ライフサイエンスコーパス: siderophore

1 atural hinduchelins are weak iron chelators (siderophores).

2 ing step in the biogenesis of the eukaryotic siderophore.

3 imide formation influence its function as a siderophore.

4 xes with enterobactin, the conserved E. coli siderophore.

5 on-limiting conditions using enterobacterial siderophores.

6 iron by high-affinity iron chelators called siderophores.

7 secretion of high-affinity chelators termed siderophores.

8 or its ability to use dozens of heterologous siderophores.

9 o metal charge transfer and/or reaction with siderophores.

10 ample is the production of metal-detoxifying siderophores.

11 ron using strain-specific chelators known as siderophores.

12 a key enzyme involved in the biosynthesis of siderophores.

13 oire of iron-chelating moieties in microbial siderophores.

14 ) were screened for their ability to produce siderophores.

15 bolites, including folates, menaquinone, and siderophores.

16 rations (1-2 pM) of hydrophilic ferrioxamine siderophores.

17 defenses distinguishes it from other E. coli siderophores.

18 olitis, pathogens can scavenge iron by using siderophores.

19 tem and by the production of iron-scavenging siderophores.

20 Anchoring a simple siderophore 2,3-dihydroxybenzoylglycine (H3L), which bea

21 describe components of a reduction-dependent siderophore acquisition pathway that relies on a bacteri

22 e regions are enriched for genes involved in siderophore acquisition, and are widely distributed in c

23 neous distributions of Staphylococcus aureus siderophores across infectious foci, challenging the par

24 mutant had a milder defect in extracellular siderophore activity and induction of epithelial cell da

25 errin biosynthesis in that species, produced siderophore activity in E. coli.

26 er gene frequencies were predictive of known siderophore activity, molecular weights, and a measure o

27 These siderophores affect iron bioavailability and thus may be

28 tes E. coli biosynthesis of the enterobactin siderophore, allowing E. coli growth and biofilm formati

29 We found that secreted siderophores altered microbiome-pathogen interactions fr

30 t the failure mode depends critically on the siderophore analog adsorption density.

31 is necessary for robust adhesion, a suite of siderophore analog surface primers was synthesized with

32 the marketed desferrioxamine mesylate (DFOM) siderophore and applied with experiments performed with

33 igned and synthesized conjugates of a native siderophore and the immunogenic carrier protein cholera

34 The structures show that both siderophore and TonB-binding is required to form a trans

35 lead to altered concentrations of mycobactin siderophores and acylated sulfoglycolipids.

36 etabolites with diverse functions, including siderophores and antibiotics, which often require export

37 ytobeneficial traits, including antibiotics, siderophores and cyclic lipopeptides biosynthesis, some

38 e FD sensors monitored uptake of both ferric siderophores and hemin by the pathogens.

39 nsition metal acquisition systems, involving siderophores and membrane-spanning metal importers, and

40 Secretion of siderophores and organic acids as biochemical weathering

41 une response that targeted bacterial stealth siderophores and protected against UTI.

42 n the presence of common microbial exudates, siderophores and small organic acids.

43 obed in the total synthesis of salmochelins (siderophores) and commercial anti-diabetic drugs (gliflo

44 The MST enzymes (menaquinone, siderophore, and tryptophan biosynthetic enzymes) are st

45 on by heavy metals - a detoxifying effect of siderophores, and exploitation of this detoxifying effec

46 s in the OM as well as the interplay between siderophore- and TonB-binding to the transporter is stil

47 the CTB-siderophore conjugate developed anti-siderophore antibodies in the gut mucosa, and when mice

48 lectively, our results demonstrate that anti-siderophore antibodies inhibit Salmonella colonization.

49 iron may be removed upon import of the holo-siderophore are presented.

50 Because siderophores are a chemically diverse group of molecules

51 Over 500 siderophores are known, but they utilize a small set of

52 Siderophores are natural metal chelating agents that str

53 Because siderophores are nonimmunogenic, we designed and synthes

54 Hydrophilic siderophores are predominantly found across regions of t

55 The siderophores are small molecules produced and released b

56 In addition to Fe, A. vinelandii siderophores are used for the acquisition of the nitroge

57 Because their cognate siderophores are water soluble, we hypothesized that the

58 -affinity iron (Fe) scavenging compounds, or siderophores, are widely employed by soil bacteria to su

59 Iron-specific molecular carriers-siderophores-are noteworthy for their structural eleganc

60 Mutagenesis reveals the aerobactin siderophore as the inhibitor.

61 Given the importance of siderophores as pathogenicity factors, we used transport

62 Second, B. subtilis synthesizes its own siderophore bacillibactin (dhbACEBF) and turns on bacill

63 ursor, 2,3-dihydroxybenzoate, instead of the siderophore bacillibactin.

64 gens, blocking microbial iron acquisition by siderophore-based immunization or other siderophore-targ

65 This siderophore-based mechanism of microbial antagonism may

66 sp diastereomers to the phylogenetic tree of siderophore beta-hydroxylases, methods to predict beta-O

67 y factors, we used transporters specific for siderophore BGCs to identify both known and uncharacteri

68 Upon siderophore binding, conformational changes in the CCSSD

69 the CCSSD:NTSD complex forms prior to ferric-siderophore binding.

70 ntage is counter-regulated by lipocalin 2, a siderophore-binding host protein, which rescues MPO from

71 nd fecal concentrations of the antimicrobial siderophore-binding peptide Lipocalin-2 (Lcn2) are obser

72 r iron theft by Ent, neutrophils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug

73 f ferribactin to pyoverdine is essential for siderophore biogenesis in fluorescent pseudomonads, such

74 e genes that are involved in quorum sensing, siderophore biosynthesis and toxin secretion, and rapidl

75 siologically relevant mode of regulation for siderophore biosynthesis in vivo.

76 e report the horizontal operon transfer of a siderophore biosynthesis pathway from relatives of Esche

77 Siderophore biosynthesis relies on cellular carbon metab

78 on, antibiotics and cytotoxins biosynthesis, siderophore biosynthesis, bioluminescence, vitamin K met

79 horismate and salicylate synthase enzymes of siderophore biosynthesis.

80 e enzymes are also regarded as essential for siderophore biosynthesis.

81 rs in accordance with increased proteins for siderophore biosynthesis.

82 ogram their metabolic pathways to prioritize siderophore biosynthesis.

83 lantibiotic ABC transporters and a putative siderophore biosynthetic cluster.

84 The siderophore biosynthetic enzyme A (SidA) ornithine hydro

85 aspartyl beta-hydroxylases are identified in siderophore biosynthetic gene clusters, which differ in

86 e was known to use reductive iron uptake and siderophore-bound iron transport to scavenge iron from t

87 inflammation, in addition to stabilizing the siderophore-bound labile iron pool.

88 acteroides thetaiotaomicron does not produce siderophores but grows under iron-limiting conditions us

89 We confirmed the selective benefit of siderophores by showing that taxa producing large amount

90 that the production of fewer iron-scavenging siderophores by the pathogen reduces the fitness of the

91 nal modeling, revealing how the chemistry of siderophores can introduce changes to the electronic str

92 Cefiderocol, a novel siderophore cephalosporin in late-stage clinical develop

93 Cefiderocol (CFDC) is a siderophore cephalosporin with activity against Gram-neg

94 The ferric-siderophore complex limits local access to iron because

95 In Gram-negative bacteria, these ferric-siderophore complexes are actively taken up using highly

96 nt for the uptake of structurally similar Fe-siderophore complexes like Fe-aerobactin.

97 The siderophore component binds iron and uses active iron tr

98 Siderophore concentrations in iron-deficient waters aver

99 Mice immunized with the CTB-siderophore conjugate developed anti-siderophore antibod

100 test this hypothesis, we immunized mice with siderophores conjugated to an immunogenic carrier protei

101 Siderophore-conjugated antibiotics that exploit such iro

102 Cefiderocol (formerly S-649266) is a novel siderophore-conjugated cephalosporin with activity again

103 tant to fluoroquinolone antimicrobials and a siderophore-conjugated lactivicin antibiotic designed to

104 isolates and have reduced susceptibility to siderophore-conjugated lactivicin, despite the in vitro

105 istant Pseudomonas aeruginosa, we focused on siderophore-conjugated monocarbams.

106 Siderophore conjugates are thus a promising strategy for

107 re microbiome members with growth-inhibitory siderophores could often suppress the pathogen in vitro

108 Our results suggest that siderophores could partly chelate Fe(III) in cloud water

109 Furthermore, using siderophore-deficient Pseudomonas aeruginosa, we discove

110 isms secrete small molecule chelators called siderophores defined by their ability to bind extracellu

111 For a variety of organic acids and siderophores, delta(53)Cr values of dissolved Cr(III) ar

112 atis (Msmeg), to identify genes required for siderophore dependent and independent fitness when iron

113 able, under mild aqueous conditions, using a siderophore derivative.

114 In the presence of a representative siderophore, desferrioxamine B (DFOB), iron (Fe) was rel

115 CAS assay originally designed for bacterial siderophores detection and later designed for fungus was

116 here the first results with 2D images of the siderophores distribution in the vicinity of the root sy

117 bind the Fe(III) complex of the hexadentate siderophore enterobactin (Kd approximately 0.4 +/- 0.1 m

118 The siderophore enterobactin is secreted by members of the f

119 import or removal of iron from the bacterial siderophore enterobactin were lethal in combination with

120 recognition of its cognate ligand, the iron siderophore enterochelin, this protein can capture and t

121 These pathogen-associated stealth siderophores evade host immune defenses and enhance bact

122 eport that enterobactin (Ent), a catecholate siderophore expressed by Escherichia coli, inhibited PMA

123 lic siderophore, which resembles a bacterial siderophore, facilitates mitochondrial iron import in eu

124 Siderophore-Fe(3+) complexes are recognised by outer-mem

125 ogel, combining self-assembled G-quartet and siderophore-Fe(3+) motifs, is strong, can be molded into

126 responsible for iron acquisition related to siderophores (fepA, fhuA, fecA, iroN, fyuA, iutA).

127 ing a signalling domain) in complex with the siderophore ferrioxamine B and TonB and combine them wit

128 orter (TBDT) that actively imports the small siderophore ferripyoverdine (Fe-Pvd) by coupling to the

129 ns on bacillibactin (feuABC) and hydroxamate siderophore (fhuBCGD) uptake systems to scavenge iron fr

130 ng biosynthesis and subsequent export of Mtb siderophores, followed by ferric iron scavenging and fer

131 on towards taxa that produce relatively more siderophores following copper contamination.

132 zobium japonicum USDA110 does not synthesize siderophores for iron utilization in aerobic environment

133 er perturbed the iron-binding properties and siderophore function of SB as evidenced by experimental

134 ncing (RNA-seq), we identified two predicted siderophore gene clusters (cbs and sch) that were regula

135 ntents and even more strongly to hydroxamate siderophore (HS) concentrations.

136 ssolution of Fe(III) (hydr)oxide minerals by siderophores (i.e., Fe-specific, biogenic ligands) is an

137 ollowed by ferric iron scavenging and ferric-siderophore import into Mtb.

138 exporter that evolved as highly specialized siderophore-import machinery in mycobacteria.

139 sting that these metabolites may function as siderophores in B. gladioli.

140 y, expression of P. aeruginosa proteases and siderophores increased significantly in the burn wound e

141 id supplemented with exogenous siderophores, siderophores increased the growth of hvKP1DeltaiucA, wit

142 at under Fe-limitation the production of all siderophores increases, while under Mo-limitation only c

143 ntributes to low iron fitness in Msmeg, in a siderophore independent manner.

144 es on the UO(2)(2+) binding with a non-toxic siderophore-inspired chelator, 2,6-bis[hydroxy(methyl)am

145 Siderophore-inspired ligands show unprecedented charge-b

146 The siderophore interaction domain is positioned in close pr

147 t mycobactins, which are then reduced by the siderophore interaction domain to facilitate iron releas

148 4), which features an additional cytoplasmic siderophore interaction domain(5).

149 lated genes corresponded to the 3 recognized siderophore iron uptake clusters, reflecting the iron-re

150 a bacteriostatic factor, Lcn2 obstructs the siderophore iron-acquiring strategy of bacteria and thus

151 Living organisms use siderophores (iron carriers in Greek) to effectively ass

152 Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a

153 Siderophores, iron-scavenging small molecules, are funda

154 g iron to competitors incapable of using the siderophore-iron complex.

155 based on manipulating an endogenous protein:siderophore:iron clearance pathway.

156 e beta-hydroxyaspartic acid diastereomers in siderophores is reported herein.

157 ed to acquire this essential nutrient is the siderophore legiobactin.

158 e agent of Legionnaires' disease, secretes a siderophore (legiobactin) that promotes bacterial infect

159 over antibody based systems is the fact that siderophores like pyoverdine can be considered as "immut

160 with Enterobacteriaceae and Staphylococcus, siderophore-like BGCs can be identified from taxa in the

161 Although siderophore-like BGCs from the infant gut are predominan

162 s to identify both known and uncharacterized siderophore-like BGCs in genomes from metagenomes from t

163 bial genomes from premature infant guts have siderophore-like BGCs, but only 3% of those assembled fr

164 yl (UO(2)(2+)) recognition motifs possessing siderophore-like selectivity, however, presents a challe

165 M. tuberculosis produces two classes of siderophore, lipid-bound mycobactin and water-soluble ca

166 tion and polarization in vitro, whereas iron siderophore-loaded NGAL suppressed T(H)17 polarization.

167 that enable 'cross-feeding' on heterologous siderophores made by neighboring organisms, although lit

168 The molecular details of ferric siderophore-mediated activation of the iron import machi

169 uggest that ecological selection will favour siderophore-mediated decontamination, with important con

170 utilizing a secreted metal chelator, akin to siderophore-mediated Fe(III) acquisition.

171 To obtain iron, these pathogens may rely on siderophore-mediated ferric iron uptake, ferrous iron up

172 rotection and opens promising avenues to use siderophore-mediated interactions as a tool for microbio

173 ystems to acquire iron from its environment: siderophore-mediated iron acquisition (SMIA) and heme-ir

174 Because siderophore-mediated iron acquisition is a virulence tra

175 pleiotropic functions mainly rely on NGAL's siderophore-mediated iron transport properties.

176 observed higher coverage of phosphonate and siderophore metabolic pathways in the star coral, Montas

177 potential utility of antimicrobial catechol siderophore mimetics in managing bacterial infections.

178 ssociated with the design and utilization of siderophore-mimicking antibiotics.

179 A series of tetradentate siderophore mimics was synthesized in which the length o

180 This was attributed to the metabolization of siderophore-mobilized Fe from the nanotube structure.

181 n-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the peripla

182 peptide assembly linking SB-217452 with the siderophore moiety.

183 show that competition for iron via secreted siderophore molecules is a good predictor of microbe-pat

184 erium tuberculosis) produces two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cM

185 phore production reveals that investments in siderophore N can represent as much as 35% of fixed N, w

186 in nature where it serves as a precursor to siderophores, neurotoxins and antibiotics.

187 nonribosomal peptide synthetase-independent siderophore (NIS) synthetase.

188 acterized FeEnt uptake by these mutants with siderophore nutrition tests, [(59)Fe]Ent binding and upt

189 technique we detected (i) the production of siderophores on bacteria inoculated ( Pseudomonas fluore

190 rate binding proteins possibly for uptake of siderophores or metabolic precursors.

191 ther in concert with soluble iron-scavenging siderophores or through direct interaction and extractio

192 Here we show that siderophores, organic compounds synthesized by microbes

193 ems that consist of bacterial small molecule siderophores, outer membrane siderophore receptors, the

194 rocess requires preferential production of a siderophore precursor, 2,3-dihydroxybenzoate, instead of

195 hways, to meet carbon and energy demands for siderophore precursors in accordance with increased prot

196 helating siderophore to be serratiochelin, a siderophore previously identified in Serratia plymuthica

197 in B (SB) is a citrate-based polycarboxylate siderophore produced and utilized by the human pathogen

198 Staphyloferrin B (SB) is a siderophore produced by the 9-gene sbn gene cluster for

199 Recently, a siderophore produced by uropathogenic Escherichia coli,

200 Pyoverdines are high affinity siderophores produced by a broad range of pseudomonads t

201 Notably, 42% of the isolates were siderophore producers.

202 ails a close association between diatoms and siderophore-producing organisms during low-iron conditio

203 We show that the proportion of siderophore-producing taxa increases along a natural hea

204 e whether conflicting selection pressures on siderophore production by heavy metals - a detoxifying e

205 However, regulation of siderophore production by Mo- and V-limitation has been

206 terrestrial diazotroph well studied for its siderophore production capacity and its role as a model

207 Inactivation of Ybt siderophore production in AIEC nearly abrogated fibrosis

208 ormation, we conducted an extensive study of siderophore production in N2 -fixing A. vinelandii under

209 fers a unique opportunity to investigate the siderophore production in two dimensions in a wide range

210 ses, while under Mo-limitation only catechol siderophore production is increased, with the strongest

211 mination of the potential nitrogen 'cost' of siderophore production reveals that investments in sider

212 Finally, siderophore production was shown to vary with the origin

213 causal link between metal contamination and siderophore production was subsequently demonstrated in

214 clusters responsible for carbon utilization, siderophore production, and pilus assembly demonstrate f

215 d exopolysaccharide production, dysregulated siderophore production, elevated ribosome synthesis, and

216 robiome that have rarely been recognized for siderophore production.

217 The siderophore-protein conjugates elicited an adaptive immu

218 Siderophores provide fitness advantages to species that

219 t, Pf-5 continues to secrete its own primary siderophore, PVDPf-5 , despite the capability and opport

220 Fluorescent siderophore pyoverdin (PVD) was produced from a soil iso

221 depletion led to increased production of the siderophore pyoverdine by P. aeruginosa to counteract th

222 al cooperation, the secretion of the peptide siderophore pyoverdine by Pseudomonas aeruginosa, under

223 Pseudomonas aeruginosa, we discover that the siderophore pyoverdine is necessary for pathogenesis in

224 stem, the authors show that secretion of the siderophore pyoverdine only incurs a fitness cost and fa

225 Other siderophores (pyoverdine, ferrichrome, deferoxamine) lik

226 ulated onto culture plates supplemented with siderophores (pyoverdines-Fe complex or desferricoprogen

227 ver, a gene encoding a TonB-dependent ferric-siderophore receptor is adjacent to the biosynthetic gen

228 nimal studies revealed that vaccination with siderophore receptor proteins protects against UTI.

229 elate and transport ferric iron (Fe(3+)) via siderophore receptor systems, and pathogenic bacteria ha

230 secretion, cell-cell signalling and classic siderophore receptors for iron acquisition in P. aerugin

231 the expression of six pyoverdine-type (PVD) siderophore receptors in response to their cognate PVD.

232 small molecule siderophores, outer membrane siderophore receptors, the TonB-ExbBD energy-transducing

233 We take advantage of siderophore redundancy within the non-pathogenic mycobac

234 trate that enterobactin (Ent), a catecholate siderophore released by E. coli, is a potent inhibitor o

235 The siderophore rhizoferrin (N(1),N(4)-dicitrylputrescine) i

236 illustrate the novel concept that microbial siderophore's iron-scavenging property may serve as an a

237 monstrate that the efflux transporter of the siderophore SA contributes to the ability of S. aureus t

238 were essential for virulence, along with the siderophore salmochelin.

239 pn; further, Spn relies on exogenous Fe(III)-siderophore scavenging to meet nutritional Fe needs.

240 entous Anabaena sp. PCC 7120 as a model of a siderophore-secreting cyanobacterium.

241 ic substrates results in an increase in both siderophore secretion (up to threefold) and Fe extractio

242 protegens Pf-5, and Pseudomonas putida S12), siderophore secretion is higher during growth on glucone

243 Aspergillus fumigatus siderophore (SidA), a member of class B flavin-dependent

244 an ascites fluid supplemented with exogenous siderophores, siderophores increased the growth of hvKP1

245 Recent work shows that immunizing mice with siderophores (small molecules that microbes produce to c

246 se the production, release, and re-uptake of siderophores, small molecule iron chelators, to scavenge

247 spectral comparison of the IEF extract and a siderophore standard (desferrioxamine; DFO) suggested th

248 The siderophores staphyloferrin A (SA) and staphyloferrin B

249 nt system), it produces two carboxylate-type siderophores staphyloferrin A and staphyloferrin B (SB),

250 ngth of five matches that present in natural siderophores such as enterobactin and azotochelin.

251 Siderophores, such as enterobactin (Ent), are small mole

252 e produced in the majority of mixed function siderophores, such as pyoverdines, which bear a photoact

253 showing that taxa producing large amounts of siderophore suffered less growth inhibition in toxic cop

254 ethionine recycling pathway as well as phyto-siderophore synthesis genes.

255 ncodes a pleiotropic enzyme also involved in siderophore synthesis, impacted virulence to a greater e

256 t senses heme to control gene expression for siderophore synthesis.

257 Pyoverdines are siderophores synthesized by fluorescent Pseudomonas spp.

258 o confirm and knowledge of the full suite of siderophores synthesized by this organism has only recen

259 ibitor of the virulence-associated pyochelin siderophore system in Pseudomonas aeruginosa.

260 n survival strategies that are separate from siderophore systems.

261 h single and double mutants for the putative siderophore systems.

262 n by siderophore-based immunization or other siderophore-targeted approaches may represent a novel st

263 proteins transport cell envelope lipids and siderophores that are important for the basic physiology

264 gous to the imide forms of other citric acid siderophores that are often observed when these molecule

265 Pyoverdines are important siderophores that guarantee iron supply to important pat

266 and it expresses transporters for many other siderophores that it does not synthesize.

267 robes optimize iron acquisition by producing siderophores that minimize diffusive losses to the envir

268 t such defenses by secreting iron-scavenging siderophores that promote iron uptake and alleviate iron

269 production of small organic molecules called siderophores that scavenge iron from host proteins(1).

270 hogen-suppressive microbiome members produce siderophores that the pathogen cannot use.

271 e elements, e.g. vitamin B12, heme, and iron-siderophores) the role of ATP remains debatable.

272 nd amphibactins as well as a novel family of siderophores, the crochelins.

273 etry-based analysis identified the chelating siderophore to be serratiochelin, a siderophore previous

274 the G-quartet gel, acts as a supramolecular siderophore to form red complexes with Fe(3+) .

275 Microbes use siderophores to access essential iron resources in the e

276 Bacteria use siderophores to mediate the transport of essential Fe(II

277 Addition of P. aeruginosa siderophores to R. microsporus spores in the zebrafish l

278 Bacteria use small molecules called siderophores to scavenge iron.

279 Many cyanobacteria secrete siderophores to sequester iron.

280 Similar to LbtU, LbtP is a siderophore transport protein and is required for robust

281 ically diverse group of molecules, with each siderophore type relying on a compatible receptor for ir

282 ng ferritin, flavodoxin, Fe transporters and siderophore uptake genes were more abundant in low-Fe wa

283 nce the probability for mutations within the siderophore uptake systems of bacteria is very low.

284 ort system, has adapted to bind tetradentate siderophores using a His and a Tyr side chain to complet

285 tom lineages, suggesting the significance of siderophore utilization by diatoms in the marine environ

286 find that the newly discovered A. vinelandii siderophore vibrioferrin is almost completely repressed

287 n, transport or utilization of mycobacterial siderophores, we identify novel putative low iron surviv

288 onstrate its applicability, metal scavengers siderophores were imaged directly from agar culture of S

289 ere microbiome members with growth-promotive siderophores were often inferior in competition and faci

290 Small iron-chelating molecules called siderophores were selected as antigens to vaccinate agai

291 Previously, we showed that a cytosolic siderophore, which resembles a bacterial siderophore, fa

292 report an immunization approach that targets siderophores, which are small molecules exported by ente

293 in the production of hydroxamate-containing siderophores, which are used by the pathogen to sequeste

294 was mediated via the secretion of bacterial siderophores, which induced iron stress on the fungus.

295 were dominated by amphibactins, amphiphilic siderophores with cell membrane affinity.

296 ential Fe(III), bacteria produce and secrete siderophores with high affinity and selectivity for Fe(I

297 ghly conserved calyx-like cavity, among them siderophores with the strongest known capability to comp

298 f host-pathogen iron competition, by mapping siderophores within infected tissue.

299 spatial distribution at millimeter scale of siderophores within the root's system.

300 the high-pathogenicity island, encoding the siderophore yersiniabactin, which belongs to the same ch