ライフサイエンスコーパス: sibship

1 ple for DNA collection (757 individuals, 297 sibships).

2 2.84) but were uncommon (34 siblings from 11 sibships).

3 0 diabetic siblings of control subjects (172 sibships).

4 ereas some are amenable to nuclear families (sibships).

5 f family relationships such as parentage and sibship.

6 at estimated for the parents from the entire sibship.

7 the single-gene cause of proteinuria in this sibship.

8 on the basis of its high recurrence rate in sibships.

9 ative-trait loci by use of sibling pairs and sibships.

10 , among sibships or among individuals within sibships.

11 onparametric" linkage analysis with affected sibships.

12 of linkage, using marker genotype data from sibships.

13 region in Alzheimer disease (AD) discordant sibships.

14 ings in genotyping, especially for multiplex sibships.

15 ent genetic variation, and unlimited size of sibships.

16 Mexican-American affected sib-pairs from 246 sibships.

17 tative-trait loci in randomly selected human sibships.

18 comprised of 709 affected sib-pairs from 472 sibships.

19 milies with parents and data from discordant sibships.

20 d maternal factors associated with unisexual sibships.

21 ng of a large sibship into two or more small sibships.

22 and paternal or maternal (but not both) half sibships.

23 individuals to infer parentage jointly with sibships.

24 incidence of recessive disease within these sibships.

25 nd are thus completely reliable in inferring sibships.

26 edigrees and similar power to the FEXAT with sibships.

27 NOA) sibships (1381 African-Americans in 592 sibships, 1116 Caucasians in 503 sibships and 1378 Mexic

28 Epidemiology Network of Arteriopathy (GENOA) sibships (1381 African-Americans in 592 sibships, 1116 C

29 otyping Service) and 1,082 subjects from 256 sibships (243 markers, the Utah Molecular Genetics Labor

30 correlations between siblings (n=682, in 291 sibships, 517 pairs) and between spouse pairs (n=206 pai

31 w method can be used to infer full- and half-sibships accurately from marker data with a high error r

32 Data included 272,429 individuals (126,701 sibships) aged 15 or more years from the total Swedish p

33 e syndrome were ascertained in nine separate sibships among the Old Order Amish.

34 Whole-cohort and within-sibship analyses were performed; the latter accounted fo

35 0.10; 95% CI, -0.13 to -0.07), but in within-sibship analysis, the association was null (mean differe

36 information and of the power of a parentage/sibship analysis.

37 e largely independent of position within the sibship and national GNI per capita.

38 te a few methods have been proposed to infer sibship and parentage among individuals from their multi

39 (say, >0.5), that it leads to more accurate sibship and parentage inferences than previous models.

40 The full-likelihood method assigns sibship and parentage relationships among all sampled in

41 t randomly a single affected child from each sibship and to apply the TDT to those data.

42 cans in 592 sibships, 1116 Caucasians in 503 sibships and 1378 Mexican-Americans in 416 sibships), fi

43 wedish National Sample of 666 high-risk full sibships and 2,596 high-risk half sibships containing at

44 Here, we assessed 30 sibships and 89 parent/case trios of presumed ocular tox

45 We extend our method to larger sibships and apply it to an NIDDM1 data set.

46 ) (centenarians or near-centenarians) in 137 sibships and identified statistically significant linkag

47 lymorphisms in 257 multiplex prostate cancer sibships and in 355 race-matched healthy unrelated contr

48 ted females and unaffected parents in single sibships and in highly consanguineous families with mult

49 or only one sex is polygamous to infer full sibships and paternal or maternal (but not both) half si

50 oci (QTLs) has previously been restricted to sibships and small pedigrees.

51 is that age cohorts will tend to be paternal sibships and social groups will be genetically substruct

52 Hypertensive sibships and their offspring and/or parents in the Hyper

53 s, paternal half sibships, and maternal half sibships and to the case of a two-generation sample of i

54 tests, using organoids analogously to large sibships and vastly amplifying the test power.

55 to calculate correlation coefficients within sibships and within spouse pairs.

56 amples, we show that, by carefully selecting sibships and/or individuals on the basis of allele shari

57 tivariable Cox models adjusted for age, sex, sibship, and baseline stroke risk factors, we observed t

58 of two or more small sibships into a single sibship, and type II errors originate from the spurious

59 gamous to infer full sibships, paternal half sibships, and maternal half sibships and to the case of

60 prevents effectively the splitting of large sibships, and reduces type II errors greatly with little

61 Sibships are commonly used in genetic dissection of comp

62 accuracy of sibship assignments, except when sibships are expected to be uniformly small or marker in

63 ng conditional logistic regression, treating sibship as the matching factor.

64 equally affected males and females in single sibships, as well as the presence of consanguinity, supp

65 sing simulated data and exome chip data from sibships ascertained for hypertension collected as part

66 Sibships ascertained through a single proband are discus

67 than pairwise methods in both parentage and sibship assignments because of the more efficient use of

68 result, it improves the overall accuracy of sibship assignments, except when sibships are expected t

69 The model is based on the between-within-sibship association model presented in 1999 by Fulker an

70 In matched full and half sibships at high risk for major depression, compared wit

71 In each sibship, both parents were found to be affected, opening

72 inical and genetic data obtained on affected sibships by the National Institute of Mental Health Alzh

73 ort study linking registry data on birth and sibship characteristics with a laboratory surveillance d

74 There was significant sibship clustering of the phenotype although in some fam

75 to reanalyze genome scan data from affected sibships collected by the Alzheimer Disease (AD) Genetic

76 f European ancestry, notable for their large sibships, communal lifestyle, and limited number of five

77 n effect of a locus into between- and within-sibship components, the method controls for spurious ass

78 als, interest in linkage and imprinting, and sibship composition.

79 risk of multiple sclerosis as a function of sibship constellation should mirror the relative risk of

80 d ratios) of each end point as a function of sibship constellation were obtained from stratified Cox

81 of infectious mononucleosis as a function of sibship constellation.

82 Thus, when sibships contain multiple affected individuals, the TDS

83 -risk full sibships and 2,596 high-risk half sibships containing at least one home-reared and one ado

84 ), with follow-up in 49 additional multiplex sibships, containing 50 ASPs.

85 Using the sibship data obtained from 32 low income Mexican America

86 ational burden for haplotype inference using sibship data when compared with using unrelated parental

87 from a normal likelihood based on multiplex sibship data, conditional on identical-by-descent sharin

88 For affected-sibship data, we describe three genotype-based weight va

89 hich is tailored for extensively accumulated sibship data.

90 ed by using 308 individuals belonging to 137 sibships demonstrating exceptional longevity.

91 The authors discuss how the sibship design can be used to detect and control for fam

92 ET versus natural conception, using a within-sibship design to account for confounding by maternal fa

93 et al. in this issue of the Journal uses the sibship design to capture the relation between birth wei

94 ssions and trait values with a family-based (sibships) design.

95 ily-based and included 436 subjects from 134 sibships discordant for AD that were analyzed using the

96 lt in an independently identified set of 217 sibships discordant for Alzheimer's disease (Consortium

97 From these, based on significance in the sibship disequilibrium test (P<0.05) or protein-altering

98 The sibship disequilibrium test (SDT) also revealed a signif

99 The sibship disequilibrium test (SDT) is designed to detect

100 scordant for AD that were analyzed using the sibship disequilibrium test (SDT, p = 0.68) and the sib

101 und that the test was more powerful than the sibship disequilibrium test of Horvath and Laird.

102 ical use and, if violated, can severely bias sibship estimates as shown by simulations in this articl

103 We also found within-sibship evidence of polygenic adaptation on taller heigh

104 I also derive sibship exclusion probabilities, and investigate the pow

105 3 sibships and 1378 Mexican-Americans in 416 sibships), finding association with LDL-C level in ARIC

106 However, two sibships (four subjects) did not map to either locus, ra

107 or concentrations from 3068 siblings in 1133 sibships from the Framingham Heart Study Third Generatio

108 We examined AO in 148 individuals in 57 sibships from the SCA2 founder population in Cuba.

109 clinic-based discordant sibships (N = 1,567 sibships) from the Colon Cancer Family Registry (Colon C

110 For example, the within-sibship genetic correlation between educational attainme

111 wever, as the number of affected sibs in the sibship grows, the relative efficiency of the TDS test v

112 Within-sibship GWAS estimates were smaller than population esti

113 In two exceptional sibships, however, children aged 10 and 13 years had FCD

114 ate cancer (CaP) who were from 230 multiplex sibships identified five regions with nominally positive

115 ies there were significant differences among sibships in larval growth and development rates, and in

116 e-wide linkage analysis was conducted in 211 sibships in which > or =2 siblings had diabetes and reti

117 There were 42 sibships in which at least 1 sibling had a stroke, and i

118 edish sample of male-male siblings, 436 full-sibships in which at least one member was reared by one

119 age 61 yr, 56% women, 75% hypertensive) from sibships in which two or more members had essential hype

120 icated these results in 2,341 male-male half-sibships, in which, controlling for clustering within fa

121 ed to partition the population into complete sibships, including, if known, prior knowledge of the di

122 We combine parentage and sibship inference analysis with simulation modelling to:

123 , can reach the same power for parentage and sibship inferences as the highly informative marker simp

124 inate from the spurious splitting of a large sibship into two or more small sibships.

125 Subgroups were formed by dividing the sibships into a group with a positive family history (FH

126 rom the spurious fusion of two or more small sibships into a single sibship, and type II errors origi

127 fixed effects) analysis of variance in which sibship is the random factor, marker genotype is the fix

128 asymptotically equivalent when the number of sibships is large.

129 properties: it uses all the siblings in the sibship; it remains valid if there are misclassification

130 formation regarding linkage and exclusion in sibships larger than size 2 increased as approximately a

131 here was, however, a weak correlation at the sibship level between mean growth rate and microsatellit

132 In 207 sibships, more than 1 child had HbSS.

133 In this study, we performed within-sibship MR analyses using 78,988 siblings, a design robu

134 Within-sibship MR estimated that 1 SD taller height lowers the

135 sing population- and clinic-based discordant sibships (N = 1,567 sibships) from the Colon Cancer Fami

136 maller distinct units, which will usually be sibships, nuclear families, or small pedigrees.

137 fect was similar for affected and unaffected sibships (odds ratio = 0.8, 95% CI = 0.5-1.2) and was ex

138 The effect of the sibship of primary reproductives on mate mortality and t

139 en a disease locus and a SNP, to accommodate sibships of arbitrary size and disease-phenotype configu

140 re variation that are applicable to affected sibships of arbitrary size and that do not require genot

141 The proposed test is naturally applicable to sibships of arbitrary size.

142 ive some suggestions regarding how to weight sibships of different sizes, in forming an overall stati

143 lic and multiallelic markers, as well as for sibships of different sizes.

144 comparisons, the authors selected the 1,721 sibships of full brothers that included at least 1 male

145 roximately all possible pairs n(n-1)/2 up to sibships of size 6.

146 We considered sibships of sizes two through five, 27 different genetic

147 We considered sibships of sizes two through four, four different exten

148 o choose statistics for studies that include sibships of various sizes.

149 ther both sexes are monogamous to infer full sibships only or only one sex is polygamous to infer ful

150 asing either the number of affected sibs per sibship or the number of unaffected control sibs.

151 measures either among all individuals, among sibships or among individuals within sibships.

152 nt linkages were found in an analysis of all sibships or in an analysis restricted to discordant sib

153 Parental genotypes were imputed from sibships or parent-offspring duos and used to calculate

154 were randomly distributed among children in sibships (P =.0012).

155 eters well-provided that the total number of sibship pairs in the pedigree data is reasonably large,

156 of both sexes being polygamous to infer full sibships, paternal half sibships, and maternal half sibs

157 accommodates many study designs: unrelateds, sibships, pedigrees, or a mixture of all three.

158 For example, within a sibship, presumed full sibs actually might be MZ twins,

159 In addition, sibship reconstruction allows the estimation of populati

160 Most current methods for sibship reconstruction from microsatellite data use stat

161 existing techniques indicate that the use of sibship reconstruction is superior to earlier methods, h

162 original and improved likelihood methods in sibship reconstruction of a large sample of individuals

163 In sibship reconstruction, type I errors come from the spur

164 of errors made by the likelihood methods in sibship reconstruction, using both analytical and simula

165 bjects and 634 white subjects in 215 and 265 sibships, respectively).

166 e and association analyses for simple random sibship samples, under the variance-components model pro

167 In affected sibship samples, we show that, by carefully selecting si

168 n expected by chance, among the members of a sibship segregating fragile X.

169 These global findings on sibship size and childhood asthma, rhinoconjunctivitis a

170 nd mutual adjustment for family composition (sibship size and/or birth order).

171 birth order differences to be separated from sibship size differences.

172 ositively associated (P < 0.0001) with total sibship size in both age groups.

173 ge of exposure to childhood infection, while sibship size may be a proxy for the probability of expos

174 (mean age, 72.4 +/- 7.4 years), the average sibship size was 2.7 per family.

175 Average AA and CA sibship size was 2.73.

176 smaller second sample (N > 70,000) in which sibship size was also assessed, thereby allowing birth o

177 ts by clinical and neuropathologic features, sibship size, and APOE genotype.

178 The authors examined whether birth order, sibship size, and childhood housing density affect risk

179 (HEXACO-PI-R) with birth order category and sibship size, controlling for participant sex and age.

180 al heritability, recombination distance, and sibship size, using fixed-size sampling.

181 nal efficiency is not affected by increasing sibship size.

182 eness; exposure to parental psychopathology; sibship size; birth order; and gender.

183 ies with exceptional longevity, satisfactory sibship sizes and numbers of living siblings, and high a

184 rger sibship sizes, with differences between sibship sizes of 1 and 6+ of d = 0.30 and d = 0.36, resp

185 th the capacity to shift the distribution of sibship sizes over generations.

186 sample size and power, allowing for varying sibship sizes, ascertainment criteria, and genetic model

187 Within sibship sizes, birth order differences in these dimensio

188 than for non-onlys collectively, and within sibship sizes, Openness was d ~ 0.10 higher for oldests

189 greeableness showed higher means with larger sibship sizes, with differences between sibship sizes of

190 , the same statistics performed well for all sibship sizes.

191 rovement on the likelihood methods to reduce sibship splitting, and thus type II errors by downscalin

192 also illustrates the potential complexity of sibship studies and the challenges they present for appr

193 lly and understanding their genetic risk via sibship studies will provide crucial insight into progre

194 dating allele frequencies with reconstructed sibships taken into account, by allowing for the use of

195 a minimal pedigree connecting those affected sibships that are in the database and determine the most

196 The fixed-effects regression analysis of the sibships that included both twins and singletons showed

197 In large sibships, the new method is slightly more powerful than

198 However, in both full and half sibships, the protective effect of adoption disappeared

199 ratio (lambda*S) estimated by restriction of sibships to those ascertained through a proband who alre

200 nic effects of membership in these high-risk sibships was substantially attenuated by high levels of

201 es, grandparents, and cousins of a core full-sibship we term the pedigree offspring.

202 Leveraging variation within sibships, we evaluated the association of age at immigra

203 nd linkage analysis of DNA samples from four sibships, we identified an approximately 2-cM interval o

204 studies of complex diseases sampled affected sibships, we propose a strategy for association testing

205 The parents of this sibship were recently included in an exome sequencing pr

206 These sibships were a subset of 322 sibships who had participa

207 A total of 501 sibships were included in the regression analysis.

208 hese techniques allow reconstruction of half sibships when some or all of the maternal genotypes are

209 del fitting was performed on 2658 unselected sibships, which provided evidence for a single common fa

210 These sibships were a subset of 322 sibships who had participated in a previous linkage stud

211 > A; p.(Arg771Gln) carriers in a large Amish sibship with Tatton-Brown-Rahman syndrome (TBRS), their

212 ens and Spielman extended the TDT for use in sibships with at least one affected and one unaffected i

213 equire parental data but requires discordant sibships with at least one affected and one unaffected s

214 This analysis included all sibships with at least one parous woman and at least one

215 There were 1,088 people from 488 sibships with at least two siblings who could contribute

216 clear factor 4-a (HNF-4alpha) in 64 affected sibships with evidence for high chromosomal sharing at i

217 Ordered subset analyses based on sibships with extreme mean values of diabetes-related qu

218 xamined the effects of various treatments of sibships with multiple affected individuals.

219 Designs including sibships with multiple affected sibs are typically the m

220 cted sibs and was based on DNA pooling), for sibships with one affected child.

221 Finally, we also demonstrate that for sibships with parents, only the parents require individu

222 These designs include sibships with parents, sibships without parents, and use

223 gnificantly different between singletons and sibships with stroke.

224 For example, for sibships with three affected, one-third fewer families a

225 ples were studied: (a) 1,184 subjects in 317 sibships, with 243 markers typed by the Utah Molecular G

226 e analysis in an initial set of 90 multiplex sibships, with parents, containing 97 independent affect

227 d high throughput genomic profiling to study sibship within and among larval tows from the 2016 stand

228 erate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes

229 g application of the principle of the TDT to sibships without parental data.

230 These designs include sibships with parents, sibships without parents, and use of unrelated controls.

231 For sibships without parents, but with unaffected as well as

232 For sibships without parents, this test is analogous to the