ライフサイエンスコーパス: sialyltransferase

1 zyme (also called lactosylceramide alpha-2,3 sialyltransferase).

2 s insensitivity to the actions of a specific sialyltransferase.

3 of the TNFR1 death receptor by the ST6Gal-I sialyltransferase.

4 bohydrate modification added by the ST6Gal-I sialyltransferase.

5 e CD22 glycan ligand(s) produced by ST6Gal-I sialyltransferase.

6 by a N-acetylgalactosamine-specific alpha2,6-sialyltransferase.

7 ains demonstrated the occurrence of membrane sialyltransferase.

8 own-regulation in expression of the ST6Gal I sialyltransferase.

9 C lic3A, indicating the presence of a second sialyltransferase.

10 ycan modification controlled by the ST3Gal-I sialyltransferase.

11 e 1S was found to be substrate for alpha-2,3-sialyltransferase.

12 ude that the lst gene encodes the H. ducreyi sialyltransferase.

13 ases, this protein represents a new class of sialyltransferase.

14 folds could be classified as a hexosyl- and sialyltransferase.

15 hereby providing higher substrate levels for sialyltransferases.

16 osyltransferases lost less activity than the sialyltransferases.

17 ptors preferentially recognized by different sialyltransferases.

18 nzae is a complex process involving multiple sialyltransferases.

19 tifs L and S conserved in all members of the sialyltransferases.

20 rmed, has not been determined for any of the sialyltransferases.

21 CMP-3F-NeuAc, a competitive inhibitor of all sialyltransferases.

22 for catalysis by the mammalian and bacterial sialyltransferases.

23 ferases, including the up-regulation of some sialyltransferases.

24 ent is mediated by beta-galactoside alpha2,6-sialyltransferase 1 (ST6Gal-1), acting on the Gal(beta4)

25 suggest that the beta-galactoside alpha-2,6-sialyltransferase 1 (ST6Gal-I) sialyltransferase, which

26 (B4GALT1) and ST6 beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) catalyze the successive ad

27 6-linked N-acetylneuraminic acid by alpha2,6-sialyltransferase 1 (ST6Gal1), thus generating a family

28 cetylglucosamine-transferase 1 and alpha-2,6-sialyltransferase 1 into COPI vesicles.

29 g O-glycan elongation by expressing alpha2,3-sialyltransferase 1 rendered LNCaP cells resistant to ga

30 PH3 in the spatial localization of alpha-2,6-sialyltransferase 1.

31 we overexpressed CMP-Neu5Ac:GalNAc-Ralpha2,6-sialyltransferase-1 to block core O-glycan synthesis.

32 xpression of the sialyltransferase alpha-2,3-sialyltransferase-3 (ST3Gal-I), resulting in increased s

33 in Il10(-/-) mice deficient for the alpha2,3 sialyltransferase 4 (ST3GAL4) responsible for 3SL biosyn

34 However, gene-based analysis of sialyltransferase 4A (SIAT4A), tachykinin receptor 1 (TA

35 RGS14) increased Gc transactivation, whereas sialyltransferase 4B (SIAT4B) had a negative effect.

36 Importantly, there was novel expression of sialyltransferase 4C (SIAT4C), small proline-rich protei

37 sferase (B3GLCT), beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5), and (alpha-N-acetyl-neura

38 tosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5), encoding glycans that

39 ctosyl-1,3)-N-acetylgalactosaminide alpha2,6-sialyltransferase 5 (ST6GalNAcV), was expressed at very

40 Sialyltransferase 6 GAL-I overexpression increased alpha

41 ST6GALNAC5 encodes sialyltransferase 7e.

42 Sialyltransferase 8Sia IV(-/-) mice, which lacked polySi

43 ltransferase, and Rattus norvegicus alpha2,6-sialyltransferase (a nonplant Golgi marker), only GALT1

44 and a propargyl group at the reducing end as sialyltransferase acceptors.

45 beta(1,3)galactosyltransferase and alpha(2,3)sialyltransferase activity and a decrease in alpha(1,3)f

46 Alterations in sialyltransferase activity and substrates differ between

47 d that residues critical to the hexosyl- and sialyltransferase activity are found in the predicted N-

48 elated inversely with fucosyltransferase and sialyltransferase activity based on enzyme assays and mi

49 ia coli strains producing Lic3A, demonstrate sialyltransferase activity in assays using synthetic flu

50 s as compared to controls, but no changes in sialyltransferase activity in PND30 and PND60 animals.

51 ays indicated CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase activity in this cell line.

52 Finally, we showed that sialyltransferase activity is required for DSiaT functio

53 were then used as acceptors for the alpha2-8-sialyltransferase activity of a recombinant truncated mu

54 The alpha2-8-sialyltransferase activity of CstIIDelta32(I53S) has pro

55 In vivo studies of cerebellar Golgi sialyltransferase activity revealed significant reductio

56 sferase-3 (ST3Gal-I), resulting in increased sialyltransferase activity, demonstrated by a reduction

57 Lic3A, encoding an alpha-2,3-sialyltransferase activity, is the first reported phase-

58 e in N-acetylgalactosamine-specific alpha2,6-sialyltransferase activity.

59 neither a 43-kDa immunoreactive protein nor sialyltransferase activity.

60 ulated using pharmacological tools to target sialyltransferase activity.

61 nd stop-loss mutations both caused increased sialyltransferase activity.

62 y active, recombinant Lst, it inhibited Lst (sialyltransferase) activity by only about 50% at the hig

63 The ST6Gal-I sialyltransferase adds an alpha2-6-linked sialic acid to

64 ansferase, hitchhiker-sialyltransferase, and sialyltransferase alone.

65 thway, can induce the mRNA expression of the sialyltransferase alpha-2,3-sialyltransferase-3 (ST3Gal-

66 ctivity of the glycosyltransferases alpha2,3-sialyltransferase, alpha1,3-fucosyltransferase-VII, and

67 that sLe(X) expression varies directly with sialyltransferase alpha2,3ST3Gal-IV expression and inver

68 osyltransferase (beta1,4GT) and/or alpha-2,3-sialyltransferase (alpha2,3ST).

69 2K) in the ST3GAL5 gene, which encodes for a sialyltransferase also known as GM3 synthase.

70 In this study, we report that the ST6Gal-I sialyltransferase, an enzyme up-regulated in numerous ca

71 ogenously administering recombinant ST6Gal I sialyltransferase and azide-modified CMP-Neu5Ac.

72 etects both addition and cleavage reactions (sialyltransferase and galactosidase), is applicable over

73 asma cells expressing low levels of alpha2,6-sialyltransferase and producing desialylated IgGs.

74 our hypothesis that cpsK encodes the GBS CPS sialyltransferase and provide further evidence that lack

75 ial literature suggesting a relation between sialyltransferase and sialic acid levels and coronary di

76 the established trans-Golgi enzyme alpha2,6-sialyltransferase and site-directed mutagenesis was used

77 These compounds were used for the study of sialyltransferases and 3-O-sulfotransferases involved in

78 high degree of functional specificity among sialyltransferases and a substantial role for ST3Gal-IV

79 f glycosylations by alpha-2,6- and alpha-2,3-sialyltransferases and alpha-1,3-fucosyltransferases IV

80 ds 1-3 catalyzed by alpha-2,6- and alpha-2,3-sialyltransferases and alpha-1,3-fucosyltransferases IV

81 zymes respond differently and indicates that sialyltransferases and fucosyltransferases recognize N-a

82 The specific interaction between sialyltransferases and GOLPH3 was important for the sial

83 d are regulated by the enzymatic activity of sialyltransferases and neuraminidases.

84 144D mutant, Photobacterium damsela alpha2-6-sialyltransferase, and Helicobacter mustelae alpha1-2-fu

85 eta1,3-galactosyltransferase, human alpha2,3-sialyltransferase, and Mus musculus alpha2,6-sialyltrans

86 v-3-hitchhiker-sialyltransferase, hitchhiker-sialyltransferase, and sialyltransferase alone.

87 ansferases FucT-VII and FucT-IV, one or more sialyltransferases, and at least one O-linked branching

88 However, it is not known which of these sialyltransferases are involved in vivo and whether they

89 gand formation, indicating that other ST3Gal-sialyltransferases are involved.

90 Sialyltransferases are key enzymes involved in the biosy

91 6Gal-1 supports extrinsic sialylation, other sialyltransferases are present in systemic circulation.

92 the plasma membrane, was not sialylated by a sialyltransferase at the TGN and that this enzyme and it

93 limited amounts of CMP-sialic acid to Golgi sialyltransferases but was unable to completely rescue t

94 t reports have documented that extracellular sialyltransferases can remodel both cell-surface and sec

95 Here we describe that all three alpha2,8-sialyltransferases can utilize oligosaccharides as accep

96 Sialyltransferases catalyze reactions that transfer a si

97 onreducing end of the galactosides through a sialyltransferase-catalyzed enzymatic reaction followed

98 kinetic parameters of rat liver alpha-(2,6)-sialyltransferase-catalyzed sialylations revealed that t

99 Rat liver alpha(2-->6) sialyltransferase catalyzes the formation of a glycosidi

100 alpha-2,3-Sialyltransferase catalyzes the transfer of sialic acid

101 tic lesion inactivating the murine ST3Gal-IV sialyltransferase causes a bleeding disorder associated

102 nsferases including a chicken GalNAcalpha2,6-sialyltransferase (chST6GalNAc I) and a porcine Galbeta(

103 asmic reticulum, suggesting that transporter-sialyltransferase complexes are not involved in transpor

104 We propose that multiple ST3Gal sialyltransferases contribute to selectin ligand formati

105 he first direct demonstration that alpha-2,3-sialyltransferase contributes to N. gonorrhoeae pathogen

106 ete segment of the CD8beta stalk by ST3Gal-1 sialyltransferase creates a molecular developmental swit

107 uncated multifunctional Campylobacter jejuni sialyltransferase CstII mutant, CstIIDelta32(I53S), to p

108 reported crystal structure of a bifunctional sialyltransferase CstII that has only one Rossmann domai

109 ps locus of type III GBS, could complement a sialyltransferase deficient lst mutant of Haemophilus du

110 s of a multifunctional Pasteurella multocida sialyltransferase (Delta24PmST1) with a donor analogue C

111 ncated multifunctional Pasteurella multocida sialyltransferase (Delta24PmST1), in the absence and pre

112 DeltaNspA mutant) or the lipooligosaccharide sialyltransferase (Deltalst mutant) had been inactivated

113 However, overexpression of alpha 2,6-sialyltransferase did not increase alpha 2,6-linked sial

114 Endoplasmic reticulum-retained forms of sialyltransferases did not redistribute the transporter

115 Our results reveal that the active sialyltransferase domain extends well beyond the predict

116 to define the boundaries of the hexosyl- and sialyltransferase domains.

117 Drosophila possesses a sole vertebrate-type sialyltransferase, Drosophila sialyltransferase (DSiaT),

118 ertebrate-type sialyltransferase, Drosophila sialyltransferase (DSiaT), with significant homology to

119 Drosophila sialyltransferase, DSiaT, was shown to be involved in th

120 fications, including fucosyltransferases and sialyltransferases, during inflammation.

121 ynthase (CMP-NeuAc:lactosylceramide alpha2,3-sialyltransferase; EC 2.4.99.-).

122 gonorrhoeae were significantly enriched for sialyltransferase enzymatic activity.

123 ted the gene encoding GD3 synthase (GD3S), a sialyltransferase expressed in the CNS that is responsib

124 riments ensured that GNE-mediated changes in sialyltransferase expression and ganglioside biosynthesi

125 ance induction did not downregulate alpha2,6-sialyltransferase expression and secreted immunosuppress

126 es, presumably because of rapid evolution of sialyltransferase expression patterns.

127 tary manner to the more well-known impact of sialyltransferase expression, can critically modulate th

128 GM3 synthase is a member of the sialyltransferase family and catalyzes the initial step

129 n in mice, pharmacological inhibition of the sialyltransferase family has, to date, not been possible

130 is closely related to the vertebrate ST6Gal sialyltransferase family, indicating an ancient evolutio

131 de range of suitable acceptors by a suitable sialyltransferase for the formation of sialosides contai

132 feasibility of pharmacological inhibition of sialyltransferases for in vivo modulation of sialoside e

133 The alpha-2,3-sialyltransferase from Neisseria gonorrheae was overprod

134 We have found that a recombinant alpha2-6 sialyltransferase from Photobacterium damsela (Pd2,6ST)

135 sense vector against CMP-NeuAc: GM3 alpha2-8 sialyltransferase (GD3-synthase) gene.

136 Recently, a second sialyltransferase gene (Hd0053) was discovered in H. duc

137 Insertional inactivation of the sialyltransferase gene (known to sialylate LNT LOS) abro

138 The sialyltransferase gene family is comprised of 16 cloned

139 ST8Sia II and ST8Sia IV, which belong to the sialyltransferase gene family, synthesize polysialic aci

140 Our data characterize the first sialyltransferase gene from a Gram- positive bacterium a

141 In BXSB the sialyltransferase gene not only overexpressed spliced tr

142 ignificant non-HLA associations included the sialyltransferase gene ST8SIA2 (rs1487982; odds ratio 2.

143 and III GBS have been described, but the CPS sialyltransferase gene was not identified.

144 Among other isolated sequences were a sialyltransferase gene, a mouse tumour virus superantige

145 A survey of DNA sequence upstream of the sialyltransferase gene, lst, in several Neisseria isolat

146 homologous to the lipooligosaccharide (LOS) sialyltransferase gene, lst, of Haemophilus ducreyi.

147 present study, we characterize a Drosophila sialyltransferase gene, thus providing experimental evid

148 tivity, is the first reported phase-variable sialyltransferase gene.

149 n beta1,4-galactosyltransferase and alpha2,6-sialyltransferase genes at early times after infection.

150 demonstrated that H. haemolyticus lacked the sialyltransferase genes lic3A and lic3B (9/10) and siaA

151 engineered mutations in St3gal2 and St3gal3, sialyltransferase genes responsible for terminal sialyla

152 r beta1,4-galactosyltransferase and alpha2,6-sialyltransferase genes.

153 r treatment increased mRNA expression of the sialyltransferases GM3 synthase (ST3GAL5) and GD3 syntha

154 ST3GalV (CMP-NeuAc:lactosylceramide alpha2,3 sialyltransferase/GM3 synthase) in the adult mouse, we g

155 This co-option of a brain sialyltransferase highlights the role of cell-surface gl

156 us consists of three parts, Mtv-3-hitchhiker-sialyltransferase, hitchhiker-sialyltransferase, and sia

157 ulatory enzymes in ganglioside biosynthesis, sialyltransferase I (ST1), sialyltransferase II (ST2), a

158 At least 6 ST3Gal sialyltransferases (I-VI) have been identified that may

159 ese results demonstrate that the deletion of sialyltransferase-I changes the character of MEFs to a h

160 ibroblast cell lines (MEFs) established from sialyltransferase-I knockout mice (GM3 synthase KO mice)

161 Furthermore, overexpression of alpha2,6-sialyltransferase-I rescued cell migration and cellular

162 The ganglioside GM3, used by sialyltransferase II (ST-II) as a substrate, was coated

163 ide biosynthesis, sialyltransferase I (ST1), sialyltransferase II (ST2), and N-acetylgalactosaminyltr

164 on of murine neuroblastoma (F-11) cells with sialyltransferase-II (ST2) resulted in a 70% reduction o

165 ere, we report a novel role for the ST6Gal-I sialyltransferase in gemcitabine resistance.

166 ngs have established a role for the ST6Gal-1 sialyltransferase in modulating inflammatory cell produc

167 The efficiency of SEEL for both sialyltransferases in HEL cells was greatly increased wi

168 MP signaling and highlight new functions for sialyltransferases in the developing ENS.

169 of alpha1,3-fucosyltransferases and alpha2,3-sialyltransferases in these two cell types.

170 ST6Gal-1) by RNA interference, but not other sialyltransferases, in a human cell line prevents the re

171 pping activity of O-glycan-specific alpha2,6 sialyltransferases, in particular, has been found to reg

172 f glycosytransferases, specifically alpha2,6 sialyltransferases, in regulating the length and lectin-

173 hemoenzymatic approach for using recombinant sialyltransferases including a chicken GalNAcalpha2,6-si

174 ween either TPST1 or TPST2 and the alpha-2,6-sialyltransferase, indicating a higher organization leve

175 ts provide clear evidence that FCW34-induced sialyltransferase inhibition reduces cancer cell metasta

176 of this mechanism provide new directions for sialyltransferase inhibitor design.

177 Targeting ST6GAL1 activity with a sialyltransferase inhibitor during cell reprogramming re

178 e sialylation; (ii) 5'-CDP, a potent forward sialyltransferase inhibitor, did not inhibit the convers

179 EGFR mutant, when treated with sialidase or sialyltransferase inhibitor, showed an increase in tyros

180 of cell-permeable and N- versus O-selective sialyltransferase inhibitors.

181 ynthesized C-5-modified 3-fluoro sialic acid sialyltransferase inhibitors.

182 ted across the Golgi stack to serve the many sialyltransferases involved in glycoconjugate sialylatio

183 The ST3Gal-I sialyltransferase is a candidate mechanistic component a

184 vation of serum sialic acid and the ST6Gal-1 sialyltransferase is part of the hepatic system inflamma

185 icroscopy showed that although the wild type sialyltransferase is properly localized in the Golgi app

186 We find that the ST3Gal-I sialyltransferase is required for core 1 O-glycan sialyl

187 branch-specific sialylation by the ST3Gal-IV sialyltransferase is required to sustain the physiologic

188 s, we here investigated the role of alpha2,3-sialyltransferase IV (ST3Gal-IV) in Ccl5- and Ccl2-media

189 ), but no differences in levels of alpha 2,3-sialyltransferase IV (ST3Gal-IV).

190 yltransferase VII (FucT-VII) and alpha(2, 3)-sialyltransferase IV (ST3GalIV), which are crucial for t

191 versatile and synthetically useful among all sialyltransferases known to date, especially for the syn

192 DP-galactose-4-epimerase, and two other NTHI sialyltransferases (lic3A and lsgB) produced biofilms th

193 uenzae contains sialylated glycoforms, and a sialyltransferase, Lic3A, has been previously identified

194 ate nucleotide sugar donor for all bacterial sialyltransferases; LOS derived from an H. ducreyi CMP-N

195 Alpha-2,3-sialyltransferase (Lst) is expressed on the outer membra

196 Here we report that a nonpolar alpha-2,3-sialyltransferase (lst) mutant of N. gonorrhoeae was sig

197 However, an H. ducreyi sialyltransferase (lst) mutant, whose LOS contain reduce

198 is express an approximately 43-kDa alpha-2,3-sialyltransferase (Lst) that sialylates the surface lipo

199 ccharide (LOS) are "capped" by a surface LOS sialyltransferase (Lst), using extracellular host-derive

200 charide (LOS) with sialic acid by gonococcal sialyltransferase (Lst), utilizing host-derived CMP-sial

201 serum resistance in F62, lipooligosaccharide sialyltransferase (Lst).

202 , we identify Pasteurella multocida alpha2-3-sialyltransferase M144D mutant, Photobacterium damsela a

203 Although both ST3Gal-IV and ST6Gal-I sialyltransferases mask galactose linkages implicated as

204 and GM3 synthase (lactosylceramide alpha2,3-sialyltransferase) mRNA in both 10T1/2 and DF1 cell cult

205 e copy number of the three linked sequences: sialyltransferase, Mtv-3 and hitchhiker, was amplified i

206 mation, a second trial comparing an isogenic sialyltransferase mutant (35000HP-RSM203) to 35000HP was

207 Comparisons among sialyltransferase mutant mice provide insights into the

208 The sialyltransferase of H. somnus strain 738 was confirmed

209 A significant proportion of the alpha2,6-sialyltransferase of protein Asn-linked glycosylation (S

210 t lst and cpsK are related but distinct from sialyltransferases of most other bacteria and, along wit

211 ructed with the participation of one or more sialyltransferases of the ST3Gal subfamily.

212 nic sialic acid-deficient mutants (disrupted sialyltransferase or CMP-acetylneuraminic acid synthetas

213 t elements of Gaa1(282) appended to alpha2,6-sialyltransferase or transferrin receptor could exit the

214 Our data show that extracellular ST6Gal-1 sialyltransferase, originating mostly from the liver and

215 -deficient CHO Lec2 cell line with different sialyltransferases partially blocked AAV9 transduction.

216 tion of the abundance of these extracellular sialyltransferases, particularly ST6Gal-1, with disease

217 OS could not function as an acceptor for the sialyltransferase, probably due to steric hindrance impo

218 The ST6Gal-I sialyltransferase produces Siglec ligands for the B-cell

219 sylation and the functional redundancy among sialyltransferases provide obstacles for revealing biolo

220 I) and a porcine Galbeta(1-3)GalNAcalpha-2,3-sialyltransferase (pST3Gal I).

221 Overall, the study demonstrates that the sialyltransferase reaction is readily reversible in the

222 Overall, a single sialyltransferase regulates selectin-ligand biosynthesis

223 3Gal-4, but not ST3Gal-3 or -6, is the major sialyltransferase regulating the biosynthesis of E-, P-,

224 ion of asialo cells with alpha(2,3)-specific sialyltransferase restored susceptibility to infection.

225 e structure with pig ST3GAL1 and a bacterial sialyltransferase revealed a similar positioning of dono

226 applied to the 36-kDa luminal domain of the sialyltransferase, rST6Gal1, in which all phenylalanines

227 ubstrate specificity studies on three cloned sialyltransferases (Sia-Ts) revealed that a 3- or 4-fluo

228 cid synthetase (siaB), one of the three NTHI sialyltransferases (siaA), and the undecaprenyl-phosphat

229 We report evidence for two additional sialyltransferases, SiaA, and LsgB, that affect N-acetyl

230 This gene encodes a functional alpha2-6-sialyltransferase (SiaT) that is closely related to the

231 High alpha2,3/6-Sialyltransferase (ST) activity and low alpha1,2-fucosyl

232 Golgi-specific sialyltransferase (ST) expressed as a chimera with the r

233 induction, mRNA coding for predominant HUVEC sialyltransferases (ST) and fucosyltransferases (FT), ke

234 In particular, expression of the sialyltransferase ST3Gal-I has been proposed as a critic

235 reverse sialylation, catalyzed by mammalian sialyltransferase ST3Gal-II.

236 e demonstrated the greater importance of the sialyltransferase ST3Gal-III compared with fucosyltransf

237 st, combined but not individual knockdown of sialyltransferases ST3Gal-III, ST3Gal-IV, and ST6Gal-I,

238 And Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (ST3Gal III) transfectants were made t

239 orted that the St3gal3 gene product alpha2,3 sialyltransferase (ST3Gal-III) is required for constitut

240 yltransferases (ST6GalNAc), and two alpha2-3-sialyltransferases (ST3Gal).

241 We evaluated the role of 3 alpha(2,3)sialyltransferases, ST3Gal-3, -4, and -6, which act on t

242 lanoma invasion through the induction of the sialyltransferase ST3GAL1.

243 ow that nerve injury-induced upregulation of sialyltransferase St3gal2 in sensory neurons leads to an

244 suppressing the mannosyltransferase alg2 and sialyltransferase st3gal2, two enzymes involved in prote

245 Iterative haploid screens revealed that the sialyltransferase ST3GAL4 was required for the interacti

246 repolarization through gene deletion of the sialyltransferase ST3Gal4.

247 igh expression of beta-galactoside alpha-2,3-sialyltransferase, ST3GAL6, in MM cell lines and patient

248 alpha1,3-fucosyltransferase and an alpha2,3-sialyltransferase (ST3GalIV) were performed on the MARY-

249 sis lectin, increased expression of alpha2,3-sialyltransferase ST3GalVI, and loss of SnL following tr

250 the observation that an additional alpha2,6-sialyltransferase, ST6 (alpha-N-acetyl-neuraminyl-2,3-be

251 leaves the amyloid precursor protein and the sialyltransferase ST6Gal I and is important in the patho

252 d for by a decrease in the expression of the sialyltransferase ST6Gal I, and an increase in the expre

253 minic acid is preferentially accepted by the sialyltransferase ST6Gal-I over ST3Gal-IV, leading to th

254 noglobulin G, produced by the human alpha2-6 sialyltransferase ST6Gal-I, were identified as potent an

255 lytic domain of two isoforms of the alpha2,6-sialyltransferase (ST6Gal I) leads to differences in the

256 Galbeta1,4GlcNAc alpha2,6-sialyltransferase (ST6Gal I) transfectants were made to

257 Knockdown of beta-galactoside alpha2,6-sialyltransferase (ST6Gal-1) by RNA interference, but no

258 The alpha-2,6-sialyltransferase (ST6Gal-I) is a key enzyme that regula

259 proach is presented that that uses alpha-2,6-sialyltransferase (ST6Gal-I) to enzymatically add 13C-N-

260 signaling, namely beta-galactoside alpha2,6-sialyltransferase (ST6Gal-I).

261 f the Golgi enzyme beta-galactoside:alpha2-6-sialyltransferase (ST6Gal-I).

262 served N-glycans within the Fc domain by the sialyltransferase ST6Gal1 accounts for the anti-inflamma

263 Here, we observed that the sialyltransferase ST6GAL1 was preferentially expressed i

264 hroleukemia cells (HEL) using SEEL using the sialyltransferases ST6Gal1 and ST3Gal1, which label N- a

265 ly quiescent, glycoprotein-specific alpha2,6-sialyltransferase (ST6Gal1) gene in gliomas inhibited in

266 indirectly, via increased expression of the sialyltransferase ST6GalNAc-II, which prevents galactosy

267 osyltransferase (T-synthase), three alpha2-6-sialyltransferases (ST6GalNAc), and two alpha2-3-sialylt

268 glycans was negatively regulated by alpha2,6 sialyltransferase ST6GalNAc2.

269 ceptor (EGFR) ligand HBEGF, and the alpha2,6-sialyltransferase ST6GALNAC5 as mediators of cancer cell

270 h are moderately related to another alpha2,8-sialyltransferase, ST8Sia III.

271 The sialyltransferase ST8Sia6 generates alpha-2,8-disialic a

272 hoeae strain F62 contain about fivefold more sialyltransferase (Stase) activity than extracts of N. m

273 This represents the first sialyltransferase structure and the first GT-B-type glyc

274 4PmST1 structure, thus, represents the first sialyltransferase structure that belongs to the glycosyl

275 d the acceptor specificities of three cloned sialyltransferases (STs) [alpha2,3(N)ST, alpha2,3(O)ST,

276 the biological and pathological functions of sialyltransferases (STs), intracellular ST activity eval

277 me to sialylate other O-glycans and by other sialyltransferases such as ST6Gal-I and ST6GalNAc-I, for

278 esembles the corresponding site in bacterial sialyltransferases, suggesting an evolutionary connectio

279 The ST6Gal I is a sialyltransferase that functions in the late Golgi to mo

280 Human B cells secrete active ST6GAL1 sialyltransferase that remodels progenitor cell surface

281 more conserved, including those encoding the sialyltransferases that attach Sia residues to glycans.

282 d in mammals by a single conserved family of sialyltransferases that have diverse linkage and accepto

283 s can be regulated by expression of specific sialyltransferases that transfer sialic acid in a specif

284 s well as the biosynthetic products of these sialyltransferases, the GM3 and GD3 gangliosides.

285 le, if any, structural relationship to other sialyltransferases, this protein represents a new class

286 substrate specificity when compared to other sialyltransferases, though the donor specificity is quit

287 glycoproteins and glycolipids requires Golgi sialyltransferases to have access to their glycoconjugat

288 Moreover, using sialyltransferases to install sialic acid can minimize s

289 evealed decreasing sensitivity of cerebellar sialyltransferases to MeHg as the developmental age of t

290 Sialyltransferases transfer sialic acid from cytidine 5'

291 acrophage lineage down-regulate the ST6Gal-I sialyltransferase via a protein kinase C/Ras/ERK signali

292 t of N-acetylgalactosamine-specific alpha2,6-sialyltransferase was significantly higher than the expr

293 An O-linked-specific alpha(2,3)-sialyltransferase was unable to restore infection in asi

294 To determine if cpsK might encode a sialyltransferase, we complemented a H. ducreyi lst muta

295 atment or genetic deficiency in the ST3Gal-I sialyltransferase, we show that desialylation of mature

296 tivity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in IgA1-producing cell lin

297 sialyltransferase, and Mus musculus alpha2,6-sialyltransferase were transiently co-expressed in N. be

298 es of only Gal 3-O-sulfotransferases and not sialyltransferases were adversely affected by a C-3 fluo

299 in compound 4 abolished all activity of the sialyltransferases whereas the fucosyltransferases showe

300 ide alpha-2,6-sialyltransferase 1 (ST6Gal-I) sialyltransferase, which is up-regulated in numerous can

301 s vesicle cargo molecules (mannosidase I and sialyltransferase-yellow fluorescent protein) were ident