ライフサイエンスコーパス: side effect

1 tion, it can lead to tinnitus as an unwanted side effect.

2 Deletion of W38 did not manifest any visible side effect.

3 estinal symptoms as the most common systemic side effect.

4 itor, demonstrating that AF is an off-target side effect.

5 its problematic anti-neurogenic or cognitive side-effect.

6 tiated early in illness but can have serious side effects.

7 mylase inhibition generally causes undesired side effects.

8 ll tolerated in mice without any significant side effects.

9 ibute to variation in treatment response and side effects.

10 accentuated therapeutic activity and reduced side effects.

11 has, however, been precluded by their severe side effects.

12 t is also known to cause a variety of severe side effects.

13 ugh a novel mechanism to circumvent existing side effects.

14 of their high production costs and frequent side effects.

15 fety profile was favorable without long-term side effects.

16 resistance and reduce the drug's peripheral side effects.

17 ained limited efficacy with some detrimental side effects.

18 easing drug accumulation in alveola reducing side effects.

19 ease motor symptomology and are fraught with side effects.

20 posing and understanding of their unexpected side effects.

21 o unexpected therapeutic activity or adverse side effects.

22 to treat pain despite their numerous adverse side effects.

23 t controls and reduces severe BTZ-associated side effects.

24 r use has been highly limited due to serious side effects.

25 ffective mood stabilizers with fewer adverse side effects.

26 decreases food intake by 21%, without overt side effects.

27 r, its administration is burdened by several side effects.

28 inhibit metastasis while conferring limited side effects.

29 ery would inevitably cause unwanted systemic side effects.

30 imize the power of chemotherapy and minimize side effects.

31 The dose was adjusted depending on side effects.

32 dren are often left with long-term treatment side effects.

33 cluded medication burden, but not medication side effects.

34 mputationally predicting frequencies of drug side effects.

35 Previous trials were associated with severe side effects.

36 urer's label that did not cause unacceptable side effects.

37 sequently, they are associated with numerous side effects.

38 ed selectivity, and minimal invasiveness and side effects.

39 sufficiently efficacious and associated with side effects.

40 ne, such efficacious PAMs may have cytotoxic side effects.

41 ation, short serum half-life, and unspecific side effects.

42 erge as novel opioid analgesics with reduced side effects.

43 BBR treatment induced more gastrointestinal side effects.

44 trategy to treat metabolic disorders without side effects.

45 signaling can alleviate pain while reducing side effects.

46 he frequencies of further, yet unidentified, side effects.

47 e intervention group had mild extrapyramidal side effects.

48 mine, is capable of preventing long-term THC side effects.

49 how limited efficacy and can provoke serious side effects.

50 s to other isoforms and thus avoid undesired side effects.

51 lance while avoiding unwanted cardiovascular side effects.

52 ut can be associated with local and systemic side effects.

53 evoid of cardiovascular and gastrointestinal side effects.

54 of thromboprophylaxis can outweigh potential side effects.

55 ed use in the clinic due to reported adverse side effects.

56 0.06) Mn(0.03) )O(2) (NCM9163), with minimal side effects.

57 ys, in order to optimize efficacy and reduce side effects.

58 l testing demonstrated no negative cognitive side effects.

59 nicity while at the same time reducing local side effects.

60 photodynamic therapy (X-PDT) with negligible side effects.

61 cells via C-type lectin receptors and reduce side effects.

62 improve therapeutic efficacy while reducing side effects.

63 n of an exogenous dye with potential adverse side effects.

64 hageal reflux can be followed by troublesome side effects.

65 has varying efficacy and causes significant side effects.

66 y to develop more selective drugs with fewer side effects.

67 rties of MOR agonists while avoiding certain side effects.

68 ly effective and associated with significant side effects.

69 ction did not differ between groups, nor did side effects.

70 y drugs, often accompanied by dose-dependent side effects.

71 viral drug resistance and treatment-limiting side effects.

72 resulting in targeted cancer therapy without side effects.

73 apeutic benefit while preventing undesirable side effects.

74 er varenicline doses to decrease varenicline side effects.

75 ying beneficial actions and/or counteracting side effects.

76 igation for COVID-19 may have cardiovascular side effects.

77 nsplantation, but at the cost of substantial side effects.

78 lutions, in a reversible manner with minimal side-effects.

79 aim to achieve more specificity and reduced side-effects.

80 heir effectiveness and often associated with side-effects.

81 antibiotic whose use is hampered by ototoxic side-effects.

82 patient prognosis, while minimising harmful side-effects.

83 ivation, increasing selectivity and reducing side-effects.

84 llow-up period, with no evidence of new late side-effects.

85 are many men radiotherapy and its associated side-effects.

86 are expensive, less feasible or have harmful side-effects.

87 as the other pathway may mediate undesirable side effects(4).

88 mained high even with the potential for mild side effects (70%).

89 rce, opioids leave patients at high risk for side effects after being dosed.

90 Delayed side effects after radioiodine therapy for hyperthyroidi

91 ration in the prevention of neuropsychiatric side-effects after STN-DBS.

92 reatment and therapeutic approach as well as side effect and toxicity profiles.

93 owever, their clinical benefit is limited by side effects and addictive potential.

94 ug-delivery system to reduce the undesirable side effects and enable the clinical application of Ade

95 e currently used in the clinic to reduce the side effects and improve the pharmacokinetic profile of

96 an and model systems, without cardiovascular side effects and improved spastic gait disorders after b

97 therapeutics, including reducing off-target side effects and increasing drug potency.

98 Ade is severely limited by the accompanying side effects and its very short half-life in vivo.

99 s can stimulate tissue regeneration, but the side effects and low effectiveness associated with subop

100 Frequent reasons for discontinuation were side effects and low HIV risk perception.

101 ent, too, may be accompanied by considerable side effects and not all patients benefit equally.

102 ective GPCR ligands with potentially reduced side effects and provides an attractive probe molecule a

103 oid unnecessary biopsies, preventing harmful side effects and reducing health expenses.

104 Because antiviral drugs can have side effects and show reduced clinical effectiveness whe

105 However, their toxicity elicits severe side effects and the Food and Drug Administration has is

106 g ciprofloxacin suffers from severe systemic side effects and was therefore chosen for this approach.

107 , use of CsA is associated with more serious side effects and worse clinical outcomes than FK506.

108 tioning for individuals with narcolepsy, but side effects and/or lack of efficacy can result in subop

109 reatment; however, its use is complicated by side-effects and challenges with reliable drug susceptib

110 ther inactive, alternatively one may produce side-effects and even toxicity.

111 s/no questions to determine reflux symptoms, side-effects and satisfaction with surgery.

112 eir high on- and off-target toxicity, severe side effects, and a narrow therapeutic window.

113 n of cisplatin; this could reduce the drug's side effects, and allow its use in cisplatin-resistant t

114 ntly available treatment, based on efficacy, side effects, and cost.

115 ntraceptive choices and their effectiveness, side effects, and impact on psychiatric symptoms.

116 result in reduced potency, cause immunogenic side effects, and limit options for formulation.

117 imens and investigate long-term survival and side effects, and when these might replace HSCT.

118 rriers to PrEP included taking a daily pill, side-effects, and cost.

119 treatment primarily because of oropharyngeal side-effects, apomorphine sublingual film provided an ef

120 bine single agent, but the treatment-related side effects are also severe.

121 leukemia (ALL) is efficacious, but long-term side effects are concerning.

122 However, whether ketamine's dissociative side effects are necessary for its antidepressant effect

123 e that causes the same magnitude of systemic side effects as oral prednisone at a 5-mg daily dose.

124 ce beta-arrestin activation, leading to such side effects as respiratory depression.

125 ation for drug repurposing, understanding of side effects as well as expansion of the druggable genom

126 ulatory therapies are limited by unavoidable side effects as well as poor solubility, stability, and

127 Neutropenia is a common side effect associated with nab-paclitaxel gemcitabine (

128 of therapeutics that suppress the classical side effects associated with conventional clinical opioi

129 effective, these therapies often have severe side effects associated with immune dysregulation and, i

130 treatment to reduce the risks and off-target side effects associated with systemic therapies.

131 Another limitation is the side effects associated with the treatment of chemothera

132 lcohol intake, but its use can be limited by side effects at high therapeutic doses.

133 ive, pan-HDAC inhibitors, exhibiting adverse side effects at therapeutic doses.

134 cy and cause neurological and cardiovascular side effects because they target upstream regulators of

135 number of transient or permanent intraocular side effects between groups.

136 imizing MFH effects on tumors and minimizing side-effects by avoiding unwanted tissue heating.

137 exciting possibility that undesirable opioid side effects can be selectively eliminated, dramatically

138 el hypothesis suggests that dangerous opioid side effects can be selectively targeted and blocked, im

139 However, severe and life-threatening side effects can occur.

140 current therapies are mostly efficient, the side effects can result in therapy stop, which makes the

141 any ill effects to animals but also reduces side effects caused by a partner drug when used in combi

142 fficacy of tumor chemotherapy and reduce the side effects caused by repeated doses drugs.

143 their ability to tackle cancers and for the side-effects caused by the drugs.

144 ing cocaine self-administration, without the side effects characteristic of balanced NTSR1 agonism.

145 The main side effects comprised transient hematotoxicity, such as

146 nd drugs sharing communities had many common side effects, consistent with related mechanisms.

147 nderstanding the mechanisms involved in this side effect could enable the development of management s

148 luding pain regulation, modulation of opioid side effects, drug reward, anxiety, cardiovascular condi

149 lls (APCs), however, they also induce severe side effects due to leakage from the site of injection i

150 ected to produce an anti-NP action devoid of side effects due to promiscuous CA modulation.

151 istinguish the electron harvesting from some side effects due to quinones in real time.

152 t include resistance, relapse and late-onset side effects due to the chemotherapy.

153 cy and the quality of patient life, avoiding side effects due to the overdosage.

154 B treatment of ROP is the potential systemic side effects, especially the risk of causing severe neur

155 efficacy, but also frequent and often severe side effects-especially when multiple drugs of the class

156 air cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycosid

157 delivery with improved efficacy and reduced side effects for cancer treatment.

158 lied to any drug for which a small number of side effect frequencies have been identified, in order t

159 ly and therapeutically diverse drugs and 994 side effects from all human physiological systems.

160 stic understanding of how vamorolone reduces side effects, guiding the future design of partial agoni

161 hese methods in cellular populations without side effects has remained challenging.

162 Moreover, one of gold salts side effects (i.e., a blue discoloration of the skin exp

163 y of life stemming from beta-blocker related side effects (ie, beta-blocker intolerance) in 56/64 pat

164 herogenesis and reduced hypertriglyceridemia side effects in comparison to the free drug and blank sH

165 pain, opioids produce a higher incidence of side effects in dental outpatients, including dizziness,

166 unotherapeutic proteins with well-documented side effects in humans.

167 fit assessment is identifying frequencies of side effects in humans.

168 (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation

169 or both its cytotoxicity in cancer cells and side effects in neurons, downstream mechanisms that lead

170 f xenograft tumor growth without any obvious side effects in normal tissues.

171 pheral (or central) effects without inducing side effects in other compartments.

172 LP results in improved efficacy and reduced side effects in patients with renal allograft rejection.

173 The EPI model caused no persistent side effects in the animals and has the potential to be

174 leted a significant proportion of Tregs, the side effects in the presence of ART prevent their clinic

175 Possible side effects include worsening cerebrospinal fluid leaks

176 rowth factor A (VEGFA) can suppress leakage, side-effects include vascular rarefaction and geographic

177 Common side effects included fatigue, myalgia, headache, arthra

178 iminates the need for stents so that serious side effects including in-stent restenosis and stent thr

179 However, APs also have metabolic side effects including increased food intake and body we

180 However, this approach has critical side effects including inflammatory coupling, tumorous v

181 on and melanoma regression; however, adverse side effects, including autoimmunity, can occur.

182 canal decompression carried risks of serious side effects, including hemorrhages and cerebrospinal fl

183 gh trametinib is highly efficacious, adverse side effects, including skin, gastrointestinal, and hepa

184 n be complicated by adverse neuropsychiatric side-effects, including impulsivity.

185 Given the potential side effects, inconvenience, and high cost of anti-VEGFs

186 gand that may curtail drug abuse without the side effects induced by G protein signaling.

187 in treating a disease, while limiting their side effects, is of broad significance.

188 Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approac

189 -related symptoms) plus 15 single symptom or side-effect items: chi(2)=370.233, root mean square erro

190 stant to these medications, while off-target side effects lead to dismal patient adherence to lifelon

191 ent of photodynamic therapy (PDT), undesired side effects like low tumor specificity and the "always-

192 limited by poor patient compliance, adverse side effects, low bioavailability, or undesirable pharma

193 electivity, which might limit cardiovascular side effects, make 3b a valuable starting point for the

194 nding of their safety profiles and potential side effects, making them easier to fast-track to clinic

195 mation, and pain while avoiding psychotropic side effects mediated by CB1.

196 sic to the aging process in hominids and are side effects neither of extended human life span nor of

197 al serous chorioretinopathy (CSCR) is a rare side-effect noted following prolonged topical minoxidil

198 CSCR is a rare side-effect noted following prolonged topical minoxidil

199 well tolerated, with no immediate or delayed side effects observed after injection.

200 whole therapy schedule, no local or systemic side effects occurred.

201 pecies from which it was derived, probably a side effect of a small brain; rather terrestrial habits;

202 otic therapy, a fundamental challenge is the side effect of bleeding.

203 aclitaxel induces peripheral neuropathy as a side effect of cancer treatment.

204 populations in colitis, a common and severe side effect of checkpoint blockade.

205 be an effective therapy for the debilitating side effect of CIPN.

206 hypofunction of salivary glands is a common side effect of radiotherapy for head and neck cancer and

207 nts when faced with adrenal suppression as a side effect of steroids or loss of QOL.

208 cal mechanisms driving clinical efficacy and side effects of a compound.

209 an improve therapeutic efficacies and reduce side effects of anticancer drugs.

210 ewly developed drug delivery systems (DDSs), side effects of cancer chemotherapy could be reduced by

211 and dental implant failure are two negative side effects of chronic aminoBP treatment.

212 nanoplatform that can potentially reduce the side effects of conventional chemotherapies.

213 ation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory dr

214 nicking activity genome-wide to evaluate the side effects of emerging genome editing tools on cells a

215 utics to reduce depression and other harmful side effects of existing medications.

216 ue to insufficient tissue compatible donors, side effects of exogenous insulin administration and/or

217 ug targets to improve specificity and reduce side effects of G protein-coupled receptor-related thera

218 Furthermore, no potential side effects of Gd-lip were found using a complex system

219 tegies may help to mitigate these unintended side effects of IOL implantation.

220 cations due to its own comorbidities and the side effects of its treatment.

221 nausea, vomiting, and diarrhea were the only side effects of letermovir reported by a single patient.

222 the human body is critical to anticipate the side effects of metal-based therapeutics and holds promi

223 ng a potential of this drug to alleviate the side effects of PDE4 inhibitors.

224 Efforts to mitigate the side effects of pharmaceuticals and counteract the life

225 ates a promising strategy for mitigating the side effects of photothermal therapy against a wide spec

226 ects on metabolic syndrome without the known side effects of potent rexinoids.

227 Early side effects of radioiodine therapy (typically mild pain

228 In patients, several side effects of S1P(1) desensitization have been attribu

229 als are necessary to confirm the effects and side effects of SEP-363856, as well as its efficacy rela

230 ptor antagonists for both reduction of motor side effects of SSRIs and augmentation of therapeutic an

231 striae and secondary adrenal suppression as side effects of steroids.

232 erging reports of the supply-side and demand-side effects of the pandemic.

233 Side effects of the systemic drugs used to treat eyes ar

234 delivery systems is crucial to reducing the side effects of therapy.

235 echanistic insights related to the metabolic side effects of these widely used drugs.

236 f pain models without exhibiting the adverse side effects of traditional opiates.

237 re and function in rodent BPD models, severe side effects of VEGF therapy prevent its use in patients

238 Alternatively, niche variation might be a side-effect of neutral genomic diversity in larger popul

239 hey steal from algae by limiting the harmful side-effects of photosynthesis.

240 ernative solutions are required to avoid the side-effects of using these drugs.

241 sorders, but responsiveness is uncertain and side effects often lead to discontinuation.

242 Meanwhile, there are no side effects on normal tissues due to the local treatmen

243 >25 million people benefit), without adverse side effects on other land challenges.

244 dose of 1,950 mg was infused with no adverse side effects or bacterial infection.

245 or VTE treatment, bleeding remains the major side effect, particularly in cancer patients.

246 d home spirometry, reporting of symptoms and side effects, patient-reported outcomes, information, a

247 s of high drug doses and minimize associated side-effects, paving the way for effective clinical tran

248 fe-long immunosuppression and its associated side effects preclude intestinal transplantation if moti

249 topotecan to melphalan did not alter the IAC side effect profile and may contribute to improved globe

250 cy of opioid ligands can explain an improved side effect profile.

251 , less adjunctive therapy, and an acceptable side-effect profile compared with sham-treated eyes.

252 apy-free treatment option with an acceptable side-effect profile that was consistent with previous st

253 this clinical trial, we assessed the safety, side-effect profile, and pharmacokinetics of TY014, a fu

254 esic without abuse liability and an improved side-effect profile.

255 nts vary, however, in both effectiveness and side-effect profile.

256 nt to the antipsychotic, antidepressant, and side effect profiles of the drug.

257 Side effect profiles suggest that SSRIs reduce dopaminer

258 rapy with more benign cardiovascular disease side effect profiles, indoor air pollution), and encoura

259 Evidence of efficacy in other species and side-effect profiles in CL has been limited.

260 h novel mechanisms of action and distinctive side-effect profiles.

261 se of omalizumab is associated with reported side effects ranging from local skin inflammation at the

262 release profile can be used to limit adverse side effects, reduce dosing frequency, and potentially i

263 chanisms responsible for severe inflammatory side effects remain poorly understood.

264 te oropharyngeal events were the most common side-effect, reported in 17 (31%) of 54 patients receivi

265 objective response rates and severe systemic side effects still remain and limit its clinical applica

266 T without premedication, but no subjects had side effect such as asthma attack.

267 Side effects such as cannabinoid hyperemesis syndrome af

268 was highly correlated with the occurrence of side effects such as hemorrhage and edema.

269 treat metabolic syndrome due to the serious side effects such as hypertriglyceridemia and altered th

270 zation reveals that MP135 maintains untoward side effects such as respiratory depression and reward b

271 However, untoward side effects such as tolerance, dependence, respiratory

272 to deplete CART19 cells to reduce long-term side effects, such as B-cell aplasia.

273 dependence, tolerance, and the appearance of side effects, such as respiratory depression and constip

274 in rodents and lacked cardiac and behavioral side effects, suggesting its potential for use in pharma

275 less constipation and respiratory depressant side effects than opioids commonly used to treat pain.

276 ain, and was associated with higher rates of side-effects than placebo.

277 orithm learns latent signatures of drugs and side effects that are both reproducible and biologically

278 tion of these enzymes can trigger collateral side effects that could preclude the practical implement

279 e for new, efficacious opioids devoid of the side effects that have made them the scourge of humanity

280 s in some individuals, and have considerable side effects that impact compliance.

281 rombocytopenia following systemic injection, side effects that might be eliminated by a gut-restricte

282 ral neuropathy is a debilitating and painful side-effect that can severely impact an individual's qua

283 However, because of their cognitive side effects, the question of their influence on the ris

284 cids must also be designed to avoid unwanted side effects; thus, the ability of such carriers to targ

285 resses cancer cells exclusively with minimal side effects to normal cells.

286 ly 1 patient reporting mild gastrointestinal side effects to OVP.

287 hibiting levodopa-induced dyskinesia [LID; a side-effect to dopamine replacement strategies in Parkin

288 of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester fu

289 The most reported side effect was conjunctivitis, occurring in 47 (34%) pa

290 haracteristics, overall outcomes and related side effects were also assessed.

291 While side effects were common and mostly mild to moderate, so

292 with adherence, planning sex in advance, or side effects were infrequent (13.9%).

293 Side effects were mild and transient in all groups.

294 Side effects were more common with hydroxychloroquine th

295 Side effects were more reported in the HCQ group than in

296 Hematologic and nonhematologic side effects were recorded according to the Common Termi

297 Side effects were relatively uncommon but included disco

298 Perioperative side-effects were negligible; one patient experienced gr

299 ts potential specificity and lack of adverse side effects when compared to more traditional modes of

300 lergen preparations and the risk of inducing side effects which results in extremely cumbersome treat