ライフサイエンスコーパス: sib

1 Genotyping data were available for 106 sib pairs (43 CA, 63 AA) from 27 CA (44% male probands)

2 combined analysis of MN cohorts 1 and 2 (187 sib-pair families) showed that markers in 6p11-p21 (D6S4

3 tin-1 and EFEMP1, in subsamples (145 and 189 sib pairs, respectively) of the data.

4 e genes including nicotinic receptors in 200 sib pairs selected from the Mid-South Tobacco Family pop

5 To date, we have collected 212 sib pairs from 46 CA and 50 AA families.

6 a subset of families (102 families; n = 224 sib pairs) from the Beaver Dam Eye Study and performed a

7 n two sets of data: (1) 325 individuals (225 sib pairs) from the Beaver Dam Eye Study (BDES), and (2)

8 629 women from 311 extended families (1,242 sib pairs) in the Framingham Heart Study Offspring cohor

9 The panel contains 350 siblings and 245 sib-pairs.

10 ains >10,000 relative pairs (including 1,249 sib pairs) that are useful for linkage analyses, we perf

11 autosomal markers in 325 individuals (N=263 sib pairs) from 102 pedigrees.

12 e Study (BDES), and (2) 297 individuals (346 sib pairs) from the Family Age Related Maculopathy Study

13 n 34 extended families (297 individuals, 349 sib pairs) ascertained through index cases with neovascu

14 itional previous population of 66 BMI >or=35 sib-pairs led to a significant LOD score of 3.8 at the 1

15 ymorphisms (SNPs) and 50K transcripts in 400 sib pairs from the MRCA family panel, has been widely us

16 ising of 278 families, 634 siblings, and 470 sib-pairs.

17 l from 267 multiplex families, including 472 sib-pairs affected with type 2 diabetes.

18 reported a two-stage genomewide screen of 48 sib pairs affected with intracranial aneurysms (IAs) tha

19 e-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage

20 analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive diso

21 cus in an extended sample (380 families, 520 sib-pairs, maximum LOD score 4.3).

22 lled between 1997 and 1999, 12 of 327 (3.7%) sibs and 11 of 161 (6.8%) parents reported a history of

23 ans without diabetes (from 162 families, 750 sib-pairs).

24 ive-compulsive disorder) was conducted on 77 sib pairs collected by the Tourette Syndrome Association

25 ning 48 cM across chromosome 18q12-q22 in 81 sib pairs affected with autoimmune thyroid disease (AITD

26 We similarly classified our data set of 82 sib pairs with AutD, identifying 45 families with AutD a

27 cally (total siblings 582, 182 families, 860 sib-pairs: LOD = 3.5).

28 hundred fifteen nuclear families yielded 870 sib pairs for linkage, with significant logarithm of odd

29 A sib-pair method has been used to examine the familiality

30 ion of Neur can induce both cells to adopt a sib fate similar to gain of function Notch.

31 hanges into GMC-1 and generates an RP2 and a sib without affecting the expression of key genes at the

32 ion of Notch in a cell committed to become a sib.

33 ring two alleles IBD at a putative QTL for a sib-pair.

34 of complexity is involved in implementing a sib pair study and interpreting the results.

35 d volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation o

36 h that associated with random selection of a sib for genotyping.

37 Numb, which prevents Notch from specifying a sib identity.

38 We are now adding sib pairs and increasing marker density on chromosome 10

39 Affected sib pair (ASP) analysis has become common ever since it

40 Affected sib-pair analysis yielded multipoint maximum LOD scores

41 atoconus sib pair families with 110 affected sib pairs of white or Hispanic origin.

42 with a sample size expanded to 139 affected sib pairs, along with 83 other affected relative pairs (

43 Of 166 affected sib pairs, 30 (12 MZ, 17 DZ, and 1 of unknown zygosity)

44 d no evidence of linkage, among 201 affected sib pairs, in the region of chromosome 2 that contains t

45 The study cohort comprised 2076 affected sib-pairs and 66 affected half-sib-pairs of the British

46 267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families.

47 to 364 ARM families with up to 329 affected sib pairs, the linkage signal on chromosome 9 vanished,

48 type model (DSM-IV OCD definite; 41 affected sib pairs) and a broad phenotype model (DSM-IV OCD defin

49 391 families, containing up to 452 affected sib pairs, we found linkage evidence in four regions: 1q

50 SM-IV OCD definite and probable; 50 affected sib pairs).

51 For samples of 500 affected sib pairs, the tests are powerful in detection of genoty

52 ographical regions containing 2,658 affected sib-pairs (ASPs).

53 porating 530 families and up to 736 affected sib pairs.

54 number of affected twin pairs among affected sib pairs to expected values in two separate samples of

55 we model locus heterogeneity among affected sib pairs with prostate cancer by including covariates i

56 hen 50% of families consisted of an affected sib pair and one parent genotyped under an additive gene

57 We performed exome sequencing on an affected sib-pair with normal ultrastructure in more than 85% of

58 use three approaches: pedigree and affected sib-pair linkage studies and association studies of popu

59 are available for unrelated cases, affected sib pairs (ASPs), or only one sibling per Asp. We constr

60 methods (e.g., variance components, affected sib pair, extremely discordant sib pairs, etc.) that tru

61 in 187 and 356 families containing affected sib pairs (ASPs) yielded apparently conflicting results,

62 or smaller pedigrees especially for affected sib pair kindreds.

63 utation frequencies were greater in affected sib pairs than in sporadic CD cases but actually decreas

64 dy of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the e

65 s not inflate type I error rates of affected sib pair (ASP) statistics in the whole parameter space,

66 oint model-free linkage analysis of affected sib pair data.

67 families recruited on the basis of affected sib pairs for asthma reveal significant association for

68 l on the trait data for a sample of affected sib pairs, with disease penetrances and disease-SNP hapl

69 nger affected sib than in the older affected sib (P < 0.02).

70 3.93 on chromosome 18, a two-point affected sib pair (ASP) LOD score of 3.11 on chromosome 16, sever

71 We find that, by choosing the affected sib who shows the most evidence for pairwise allele shar

72 We focus on the affected sib-pair study design and develop test statistics that a

73 (APP) region is strongly linked to affected sib pairs of the oldest current age (i.e., age either at

74 int linkage methods were applied to affected sib-pairs with inflammatory bowel disease, and significa

75 A genome-wide scan (GWS) using affected sib pair linkage analysis was performed on 218 sibling p

76 Two-point linkage analysis using affected sib pairs yielded LOD scores of 3.15 at D12S1623 and 1.4

77 A genome-wide affected sib-pair linkage study with 221 Japanese families with c

78 in an additional 140 families with affected sib pairs.

79 tely 13 times higher in the younger affected sib than in the older affected sib (P < 0.02).

80 to increased allele sharing between affected sibs.

81 Clinical severity of mildly affected sibs with the same PMM2 mutations did not correlate with

82 in the families with three or more affected sibs compared with sib pairs.

83 ased in families with three or more affected sibs, raising the possibility of genetic heterogeneity.

84 le of 105 families with two or more affected sibs.

85 specific high-risk HLA genotypes or affected sibs' ages at disease onset, provided evidence of linkag

86 rwise allele sharing with the other affected sibs in families, the test statistic is increased by >20

87 e of whom has autism; the remaining affected sibs carry diagnoses of either Asperger syndrome or perv

88 ecessive disease: one allele in the affected sibs and multiple alleles in unaffected sibs and parents

89 family composed by a father and two affected sibs with Adams Oliver syndrome (AOS) (OMIM 100300).

90 lected because each had exactly two affected sibs, we observed a remarkably high proportion of affect

91 ort, we have used a covariate-based affected-sib-pair linkage method to analyze the chromosome 21 cli

92 imum LOD scores (MLS) obtained from affected-sib-pair analysis of all 345 families yielded suggestive

93 Similarly, in affected-sib-pair analysis of our schizophrenia dataset (241 sibl

94 e high proportion of twins found in affected-sib-pair studies can be adequately explained by the high

95 archers are increasingly relying on affected-sib-pair (ASP) data.

96 th the conditional analysis and the affected-sib-pair two-locus analysis provided further evidence fo

97 -dimensional, linear Ising model to affected-sib-pair (ASP) analysis in genetics.

98 By expanding the traditional affected-sib-pair design to include unaffected and discordant sib

99 tative trait in the analysis, using affected-sib-pair data.

100 5 years, overall survival (OS) was 44% after sib alloHSCT, 36% after MUD alloHSCT, and 19% after chem

101 All sib pairs were concordant for a diagnosis of Gilles de l

102 Not all sib pairs in the sample were concordant for hoarding.

103 results indicate that, in African Americans, sibs and parents of sarcoidosis cases have about a 2.5-f

104 009), SimWalk2 Statistic A (P = 0.0002), and sib-pair analyses (maximum likelihood score = 6.07) all

105 By single nucleotide polymorphism-based and sib-pair analysis, we show that that weight loss is a he

106 gnifies sex biases and promotes helping; and sib-mating, promiscuity, and reproductive autonomy also

107 without parental genotypes), sib trios, and sib quads.

108 a was also found for male family members and sibs born later in the birth order.

109 dispositions of children toward parents and sibs are expected to be sensitive to cues of marital sta

110 a multivariate model fit to the parents and sibs data, the familial relative risk adjusted for age,

111 ves of MSGB differences between probands and sibs (area under the receiver operator curves, 0.57 [95%

112 kage Analysis Testing), that can perform any sib pair statistical test currently in use, as well as a

113 advocate the ASP/DSP design with appropriate sib-pair statistics that test the difference in allele s

114 multipoint identity by descent (IBD) between sib pairs and false-positive evidence for multipoint mod

115 , the intraclass correlations (ICCs) between sib-pairs (pairs of unaffected siblings and schizophreni

116 ned by the overall trait correlation between sibs in a population.

117 nt antibiotic stress than their IOP-burdened sibs.

118 of the linkage evidence derives from the CA sib pairs.

119 er and type 1 diabetes in 364 U.S. Caucasian sib-pair families (P < 0.006).

120 Both the H-cell and the glutamatergic H-cell sib are the asymmetric progeny of the MP3 midline precur

121 H-cell sib cell fate is dependent on Notch signaling, whereas H

122 ons (EC)) and the other forcing it (circular sib mating (CM)).

123 by promoting the reproduction of their clone sibs.

124 We detected sib-pair linkage of 5q34 GABA(A) receptor genes to alcoh

125 A candidate gene search of diabetic sibs discordantly affected, concordantly affected and co

126 and hence on type I error rates of different sib-pair linkage approaches that assume LE.

127 design to include unaffected and discordant sib pairs, analytical power and robustness to type I err

128 ter space, and that, in any case, discordant sib pairs (DSPs) can be used to control for marker-marke

129 ntitative traits, such as extreme discordant sib pairs.

130 nts, affected sib pair, extremely discordant sib pairs, etc.) that truncate all "negative evidence ag

131 f association in family triads or discordant sib pairs but are not theoretically valid in multiplex f

132 ly applicable to case-control and discordant-sib-pair studies.

133 o 19-amino-acid proteins (Ibs) opposite each sib gene.

134 ngly suggests that one should incorporate EC sib pairs along with ED sib pairs, in both design and an

135 hould incorporate EC sib pairs along with ED sib pairs, in both design and analysis.

136 Elliptical sib pair analysis showed significant associations of the

137 ngs (study participants), forming an exposed sib-pair.

138 Each exposed sib-pair was matched up to 5 unexposed sib-pairs from th

139 ata, we identified in a sample of 961 female sib-pairs, three genome-wide significant QTLs for apolip

140 essivity, the beta(FS) was greater in female sibs, which was attributable to their higher leptin conc

141 ed, and no phenotype was observed for a five-sib deletion strain.

142 nt marker densities and heterozygosities for sib pairs (with and without parental genotypes), sib tri

143 Our simulation study shows that, for sib-pair data, even when the coverage probability of the

144 of ancestral, sexually dimorphic traits for sib-rearing.

145 For sibs and parents combined, lambda was 2.49 (95% confiden

146 24 (95% confidence interval: 1.16, 3.92) for sibs and 2.82 (95% confidence interval: 1.41, 5.05) for

147 d, one or more individuals from each of four sib groups displayed a genotype that was identical to th

148 s screened with heterologous liver cDNA from sib-pairs of contrasting HDL-C phenotypes on two differe

149 As large full sib family sizes can be obtained in fish, the practical

150 ilies composed of mother, father, and 2 full sibs delivered between 38 and 41 weeks' gestation within

151 dicted to be particularly evident among full sibs.

152 dairy cattle breeding schemes but from full sibs it contributes considerably to accuracy within fami

153 to state birth certificates to identify full sibs and half-sibs and to obtain information on birth or

154 t to discriminate memory from nonmemory full sibs.

155 ly discordant pairs that are ostensibly full sibs may be half sibs.

156 Full-sib (beta(FS)) regression slopes were robustly estimated

157 loci (QTL) scan was performed within 10 full-sib families that had received a natural seawater IPN ch

158 ge map was generated from a set of 1976 full-sib progeny, with the positioning of 8793 expressed gene

159 201 AFLP and SSR markers scored on 228 full-sib individuals of autotetraploid potato is used to illu

160 3 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one indiv

161 A total of 1321 trees, representing 37 full-sib F(1) families from 3 environments in British Columbi

162 an was performed on the offspring of 50 full-sib families, for traits related to fitness (length, wei

163 A full-sib design was set up in which families of Culex pipiens

164 ity loci in outbred populations using a full-sib family as an example.

165 mapping in autotetraploid species for a full-sib family derived by crossing two parents.

166 on patterns from molecular markers in a full-sib family derived from an arbitrary polyploid combining

167 h-resolution genetic linkage map from a full-sib family of 124 individuals and their parents using th

168 ge analysis of polymorphic markers in a full-sib family of autotetraploids.

169 ation rate per site per generation in a full-sib family of Drosophila melanogaster recently sampled f

170 as constructed from 90 individuals in a full-sib family, combining 2719 SNP and 84 SSR segregating ma

171 ) linkage maps were constructed using a full-sib population of 238 plants and SSR and STS markers to

172 set of SSR and AFLP markers scored in a full-sib population of tetraploid potato.

173 variation in the drought response of a full-sib second generation (F(2)) mapping population from a c

174 additional diallel cross was done among full-sib progeny from a cross of a self-sterile and a self-fe

175 tionships, such as unrelated, half- and full-sib, or parent-offspring, little attention has been paid

176 fying shared haplotype segments between full-sib individuals.

177 Using four shell colors full-sib families of the Pacific oyster Crassostrea gigas, we

178 ci (QTL) using the double haploid (DH), full-sib (FS) and hierarchical (HI) designs implemented in ou

179 ages of growth using a three generation full-sib design population which originated from a cross betw

180 ossing populations, hybrid generations, full-sib families and selfing lines) have recently received m

181 ion of a large sample of individuals in full-sib families of the same small size, the same large size

182 partition individuals in a sample into full-sib and half-sib families using genetic marker data with

183 We found that despite 16 rounds of full-sib crossings the D. suzukii strain that we sequenced ha

184 ned to exploit the genetic structure of full-sib families.

185 in most traits due to one generation of full-sib mating.

186 ment is by either self-fertilization or full-sib mating.

187 puting genome-wide genotypes in outbred full-sib families from single nucleotide polymorphism (SNP) a

188 ver generations is described for self-, full-sib-, and half-sib-generated RILs with no dominance in t

189 k tolerant and two heat shock sensitive full-sib oyster families.

190 elf-medication behaviour across several full-sib families to evaluate the plasticity of diet choice a

191 crosses: the first included many small full-sib families and the second was derived from five genera

192 maturity was performed on a tetraploid full-sib family of potato comprising 227 clones from a cross

193 markers scored on two parents and their full-sib progeny.

194 gregation ratios was assembled for this full-sib family, and a total of 409 SNP markers were mapped o

195 ) obtained from mesocarp tissues of two full-sib progeny contrasting for CI, about 48 and 13% of whic

196 method is evaluated in simulations with full-sib families.

197 as evaluated in the F(1) progeny of 169 full-sibs of the cross.

198 x P. elliottii pseudo-backcross of 345 full-sibs (BC1).

199 pairs (with and without parental genotypes), sib trios, and sib quads.

200 ethod, was asymptotically greatest with half sibbing, less with sibbing, and least with selfing.

201 rs that are ostensibly full sibs may be half sibs.

202 Cosegregation information from half sibs contributes little to accuracy of GEBVs in current

203 ing the importance of identification of half sibs.

204 population included 599 clones from 17 half-sib families, which were successfully genotyped using 43

205 families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioi

206 Fgrm = 0.125, a value resulting from a half-sib mating, LBS declined by 72% for females and 95% for

207 2076 affected sib-pairs and 66 affected half-sib-pairs of the British Genetics of HyperTension study.

208 dividuals in a sample into full-sib and half-sib families using genetic marker data without parental

209 Full and half-sib groups of T. nubilale were obtained from a nested ma

210 is described for self-, full-sib-, and half-sib-generated RILs with no dominance in true crossovers.

211 e-based methods of QTL analysis such as half-sib regression interval mapping and a variance component

212 f inheriting an allele deviated between half-sib families.

213 nvestigate the power of differentiating half-sib, avuncular and grandparent-grandoffspring relationsh

214 ating genetic variance components given half-sib covariances estimated by our experimental design.

215 e reconstructed multiple interconnected half-sib families in the Vinson population, with some genets

216 rent-child trios, and arbitrarily large half-sib pedigrees.

217 opportunities and rewards for producing half-sib clutches, and thereby its exposure to selection pres

218 A subsequent half-sib breeding design revealed an amount of additive genet

219 of heritability are available from the half-sib pedigree design: the sire, dam and genotypic estimat

220 nts from a natural population and their half-sib seeds.

221 d 489 Suffolk animals in five and three half-sib families, respectively, were genotyped for microsate

222 foliator Thaumetopoea pityocampa) using half-sib families drawn from a sample of the population of Pi

223 val mapping by linear regression within half-sib families and a variance components analysis of a six

224 certificates to identify full sibs and half-sibs and to obtain information on birth order and demogr

225 t account for the presence of full- and half-sibs commonly found in large clutches of many organisms.

226 s included 39,361 individuals (sibs and half-sibs).

227 e fit in terms of recruitment than were half-sibs sired by social mates.

228 duct--rather than the squared difference--in sib trait values, is, in general, less powerful than VC

229 classify the major sources of discretion in sib pair linkage analysis.

230 The minimum shared haplotype in sib pairs with similar trait values spans 4.9 cM and is

231 quares-based VC method for mapping of QTL in sib pairs (Elston et al.).

232 us expression of maternal genes to result in sib-care, the hallmark of highly evolved social life in

233 milial risk ratio (lambda) of sarcoidosis in sibs and parents of cases, the authors studied 179 Afric

234 aplodiploidy is developed which incorporates sib mating, deleterious mutations generated by mutation,

235 -Elston method was developed for independent sib pairs; its generalization to nonindependent sib pair

236 rkers in nuclear families and in independent sib pairs.

237 These families included 39,361 individuals (sibs and half-sibs).

238 both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of

239 Multiple genome-wide scans involving sib-pairs or limited pedigrees have been extensively use

240 was performed with data from 67 keratoconus sib pair families with 110 affected sib pairs of white o

241 x trait with a sibling relative risk (lambda(sibs)) between 18 and 36.

242 we assumed relative risk to siblings (lambda(sibs)) values of 1.15, 1.2, 1.3, or 1.4.

243 ed independently in a study of affected LOAD sib-pairs.

244 howing their differential expression in male sib pairs discordant for idiopathic ASD.

245 A polymerase chain reaction-mediated sib-selection technique was successfully adapted for the

246 re genotyped for 335 markers, and multipoint sib pair linkage analyses were conducted.

247 These processes include mutation, sib competition, and invisible fractions.

248 pairs; its generalization to nonindependent sib pairs is not straightforward.

249 nkage to chromosome 2q (D2S116 nonparametric sib-pair LOD score [MLS] 1.12 at 198 cM).

250 to simultaneously estimate, on the basis of sib-pair linkage data, both the position of a trait locu

251 ion to model the squared trait difference of sib pairs with the shared allele identical by descent (I

252 A new function of sib-pair phenotypes, the product of pair values correcte

253 ontinuing to survive after 20 generations of sib x sib mating.

254 e analysis was followed by identification of sib pairs with linkage and construction of core shared h

255 nflation as a function of the resemblance of sib pairs and the criteria for discordance used for sele

256 in 11 additional individuals (including one sib-pair).

257 Considering only sib pairs compared with unrelated persons, distance corr

258 ry number of prior generations of selfing or sib-mating.

259 individuals, as indicated by the sib-sib OR (sib-sib OR adjusted for known risk factors (95% CI): 4.2

260 ternity was high, indicating that outcrossed sibs within families were sired by the same father.

261 loci with locus-specific disease prevalence/sib-risk ratios (lambda(s)) <1.4.

262 f a recurrent depression locus in a previous sib-pair study.

263 io, lambdas, and sibling-sibling odds ratio (sib-sib OR), for the adverse pregnancy outcomes of prete

264 g errors at each locus in each reconstructed sib family.

265 More-robust sib-pair designs and appropriate methods for their analy

266 onal pairs in the Drosophila nerve cord, RP2/sib, has a complicated migratory route.

267 In the NB4-2 --> GMC-1 --> RP2/sib lineage, a well-studied neuronal lineage in the vent

268 In the typical GMC-1-->RP2/sib lineage, we found that loss of Neur activity causes

269 n, in a typical lineage, NB4-2-->GMC-1-->RP2/sib, suggest that at least part of the process operates

270 We have previously shown that RP2/sib, a well-studied neuronal pair in the Drosophila vent

271 In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down r

272 ng ruled out linkage at 14q21-23 (lambda(s) [sib recurrence risk or genotypic risk ratio] = 1.8).

273 he implicit assumption that randomly sampled sib pairs share half their alleles identical by descent

274 Studies of a second sib with severe liver disease and other living family me

275 Even though we select sibs on the basis of a nonparametric statistic, the addi

276 Sib-sib correlations were calculated with the SAGE 5.0 progr

277 utcome of assigning alloHSCT with a sibling (sib) or matched unrelated donor (MUD) to patients younge

278 Across arthropod societies, sib-rearing (e.g. nursing or nest defence) may be provid

279 entral nerve cord, Notch signaling specifies sib fate to one of the daughter cells of GMC-1.

280 The squared sib-pair phenotype difference (SQD) has been used as a d

281 The sib-sib correlation for DR severity was 0.1358 in the to

282 The sib-TDT analysis also showed significant association bet

283 disequilibrium test (SDT, p = 0.68) and the sib transmission/disequilibrium test (Sib-TDT, p = 0.81)

284 unaffected individuals, as indicated by the sib-sib OR (sib-sib OR adjusted for known risk factors (

285 n in the data, because it only considers the sib-pair trait-value difference.

286 compared to other proposed functions of the sib-pair phenotypes.

287 h the distribution of phenotypes amongst the sibs of the individual and this depends on the genotypes

288 ds and their parents is preferred, and three sibs will be required to have close power if parents are

289 In addition to sib-pair linkage and case-control association analyses,

290 to have greater power than does traditional sib-pair analysis.

291 ely to be ascertained than affected non-twin sib pairs (or 7 times more likely if "stoppage" plays a

292 ulation included 69 community-dwelling twin, sib-sib, or parent-offspring pairs (n = 138), comprising

293 common diseases, sampling affecteds and two sibs will generally be more efficient than trios.

294 based on affected, discordant, or unaffected sib pairs, as well as on pairs defined by threshold valu

295 cted sibs and multiple alleles in unaffected sibs and parents.

296 posed sib-pair was matched up to 5 unexposed sib-pairs from the Multi-Generation Registry by birth an

297 th three or more affected sibs compared with sib pairs.

298 ng association, even for disease models with sib relative risk as low as lambda S=1.1, or when eviden

299 ically greatest with half sibbing, less with sibbing, and least with selfing.

300 ing to survive after 20 generations of sib x sib mating.