ライフサイエンスコーパス: side chain

1 terification of benzoic acid with CoA (Taxol side chain).

2 so the adjoining carbon atom in the extended side chain.

3 eteroaromatic substituent, and a hydrophobic side chain.

4 ic acid at C(3) and at the cyclopentane ring side chain.

5 eduction of the distal keto group on the new side chain.

6 the individuality of the different aminoacid side chain.

7 tency depending on the size and shape of the side chain.

8 ide and the other to the bases on the Calpha side chain.

9 )-homologous amino acid with a proteinogenic side chain.

10 ivated coupling partner to install the ester side chain.

11 either to the cyclohexene ring or the butane side chain.

12 , presumably by turning aside the Metbeta149 side chain.

13 ha-carbon and from tertiary C-H bonds in the side chain.

14 gether in a fixed orientation in the monomer side chain.

15 bon atoms including all those of the valeryl side chain.

16 tural fluctuations that reorient surrounding side chains.

17 heavily branched with arabinan and galactan side chains.

18 y coordinated by a ring of anionic aspartate side chains.

19 the solvent accessibility of these and other side chains.

20 ons distributed over several HLA and peptide side chains.

21 ocycles, or (iii) generating extended biaryl side chains.

22 ring backbones separated by insulating alkyl side chains.

23 acids with different lengths of hydrophobic side chains.

24 ling installation of previously incompatible side chains.

25 nified atoms of the polypeptide backbone and side chains.

26 more sensitivity to local configuration and side chains.

27 n Ile, Leu, and Val methyl probes in protein side chains.

28 degrees C for conjugated polymers with alkyl side chains.

29 ng on arabinosyl- and galactosyl-rich pectin side chains.

30 nsely branched with monomeric and/or dimeric side chains.

31 attributed to zinc coordination by imidazole side chains.

32 ntly based on differences in their dendritic side chains.

33 s of a new class of polyfurans bearing ester side chains.

34 the protein backbone, while the other probes side chains.

35 y, although with a reduced content of chiral side chains.

36 ity for analogs that possess larger aromatic side chains.

37 ed beta(2)-homologous amino acids with polar side chains.

38 radicals that react with solvent-accessible side chains (14 out of 20 amino acid side chains) to ful

39 and C rings are ~7.0 angstrom from the F673 side-chain 4-(19)F.

40 (~25%), and xyloglucans possessing monomeric side chains (~5%).

41 es via the precise positioning of amino acid side chains, a binding mechanism reminiscent of endogeno

42 how that csdAB and csdCD are involved in Glc side-chain addition on the CWPS components rhamnan and p

43 poration of a defined sequence of amino acid side-chains along the PNA backbone yields amphiphiles ha

44 that p.D50A changed locations of amino acid side chains altering RNA binding sites in the RRM.

45 irus-mimetic zwitterionic surface, a betaine side chain and an ultralow critical micelle concentratio

46 dopt the trans, gauche conformation of their side chain and consequently be highly equatorially selec

47 e explored the modification of the steroidal side chain and inserted a methylene moiety in position C

48 e pools of discrete contacts between protein side chains and defined small molecule ligand substructu

49 , and unambiguous building of ordered acidic side chains and glycans.

50 pai-pai interactions with aromatic rings of side chains and hydrophilic interactions with the backbo

51 depends on the identity of the inserted Nte side chains and not on Nte orientation.

52 and its paralog CBP acetylate histone lysine side chains and play critical roles in regulating gene t

53 , with coupling of the dynamics of histidine side chains and those of remote key backbone elements of

54 HBC) derivatives carrying three diacetylenic side chains and three saturated alkyl chains at differen

55 ated with observations of changes in protein side-chain and hydration dynamics around the E-F loop of

56 didate for hexanoic acid activation (Taxol C side chain), and TmAAE4 as suitable candidate for esteri

57 tion of longer (containing up to five atoms) side chains, and thus, larger (11- to 12-membered) diare

58 the incorporated nucleotide and the arginine side chain are broken, but the templating base remains e

59 The rotameric preferences of R1 side chain are determined by the type of the secondary s

60 hains but different functional groups on the side chain are employed to clarify the contributions of

61 e motions of local water molecules and polar side chains are continuously convoluted with the isomeri

62 The lengths of the side-chains are tunable based on reaction temperatures.

63 e allostery-suppressing ligand decouples the side-chain arrangement at the inter-domain interface the

64 ), are modulated by the nature of amino acid side chains as well as by local solvent exposure.

65 al linkages, including to several amino acid side chains as well as nucleic acids termini and bases,

66 More remote stereogenic centers in the side chain, as in the 8-position of N-acetylneuraminic a

67 ealed that ascr#18 is converted into shorter side-chained ascarosides that confer repellency.

68 nd nucleobase attached via amide spacer to a side chain at Cgamma on the repeating aeg units of PNA o

69 ibe the visible-light-driven installation of side chains at dehydroalanine residues in proteins throu

70 nction are essentially determined by how the side-chain atoms interact with each other.

71 t pyridomycin have been prepared with the C2 side chain attached to the macrocyclic core structure by

72 This action buries ionic side chains away from the bulk water, while allowing wat

73 is was observed for residues orienting their side chains away from the ligands.

74 zing semiconductor polymers with appropriate side chains, backbones, cross-linking networks, and flex

75 Amino acids involved in side chain-base hydrogen bonds favor strand and coil sec

76 ructures can be determined by the amino acid side chain, because it is repositioned by linker torsion

77 formed by interdigitated Gln and His residue side chains belonging to the prion-like domain.

78 These NESs have multiple charged side chains binding close to CRM1 position 571, but this

79 cross some 4 billion y of protein evolution, side-chain binding, in which the phosphate moiety does n

80 m the simulations with one and three charged side chains bracket the experimental rate constants, as

81 rather than a binary switch, with Y- or W106 side-chain burial correlated with increased FliM(N) affi

82 aI, these portals are obstructed by aromatic side chains but are still fully hydrated and thus suppor

83 labeling of functional groups on amino acid side chains by targeted reagents with high specificity,

84 irrors the hydrogen bonding potential of the side chain (C-H < S-H < O-H).

85 ount of alkyl side-chains with compact bulky side-chains (CBS).

86 deduce secondary structure from backbone and side-chain chemical shift data.

87 r drastically in aromatic backbone and alkyl side chain chemistry.

88 lding to all-atom-based methods that include side-chain chemistry and can predict how disease-associa

89 onomers is attributed to a unique multi-acid side-chain chemistry and structure that facilitates prot

90 dration that orients a pendant carboxymethyl side chain cis to the bulky octahydronapthalene substitu

91 the macrocycle and also modify its size, its side-chain composition, and the nature of the centrally

92 by orders of magnitude due to diacylglycerol side-chain composition.

93 Carbohydrate side chain conformation confers a significant influence

94 osition 1 predicted to alter the HLA Trp-167 side-chain conformation abrogated TCR binding, indicatin

95 Simultaneous optimization of side chain conformations across all conformations increa

96 or the most part a much greater diversity of side chain conformations is observed.

97 Conserved side chains contributed by both domains coordinate two b

98 Genetic enhancement of the alkyl side-chain could lead to the development of novel chemic

99 ocket located outside the active site, and a side chain crafted to act as a latch to inhibit turnover

100 ere obtained by attaching an albumin-binding side chain derived from octadecanedioic (C18) or icosane

101 sporter-lipopolysaccharide interactions with side-chain details and uncover how the capture and extru

102 nformations based on the location of the Phe side chain (DFGin, DFGout, and DFGinter or intermediate)

103 nce by correctly predicting 69.1% of all the side-chain dihedral angles using a stringent tolerance c

104 reproducibility of structural features from side chains down to water and ion atoms.

105 cisely dictated by the placement of reactive side chains during the reductive amination reaction.

106 d timescale, similar to AM2, indicating that side chain dynamics are the essential driver of proton s

107 We show here that the fast-internal side chain dynamics of several proteins are unaffected b

108 cific probing of hydration water motions and side-chain dynamics at nine selected sites around the su

109 Here the fast side-chain dynamics of the alpha-helical sensory rhodops

110 sh-like polymer networks with crystallizable side chains, e.g., poly(valerolactone), affording indepe

111 r release is nearly cancelled by the loss of side-chain entropies as the two proteins approach each o

112 ylation status and symmetry of each arginine side chain even in highly repetitive RGG amino acid sequ

113 clusters of hydrophobic residues near acidic side chains, explaining why ADs often have a biased amin

114 ond, we showed that PTP1B (13)C-methyl group side chain fast time-scale dynamics and (15)N backbone f

115 rface while semiperfluorinated and aliphatic side-chains fill their respective separate channel netwo

116 termined by TPR domain contacts to substrate side chains five to fifteen residues C-terminal to the g

117 For some ligands, a change in side-chain flexibility appears to be responsible for sel

118 discussed in terms of preorganization of the side chain for binding to the ribosomal decoding A site.

119 , and uses convenient transformations of the side chain for incorporation of fluoroalkyl-substituted

120 herein a surface residue with a single bulky side chain forms the end of the substrate binding cavity

121 (COS) with epichlorohydrin (ECH), where the side-chain forms in situ.

122 idinium occupies the site of a 'missing' Arg side chain found in other fungal species where (i) the C

123 intermolecular hydrogen bonding between the side-chain functionalities and TBD in the transition sta

124 ble for hydrazide linkers containing various side-chain functionalities and topicities.

125 The extent of participation of side-chain functionalities during the 1,5,7-triazabicycl

126 eferences and indicating the contribution of side-chain functionalities in regioselective ROP process

127 lecular understanding of the curious role of side-chain functionalities was demonstrated via density

128 into three categories: protein domains with side-chain functionality that alters the native linear-c

129 elling, attributed to the hydroxylated alkyl side-chain functionalization.

130 phenylacetyl moiety and the conformation and side chain functions of the central turn dipeptide resid

131 By virtue of a branched N-acylamide side chain, GalNAzMe is not interconverted by epimerizat

132 tive site to prevent a steric clash with the side chain gamma-methyl of Val184.

133 e with crystallization temperature and mBB's side chain grafting density.

134 ronments and structural diversity enabled by side-chain groups.

135 a serine or threonine residue whose hydroxyl side chain H-bonds to an over-coordinated carbonyl oxyge

136 are cyclized from one of the termini onto a side chain, have received little attention.

137 ylation of both the thiophene system and its side chain, hydrodehalogenation of halothiophenes, or el

138 like features including interfacial aromatic side chains, hydrophobic lengths compatible with bilayer

139 ion may hinder twisting of beta3 because its side chain hydroxyl forms a hydrogen bond with Thr-498.

140 nteract with both the backbone amide and the side-chain hydroxyl (bidentate interaction) to promote b

141 he variants, only the ones with a protonable side chain, i.e., His, Asp, and Glu, were able to mediat

142 tein-i.e., multi-state design-determines the side chain identity by optimizing the energetic contribu

143 kely causes displacement of the Tyr138 (TM3) side chain, important for transport of taurine.

144 al histidine and a second internal histidine side chain in a configuration called the histidine brace

145 timizing the energetic contributions of that side chain in each of the backbone conformations.

146 phenyl ring that contains an antiestrogenic side chain in endoxifen.

147 cule stabilized by hydrogen bonding to a Gln side chain in the active site, offering a structural exp

148 The arrangement of histidine side chains in influenza A M2 tetramer determines their

149 hynyl, 1,7-octadiynyl, and tripropargylamino side chains in the 7-position of the 5-aza-7-deazapurine

150 ic iodonium salts substituted with aliphatic side chains in the carbon bridge.

151 that the greater number of larger, aromatic side chains in the ENaC M2 helix may contribute to the c

152 e inner leaflet, ordered lysine and arginine side chains in the membrane interfacial regions, and lip

153 ggregated strands, random coils and aromatic side chains in the muscle fibres of both muscles.

154 olecular Modeling Suite to recombine protein side chains in these contact pools to generate hundreds

155 of polyolefins functionalized with aromatic side chains in which at least one CC bond is replaced wi

156 strated that TMEM175 p.M393T creates a polar side-chain in the hydrophobic core of the transmembrane,

157 ins have a different terminal-functionalized side chain incorporated into the glucuronic acid unit th

158 polarization transfer from water and mobile side chains indicate that 0N4R tau fibrils exhibit heter

159 e via lipid-tethers and hypervariable region side-chain interactions in distinct nano-domains.

160 mational entropy associated with nonspecific side-chain interactions, we develop the FuzDrop method t

161 , including the peptide backbone, amino acid side chains, internal water molecules, or cofactors.

162 unctionalities (more than 50 unique residues/side chains) into diverse protein scaffolds and sites.

163 tion revealed that the hydrophobic thioether side chain is packed by the aromatic rings of Tyr(312) a

164 derivatives with an amino substituent in the side chain is reported.

165 the intrinsic hydrophobicity of the cysteine side chain is that it exhibits both polar as well as hyd

166 reviously showed that an extended alkyl-aryl side chain is the key structural element determining the

167 ing conformation of 3TC-TP, where the Met184 side-chain is pushed away by the oxathiolane of 3TC-TP a

168 and Young's modulus by concurrently altering side chain length and crosslink density.

169 olling the degree of crystallinity and alkyl side chain length.

170 ing in planta variation of cannabinoid alkyl side-chain length remain uncharacterised.

171 fatty acid starter unit synthesis and alkyl side-chain length.

172 otein, secondary structure, and perhaps even side-chain levels.

173 uctural snapshots reveal that the amino acid side chains lining the binding pockets switch in a coord

174 cting pore, formed by hydrophobic amino acid side chains, located ~60 angstrom from the toxin binding

175 arabinose level suggests that long arabinan side-chains maintain cell wall flexibility in water defi

176 method is applicable for backbone amide and side chain methyl groups and represents a time and cost-

177 solution-state NMR experiments to assign the side-chain methyl groups of the 64-kDa Mre11 nuclease an

178 have previously discovered that backbone or side chain methylation of NRP residues is carried out by

179 hosphonium-conjugated ATO with varying alkyl side chains (Mito(4)-ATO, Mito(10)-ATO, Mito(12)-ATO, an

180 re the first to point to simple C3 aliphatic side-chain modification of MTM as an effective strategy

181 configurational entropy that originates from side-chain modifications of the linker as the key factor

182 e manifested in alterations of fast internal side chain motion that is detectable by NMR relaxation.

183 ave a similar distribution of methyl-bearing side-chain motion that is largely independent of membran

184 Our findings suggest that large hydrophobic side chains occlude the pore, forming a physical gate, a

185 ically interacts with UDP-GlcUA, whereby the side chain of Arg259 H-bonds and forms a salt bridge wit

186 ein arginine deiminases (PADs) hydrolyze the side chain of arginine to form citrulline.

187 PE phenyl ring containing the antiestrogenic side chain of endoxifen or a free hydroxyl.

188 n at the site occupied by the antiestrogenic side chain of endoxifen results in early apoptosis simil

189 y simulations, we observed that the carboxyl side chain of Glu89 (located along the arch motif in hEx

190 12) and Trp(273), as well as the hydrocarbon side chain of Ile(310) Our results suggest that placing

191 install reactive hydrazide handles onto the side chain of internal glutamine residues.

192 Pyruvate interacts with the side chain of Lys-43 and with the peptide backbone of Se

193 In addition, the side chain of Lys225 in the linker domain blocks the act

194 ique cation-pai interaction by inserting the side chain of lysine K115 into a tetra-tryptophan cage a

195 ting Escherichia coli ribosome, the extended side chain of macrolides interacts with 23S ribosomal RN

196 ncoming dCTP hydrogen bonds with an arginine side chain of Rev1.

197 the N-substitution of the 3-phenylisoserine side chain of taxoids.

198 networks expose pores functionalized by the side chain of the cyclic peptide, suggesting a general m

199 es between the new N terminus of I16 and the side chain of the highly conserved D194.

200 Protonation of oxygen in the side chain of the Me(3)SiO group (followed by the elimin

201 t can directly mimic the binding mode of the side chains of alpha-helical hot spots, offering a new c

202 yphenyl)porphyrin cobalt(II) (TMPPCo) on the side chains of an ionomer (polyfluorene, PF) to obtain a

203 polyLacNAc structures within oligosaccharide side chains of both animal and human mucins.

204 The methyl-bearing side chains of both proteins are, on average, more dynam

205 rosides in C. elegans, instead activates the side chains of certain ascarosides for shortening throug

206 that OPs can transmethylate the N, S, and O side chains of His, Cys, Glu, Asp, and Lys residues.

207 M binding to an internal ring of hydrophobic side chains of L279 residues.

208 This density is surrounded by the side chains of lysine residues 290 and 294 from R2 and l

209 o-gamma-AA peptides could mimic the critical side chains of p53 and disrupt p53/MDM2 PPI effectively.

210 led sample is sufficient to characterise the side chains of six different amino acid types.

211 of an "abnormal" S&S effect by changing the side chains of the achiral soldier.

212 orm thin solvation shells wrapping the polar side chains of the Nafion component.

213 sed by the specific interactions between the side chains of the Nte residues and the FimA core and no

214 h a central ion-conduction pore lined by the side chains of the pore-lining helices.

215 otectant through preferential exclusion from side chains of the protein.

216 are poorly activated by Rca, indicating the side chains of these residues form a critical interactio

217 footprint broadly several amino acid residue side chains on the time scale of submilliseconds.

218 tuations between hydration water and protein side chains on the time scales of a few picoseconds and

219 he latter via the addition of a 2-aminoethyl side chain onto a lactam moiety.

220 haracterized by the presence of an elongated side chain or 26,27-dimethylene bridge.

221 on C-22 together with either lengthening the side chain or introducing a ring at the terminal end.

222 these observed conformations, including the side chain orientations, are stabilized by not only ster

223 ein while simultaneously sampling amino acid side chain orientations.

224 Bioinformatics studies to match side-chain orientations of a novel hydantoin triazole ch

225 Our data suggest that cross-strand side chain packing interactions within the same beta-she

226 Thus, accurate protein side-chain packing (PSCP) is a critical step toward prot

227 oxal (MGO)-induced glycation on nucleophilic side chains, particularly arginines, under metabolic str

228 of a mononuclear iron coordinated by two Tyr side-chain phenolates and one carboxylate from Glu.

229 , we examined whether the differences in the side-chain polarity of these AAs trigger distinct allost

230 ormant RAFT agent, which subsequently allows side-chain polymers to be grafted from the pendant RAFT

231 e preferences stand in stark contrast to the side chain populations observed for these sugars both in

232 of catechols and amines in the same monomer side chain produced optimal cooperative effects in impro

233 the stability of the conventional amino acid side-chain-protecting groups, t-Bu, Boc, Trt, and Pbf, a

234 yperpolarized "structural" waters and labile side-chain protons; and the possibility that faster solv

235 ented myristoylation of an N-terminal lysine side chain, providing evidence that NMT acts both as N-t

236 of global conformational changes into local side chain proximity adjustments, a property not capture

237 Thereby side-chain rearrangements ensure optimal shape complemen

238 ly implied extraordinary carbon backbone and side-chain rearrangements.

239 While side chain redistribution does not have a significant im

240 alogues in an E(52)Q-photobeta(2), where the side chain remains deprotonated, recovered photochemical

241 aled the different mechanisms used for ester side-chain removal from the different plasticizers (este

242 The protection of allosteric relay side chains reported by XFMS confirmed the intermediate

243 t alternation of cationic versus hydrophobic side chains, representing a significant improvement over

244 the overall conformation of backbone and key side-chain residues.

245 equences of GH-ligand complexes reveals that side chain restriction begins with the enzyme-substrate

246 ich controls the expression of capsule and O side chains, resulted in dramatic complement resistance

247 e equatorially coordinated histidine residue side-chains, resulting in a novel bridging interaction.

248 Reducing the side-chain rotamer isomerization barriers in the all-ato

249 residue before the DFGmotif, and the DFG-Phe side-chain rotamer, utilizing a density-based clustering

250 In addition, we apply pools of side chain rotamers interacting with the target ligand t

251 Increasing the side chain size from phenyl to pyrenyl results in a rate

252 Comparing side-chain solvent accessibilities between these three s

253 The side chains stabilizing both the flipped base and the di

254 emithramycin B (PMB), creating the C3 pentyl side chain, strictly followed by reduction of the distal

255 ed molecular pattern of stretches of anionic side chains strongly bound by CR4.

256 cose carbonate)s (PGCs) containing carbonate side chain substituents in the 2- and 3-positions, where

257 privileged scaffolds that primarily project side-chain substituents for complementary interactions w

258 rity was found for analogous PGCs with ether side-chain substituents.

259 d result in a steric clash with a tryptophan side chain, suggesting that 2'-O-methylation protects sm

260 ach led to a pyridine series with an alcohol side chain that could interact with the DFG loop and sig

261 ngle substitutions and deletions to identify side chains that are critical for the inhibitory binding

262 ns of glycosidase inhibitors with restricted side chains that confer higher selectivity and/or affini

263 otonated Ci1 or removal of the Ci1 glutamate side chain, the hydrogen-bonded system is less rigid, an

264 ading to an N-terminal amidine rendering the side chain thiol available for further modification.

265 e face and homocytosine (C(5)) on the Calpha side chain through the triazole linker was achieved by s

266 for the activation of butyric acid (Taxol D side chain), TmAAE13 as the best candidate for generatin

267 c acid (N-debenzoyl-N-(2-methylbutyryl)taxol side chain), TmAAE15 as a highly efficient candidate for

268 nerating a CoA ester of tiglic acid (Taxol B side chain), TmAAE3 and TmAAE13 as suitable for the acti

269 determine the energetic contribution of each side chain to forming an interaction.

270 h PMestOx and the complete conversion of the side chain to the N,N-dimethyl-1,3,5-triazine-2,4-diamin

271 mbrane systems, and (ii) "rigid" dendronized side chains to enhance the membrane lytic property.

272 n-related modifier (SUMO) proteins to lysine side chains to produce branched proteins.

273 ently, chemotype 1 was made with appropriate side-chains to mimic uPA at this interface.

274 proton transfer (ESPT) occurs from cationic side-chains to suitably basic solvents, resulting in flu

275 essible side chains (14 out of 20 amino acid side chains) to fulfill the footprinting.

276 ies including head-to-tail cyclization (C1), side-chain-to-tail cyclization (C2), and a disulfide bon

277 es this tunnel and leverages upon the gating side chains triggering the CD loop to furl, which moves

278 vities, suggesting that the structure of the side chain, triterpenoid core, and oligosaccharide domai

279 strates with systematically growing aromatic side chains using accurate competitive linear regression

280 greater rigidity, by subtly altering certain side chain vectors, or by adjusting the global shape of

281 ides, we showed that a particular amino acid side chain was essential for these interactions.

282 sponsive polymer with an amide moiety on its side chain, was studied in aqueous solutions with a seri

283 Moreover, side chains were added onto the I(2)aa and I(9)aa ring s

284 acid tert-butyl esters possessing unnatural side chains were also accessed via glycine Schiff base a

285 mers with rubbery poly(4-methylcaprolactone) side chains were cross-linked in formulations that inclu

286 Ornithine side chains were further modified into arginine by an ab

287 ly react with primary amines (e.g. on lysine side chains), whereas those of alphaM complement compone

288 by asking whether the V18, A21, V40, and A42 side chains which are exposed on the Abeta42 fibril surf

289 tricts the conformational flexibility of the side chain, which can result in changes in biological ch

290 nucleophilic attack by a specific amino acid side chain, which leads to conjugate formation.

291 lectron-withdrawing tg conformation of their side chains, which is reflected in the excellent equator

292 thermore, we demonstrate that capping acidic side chains with carbodiimide chemistry obstructs this p

293 ses, such as amino acids containing extended side chains with different chemical properties and glyci

294 ated O- to C-acyl rearrangement to unite the side chains with the tetramic acid core and subsequent a

295 atically replacing a certain amount of alkyl side-chains with compact bulky side-chains (CBS).

296 osomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold h

297 nd siloxane backbones with grafted imidazole side-chains, with dissolved Li(+), Cu(2+), or Zn(2+) sal

298 othiolate electrophiles directly on cysteine side chains within peptides and proteins.

299 ent TMDs that contain unshielded hydrophilic side chains within the lipid bilayer, and it disengages

300 t the hypothesis that eliminating this bulky side chain would create an opening and permit the substr