ライフサイエンスコーパス: sialoprotein

1 lating endopeptidase homolog), and Bsp (bone sialoprotein).

2 l10, osterix, alkaline phosphatase, and bone sialoprotein.

3 omologous to the cDNA sequence of rat dentin sialoprotein.

4 role in mediating the PTH induction of bone sialoprotein.

5 all as assessed by immunostaining for dentin sialoprotein.

6 -binding properties and bone tropism to bone sialoprotein.

7 n high levels of sialic acid similar to bone sialoprotein.

8 rter into linkage-specific alpha2,6-N-linked sialoproteins.

9 Bone sialoprotein accumulates within bone acidic glycoprotein

10 bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen) in

11 n gene confirms our finding that both dentin sialoprotein and dentin phosphoprotein are encoded by a

12 eened a mouse molar tooth library for dentin sialoprotein and dentin phosphoprotein cDNA clones.

13 support the previous suggestion that dentin sialoprotein and dentin phosphoprotein have distinct fun

14 dentin extracellular matrix proteins, dentin sialoprotein and dentin phosphoprotein, are expressed as

15 major noncollagenous dentin proteins, dentin sialoprotein and dentin phosphoprotein, are specific cle

16 Two dentin proteins, dentin sialoprotein and dentin phosphoprotein, have been shown

17 Dspp, and cleaved into two peptides, dentin sialoprotein and dentin phosphoprotein, that are localiz

18 two distinct extracellular proteins: dentin sialoprotein and dentin phosphoprotein.

19 o lead to a loss of function of both dentine sialoprotein and dentine phosphoprotein.

20 rominently accelerated collagen type I, bone sialoprotein and osteocalcin protein expression.

21 of osteoblastic differentiation (i.e., bone sialoprotein and osteocalcin) in the preosteoblasts, sug

22 sion of osteoblast marker genes such as bone sialoprotein and osteocalcin.

23 normalized the altered distributions of bone sialoprotein and osteopontin in Hyp mouse alveolar bone.

24 The bone matrix proteins dentin sialoprotein and osteopontin, but not transforming growt

25 cyte marker), while osteoblast markers, bone sialoprotein and osteopontin, remained unchanged.

26 ted that BMP-2 decreased mRNA levels of bone sialoprotein and type I collagen dose-dependently (10-30

27 reases in the expression of major bone (bone sialoprotein) and cartilage (type II collagen) matrix pr

28 rentiation markers such as osteocalcin, bone sialoprotein, and dentin matrix protein 1 (DMP1) was als

29 gamma-carboxyglutamate protein, COL1A1, bone sialoprotein, and dentin matrix protein1.

30 d with significant reductions in Runx2, bone sialoprotein, and osteocalcin expression, paralleled by

31 n markers Runx-2, alkaline phosphatase, bone sialoprotein, and osteocalcin.

32 nked glycoproteins) family of proteins, bone sialoprotein, and osteopontin, bound first to a cell sur

33 steogenic markers alkaline phosphatase, bone sialoprotein, and Runt-related transcription factor 2 re

34 NCPs were separated into osteopontin-, bone sialoprotein-, and dentin matrix protein-1-enriched frac

35 Surprisingly, osteocalcin and bone sialoprotein are also expressed by malignant but not nor

36 Osteocalcin and bone sialoprotein are the most abundant noncollagenous bone m

37 SPACR (sialoprotein associated with cones and rods), is the maj

38 ranscription factor 2 at 7 days and for bone sialoprotein at days 7 and 10 as well as higher OPN leve

39 that the Staphylococcus aureus MSCRAMM bone sialoprotein-binding protein (Bbp) might recognize host

40 e, exotoxin, Ser-Asp fibrinogen-binding bone sialoprotein-binding protein, fibrinogen and keratin-10

41 eonectin, whereas alkaline phosphatase, bone sialoprotein, bone Gla protein, and collagen II, all ind

42 nscription factor (RUNX)-2, integrin binding sialoprotein, bone morphogenetic protein-2, osteocalcin,

43 Bone sialoprotein (BSP) and apatite co-localize in the extrac

44 BP and IGF promoted gene expression of bone sialoprotein (BSP) and OPN.

45 Bone sialoprotein (BSP) and osteocalcein (OCN) markers were u

46 B or TGF-beta resulted in a decrease in bone sialoprotein (BSP) and osteocalcin (OCN) mRNAs while PDG

47 u hybridization, for gene expression of bone sialoprotein (BSP) and osteocalcin (OCN), and histomorph

48 lendronate suppressed the expression of bone sialoprotein (BSP) and osteonectin in both femurs and bo

49 es associated with mineralized tissues, bone sialoprotein (BSP) and osteopontin (OPN), and a cell-sur

50 Bone sialoprotein (BSP) and osteopontin (OPN, ETA-1) are expr

51 l correlation between the expression of bone sialoprotein (BSP) and skeletal metastasis of breast can

52 tochemistry methods were used to detect bone sialoprotein (BSP) distribution in Hyp and WT mouse mola

53 y to determine the relationship between bone sialoprotein (BSP) expression and osteocalcin expression

54 rowth and enhanced osteocalcin (OC) and bone sialoprotein (BSP) gene expression in human prostate can

55 The bone sialoprotein (Bsp) gene provides an excellent model for

56 Expression of the bone sialoprotein (BSP) gene, a marker of bone formation, is

57 Bone sialoprotein (BSP) has been shown to induce limited gela

58 r phosphoproteins osteopontin (OPN) and bone sialoprotein (BSP) have been implicated in biological fu

59 d glycoproteins), osteopontin (OPN) and bone sialoprotein (BSP) in the Galnt1-null mice relative to t

60 Bone sialoprotein (BSP) is a member of the SIBLING family wit

61 Bone sialoprotein (BSP) is a multifunctional, highly phosphor

62 Bone sialoprotein (BSP) is a secreted glycophosphoprotein nor

63 Bone sialoprotein (BSP) is an acidic 301 amino acid protein e

64 Bone sialoprotein (BSP) is an acidic phosphoprotein with coll

65 Bone sialoprotein (BSP) is an extracellular matrix (ECM) prot

66 Bone sialoprotein (BSP) is an extracellular matrix protein fo

67 cted in microdot cultures of UMR-106-01 Bone Sialoprotein (BSP) osteoblast cells.

68 ated proteins, i.e., osteopontin (OPN), bone sialoprotein (BSP), alkaline phosphatase (ALP), osteocal

69 g bone acidic glycoprotein-75 (BAG-75), bone sialoprotein (BSP), and alkaline phosphatase that are th

70 related transcription factor 2 (RunX2), bone sialoprotein (BSP), and osteocalcin (OCN) messenger RNA

71 Dentin matrix protein-1 (DMP1), bone sialoprotein (BSP), and osteopontin (OPN) are three SIBL

72 The mRNA expressions of bone sialoprotein (BSP), collagen type I (COL-I), osteocalcin

73 roteins: full-length osteopontin (OPN), bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), dent

74 and expression of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix formati

75 f a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products

76 Immunohistochemistry for bone sialoprotein (BSP), integrin beta1 and collagen type 1 a

77 s of mineral-associated genes including bone sialoprotein (BSP), OC, and osteopontin (OPN) in the cel

78 liferating cell nuclear antigen (PCNA), bone sialoprotein (BSP), osteocalcin (OCN), and tartrate-resi

79 mentoblast population (OC/CM) expressed bone sialoprotein (BSP), osteopontin (OPN), and OC, markers s

80 ineralized tissue-associated markers of bone sialoprotein (BSP), Type I collagen (COL I), osteocalcin

81 ted markers, e.g., osteocalcin (OCN) or bone sialoprotein (BSP).

82 containing the response element of rat bone sialoprotein (BSP).

83 y collagen and potentially nucleated by bone sialoprotein (BSP).

84 entially expressed gene was found to be bone sialoprotein (Bsp).

85 this hypothesis, we infected 5-day-old bone sialoprotein (BSP)/avian retroviral receptor gene (TVA)

86 These blood-based biomarkers were bone sialoprotein (BSP, Discovery false discovery rate [FDR]-

87 or core binding factor alpha-1 [Cbfa1], bone sialoprotein [BSP], osteocalcin [OCN], and osteopontin [

88 (osteocalcin [OCN], osteopontin [OPN], bone sialoprotein [BSP], osteoprotegerin [OPG] and receptor a

89 ne marrow mesenchymal stem cell, BMMSC; bone sialoprotein, BSP; hydroxyapatite/tricalcium phosphate,

90 integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix p

91 et genes, osteocalcin, osteopontin, and bone sialoprotein but did not significantly alter Runx2 level

92 rate that TCR-induced exclusion of the large sialoprotein CD43 from the synapse is an active event me

93 a significant decrease in expression of bone sialoprotein, characteristics of periodontal ligament in

94 entin sialophosphoprotein (DSPP) into dentin sialoprotein, dentin phosphoprotein, and dentin glycopro

95 Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) are e

96 r matrix protein that is cleaved into dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) with

97 Two acidic proteins, dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), are

98 that is processed into two proteins: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP).

99 two distinct proteins referred to as dentin sialoprotein (Dsp) and dentin phosphoprotein (Dpp).

100 ialophosphoprotein (DSPP) consists of dentin sialoprotein (DSP) and dentin phosphoprotein (DPP).

101 ly two structural/functional domains: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP).

102 osphoprotein (DSPP) is processed into dentin sialoprotein (DSP) and dentin phosphoprotein.

103 Dentin sialoprotein (DSP) and phosphophoryn (PP) are the two no

104 Dentin sialoprotein (DSP) and phosphophoryn (PP) are two major

105 requires two highly acidic proteins, dentin sialoprotein (DSP) and phosphophoryn (PP).

106 Dentin sialoprotein (DSP) is a dentin extracellular matrix prot

107 Dentin sialoprotein (DSP) is a glycoprotein that is critical fo

108 Dentin sialoprotein (DSP) is essential for dentinogenesis and p

109 (DSPP) is cleaved into the N-terminal dentin sialoprotein (DSP) proteoglycan and the C-terminal denti

110 The expression of dentin sialoprotein (DSP) specifically marked dentin synthesis

111 alcin; and late markers like DMP2 and dentin sialoprotein (DSP) that are expressed by terminally diff

112 matrix protein that is processed into dentin sialoprotein (DSP), dentin glycoprotein (DGP) and dentin

113 ssion of dentin phosphoprotein (DPP), dentin sialoprotein (DSP), dentin matrix protein-1, and osteoca

114 chimeric protein composed of 3 parts: dentin sialoprotein (DSP), DPP, and dentin glycoprotein (DGP).

115 ssed by immunostaining for nestin and dentin sialoprotein (DSP).

116 nstream target genes such as DMP1 and dentin sialoprotein (DSP).

117 ntin phosphoprotein (DPP), generating dentin sialoprotein (DSP)/DGP and DPP.

118 llows: Dentin matrix protein (DMP-1), dentin sialoprotein (DSPP), and matrix extracellular phosphogly

119 with AMC spheroids/FDBG treatment, and bone sialoprotein expression and cell proliferation were more

120 2 preceded increases in osteocalcin and bone sialoprotein expression and this increase in Osf2 bindin

121 se results suggest that osteocalcin and bone sialoprotein expression is coordinated and regulated thr

122 y is to investigate how osteocalcin and bone sialoprotein expression is regulated in prostate cancer

123 teopontin and osteocalcin and decreased bone sialoprotein expression was detected within 7 days and m

124 by reduced mineralization and decreased bone sialoprotein expression.

125 itioned medium-mediated osteocalcin and bone sialoprotein gene expression in prostate cancer cells.

126 fferentiated MC4 cells, osteocalcin and bone sialoprotein gene expression were both down-regulated by

127 pment (e.g. Col1a1, Postn/Osf2, and the bone sialoprotein gene or BSP), genes that are expressed in t

128 Bone sialoprotein (gene: Ibsp; protein: BSP) is a multifuncti

129 scription factor in the osteocalcin and bone sialoprotein genes that cannot be resolved by traditiona

130 of osteoblast-specific osteocalcin and bone sialoprotein genes, alkaline phosphatase activity, and m

131 alkaline phosphatase, osteocalcin, and bone sialoprotein genes, and temporally associates with these

132 phosphoproteins such as osteopontin and bone sialoprotein have yielded important biological informati

133 Both exosomal miR-19a and Integrin-Binding Sialoprotein (IBSP) are found to be significantly upregu

134 ferentiation genes osterix (Sp7), Atf4, bone sialoprotein (Ibsp), and osteocalcin (Bglap) without aff

135 Dmp1/DMP1), osteopontin (Spp1/OPN), and bone sialoprotein (Ibsp/BSP).

136 (DSPP), dentin matrix protein 1 (DMP1), bone sialoprotein II (IBSP), and bone morphogenetic proteins

137 phosphatase/ALPL, osteopontin/SPP1, and bone sialoprotein II/IBSP) in a subset of the hMSC population

138 n wild-type animals, the inclusion of dentin sialoprotein in the forming aprismatic enamel may accoun

139 osphatase), Ocn (osteocalcin), and Bsp (bone sialoprotein) in response to recombinant PP and stably t

140 teoblastic marker genes, namely Ocn and bone sialoprotein, in Atf4(-/-) developing bones.

141 ial protein, and those of pFv, an endogenous sialoprotein, involve binding interactions with overlapp

142 otein Fv (Fv binding protein (pFv)), a human sialoprotein involved in gut-associated immunity, have b

143 Bone sialoprotein is a 70-kDa extracellular matrix component

144 Bone sialoprotein is a major noncollagenous protein of bone.

145 uld promote periodontal regeneration in bone sialoprotein knockout mice (Ibsp(-/-) mice), which are k

146 Similar fragments of bone sialoprotein, like the intact protein, did not functiona

147 lcium deposition and gene expression of bone sialoprotein, lipoprotein lipase, and fatty acid binding

148 d osteocalcin mRNA levels and increased bone sialoprotein mRNA, consistent with an inhibition of term

149 increase in the steady-state levels of bone sialoprotein mRNAs within primary cultures of embryonic

150 (NEU1), promotes the interaction between the sialoprotein, mucin 1 (MUC1), and the opportunistic path

151 t while the immunostaining signals of dentin sialoprotein (N-terminal fragment of DSPP) were decrease

152 es in response to added native purified bone sialoprotein (nBSP) and its dephosphorylated form (dBSP)

153 a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids that conta

154 a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids with diver

155 Podocalyxin (PC), the major sialoprotein of glomerular epithelial cells (GECs), help

156 dontoblastic gene expression, such as dentin sialoprotein, on the untreated control resin was recover

157 enic animal approach we have extended dentin sialoprotein or dentin phosphoprotein expression through

158 us normal human valves for osteopontin, bone sialoprotein, osteocalcin, alkaline phosphatase, and the

159 d osterix-producing cells and increased bone sialoprotein, osteocalcin, and BMP-7 expression.

160 d increased mRNA levels of osteopontin, bone sialoprotein, osteocalcin, and Cbfa1 in the calcified va

161 llel, a decreased expression of Runx-2, bone sialoprotein, osteocalcin, and RANK-L.

162 c markers such as Runx2, Osterix, DMP1, Bone sialoprotein, Osteocalcin, NFATc1, and Schnurri-2, which

163 ription factor 2, Type I collagen, ALP, bone sialoprotein, osteopontin), osteocalcin, CEMP1, and CAP,

164 gand N-linked glycoproteins (SIBLINGs): bone sialoprotein, osteopontin, and dentin matrix protein 1,

165 on of interleukin-6, interleukin-1beta, bone sialoprotein, osteoprotegerin, receptor activator of nuc

166 onstrated that a sizeable proportion of bone sialoprotein particles were located within a 50-nm radiu

167 Plasma apolipoprotein (apo) E, a sialoprotein, plays an important role in reverse cholest

168 nd reduced sialylation of the major podocyte sialoprotein, podocalyxin.

169 revealed that (a) human osteocalcin and bone sialoprotein promoter activities in an androgen-independ

170 ed stimulation of human osteocalcin and bone sialoprotein promoter activities occurs through increase

171 s found to induce human osteocalcin and bone sialoprotein promoter activities via increased CRE/CRE-b

172 ased or repressed human osteocalcin and bone sialoprotein promoter activities.

173 osteoblast-specific element within the bone sialoprotein promoter and demonstrate its regulation by

174 etion analysis of human osteocalcin and bone sialoprotein promoter regions identified cyclic AMP (cAM

175 Overexpression of dentin sialoprotein results in an increased rate of enamel mine

176 ctin, type I collagen, osteopontin, and bone sialoprotein) showed any detectable effect on PG metabol

177 Bone sialoprotein specifically binds proMMP-2 and active MMP-

178 line phosphatase, bone Gla protein, and bone sialoprotein, suggesting an osteogenic phenotype.

179 1, and higher levels of osteopontin and bone sialoprotein than the normal.

180 kappaB ligand (RANKL), and integrins binding sialoprotein to be genes upregulated at the TB interface

181 potential interaction of MMP-20 with dentin sialoprotein was confirmed by coimmunoprecipitation and

182 of the Col11a1 "6b" exonal sequence to bone sialoprotein was demonstrated with overlapping peptides.

183 n both genotypes, and the expression of bone sialoprotein was similar in tumor-bearing bones of both

184 Bone sialoprotein was the only osteoblast marker strongly ind

185 toblast-specific cDNA which codes for dentin sialoprotein, we discovered a 801-base pair open reading

186 To better regulate these sialoproteins, we asked whether endothelial cells (ECs)

187 rotein (BMP)-2, BMP-7, osteopontin, and bone sialoprotein were evaluated in alveolar sockets.

188 proteins, osteopontin, osteonectin, and bone sialoprotein, were identified in the protein extracts; t

189 actor 2), osteocalcin, osteopontin, and bone sialoprotein, were reduced proportionate to the reductio

190 pro-adhesive molecules osteopontin and bone sialoprotein, which is in contrast to the high levels of

191 Podocalyxin is a type 1 transmembrane sialoprotein with an N-terminal mucin-like domain.