humans

192 es and up-regulation of genes encoding trans-sialidase-like and ribosomal proteins.

193 repression of TLR function by Siglecs and a sialidase-mediated de-repression that allows positive fe

194 is dependent on the N-glycan of TRPV5 and a sialidase-mediated stimulation that is lipid raft-depend

195 Thus, our study suggests that NanH sialidase might play roles in bacterial colonization by

196 Sialidase mimicked this stimulatory action.

197 In addition, sialidase modified the N-glycan of transferrin, a model

198 g unilateral hindlimb ischemia +/- the alpha-sialidase NA (neuraminidase).

199 erium has been shown to express two distinct sialidases, namely, SiaHI and NanH, with the latter bein

200 Upon scavenging by the bacterial sialidase NanA, Sias serve as carbon sources for the bac

201 S. pneumoniae encodes up to three sialidases, NanA, NanB, and NanC, that have been implica

202 There are three pneumococcal sialidases: NanA, NanB, and NanC.

203 uring infection, Salmonella used its two GHs sialidase nanH and amylase malS for internalization by t

204 arches predicted two additional G. vaginalis sialidases, NanH2 and NanH3.

205 dase-positive strains but absent from all 19 sialidase-negative isolates, including 16 strains that w

206 Cleavage of sialidase Neu1 by caspase 3 was shown to be directly inv

207 ere we show that deficiency of the lysosomal sialidase NEU1 leads to the spontaneous occurrence of an

208 e active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sia

209 y of human sperm samples for the presence of sialidases NEU1 and NEU3 identified a lack of one or bot

210 to detect mRNAs for the four known mammalian sialidases, NEU1, -2, -3, and -4, NEU1 mRNA was expresse

211 The human plasma membrane sialidase NEU3 is a key enzyme in the catabolism of memb

212 In the same cells, stable overexpression of sialidase NEU3 significantly enhances cell resistance to

213 ead NEU1 mutant, NEU1-G68V, or another human sialidase, NEU3, did not.

214 Compared with control, mice lacking the sialidase neuraminidase 3 have reduced HFD-induced adipo

215 induces Fc-independent platelet activation, sialidase neuraminidase-1 translocation and desialylatio

216 ose, and 6'-sialyllactose), linkage-specific sialidases (neuraminidase and sialidase S), lectins (Maa

217 plore the mechanisms through which the human sialidase, neuraminidase-1 (NEU1), promotes the interact

218 , which have been recently shown to be novel sialidase/neuraminidase inhibitors, could only be tentat

219 We report the presence of two sialidases (neuraminidases Neu1 and Neu3) on mammalian s

220 on IAV NA and HA activities and on bacterial sialidases (neuraminidases) suggest a host-variable prot

221 sugar on glycoproteins, which are removed by sialidases (neuraminidases).

222 ved in an UPEC epididymitis mouse model, and sialidases on the sperm surface are considered to be act

223 e L858R/T790M EGFR mutant, when treated with sialidase or sialyltransferase inhibitor, showed an incr

224 Pretreatment of host cells with sialidase or trypsin reduces or nearly eliminates, respe

225 Sialidase (or saline solution) was infused to the injury

226 what appears to be a sialidase - TGF-beta1 - sialidase positive feedback loop.

227 nanH2, nanH3, or both were present in all 15 sialidase-positive strains but absent from all 19 sialid

228 also activate fibroblasts, and we found that sialidases potentiate fibrocyte differentiation.

229 gest that a positive feedback loop involving sialidases potentiates fibrosis, and suggest that sialid

230 en with gonococcal infections have levels of sialidases present in cervicovaginal secretions that can

231 release, and this was partially abrogated by sialidase pretreatment, which removes cell surface anion

232 NeuAc/NeuGc abundances) and linkage-specific sialidases prior to infection indicated that the influen

233 Sialidases produced by some members of the colonic micro

234 outgrowth of Gardnerella vaginalis, a major sialidase producer and one of the most abundant organism

235 NanB is an intramolecular trans-sialidase producing 2,7-anhydro-Neu5Ac selectively from

236 Infection with sialidase-producing P. timonensis resulted in elongated

237 In mice with sialidase-producing vaginal microbiotas, mutant F. nucle

238 These data suggest that sialidases promote adipose and liver inflammation in res

239 DAS181, a recombinant sialidase protein containing the catalytic domain of Act

240 Resistance of Neu5Gc-containing polySia to sialidases provides a potential explanation for the rari

241 me extent that erythrocyte pretreatment with sialidase purified from Clostridium perfringens did (P <

242 These features facilitate a novel sialidase reaction in which the final step of product fo

243 The three sialidase-related proteins in P. gingivalis showed the c

244 the catalytic domain of Actinomyces viscosus sialidase, removes cell surface sialic acid, and we prop

245 Bacteroidetes sialate-O-acetylesterases and sialidases, respectively, and subsequent utilization of

246 allow virus internalization and the NA is a sialidase responsible for cleaving sialic acid to aid vi

247 The principle sialidases responsible for this desialylation appear to

248 ucins is mediated by an intramolecular trans-sialidase (RgNanH).

249 nkage-specific sialidases (neuraminidase and sialidase S), lectins (Maakia amurensislectin andSambucu

250 irway epithelia express catalytically active sialidase(s).

251 imal RVs (of P[1], P[2], P[3], and P[7]) are sialidase sensitive, human RVs and the majority of anima

252 The existing paradigm is that 'sialidase-sensitive' animal rotavirus strains bind to gl

253 ed 16 new putative T2S substrates, including sialidase, several proteins participating in chitin util

254 We propose that the three pneumococcal sialidases share a common catalytic mechanism up to the

255 Overall, the pneumococcal sialidases show remarkable mechanistic diversity while m

256 g site and unusual kinetic properties of the sialidase site which promote receptor binding via this s

257 ue to unusual kinetic characteristics of the sialidase site which specifically enhance binding to hum

258 ch is discrete from the enzymatically active sialidase site.

259 lls >20 hr earlier than immunodominant trans-sialidase-specific T cells.

260 y in living cells by using a new fluorescent sialidase substrate, 2-(benzothiazol-2-yl)-4-bromophenyl

261 ation model of sepsis to show that microbial sialidases target the sialic acid-based recognition of C

262 Trypanosoma cruzi trans-sialidase (TcTS) is a key target protein for Chagas dise

263 ular TGF-beta1, forming what appears to be a sialidase - TGF-beta1 - sialidase positive feedback loop

264 pneumococcal neuraminidase, NanA, which is a sialidase that catalyzes the cleavage of terminal sialic

265 ize MSO, B. longum subsp. infantis deploys a sialidase that cleaves alpha2-6 and alpha2-3 linkages.

266 Influenza neuraminidase (NA) is a sialidase that contributes to viral mobility by removing

267 Neuraminidase (NA) is a sialidase that is one of the major surface glycoproteins

268 epithelia express catalytically active NEU1 sialidase that regulates EGFR- and MUC1-dependent signal

269 oduces an intramolecular trans-sialidase (IT-sialidase) that cleaves off terminal alpha2-3-linked sia

270 In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solut

271 ociated bacterium Gardnerella vaginalis uses sialidase to break down and deplete sialic acid-containi

272 hese studies show that G. vaginalis utilizes sialidase to support the degradation, foraging, and depl

273 We chemically fused a recombinant sialidase to the human epidermal growth factor receptor

274 Conversely, addition of sialidases to human peripheral blood mononuclear cells i

275 side receptors can restore susceptibility of sialidase-treated MDCK cells to infection by both recent

276 tative analysis of AAV9 binding to parental, sialidase-treated or sialic acid-deficient mutant CHO ce

277 rotein Misfolding Cyclic Amplification using sialidase-treated PrP(C) substrate and then restored to

278 ptor-bearing streptococci, agglutinated with sialidase-treated red blood cells, and formed monospecie

279 rs were assigned indirectly through alpha2-3 sialidase treatment and sialic acid linkage-specific alk

280 owed that the increased TRPV5 activity after sialidase treatment is caused by inhibition of lipid raf

281 Sialidase treatment of eosinophils revealed that Siglec-

282 e, this binding was substantially reduced by sialidase treatment of erythrocytes.

283 Sialidase treatment of fibrinogen reversed the suppressi

284 ays in vitro and distinct properties in vivo Sialidase treatment of heavily sialylated CHO-sKlotho in

285 Sialidase treatment of PC12 cells enabled Gal-3 to bind

286 Sialidase treatment significantly enhanced hindlimb moto

287 immunizations with the unique T. cruzi trans-sialidase (TS) antigen protect against gastric and syste

288 targeting epitopes encoded by variant trans-sialidase (TS) genes.

289 ed, suggesting a common mechanism with other sialidases up to the final step of product formation.

290 ucosal T. cruzi infection and T. cruzi trans-sialidase vaccination.

291 Secretion of reactive oxygen species and sialidase varied quantitatively (P < 0.01) among strains

292 alpha2-->3,6,8,9 sialidase was used to remove the sialic acid residues on

293 In CNS axons, P38MAPK and Neu3 sialidase were not activated by axotomy.

294 ditionally, we verified that mouse and human sialidases were able to release Neu5Gc from red meat.

295 anI sialidase being the major C. perfringens sialidase when produced, FP and Db strains had little su

296 eatment of cultured hippocampal neurons with sialidase, which cleaves GT1b (and other sialoglycans),

297 th the expression of an intramolecular trans-sialidase, which releases 2,7-anhydro-Neu5Ac, rather tha

298 ite-derived neurotrophic factor (PDNF)/trans-sialidase with neurotrophic receptors TrkA and TrkC, as

299 metagenomic sequencing identified bacterial sialidases with previously unobserved substrate preferen

300 Here, we sought to define if uncharacterized sialidases would provide distinct paradigms in sialic ac